Title,"Funding Opportunity Number","Grants URL","Funding Status","Expiration Date",Purpose,"Grant Mechanism","Priority Area",Program,"Research Area"
"Notice of Change: NINDS Participation in RFA-EY-25-001: BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)",NOT-NS-25-012,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-25-012.html,Notices,2028-01-01,"NINDS is joining for BRAIN.",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative: Brain Behavior Quantification and Synchronization- Next Generation Sensor Technology Development (U01 Clinical Trial Optional)",NOT-MH-24-365,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-24-365.html,Notices,2028-01-01,"This NOFO solicits applications for next generation sensor and bioelectronic device development that will synchronize with brain recordings. The sensor and neural recording data will be used to generate new computational models of behavior in human and animal models. There has been a lack of quantitative approaches and models to understand the complexity of human and animal behavior in naturalistic settings. This NOFO focuses on the development of next generation sensors to acquire data and synchronize it with simultaneous brain recordings to build computational models.",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)",NOT-NS-24-130,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-24-130.html,Notices,2028-01-01,"This announcement supports Specialized Projects to develop current or emerging technologies to generate comprehensive atlases of brain connectivity, with an emphasis on human, non-human primate (NHP), and mouse.  Projects validating approaches using other species are also permitted if well justified.  Applications may address any aspects of the data collection, analysis, and dissemination pipelines, to enable faster and more cost-effective generation and interpretation of brain-wide wiring diagrams.  Projects will offer distinct capabilities and competencies aimed at developing and optimizing current technologies or entirely new and potentially risky approaches.  They will be integrated into the BRAIN CONNECTS Network, consisting of other Specialized Projects from this FOA, and Comprehensive Centers from its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.",,,,
"Notice of Termination of RFA-NS-24-028: BRAIN Initiative Connectivity across Scales Data Coordinating Center (BRAIN CONNECTS DCC) (U24 Clinical Trial Not Allowed)",NOT-NS-24-127,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-24-127.html,Notices,2028-01-01,"Expiring this NOFO.",,,,
"Notice of Change to receipt date for RFA-NS-23-023: BRAIN Initiative: Targeted BRAIN Circuits Planning Projects  TargetedBCPP (R34 Clinical Trials Not Allowed)",NOT-NS-24-083,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-24-083.html,Notices,2028-01-01,"Canceling the June 2024 receipt date.",,,,
"Notice of Change: Cancelation of RFA-NS-23-024 ""BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 Clinical Trial Not Allowed)""",NOT-NS-24-088,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-24-088.html,Notices,2028-01-01,"Canceling NOFO.",,,,
"Notice of Change: Cancelation of RFA-NS-22-041 ""BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01 Basic Experimental Studies with Humans Required)""",NOT-NS-24-090,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-24-090.html,Notices,2028-01-01,"Canceling NOFO.",,,,
"Notice of Change: Cancelation of RFA-NS-23-025 ""BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01 Clinical Trials Optional)""",NOT-NS-24-087,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-24-087.html,Notices,2028-01-01,"Canceling NOFO.",,,,
"Request for Information (RFI): BRAIN Initiative: Opportunities and Challenges for Coordinated Neural Stimulating and Recording Efforts to Advance Understanding of Human Neuroscience and Behavior",NOT-NS-24-080,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-24-080.html,Notices,2028-01-01,"This is a Request for Information (RFI) from the NIH BRAIN Initiative that solicits input about advancing human neuroscience research on brain-behavior relationships through coordinated efforts involving neural stimulation and recording. 
This RFI seeks input from scientific research communities, healthcare providers, patient advocacy groups, people with lived experience of brain or behavioral health disorders, educators, and other interested parties. The NIH encourages organizations (e.g., patient advocacy groups, professional organizations) to submit a single response reflective of the views of the organization and membership as a whole.",,,,
"Notice of Change: Extension of RFA-NS-24-028 - BRAIN Initiative Connectivity across Scales Data Coordinating Center (BRAIN CONNECTS DCC) (U24 Clinical Trial Not Allowed)",NOT-NS-24-025,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-24-025.html,Notices,2028-01-01,"The purpose of this notice is to extend RFA-NS-24-028BRAIN Initiative Connectivity across Scales Data Coordinating Center (BRAIN CONNECTS DCC) (U24 Clinical Trial Not Allowed) by one additional council round.
An additional receipt date, August 21, 2024, has been added and the new expiration date is August 22, 2024.",,,,
"Notice of Special Interest (NOSI): Translation of BRAIN Initiative Technologies to the Marketplace",NOT-MH-24-115,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-24-115.html,Notices,2027-04-06,"This Notice of Special Interest (NOSI) encourages the translation of the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative-supported technologies from academic and other non-small business research sectors to the marketplace. Small Business Concerns (SBCs) are encouraged to submit Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grant applications that propose to further develop, optimize, validate and scale such technologies for commercial dissemination. Additionally, SBIR and STTR applications supporting the development and commercialization of novel technologies that fit within the mission of the BRAIN Initiative are encouraged.",,,,
"Notice of Change: Post-Submission Materials for RFA-NS-24-005 - BRAIN Initiative: Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)",NOT-NS-24-042,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-24-042.html,Notices,2028-01-01,"Allowing post-submission materials.",,,,
"Request for Information (RFI): BRAIN Initiative: Brain Behavior Quantification and Synchronization: Guidance for Opportunities in Development of Sensor Technology Hubs",NOT-MH-24-125,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-24-125.html,Notices,2028-01-01,"This is a request for information to gather ideas and commentary on the potential development and program planning of hubs or centers for testing sensor performance. Responses will be examined for enthusiasm and general support for the creation of several hubs for testing sensors that are developed by not only NIH awardees, but the broader engineering community.",,,"BBQS, Investigative Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)",NOT-NS-24-017,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-24-017.html,Notices,2028-01-01,"This Notice of Intent to Publish is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects for the following Notice of Funding Opportunity (NOFO), which is expected to be published in January 2024, with an anticipatedapplication receipt date in May 2024.
The Brain Research through Advancing Innovative Neurotechnologies(BRAIN) Initiative intends to promote a new initiative by publishing a NOFO to solicit applications that would support development and preclinical testing, beginning withproof of concept,of next-generation recording and/or modulation devices for human use to further our understanding of the human central nervous system and treat nervous system disorders.",,,,
"Notice of Change to Funding Opportunity Announcement, RFA-DC-24-001, BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Basic Experimental Studies with Humans Required)",NOT-DC-24-004,http://grants.nih.gov/grants/guide/notice-files/NOT-DC-24-004.html,Notices,2028-01-01,"The purpose of this Notice is to inform interested applicants that late applications will be accepted for RFA-DC-24-001 "" BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Basic Experimental Studies with Humans Required)"" .",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative Connectivity across Scales Data Coordinating Center (BRAIN CONNECTS DCC) (U24 Clinical Trial Not Allowed)",NOT-NS-24-009,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-24-009.html,Notices,2028-01-01,"This Notice of Funding Opportunity (NOFO) solicits applications for one or more Data Coordinating Centers (DCCs) to support BRAIN CONNECTS, a networked consortium of Comprehensive Centers and Specialized Projects funded under RFA-NS-22-047, RFA-NS-22-048, and RFA-NS-22-049.  The goals of these awards are to develop the research capacity and technical capabilities for comprehensive brain-wide connectivity mapping in mouse, human, and non-human primate (NHP).  BRAIN CONNECTS projects will collect and process unprecedented volumes of anatomical data by scaling up cutting-edge acquisition modalities and analysis methods, to demonstrate the feasibility of collecting, reconstructing, analyzing, integrating, disseminating, and interpreting connectivity maps from entire brains. The resulting feasibility data from these awards are expected to inform NIH decisions on program continuation in a potential subsequent five-year funding period for production of brain-wide wiring diagrams. 
NIH expects to fund one or more BRAIN CONNECTS DCCs, which will collaborate with CONNECTS data generating projects to (1) coordinate activities of the BRAIN CONNECTS Network, (2) develop and harmonize common data processing pipelines, (3) integrate and disseminate data analytic tools and capabilities, (4) establish a unified knowledge base for connectivity data of diverse modalities, and (5) organize and implement outreach and engagement to the wider research community and the general public.  Awards will be integrated into the BRAIN CONNECTS Network as a coordinated effort aimed at developing the ability to generate wiring diagrams spanning entire brains across multiple scales and species.",,,,
"Notice of Change to Application and Submission Information for RFA-NS-23-026 ""BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)""",NOT-NS-23-086,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-23-086.html,Notices,2028-01-01,"The purpose of this notice is to inform applicant of a change to the Application and Submission Information - Post Submission Materials for RFA-NS-23-026 ""BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)"".",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)",NOT-NS-23-035,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-23-035.html,Notices,2028-01-01,"Reissue of RFA-NS-18-020: Understanding the dynamic activity of brain circuits is central to the NIH BRAIN Initiative.  This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS).  This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain.  It is expected that the proposed research may be high-risk, but if successful, could profoundly change the course of neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS.  Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, magnetic, acoustic and/or genetic recording/manipulation.  Applications that seek to integrate multiple approaches are encouraged.  If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative: Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)",NOT-NS-23-036,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-23-036.html,Notices,2028-01-01,"Reissue of RFA-NS-18-019: Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS).  These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research.Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS.  Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording/manipulation.  Applications that seek to integrate multiple approaches are encouraged.  If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.",,,,
"Notice of Early Expiration of NINDS BRAIN Initiative Funding Opportunity Announcements (FOA) RFA-NS-21-026 and RFA-NS-21-027",NOT-NS-23-037,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-23-037.html,Notices,2028-01-01,"The purpose of this notice is to inform applicants of the early expiration of RFA-NS-21-026 ""BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)"" and RFA-NS-21-027 ""BRAIN Initiative: Optimization of Transformative Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)"".  The remaining receipts date of May 1, 2023 and October 27, 2023 have been cancelled.",,,,
"Notice of Special Interest (NOSI): BRAIN Initiative: Developing Data Archive, Informatics Tools and Data Standards for Brain Behavior Quantification and Synchronization (BBQS)",NOT-MH-23-115,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-23-115.html,Notices,2026-07-15,"This NOSI supports creation of data archive(s), development of software tools, and establishment of data standards for BBQS-related studies to address the above-described challenges in the research program. The informatics infrastructure and tools to be developed under this NOSI are expected to be widely used by BBQS investigators, as well as by a broader community. Applications in response to this NOSI should therefore clearly justify the importance and implications of the proposed informatics infrastructure or tools to the BBQS program, and identify the potential user base. The projects funded under this NOSI are expected to support, communicate and collaborate with the funded BBQS research projects. Applicants should therefore familiarize themselves with the BBQS research program and funded projects (https://www.braininitiative.nih.gov/funding/initiatives.htm; also see RFA-MH-22-240 and RFA-DA-23-030).",,,,
"Notice of Correction to Eligibility Criteria for RFA-NS-22-011 ""BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)""",NOT-NS-23-047,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-23-047.html,Notices,2028-01-01,"The purpose of this notice is to inform applicants of a correction to the Eligibility Information for RFA-NS-22-011 ""BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed). For this Funding Opportunity Announcement (FOA), ""Section III. Eligibility Information"" has been corrected to allow intramural participation. This is consistent with the intramural participation language in ""Section IV. Application and Submission Information, 7. Other Submission Requirements and Information"".",,,,
"Notice of Pre-Application Technical Assistance Webinar for RFA-DA-23-030, ""BRAIN Initiative: Brain-Behavior Quantification and Synchronization  Transformative and Integrative Models of Behavior at the Organismal Level (R34 Clinical Trial Not Allowed)""",NOT-DA-22-083,http://grants.nih.gov/grants/guide/notice-files/NOT-DA-22-083.html,Notices,2028-01-01,"On October 11, 2022, the National Institute on Drug Abuse and BRAIN Initiative published the Funding Opportunity Announcement, RFA-DA-23-030, BRAIN Initiative: Brain-Behavior Quantification and Synchronization  Transformative and Integrative Models of Behavior at the Organismal Level (R34 Clinical Trial Not Allowed) to solicit applications supporting planning activities that will lay the groundwork for a scientific projects aiming to 1) develop and apply cutting-edge tools and methods for minimally invasive, multi-dimensional, high-resolution measurement of behavior at the level of the organism, with synchronous capture of data from the environment; and/or 2) develop computational methods that allow for integration of multidimensional behavioral and environmental data into a conceptual and/or computational model of behavior as a complex dynamic system.
This Notice provides information regarding two upcoming Pre-Application Webinars for the above-referenced FOA. At these Webinars, Program and Review Officials from NIDA and other institutes participating in the BRAIN Initiative will provide a brief overview of this RFA and address questions from prospective applicants.
Webinar Information
Option 1
Date: Tuesday, November 22, 2022,
Time: 11 am EST
The webinar will be hosted through Zoom. Participants must register in advance for the webinar through the following link, after which a link to join the webinar will be e-mailed to the participant:
NIH Zoom Webinar link: https://scgcorp.zoom.us/meeting/register/tZUkcOGrrj4jGtBm0XWaz_OYurAyDm…
Option 2
Date: Monday, November 28, 2022,
Time: 1 pm EST
The webinar will be hosted through Zoom. Participants must register in advance for the webinar through the following link, after which a link to join the webinar will be e-mailed to the participant:
NIH Zoom Webinar link: https://scgcorp.zoom.us/meeting/register/tZIqd-qvrTkrGNE22c1MQMmAdJ8Zf4…",,,,
"Notice of Pre-Application and Technical Assistance Webinar for RFA-MH-22-240, ""BRAIN Initiative: Brain Behavior Quantification and Synchronization (R61/R33 Clinical Trial Optional)""",NOT-MH-22-315,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-22-315.html,Notices,2028-01-01,"This notice alerts applicants about an upcoming Pre-Application and Technical Assistance Webinar for RFA-MH-22-240 on October 24, 2022.",,,,
"Notice of Pre-Application and Technical Assistance Webinar for RFA-MH-22-240, ""BRAIN Initiative: Brain Behavior Quantification and Synchronization (R61/R33 Clinical Trial Optional)""",NOT-MH-22-290,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-22-290.html,Notices,2028-01-01,"This notice alerts applicants about an upcoming Pre-Application and Technical Assistance Webinar for RFA-MH-22-240 on September 22, 2022.",,,,
"Notice of Correction to Key Dates for RFA-NS-22-040 ""BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Not Allowed)""",NOT-NS-22-112,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-22-112.html,Notices,2028-01-01,"The purpose of this notice is to correct the key dates section of RFA-NS-22-040 ""BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Not Allowed)"".",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative: Engineering and optimization of molecular technologies for functional dissection of neural circuits (UM1 Clinical Trial Not Allowed)",NOT-MH-22-265,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-22-265.html,Notices,2028-01-01,"This BRAIN Initiative FOA is to further develop molecular tools of high impact that are targetable to brain cell types for the monitoring and manipulation of neural circuits in experimental animals.  This FOA is part of the BRAIN Initiative Armamentarium for Brain Cell Access transformative project.  This will support iterative improvement of molecular payloads capable of monitoring and manipulating neural cell activity and that can be delivered to specific brain cell types using targeting technologies.",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative: Transformative Brain Non-invasive Imaging Technology Development",NOT-EB-22-007,http://grants.nih.gov/grants/guide/notice-files/NOT-EB-22-007.html,Notices,2028-01-01,"The NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative intends to issue RFA-EB-22-001, BRAIN Initiative: Transformative Brain Non-invasive Imaging Technology Development.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 
The FOA is expected to be published in summer 2022 with an expected application due date in fall 2022
This FOA will utilize the UG3/UH3 activity code. Details of the planned FOA are provided below.",,,,
"Notice to Extend RFA-MH-21-180, BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access and Manipulation to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)",NOT-MH-22-250,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-22-250.html,Notices,2028-01-01,"This Notice modifies key dates of RFA-MH-21-180.",,,,
"Notice of Informational Webinar for BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS) Funding Opportunity Announcements",NOT-NS-22-100,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-22-100.html,Notices,2028-01-01,"This Notice is to announce the availability of an informational webinar video with overview information on program goals, application instructions, and project responsiveness for RFA-NS-22-047, RFA-NS-22-048,and RFA-NS-22-049, which are the initiating FOAs for the BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS) Program. The pre-recorded video is optional and is not required for submission of an application.",,,,
"Notice of Change to NOT-NS-21-014 ""Notice of Special Interest (NOSI): Availability of Administrative Supplements for BRAIN Initiative Awardees to Support Resource Dissemination""",NOT-NS-22-106,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-22-106.html,Notices,2028-01-01,"The purpose of this notice is to clarify the Eligibility Criteria for NOT-NS-21- 014 ""Notice of Special Interest (NOSI): Availability of Administrative Supplements for BRAIN Initiative Awardees to Support Resource Dissemination"".",,,,
"Notice to Extend the Response Date for NOT-NS-22-044 ""BRAIN Initiative: Request for Information (RFI) on Industry Collaboration in Development and Dissemination of Non-Invasive Brain Imaging Technologies""",NOT-NS-22-093,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-22-093.html,Notices,2028-01-01,"The purpose of this notice is to extend the response date for NOT-NS-22-044 ""BRAIN Initiative: Request for Information (RFI) on Industry Collaboration in Development and Dissemination of Non-Invasive Brain Imaging Technologies"".",,,,
"Notice of Change to Due Dates and Eligibility Criteria for NOT-NS-21-014, ""Notice of Special Interest (NOSI): Availability of Administrative Supplements for BRAIN Initiative Awardees to Support Resource Dissemination""",NOT-NS-22-082,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-22-082.html,Notices,2028-01-01,"The purpose of this notice is to inform applicants of a change to the Due Dates and Eligibility Criteria for NOT-NS-21-014 ""Notice of Special Interest (NOSI): Availability of Administrative Supplements for BRAIN Initiative Awardees to Support Resource Dissemination"".",,,,
"BRAIN Initiative: Request for Information (RFI) on Industry Collaboration in Development and Dissemination of Non-Invasive Brain Imaging Technologies",NOT-NS-22-044,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-22-044.html,Notices,2028-01-01,"This Request for Information (RFI) is issued by the Institutes and Centers of The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. We are soliciting input on opportunities to facilitate collaborations between academic/clinical researchers and potential commercial partners, to enhance the development and dissemination of non-invasive brain imaging technologies. Input is requested from stakeholders such as academic investigators and industry representatives, and the general public.",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)",NOT-NS-22-047,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-22-047.html,Notices,2028-01-01,"This Funding Opportunity Announcement (FOA) supports Specialized Projects to develop current or emerging technologies to generate comprehensive atlases of brain connectivity, with an emphasis on human, non-human primate (NHP), and mouse.  Projects validating approaches using other species are also permitted if well justified.  Applications may address any aspects of the data collection, analysis, and dissemination pipelines, to enable faster and more cost-effective generation and interpretation of brain-wide wiring diagrams.  Projects will offer distinct capabilities and competencies aimed at developing and optimizing current technologies or entirely new and potentially risky approaches.  They will be integrated into the BRAIN CONNECTS Network, consisting of other Specialized Projects from this FOA, and Comprehensive Centers from its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Comprehensive Centers for Human and Non-Human Primate Brain (UM1 Clinical Trial Not Allowed)",NOT-NS-22-045,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-22-045.html,Notices,2028-01-01,"This Funding Opportunity Announcement (FOA) supports Comprehensive Centers to develop and test technologies that can be scaled to brain-wide atlases of human and non-human primate circuit connectivity.  Centers will establish data collection, analysis, and dissemination pipelines to demonstrate the feasibility of mapping region-to-region connectivity with a minimum resolution of individual cells and/or axon fibers.  They will demonstrate the significance of the approach within the context of a chosen CNS sub-volume, by testing specific hypotheses relating circuit structure to function.  They will also incorporate toolsets and infrastructure for integrating separately collected data from smaller volumes, as well as from other data collection modalities, and for enabling the neuroscience community to interact with and mine the data for new research questions.  Centers will be integrated into the BRAIN CONNECTS Network, consisting of projects from this FOA and its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Comprehensive Centers for Mouse Brain (UM1 Clinical Trial Not Allowed)",NOT-NS-22-046,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-22-046.html,Notices,2028-01-01,"This Funding Opportunity Announcement (FOA) supports Comprehensive Centers to develop and test technologies that can be scaled to brain-wide atlases of mouse circuit connectivity.  Centers will establish data collection, analysis, and dissemination pipelines to demonstrate the feasibility of mapping cell-to-cell connectivity with a minimum resolution of synaptic connections.  They will demonstrate the significance of the approach within the context of a chosen CNS sub-volume, by testing specific hypotheses relating circuit structure to function.  They will also incorporate toolsets and infrastructure for integrating separately collected data from smaller volumes, as well as from other data collection modalities, and for enabling the neuroscience community to interact with and mine the data for new research questions.  Centers will be integrated into the BRAIN CONNECTS Network, consisting of projects from this FOA and its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.",,,,
"Notice of Change to Key Dates of RFA-MH-21-175, ""BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)""",NOT-MH-21-345,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-21-345.html,Notices,2028-01-01,"This Notice modifies key dates of RFA-MH-21-175.",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Required)",NOT-NS-21-062,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-062.html,Notices,2028-01-01,"This FOA will support integrated, interdisciplinary research teams from prior BRAIN technology and/or integrated approaches teams, and/or new projects from the research community that focus on examining circuit functions related to behavior, using advanced and innovative technologies.  The goal will be to support programs with a team science approach that can realize meaningful outcomes within 5-plus years.  Awards will be made for 5 years, with a possibility of one competing renewal.  Applications should address overarching principles of circuit function in the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis.  Applications should incorporate theory-/model-driven experimental design and should offer predictive models as deliverables. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions.  Applications are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate. Applications will be required to manage their data and analysis methods in a prototype framework that will be developed and used in the proposed U19 project and exchanged with other U19 awardees for further refinement and development. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Budgets should be commensurate with multi-component teams of research expertise  including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate - that seek to cross boundaries of interdisciplinary collaboration.",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Not Allowed)",NOT-NS-21-063,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-063.html,Notices,2028-01-01,"This FOA will support integrated, interdisciplinary research teams from prior BRAIN technology and/or integrated approaches teams, and/or new projects from the research community that focus on examining circuit functions related to behavior, using advanced and innovative technologies. The goal will be to support programs with a team science approach that can realize meaningful outcomes within 5-plus years.  Awards will be made for 5 years, with a possibility of one competing renewal.  Applications should will incorporate overarching principles of circuit function in the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis.  Applications should incorporate theory-/model-driven experimental design and should offer predictive models as deliverables. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions.  Applications are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate. Applications will be required to manage their data and analysis methods in a prototype framework that will be developed and used in the proposed U19 project and exchanged with other BRAIN U19 awardees for further refinement and development. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Programs should employ multi-component teams of research expertise  including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate - that seek to cross boundaries of interdisciplinar",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01 Clinical Trial Required)",NOT-NS-21-064,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-064.html,Notices,2028-01-01,"Invasive surgical procedures provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans.  Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a manner that addresses research questions with appropriate statistical power.  Therefore, this RFA seeks applications to assemble diverse, integrated, multi-disciplinary teams that cross boundaries of interdisciplinary collaboration to overcome these fundamental barriers and to investigate high-impact questions in human neuroscience.  Projects should maximize opportunities to conduct innovative in vivo neuroscience research made available by direct access to brain recording and stimulating from invasive surgical procedures. Projects should employ approaches guided by specified theoretical constructs and quantitative, mechanistic models where appropriate.
Awardees will join a consortium work group, coordinated by the NIH, to identify consensus standards of practice, including neuroethical considerations, to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.",,,,
"Notice of Change in Application Type for BRAIN Initiative: Team-Research BRAIN Circuit Programs  TeamBCP",NOT-NS-21-065,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-065.html,Notices,2028-01-01,"Change of application types allowed for BRAIN Initiative: Team-Research BRAIN Circuit Programs  TeamBCP, RFA-NS-19-002 (U19 Clinical Trial Required) and RFA-NS-19-003 (U19 Clinical Trial Not Allowed).  
Effective immediately, this Notice allows Type 2, renewal applications for the remaining receipt date on October 29, 2021 by 5:PM local time of the applicant organization.  Acceptance of new Type 1 applications remains unchanged.",,,,
"Notice of Correction to Eligibility Information of RFA-MH-21-180, ""BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access and Manipulation to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)""",NOT-MH-21-280,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-21-280.html,Notices,2028-01-01,"This notice corrects the eligibility information for RFA-MH-21-180, ""BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access and Manipulation to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)"" to clarify that NIH intramural candidates are eligible to apply.",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative Cell Atlas Network (BICAN): Comprehensive Center on Human and Non-human Primate Brain Cell Atlases (UM1 Clinical Trial Not Allowed)",NOT-MH-21-260,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-21-260.html,Notices,2028-01-01,"NOITP for RFA-MH-21-235 This Funding Opportunity Announcement (FOA) intends to support a group of large-scale Comprehensive Centers that will adopt scalable technology platforms and streamlined sampling strategies and assay cascade to create comprehensive and highly granular brain cell atlases of human and non-human primates with an emphasis on human. The Centers are expected to characterize all brain cell types (neurons, glia, and other non-neuronal cells) at high-resolution. The overarching goal of the BICAN is to build reference brain cell atlases that will be widely used throughout the research community, providing a molecular and anatomical foundational framework for the study of brain function and disorders.",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative Cell Atlas Network (BICAN): Specialized Collaboratory on Human, Non-human Primate, and Mouse Brain Cell Atlases (U01 Clinical Trial Not Allowed)",NOT-MH-21-261,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-21-261.html,Notices,2028-01-01,"NOITP for RFA-MH-21-236 This Funding Opportunity Announcement (FOA) intends to support a group of Specialized Collaboratories that will adopt scalable technology platforms and streamlined sampling strategies and assay cascade to create comprehensive and highly granular brain cell atlases in human, non-human primates, and mouse, in coordination and collaboration with other BICAN projects. In particular, the Specialized Collaboratories are expected to complement the Comprehensive Centers in BICAN with distinct capabilities, competencies, and research aims. The overarching goal of the BICAN is to build reference brain cell atlases that will be widely used throughout the research community, providing a molecular and anatomical foundational framework for the study of brain function and disorders.",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative Cell Atlas Network (BICAN): Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) (U24 Clinical Trial Not Allowed)",NOT-MH-21-262,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-21-262.html,Notices,2028-01-01,"NOITP for RFA-MH-21-237 This Funding Opportunity Announcement (FOA) intends to support a Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) that will be composed of four components to establish respectively (1) a common sequencing data processing pipeline, (2) a common imaging data processing pipeline, (3) a comprehensive brain cell knowledge base, and (4) an engaging and outreach component to coordinate the research within and beyond BICAN. The overall goals of CUBIE are to (i) enable the exploration of large-scale brain cell atlas data and knowledge, and inspire research in brain function and disorders; and (ii) ensure research rigor and data reproducibility by making the data to be findable, accessible, interoperable, and reusable, and the process transparent. An application is expected to propose only one of the above four respective components.",,,,
"Notice of Change: Receipt date added for RFA-EB-20-002, ""BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)",NOT-EB-21-006,http://grants.nih.gov/grants/guide/notice-files/NOT-EB-21-006.html,Notices,2028-01-01,"The purpose of this Notice is to inform interested applicants that the expiration date in PAR-18-205 "" NIBIB Biomedical Technology Resource Centers (P41 Clinical Trials Optional)"" will be extended by one receipt cycle (See changes in bold italics below).
Part 1. Overview
Key Dates
Currently Reads: Expiration Date January 8, 2021
Modified to Read: Expiration Date May 8, 2021
All other aspects of this FOA remain unchanged.",,,,
"Notice of Intent to Publish the Reissuance of RFA-NS-18-020, BRAIN Initiative: Novel Technologies and Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)",NOT-NS-21-051,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-051.html,Notices,2028-01-01,"Reissue of RFA-NS-18-020: Understanding the dynamic activity of brain circuits is central to the NIH BRAIN Initiative.  This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS).  This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain.  It is expected that the proposed research may be high-risk, but if successful, could profoundly change the course of neuroscience research. 
Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS.  Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, magnetic, acoustic and/or genetic recording/manipulation.  Applications that seek to integrate multiple approaches are encouraged.  If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.",,,,
"Notice of Intent to Publish the Reissuance of RFA-NS-18-019, BRAIN Initiative: Optimization of Transformative Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)",NOT-NS-21-052,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-052.html,Notices,2028-01-01,"Reissue of RFA-NS-18-019: Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS).  These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research.
Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS.  Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording/manipulation.  Applications that seek to integrate multiple approaches are encouraged.  If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.",,,,
"Notice of Change to Key Dates for RFA-NS-20-006 ""BRAIN Initiative: Biology and Biophysics of Neural Stimulation and Recording Technologies (R01 Clinical Trials Optional)""",NOT-NS-21-046,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-046.html,Notices,2028-01-01,"This notice informs applicants of a change to the Key Dates for RFA-NS-20-006 ""BRAIN Initiative: Biology and Biophysics of Neural Stimulation and Recording Technologies (R01 Clinical Trials Optional)"". Two of the receipt dates, the October 1, 2021 and June 1, 2022 receipt dates have been cancelled from this Funding Opportunity Announcement (FOA).",,,,
"BRAIN Initiative: Request for Information (RFI) on Development and Dissemination of Human Brain Imaging Technologies",NOT-NS-21-024,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-024.html,Notices,2028-01-01,"The purpose of this Request for Information (RFI) is to solicit public input for NIH on investments for The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative in non-invasive human brain imaging technologies.",,,,
"Notice of Change to Funds Available and Anticipated Number of Awards for RFA-MH-21-140, ""BRAIN Initiative Cell Census Network (BICCN) Scalable Technologies and Tools for Brain Cell Census (R01 Clinical Trial Not Allowed)""",NOT-MH-21-155,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-21-155.html,Notices,2028-01-01,"This notice increases the Funds Available and Anticipated Number of Awards for RFA-MH-21-140.",,,,
"Notice of Change to Key Dates for RFA-NS-19-002 ""BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Required)",NOT-NS-21-002,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-002.html,Notices,2028-01-01,"The purpose of this notice is to inform interested applicants of a change to the Key Dates and the specific research requirements for RFA-NS-19-002 ""BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Required)"". The dates have been modified to add a new application due date of October 29, 2021. See changes below inbold italics.",,,,
"Notice of Change to Key Dates for RFA-NS-19-003 ""BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Not Allowed)",NOT-NS-21-003,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-003.html,Notices,2028-01-01,"The purpose of this notice is to inform interested applicants of a change to the Key Dates and the specific research requirements for RFA-NS-19-003 ""BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Not Allowed)"". The dates have been modified to add a new application due date of October 29, 2021. See changes below inbold italics.",,,,
"Notice of Change to Key Dates for RFA-NS-19-001 ""BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01 Clinical Trial Required)""",NOT-NS-21-009,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-009.html,Notices,2028-01-01,"The purpose of this notice is to inform interested applicants of a change to the Key Dates and the specific research requirements for RFA-NS-19-001 ""BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01 Clinical Trial Required)"". The dates have been modified to add a new application due date of October 29, 2021. See changes below inbold italics.",,,,
"Notice of Change to Key Dates for RFA-NS-18-019 ""BRAIN Initiative: Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)""",NOT-NS-20-108,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-20-108.html,Notices,2028-01-01,"The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-019 ""BRAIN Initiative: Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)"".  This Funding Opportunity Announcement has been extended by one council round.  The dates have been modified to add a New Application Due Date of May 4, 2021.",,,,
"Notice of Change to Key Dates for RFA-NS-18-020 ""BRAIN Initiative: New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)""",NOT-NS-20-109,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-20-109.html,Notices,2028-01-01,"The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-020 ""BRAIN Initiative: New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)"".  This Funding Opportunity Announcement has been extended by one council round.  The dates have been modified to add a New Application Due Date of May 4, 2021.",,,,
"Notice to Extend RFA-MH-19-135 - BRAIN Initiative: Development of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in Human and Non-Human Primate Brain (UG3/UH3 Clinical Trial Optional)",NOT-MH-20-080,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-20-080.html,Notices,2028-01-01,"The purpose of this Notice is to extend RFA-MH-19-135, BRAIN Initiative: Development of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in Human and Non-Human Primate Brain (UG3/UH3 Clinical Trial Optional)",,,,
"Notice to Extend RFA-MH-20-135 BRAIN Initiative: Tools to Facilitate High-Throughput Microconnectivity Analysis (R01 Clinical Trial Not Allowed)",NOT-MH-20-081,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-20-081.html,Notices,2028-01-01,"The purpose of this Notice is to extend RFA-MH-20-135, BRAIN Initiative: Tools to Facilitate High-Throughput Microconnectivity Analysis (R01 Clinical Trial Not Allowed)",,,,
"Notice of Change to Key Dates for RFA-NS-18-021 ""BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Required)""",NOT-NS-20-103,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-20-103.html,Notices,2028-01-01,"The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-021 ""BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Required)"".  This Funding Opportunity Announcement has been extended by one council round.  The dates have been modified to add a New Application Due Date of February 22, 2021.",,,,
"Notice of Change to Key Dates for RFA-NS-18-022 ""BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44 Clinical Trial Required)""",NOT-NS-20-104,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-20-104.html,Notices,2028-01-01,"The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-022 ""BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44 Clinical Trial Required)"".  This Funding Opportunity Announcement has been extended by one council round.  The dates have been modified to add a New Application Due Date of February 22, 2021.",,,,
"Notice of Change to Key Dates for RFA-NS-18-023 ""BRAIN Initiative: Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH3 Clinical Trial Required)""",NOT-NS-20-105,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-20-105.html,Notices,2028-01-01,"The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-023 ""BRAIN Initiative: Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH3 Clinical Trial Required)"".  This Funding Opportunity Announcement has been extended by one council round.  The dates have been modified to add a New Application Due Date of February 22, 2021.",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for ""BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32)""",NOT-MH-20-062,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-20-062.html,Notices,2028-01-01,"Notice Intent Publish Funding Opportunity Announcement BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award NRSA) Individual Postdoctoral Fellowship F32)"" Notice Number: NOT-MH-20-062 Key Dates Release Date: June 17, 2020 Estimated Publication Date Funding Opportunity Announcement: August 14, 2020 First Estimated Application Due Date: December 08, 2020 Earliest Estimated Award Date: July 01, 2021 Earliest Estimated Start Date: July 01, 2021 Related Announcements Reissue RFA-MH-18-510 - BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award NRSA) Individual Postdoctoral Fellowship F32) Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose NIMH, other NIH Institutes Centers participating theBrain Research through Advancing Innovative Neurotechnologies®(BRAIN) Initiative, intends reissue ""BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award NRSA) Individual Postdoctoral Fellowship F32)."" Notice being provided allow potential applicants sufficient time develop meaningful mentoring teams responsive projects. Funding Opportunity Annoucement FOA) expected be published Summer 2020 an initial expected application due date December 2020. FOA utilize F32 activity code. Details the planned FOA provided below. Research Initiative Details purpose the BRAIN Initiative Fellows F32) program to enhance research training promising postdoctorates, early their postdoctoral training period, have potential become productive investigators research areas will advance goals the BRAIN Initiative. Applications encouraged any research area is aligned one more the seven high-priority areas the BRAIN Initiative, including neuroethics. Applicants expected propose research training an area clearly complements predoctoral research. Formal training analytical tools appropriate the proposed research expected be integral component the research training plan. order maximize training potential the F32 award, program encourages applications individuals have yet completed terminal doctoral degree who expect do within 12 months the application due date. the application due date, candidates not completed than 12 months postdoctoral training. Funding Information Estimated Total Funding TBD Expected Number Awards TBD Estimated Award Ceiling TBD Primary CFDA Numbers 93.242, 93.173, 93.866, 93.853, 93.286, 93.213, 93.867, 93.865, 93.279, 93.273 Anticipated Eligible Organizations Public/State Controlled Institution Higher EducationPrivate Institution Higher EducationNonprofit 501(c)(3) IRS Status than Institution Higher Education)Small BusinessFor-Profit Organization than Small Business)Eligible Agencies the Federal GovernmentNon-domestic non-U.S.) Entity Foreign Organization) Applications not being solicited this time. Inquiries Please direct inquiries to: Ashlee Van’t Veer, PhD National Institute Mental Health NIMH) 301-443-3107 BRAIN.Initiative.Training@nih.gov",,,,
"Notice to Extend RFA-MH-20-120 BRAIN Initiative: Secondary Analysis and Archiving of BRAIN Initiative Data (R01 Clinical Trial Not Allowed)",NOT-MH-20-052,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-20-052.html,Notices,2028-01-01,"Notice Extend RFA-MH-20-120 BRAIN Initiative: Secondary Analysis Archiving BRAIN Initiative Data R01 Clinical Trial Allowed) Notice Number: NOT-MH-20-052 Key Dates Release Date: 11, 2020 Related Announcements RFA-MH-20-120 Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this Notice to extend RFA-MH-20-120, BRAIN Initiative: Non-Invasive Neuromodulation - New Tools Techniques Spatiotemporal Precision R01 Clinical Trial Optional) Part 1. Overview Information Key Dates Currently reads: Application Due Date(s) September 6, 2019 June 11, 2020, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due these dates. late applications be accepted this Funding Opportunity Announcement. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Applicable Scientific Merit Review: March 2020 October 2020 Advisory Council: 2020, January 2021 Earliest Start Date: July 2020, April 2021 Expiration Date: June 12, 2020 Modified read: Application Due Date(s) September 6, 2019, June 11, 2020, February 26, 2021 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due these dates. late applications be accepted this Funding Opportunity Announcement. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Applicable Scientific Merit Review March 2020 October 2020, June 2021 Advisory Council 2020, January 2021, August 2021 Earliest Start Date July 2020, April 2021, September 2021 Expiration Date February 27, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Ming Zhan, Ph.D. National Institute Mental Health NIMH) Telephone: 301-827-3678 Email: ming.zhan@nih.gov",,,,
"Notice of Correction to Key Dates for RFA-NS-20-029 ""BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01 Clinical Trials Optional)""",NOT-NS-20-063,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-20-063.html,Notices,2028-01-01,"Notice Correction Key Dates RFA-NS-20-029 BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP U01 Clinical Trials Optional)"" Notice Number: NOT-NS-20-063 Key Dates Release Date: April 28, 2020 Related Announcements RFA-NS-20-029 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to notify potential applicants a correction the Key Dates RFA-NS-20-029 BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP U01 Clinical Trials Optional)"". Advisory Council Review Earliest Start Dates been modified show correct dates. Changes show in bold italics below. changes effective immediately. Currently Reads: Part 1. Overview Information Key Dates Advisory Council Review January 2022 January 2023 Earliest Start Date February 2022 February 2023 Modified Read: Part 1. Overview Information Key Dates Advisory Council Review January 2021 January 2022 Earliest Start Date February 2021 February 2022 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Karen K David, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email:BRAINCircuits@nih.gov",,,,
"Notice of Change to the Cooperative Agreement in RFA-MH-19-149, BRAIN Initiative Cell Census Network (BICCN)  Specialized Collaboratory on Human and Non-Human Primate Brain Cell Atlases (U01 Clinical Trial Not Allowed)",NOT-MH-19-040,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-19-040.html,Notices,2028-01-01,"Notice Change the Cooperative Agreement RFA-MH-19-149, BRAIN Initiative Cell Census Network BICCN) – Specialized Collaboratory Human Non-Human Primate Brain Cell Atlases U01 Clinical Trial Allowed) Notice Number: NOT-MH-19-040 Key Dates Release Date: August 2, 2019 Related Announcements RFA-MH-19-149 Issued National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to change cooperative agreement language in RFA-MH-19-149, "" BRAIN Initiative Cell Census Network BICCN) Specialized Collaboratory Human Non-Human Primate Brain Cell Atlases U01 Clinical Trial Allowed). Currently Reads: Cooperative Agreement Terms Conditions Award following special terms award in addition to, not lieu of, otherwise applicable U.S. Office Management Budget OMB) administrative guidelines, U.S. Department Health Human Services DHHS) grant administration regulations 45 CFR Parts 75, other HHS, PHS, NIH grant administration policies. administrative funding instrument used this program be cooperative agreement, assistance"" mechanism rather an acquisition"" mechanism), which substantial NIH programmatic involvement the awardees anticipated during performance the activities. Under cooperative agreement, NIH purpose to support stimulate recipients' activities involvement and otherwise working jointly the award recipients a partnership role; is to assume direction, prime responsibility, a dominant role the activities. Consistent this concept, dominant role prime responsibility resides the awardees the project a whole, although specific tasks activities be shared among awardees the NIH defined below. PD(s)/PI(s) have primary responsibility for: PD(s)/PI(s) have primary authority responsibility define objectives approaches to plan conduct proposed research. She/he assume responsibility accountability the applicant organization to NIMH performance proper conduct all research, including NIH intramural component, applicable, accordance the Terms Conditions Award. Principal Investigator be member the Steering Committee will responsible scheduling Steering Committee meetings disseminating meeting notes all participants within 2 weeks each meeting below under Collaborative Responsibilities). Awardee Institution and/or Research Project Leader's Institution retain primary custody and primary rights data specified under NIMH approved Intellectual Property Patent Rights Agreements New Chemical Entities the data research resource sharing plans described below). PD/PI provide the NIMH Program Official Project Scientist(s) access data generated under cooperative agreement allow to periodically review data consistent current DHHS, PHS, NIH policies. Timely publication major findings the Steering Committee members encouraged. Publication oral presentation work done under agreement require appropriate acknowledgment NIMH support, including assigned cooperative agreement award number. NIH staff substantial programmatic involvement is above beyond normal stewardship role awards, described below: Project Scientist(s) interacts scientifically the funded PIs the collaborators their cooperative agreement grants, may provide appropriate assistance, including: 1) assisting research planning, 2) suggesting studies within scope the cooperative agreement objectives research activities, 3) presenting experimental findings published sources from relevant contract projects, 4) participating the design experiments, 5) participating the analysis results, 6) advising management technical performance. Project Scientist(s) be member(s) the Steering Committee. FIH, EFS, Phase Ib Phase II/PoC studies be reviewed an appropriate NIMH Data Safety Monitoring Board DSMB) ensure safety participants the validity integrity the data. study protocol(s) consent form(s) be reviewed the DSMB prior initiation the project. DSMB review study reports a regular basis monitor subject enrollment retention, safety, quality data collection, integrity the study. Applicants should refer NIH’s policy data safety monitoring https://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-038.html) well the NIMH Guidelines Data Safety Monitoring http://www.nimh.nih.gov/funding/grant-writing-and-application-process/n…. Additionally, NIMH Program Official be responsible the normal scientific programmatic stewardship the award, including monitoring implementation the data research resource sharing plans will named the award notice. noted previously, both NIMH Project Scientist Program Official be given access the data generated under cooperative agreement, will allow to periodically review data ensure consistency current DHHS, PHS, NIH Policies. Participation NIH Intramural Scientists: NIH intramural scientist not serve the PD(s)/PI(s) may participate a collaborator, consultant. However, Intramural scientist not receive salary, equipment, supplies, other remuneration awards resulting this FOA. Intramural scientist must obtain written approval his/her NIH Institute Scientific Director the amount resources may allocated the project. approval must also specify the conduct the project comply the DHHS regulations research involving human subjects applicable) with PHS policy vertebrate animal research. participation an intramural scientist independent and unrelated the role the NIMH Project Scientist. applications include NIH intramural components, intramural resource level be included the total cost the overall application. involvement Intramural scientists needs be consistent NIH Policy. http://www1.od.nih.gov/oir/sourcebook/ethic-conduct/ethical-conduct-toc… Intramural research scientists participating collaborators the same rights responsibilities other researchers are participating investigators the funded cooperative agreement grants. Most often investigators be members the Steering Committee, since will likely considered key personnel. Areas Joint Responsibility include: governing Steering Committee composed the PD(s)/PI(s), CRO lead CTSA lead applicable), key personnel, NIMH Project Scientist(s), NIMH Program Official be established assist monitoring developing scientific content direction the program. total membership NIMH staff not exceed one-third 1/3) the membership the Steering Committee. all cases, role NIMH be assist, participate deliberations, facilitate discussion not direct activities. Steering Committee serve the governing board awardees. awardees under initiative program bound the policies procedures developed the Steering Committee; adoption such policies procedures requires majority vote. Awardees under FOA be required accept implement policies approved the Steering Committee. Membership the Steering Committee include PD(s)/PI(s) each U01 award, a designated representative the case Multiple PD/PI award. member have vote. NIMH Project Scientist be voting member the Steering Committee. chair be chosen a majority vote the Steering Committee, years service chair determined the committee. chair responsible preparing meeting agendas, scheduling chairing meetings, for preparing concise minutes will delivered Steering Committee members within 30 days the meeting. Virtual meetings appropriate. NIMH Project Scientist not serve the Chair the Steering Committee. Steering Committee members meet periodically review progress, plan design research activities, establish priorities. frequency meetings, fewer two per year, be determined the PD(s)/PI(s) will responsible scheduling time place generally one the performance sites) for preparing concise proceedings minutes action items one-two page summary) will delivered the members the Committee within 2 weeks the meeting. Dispute Resolution: Any disagreements may arise scientific programmatic matters within scope the award) between award recipients the NIH be brought Dispute Resolution. Dispute Resolution Panel composed three members be convened. will three members: designee the Steering Committee chosen without NIH staff voting, NIH designee, a third designee expertise the relevant area is chosen the two; the case individual disagreement, first member be chosen the individual awardee. special dispute resolution procedure does alter awardee's right appeal adverse action is otherwise appealable accordance PHS regulation 42 CFR Part 50, Subpart D DHHS regulation 45 CFR Part 16. Intellectual Property Patent Rights New Chemical Entities Devices Since development new pharmacological treatments psychiatric disorders a major objective this effort active involvement pharmaceutical laboratories encouraged would facilitated the existence appropriate patent coverage, is expected applicants provide plans address handling intellectual property new chemical entities devices under FOA. Under earlier National Cooperative Drug Discovery/Development Groups NCDDG) the Treatment Mental Disorders, Drug Alcohol Addiction program, successful applicants required supply following confidential materials the NIMH Program Official listed under Section VII. Agency Contacts. Similar the NCDDG, applicants expected address three items noted below under FOA, consistent achieving goals this program: 1. applicant expected provide detailed description the approach be used handling intellectual property for licensing where appropriate, particular where invention involve investigators more one institution. Procedures expected be described resolution legal problems should arise, consistent achieving goals the program. attention drawn the NIH Extramural Technology Transfer Policies Documents https://grants.nih.gov/grants/intell-property.htm]. 2. formal statement Intellectual Property among PD(s)/PI(s) their institutions well a detailed description procedures be followed resolution legal problems may develop, expected be signed dated the organizational official authorized enter intellectual property arrangements each PD(s)/PI(s) their institution(s). signed agreement expected be submitted prior award the appropriate NIMH staff the addresses provided under Section VII. Agency Contacts. 3. Prior the award, PD(s)/PI(s) expected provide signed statement acceptance the participation NIMH staff during performance the award outlined under NIH Staff Responsibilities"" in Section VI.2 - Cooperative Agreement Terms Conditions Award. Note: NOT submit documents 1-3 above the application. However, awards not made until documents received approved NIMH. Progress Reviews Progress the project be reviewed annually the NIMH Project Officer the time each non-competing continuation application assure satisfactory progress being in achieving project objectives, especially respect enrollment quality data collection, timely data sharing appropriate consistent achieving goals the program, to ensure site following procedures recommended approved the project Steering Committee. acceptance these awards, awardees agree abide decisions policies the project Steering Committee the terms conditions listed above referenced the Notice Grant Award. Modified Read: Cooperative Agreement Terms Conditions Award following special terms award in addition to, not lieu of, otherwise applicable U.S. Office Management Budget OMB) administrative guidelines, U.S. Department Health Human Services DHHS) grant administration regulations 45 CFR Parts 74 92 Part 92 applicable State local Governments eligible apply) , other HHS, PHS, NIH grant administration policies. administrative funding instrument used this program be cooperative agreement, assistance"" mechanism rather an acquisition"" mechanism), which substantial NIH programmatic involvement the awardees anticipated during performance the activities. Under cooperative agreement, NIH purpose to support stimulate recipients' activities involvement and otherwise working jointly the award recipients a partnership role; is to assume direction, prime responsibility, a dominant role the activities. Consistent this concept, dominant role prime responsibility resides the awardees the project a whole, although specific tasks activities be shared among awardees the NIH defined below. PD(s)/PI(s) have primary responsibilities described below: Define details the project within guidelines this FOA. Oversee perform scientific activities. Administratively manage Collaboratory grant. Accept close coordination, cooperation, participation NIH BRAIN program staff the scientific, technical, administrative management the BICCN. Inform NIH program official all major interactions other members the Steering Group. Provide milestones cost the Collaboratory operation the NIH BRAIN program staff requested usually the outset the award annually thereafter, also other times requested the program staff). common brain samples, common coordinate systems, standard nomenclature generate integrate data, metadata, knowledge. Demonstrate capability flexibility modifying brain regions study, data formats metadata. Ensure the products the production effort meet quality standards. Share data resources according the data release resource sharing policies developed and this project appropriate consistent achieving goals the program. Share Specific Aims Research Strategy the project other members the BICCN the purpose collaboration coordination. Fully disclose algorithms, software source code the members the Network the purpose scientific evaluation. disclose confidential pre-public information confidential information obtained other members the Network. Submit data quality assessment and/or validation any manner specified the Steering Group, External Scientific Panel, and/or NIH BRAIN program ensure scientific rigor; Adhere NIH policies regarding intellectual property other policies might established during course this activity. Awardees retain custody and primary rights the data resources developed under awards, subject Government rights access consistent current DHHS, PHS, NIH policies. Participate BICCN activities, including periodic meetings report Collaboratory’s progress, coordinate publication research results. Coordinate collaborate other U.S. international groups may generating relevant cell census datasets; Serve a member the BICCN Steering Committee. Submit periodic progress reports agreed upon the Steering Committee. Accept implement common guidelines procedures approved the Steering Committee, External Scientific Panel, NIH. NIH staff substantial programmatic involvement is above beyond normal stewardship role awards, described below: Program Officer be assigned this award. Program Officer be responsible normal scientific programmatic stewardship guidance the overall project within NIMH will ensure the generation cell census datasets resources relevant the diverse research community served the NIH Institutes Centers. Program Officer be responsible milestone negotiations ensure the milestones achieved goals being met. addition, NIH Program Officer responsible monitoring implementing Data Sharing Plan http://grants.nih.gov/grants/policy/data_sharing/index.htm). NIH Program Officer attend Steering Group meetings a non-voting participant. NIH Program Officer be named the award notice. or extramural NIH program staff member be assigned the Project Scientist(s) this award. same person serve the Project Scientist multiple BRAIN Initiative awards. Project Scientist(s) interact scientifically the PDs/PIs other named personnel that award, a partner the research, including providing technical assistance, advice, coordination the BICCN its component parts. However, role NIH staff be facilitate not direct activities. is anticipated decisions all activities be reached consensus the BICCN Steering Committee that NIH staff be given opportunity offer input this process. NIH BRAIN Project Team be composed Program Officials other relevant extramural staff NIH Institutes Centers the Project Scientist(s). primary role to ensure the datasets resources generated represent diverse interests the participating NIH Institutes Centers, advise brain cell census activities relevant their individual Institute/Center mission, monitor overall progress, attend Steering Group meetings required, report back their Institute/Center. NIH BRAIN Project Team establish External Scientific Panel ESP) help evaluate progress the BICCN. NIH intramural scientists involved the BICCN have same rights responsibilities the comparable extramural Project Scientists involved the BICCN. intramural scientist not receive salary, equipment supplies, other remuneration awards resulting this FOA. intramural scientist must obtain written approval his/her NIH Institute Scientific Director the amount resources may allocated the project. approval must also specify the conduct the project comply the DHHS regulations research involving human subjects applicable) with PHS policy vertebrate animal research. participation an intramural scientist independent and unrelated the role the NIH Project Scientist(s). involvement intramural scientists needs be consistent NIH Policy. http://sourcebook.od.nih.gov/ethic-conduct/ethical-conduct-toc.htm Areas Joint Responsibility include: BRAIN Cell Census Network BICCN) Steering Committee: Steering Committee be composed the PD(s)/PI(s), NIH program staff member(s) External Scientific Panel members experts be named after award). Steering Committee be established help monitor progress, encourage improvements, coordinate production brain cell census datasets resources through BICCN. is anticipated additional coordination mechanisms be set with U.S. international groups may join effort. BICCN Steering Committee members meet periodically plan design activities, review discuss progress, establish priorities policies. chair a co-chair be designated a rotating basis needed. PD(s)/PI(s), external scientific advisor have vote and NIH have vote through participation the Project Scientist(s). Awardee members the Steering Committee be required accept implement policies approved the Steering Committee. BICCN Steering Committee will: Discuss progress meeting research community's need cell census datasets. Facilitate development uniform procedures policies, example data standards, quality measures assessment, nomenclature annotation conventions data depositions, so forth. Awardee members the Steering Group be required accept implement common guidelines procedures approved the Steering Group. Coordinate improve cell census data production, example reporting progress, disseminating best practices collectively evaluating new procedures, resources, technologies. Establish subcommittees needed address particular issues. Subcommittees include representatives the BICCN, NIH BRAIN Project Team, possibly experts. Subcommittees be formed to: 1) develop implement data production analysis standards including spatial semantic standards integrating heterogeneous data sets information; 2) address data submission, management, analysis issues; 3) develop quality standards methods quality control assurance; 4) develop common reagents informatics tools. these cases, common policies, uniform practices needed), data exchange be critical the success the effort will enable harmonization eliminate duplication/overlap. External Scientific Panel ESP): ESP provide recommendations the NIH BRAIN Project Team BICCN the progress scientific direction all components the program. ESP be composed four six senior scientists represent broad research community have relevant expertise, although membership be enlarged permanently on ad hoc basis needed. ESP meet twice year; meetings be conducted telephone conference. least once year, will a joint meeting the Steering Committee the members both ESP Steering Committees interact directly. ESP make recommendations regarding progress the BICCN present advice the NIH BRAIN Project Team changes, any, may necessary the BICCN program. Dispute Resolution: Any disagreements may arise scientific programmatic matters within scope the award) between award recipients the NIH be brought Dispute Resolution. Dispute Resolution Panel composed three members be convened. will three members: designee the Steering Committee chosen without NIH staff voting, NIH designee, a third designee expertise the relevant area is chosen the two; the case individual disagreement, first member be chosen the individual awardee. special dispute resolution procedure does alter awardee's right appeal adverse action is otherwise appealable accordance PHS regulation 42 CFR Part 50, Subpart D DHHS regulation 45 CFR Part 16. Inquiries Please direct inquiries to: Yong Yao, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-6102 Email: yyao@mail.nih.gov",,,,
"Notice of Change to Application Types Allowed for RFA-NS-18-021 ""BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Required)""",NOT-NS-19-072,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-19-072.html,Notices,2028-01-01,"Notice Change Application Types Allowed RFA-NS-18-021 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UG3/UH3 Clinical Trial Required)"" Notice Number: NOT-NS-19-072 Key Dates Release Date: June 28, 2019 Related Announcements RFA-NS-18-021 Issued National Institute Neurological Disorders Stroke NINDS) National Institute Deafness Other Communication Disorders NIDCD) Purpose purpose this notice to inform applicants revision applications be accepted response RFA-NS-18-021 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UG3/UH3 Clinical Trial Required)"". Changes listed below bold italics). notice be effective the October 21, 2019 due date subsequent due dates. Currently Reads: Section II. Award Information Application Types Allowed? New Resubmission Modified Read: Section II. Award Information Application Types Allowed New Resubmission Revision other aspects this FOA remain unchanged.? Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: nick.langhals@nih.gov",,,,
"Notice of Change to Application Types Allowed for RFA-NS-18-022 ""BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44 Clinical Trial Required)""",NOT-NS-19-073,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-19-073.html,Notices,2028-01-01,"Notice Change Application Types Allowed RFA-NS-18-022 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System U44 Clinical Trial Required)"" Notice Number: NOT-NS-19-073 Key Dates Release Date: June 28, 2019 Related Announcements RFA-NS-18-022 Issued National Institute Neurological Disorders Stroke NINDS) National Institute Deafness Other Communication Disorders NIDCD) Purpose purpose this notice to inform applicants revision applications be accepted response RFA-NS-18-022 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System U44 Clinical Trial Required)"". Changes listed below bold italics). notice be effective the October 21, 2019 due date subsequent due dates. Currently Reads: Section II. Award Information Application Types Allowed? New Resubmission Modified Read: Section II. Award Information Application Types Allowed New Resubmission Revision other aspects this FOA remain unchanged.? Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: nick.langhals@nih.gov",,,,
"Notice of Change to Application Types Allowed for RFA-NS-18-023 ""BRAIN Initiative:  Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH3 Clinical Trial Required)""",NOT-NS-19-074,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-19-074.html,Notices,2028-01-01,"Notice Change Application Types Allowed RFA-NS-18-023 BRAIN Initiative: Clinical Studies Advance Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UH3 Clinical Trial Required)"" Notice Number: NOT-NS-19-074 Key Dates Release Date: June 28, 2019 Related Announcements RFA-NS-18-023 Issued National Institute Neurological Disorders Stroke NINDS)National Institute Deafness Other Communication Disorders NIDCD) Purpose purpose this notice to inform applicants revision applications be accepted response RFA-NS-18-023 BRAIN Initiative: Clinical Studies Advance Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UH3 Clinical Trial Required)"". Changes listed below bold italics). notice be effective the October 21, 2019 due date subsequent due dates. Currently Reads: Section II. Award Information Application Types Allowed? New Resubmission Modified Read: Section II. Award Information Application Types Allowed New Resubmission Revision other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: nick.langhals@nih.gov",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative: Proof of Concept Development of Early Stage Next Generation Human Brain Imaging (R01 Clinical Trial Not Allowed)",NOT-EB-19-010,http://grants.nih.gov/grants/guide/notice-files/NOT-EB-19-010.html,Notices,2028-01-01,"Notice Intent Publish Funding Opportunity Announcement BRAIN Initiative: Proof Concept Development Early Stage Next Generation Human Brain Imaging R01 Clinical Trial Allowed) Notice Number: NOT-EB-19-010 Key Dates Release Date:May 09, 2019 Estimated Publication Date Funding Opportunity Announcement: June 03, 2019 First Estimated Application Due Date: September 03, 2019 Earliest Estimated Award Date: 20, 2020 Earliest Estimated Start Date: July 01, 2020 Related Announcements RFA-EB-17-003 Issued National Institute Biomedical Imaging Bioengineering NIBIB) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose NIH Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative intends reissue RFA-EB-17-003, Proof Concept Development Early Stage Next Generation Human Brain Imaging R01 Clinical Trials Allowed), modifications. funding opportunity aims support early stage development entirely new novel noninvasive human brain imaging technologies methods will lead transformative advances our understanding the human brain. FOA solicits unusually bold potentially transformative approaches supports small scale, proof concept development based exceptionally innovative, original and/or unconventional concepts. FOA utilize R01 activity code. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. Notice encourages investigators expertise insights this area noninvasive human brain imaging technologies methods begin consider applying this new FOA. Research Initiative Details TBD Funding Information Estimated Total Funding TBD Expected Number Awards TBD Estimated Award Ceiling TBD Primary CFDA Numbers TBD Anticipated Eligible Organizations Public/State Controlled Institution Higher Education Private Institution Higher Education Nonprofit 501(c)(3) IRS Status than Institution Higher Education) Nonprofit without 501(c)(3) IRS Status than Institution Higher Education) Small Business For-Profit Organization than Small Business) State Government Indian/Native American Tribal Government Federally Recognized) County governments City township governments Special district governments Independent school districts Public housing authorities/Indian housing authorities Indian/Native American Tribally Designated Organization Native American tribal organizations than Federally recognized tribal governments) U.S. Territory Possession Indian/Native American Tribal Government than Federally Recognized) Non-domestic non-U.S.) Entity Foreign Organization) Regional Organization Eligible Agencies the Federal Government Applications not being solicited this time.  Inquiries Please direct inquiries to: Shumin Wang, PhDNational Institute Biomedical Imaging Bioengineering NIBIB)301-594-9001shumin.wang@nih.gov",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative: Development of Next Generation Human Brain Imaging Tools and Technologies (U01 Clinical Trial not allowed)",NOT-EB-19-011,http://grants.nih.gov/grants/guide/notice-files/NOT-EB-19-011.html,Notices,2028-01-01,"Notice Intent Publish Funding Opportunity Announcement BRAIN Initiative: Development Next Generation Human Brain Imaging Tools Technologies U01 Clinical Trial allowed) Notice Number: NOT-EB-19-011 Key Dates Release Date: 09, 2019 Estimated Publication Date Funding Opportunity Announcement: June 03, 2019 First Estimated Application Due Date: September 03, 2019 Earliest Estimated Award Date: 20, 2020 Earliest Estimated Start Date: July 01, 2020 Related Announcements RFA-EB-17-004 Issued National Institute Biomedical Imaging Bioengineering NIBIB) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose NIH Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative intends reissue RFA-EB-17-004, Development Next Generation Human Brain Imaging Tools Technologies U01 Clinical Trials Allowed), modifications. funding opportunity aims support full development entirely new next generation noninvasive human brain imaging tools methods will lead transformative advances our understanding the human brain. FOA seeks innovative applications are ready full-scale development breakthrough technologies the intention delivering working tools. FOA utilize U01 activity code. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. Notice encourages investigators expertise insights this area noninvasive human brain imaging technologies methods begin consider applying this new FOA. Research Initiative Details TBD Funding Information Estimated Total Funding TBD Expected Number Awards TBD Estimated Award Ceiling TBD Primary CFDA Numbers TBD Anticipated Eligible Organizations Public/State Controlled Institution Higher Education Private Institution Higher Education Nonprofit 501(c)(3) IRS Status than Institution Higher Education) Nonprofit without 501(c)(3) IRS Status than Institution Higher Education) Small Business For-Profit Organization than Small Business) State Government Indian/Native American Tribal Government Federally Recognized) County governments City township governments Special district governments Independent school districts Public housing authorities/Indian housing authorities Indian/Native American Tribally Designated Organization Native American tribal organizations than Federally recognized tribal governments) U.S. Territory Possession Indian/Native American Tribal Government than Federally Recognized) Non-domestic non-U.S.) Entity Foreign Organization) Regional Organization Eligible Agencies the Federal Government Applications not being solicited this time   Inquiries Please direct inquiries to: Shumin Wang, PhDNational Institute Biomedical Imaging Bioengineering NIBIB)shumin.wang@nih.gov",,,,
"Notice of Change to Key Dates for RFA-NS-18-014 ""BRAIN Initiative: Targeted BRAIN Circuits Planning Projects - TargetedBCPP (R34 Clinical Trial Not Allowed)""",NOT-NS-19-034,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-19-034.html,Notices,2028-01-01,"Notice Change Key Dates RFA-NS-18-014 BRAIN Initiative: Targeted BRAIN Circuits Planning Projects - TargetedBCPP R34 Clinical Trial Allowed)"" Notice Number: NOT-NS-19-034 Key Dates Release Date: April 18, 2019 Related Announcements RFA-NS-18-014 Issued National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Office Behavioral Social Sciences Research OBSSR) Office Research Women’s Health ORWH) Purpose purpose this Notice to inform applicants a change the Key Dates RFA-NS-18-014 Targeted BRAIN Circuits Planning Projects - TargetedBCPP R34 Clinical Trial Allowed)"". Three new receipt dates been added the FOA: November 6, 2019, July 1, 2020,and November 10, 2020. Additionally, Peer Review Contact changed Alexei Kondratyev, Ph.D. Currently Reads: Part 1. Overview Information Key Dates Application Due Date(s) March 15, 2018; July 17, 2018; July 15, 2019 Scientific Merit Review June 2018; October 2018; October 2019 Advisory Council Review August 2018; January 2019; January 2020 Earliest Start Date September 2018; April 2019; April 2020 Expiration Date July 16, 2019 Modified Read: Part 1. Overview Information Key Dates Application Due Date(s) March 15, 2018; July 17, 2018; July 15, 2019; November 6, 2019; July 1, 2020; November 10, 2020 Scientific Merit Review June 2018; October 2018; October 2019; February 2020; October 2020; February 2021 Advisory Council Review August 2018; January 2019; January 2020; May 2020; January 2021; 2021 Earliest Start Date September 2018; April 2019; April 2020; June 2020; February 2021; June 2021 Expiration Date November 10, 2021 Currently Reads: Section II. Award Information Funds Available Anticipated Number Awards BRAIN Initiative partner componentsintend commit estimated total 2.5M fund 10 awards. Modified Read: Section II. Award Information Funds Available Anticipated Number Awards BRAIN Initiative partner componentsintend commit estimated total 2.5M fund 10 awards for FY21.                Currently Reads: Section VII. Agency Contact(s) Scientific/Research Contact(s) James Gnadt, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email:BRAINCircuits@NIH.GOV Peer Review Contact(s) Nick Gaiano, PhD Center Scientific Review CSR) Telephone: 301-435-1033 Email:nick.gaiano@nih.gov Modified Read: Section VII. Agency Contact(s) Scientific/Research Contact(s) Karen K David, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email:BRAINCircuits@NIH.GOV Peer Review Contact(s) Alexei Kondratyev, Ph.D. Center Scientific Review CSR) Telephone: 301-465-1785 Email: alexei.kondratyev@nih.gov other aspects this FOA remain same. Inquiries Please direct inquiries to: Karen K David, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: BRAINCircuits@nih.gov",,,,
"Notice of Data Sharing Policy for the BRAIN Initiative",NOT-MH-19-010,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-19-010.html,Notices,2028-01-01,"Notice Data Sharing Policy the BRAIN Initiative Notice Number: NOT-MH-19-010 Key Dates Release Date:January 22, 2019 Related Announcements RFA-EY-18-001 RFA-MH-18-510 RFA-MH-19-135 RFA-MH-19-136 RFA-MH-19-147 RFA-MH-19-400 RFA-NS-18-018 RFA-NS-18-019 RFA-NS-18-020 RFA-NS-18-021 RFA-NS-18-022 RFA-NS-18-023 RFA-NS-18-030 RFA-NS-19-001 RFA-NS-19-002 RFA-NS-19-003 Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy ShriverNational Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this notice to inform prospective applicants current awardees a new policy concerning data collected support awards are funded the BRAIN Initiative. Specifically, Notice clarifies expectation applicants BRAIN Initiative funding opportunity announcements: 1) submit data one the BRAIN data archives sharing; 2) include specific required elements the Resource Sharing Plan further detailed below; 3) include costs attributed data preparation submission a data archive grant applications. BRAIN Initiative Overview Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative aimed revolutionizing our understanding the human brain. accelerating development application innovative technologies, researchers be able produce new dynamic picture the brain that, the first time, show individual cells complex neural circuits interact both time space. is expected the application these new tools technologies ultimately lead new ways treat prevent brain disorders. NIH one several federal agencies involved the BRAIN Initiative. Planning the NIH component the BRAIN initiative guided the long-term scientific plan, BRAIN 2025: Scientific Vision,"" details seven high-priority research areas calls a sustained federal commitment 4.5 billion over 12 years. Notice related FOAs issued part the BRAIN initiative based careful consideration the NIH the recommendations the BRAIN 2025 Report, input the NIH BRAIN Multi-Council Working Group. Videocasts the NIH BRAIN Multi-council Working Group available athttp://www.braininitiative.nih.gov/about/mcwg.htm. enable rapid progress development new technologies well in theory data analysis, BRAIN Initiative encourages collaborations between neurobiologists scientists statistics, physics, mathematics, engineering, computer information sciences. BRAIN Initiative Data Sharing BRAIN 2025 report calls establishing platforms sharing data related the BRAIN Initiative. response, NIH released RFAs related data archives RFA-MH-19-145andRFA-MH-17-255), data standards RFA-MH-19-146andRFA-MH-17-256), software integrate analyze data RFA-MH-19-147andRFA-MH-17-257). of those efforts focused data a sub-domain are usually defined the data collection methodology. Data archives have established include: 1) Neuroscience Multi-omic Data Archive https://nemoarchive.org/about.php, R24MH114788) hold data omics experiments. 2) Brain Image Library http://www.brainimagelibrary.org/index.html, R24MH114793) hold microscopy data. 3) Data Archive the BRAIN Initiative https://dabi.loni.usc.edu, R24MH114796) hold data related human electrophysiology experiments. 4) OpenNeuro https://openneuro.org/, R24MH117179) hold magnetic resonance imaging data. 5) Block Object Storage Service https://bossdb.org/, R24MH114785) hold electron microscopy data. few additional data archives distinct sub-domains expected be funded. complete list BRAIN Initiative infrastructure awards be foundhere. awardees the RFAs listed above creating informatics infrastructure necessary BRAIN Initiative awardees others share data are collecting the research community. BRAIN Initiative applications both new resubmissions) submitted after March 1, 2020, applicants required share data collect using BRAIN Initiative informatics infrastructure both data archives relevant data standards),consistent authorities under 21st Century Cures Act these awards authorized under Act. . BRAIN Initiative fellowship applications using any the F activity codes) not required share data are collecting, they encouraged use informatics infrastructure part their training activities. general expectation that data BRAIN Initiative awards be submitted the archives every 6 months. Submitting data an archive distinct sharing data the research community. Submitted data generally held a private enclave until data shared the research community. Frequent submission allows those measuring data perform quality control checks the data deposited. Submitting data an ongoing basis often easier trying package data the end an award period. After data been submitted the appropriate data archive, will shared the research community papers using data been published at end the award period, whichever occurs sooner. calendar submitting data the relevant archive sharing data the research community depend the exact details the experiments are being conducted. applications BRAIN Initiative FOAs required include Resource Sharing Plan part the application. Consistent authorities under 21st Century Cures Act these awards authorized under Act, t portion that plan dealing data must include: 1) summary the data will shared 2) description the standard(s) will used describe data set 3) data archive(s) will house data 4) proposed timeline submitting data the archive sharing data the research community. applications involve human subjects, Resource Sharing Plan should a description whether how consents will used obtain data affect research can done that data. Consents would allow data be used General Research are appropriate all experiments, applicants should consents allow broad data sharing whenever possible. resource sharing plan required matter level funding requested. Costs associated preparing submitting data a data archive should included grant applications. BRAIN Initiative awardees have received awards prior the effective date this Notice encouraged share data. awards prior the effective date this Notice, administrative supplements be necessary prepare such data sets submission an appropriate repository. Investigators should discuss such supplements their assigned program officer. existing BRAIN Initiative awardees already data sharing expectations part their awards. Notice does alter existing data sharing expectations milestones. Inquiries Please direct inquiries to: technical assistance data submission, please contact relevant data archive. other inquiries please contact: Ming Zhan, Ph.D. National Institute Mental Health NIMH) Telephone: 301-827-3678 E-mail:ming.zhan@nih.gov",,,,
"Notice of Correction to Key Dates for RFA-NS-19-002 ""BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Required)""",NOT-NS-19-018,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-19-018.html,Notices,2028-01-01,"Notice Correction Key Dates RFA-NS-19-002 BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP U19 Clinical Trial Required)"" Notice Number: NOT-NS-19-018 Key Dates Release Date: November 8, 2018 Related Announcements RFA-NS-19-002 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform potential applicants changes Advisory Council Review  Dates RFA-NS-19-002 BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP U19 Clinical Trial Required)"". Part 1. Overview Information Key Dates Currently Reads: Advisory Council Review 2018, 2019 May 2020 Modified Read: Advisory Council Review 2019, 2020 and May 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: James Gnadt, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: BRAINCircuits@nih.gov  ",,,,
"Notice of Correction to Key Dates for RFA-NS-19-003 ""BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Not Allowed)""",NOT-NS-19-019,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-19-019.html,Notices,2028-01-01,"Notice Correction Key Dates RFA-NS-19-003 BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP U19 Clinical Trial Allowed)"" Notice Number: NOT-NS-19-019 Key Dates Release Date: November 8, 2018 Related Announcements RFA-NS-19-003 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform potential applicants corrections the Council Review  Dates RFA-NS-19-003 BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP U19 Clinical Trial Allowed)"". Part 1. Overview Information Key Dates Currently Reads: Advisory Council Review 2018, 2019 May 2020 Modified Read: Advisory Council Review 2019, 2020 and May 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: James Gnadt, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: BRAINCircuits@nih.gov",,,,
"BRAIN Initiative: Notice of Support for Research on the Fundamental Neurobiology of Endogenous Opioid Systems",NOT-DA-18-046,http://grants.nih.gov/grants/guide/notice-files/NOT-DA-18-046.html,Notices,2028-01-01,"BRAIN Initiative: Notice Support Research the Fundamental Neurobiology Endogenous Opioid Systems Notice Number: NOT-DA-18-046 Key Dates Release Date:October 9, 2018 Related Announcements None Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative aimed revolutionizing neuroscience through development application innovative technologies map neural circuits, monitor modulate activity, understand they contribute thoughts, sensations, emotions behavior.  NIH issued variety Funding Opportunity Announcements FOAs) will support projects apply technologies understand neural circuit function the context specific circuits, resulting a diverse portfolio research the fundamental biology nervous system function.   announcement to inform research community NIH welcomes applications leverage tools technology emerging the BRAIN Initiative towards elucidating mechanisms which endogenous opioid systems regulate sensory processing, affect cognition appropriate the goals requirements specific BRAIN Initiative FOAs.  overuse opioids created public health crisis, the NIH responding this crisis through conventional Institute Center appropriations special programs such the HEAL Initiative .  However, because BRAIN Initiative specifically aims understand neural circuit activity translates sensory, emotional cognitive functions opioids produce effects engaging endogenous opioid circuits normally regulate same functions, BRAIN uniquely positioned advance knowledge this area. Examples research could supported include use the innovative tools technology profile transcriptome methylome opioid-related neurons , live imaging intracellular signaling cascades identify spatiotemporal aspects cellular signaling engaged opioid receptor activation, brain-wide optical imaging cellular activity cell-types engaged opioids under different conditions, changes connectivity network activity across trajectory opioid assessed optical imaging multiplexed high density electrophysiological recording. Because chronic opioid disrupts cognitive functions emotional regulation the extent being risk survival, study the opioid-dependent brain presents unique opportunity discover how  reprogramming neural substrates circuits translates reprogramming motivation, mood decision-making processes. Interested parties should check information goals requirements specific BRAIN FOAs may appropriate, contact Scientific/Program staff listed the text the respective announcements.  For list active upcoming FOAs.  Inquiries Please direct inquiries to: Olivier Berton, PhD National Institute Drug Abuse Telephone: 301) 827-7771 Email: olivier.berton@nih.gov",,,,
"Notice of Correction of PA-18-871, ""BRAIN Initiative: Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (SBIR) (R43/R44 Clinical Trial Not Allowed) """,NOT-MH-18-051,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-18-051.html,Notices,2028-01-01,"Notice Correction PA-18-871, BRAIN Initiative: Development Optimization, Validation Novel Tools Technologies Neuroscience Research SBIR) R43/R44 Clinical Trial Allowed) "" Notice Number: NOT-MH-18-051 Key Dates Release Date: September 04, 2018 Related Announcements PA-18-871 Issued National Institute Mental Health NIMH) Purpose purpose this Notice clarify Application Types allowed in PA-18-871, BRAIN Initiative: Development Optimization, Validation Novel Tools Technologies Neuroscience Research SBIR) R43/R44 Clinical Trial Allowed). Currently reads Section II. Award Information  Application Types Allowed New Phase I) Renewal Phase II* Direct Phase II not allowed) Resubmission phases) Revision The OER Glossary and SF424 R&R) SBIR/STTR Application Guide provide details these application types. Modified read  Section II. Award Information    Application Types Allowed  New Phase I, Fast Track) Renewal Phase II* Direct Phase II not allowed) Resubmission phases) Revision The OER Glossary and SF424 R&R) SBIR/STTR Application Guide provide details these application types. other aspects this FOA remain unchanged.  Inquiries Please direct inquiries to: Margaret Grabb, PhD National Institute Mental Health NIMH) Telephone:  301-443-3563 Email:  mgrabb@mail.nih.gov",,,,
"Notice of Change of Receipt Date for RFA-NS-18-019 ""BRAIN Initiative: Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)""",NOT-NS-18-086,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-18-086.html,Notices,2028-01-01,"Notice Change Receipt Date RFA-NS-18-019 BRAIN Initiative: Optimization Transformative Technologies Large Scale Recording Modulation the Nervous System U01 Clinical Trials Allowed)"" Notice Number: NOT-NS-18-086 Key Dates Release Date: August 10, 2018 Related Announcements RFA-NS-18-019 Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) Purpose purpose this notice to inform interested applicants there be change receipt dates the Funding Opportunity Announcement FOA) RFA-NS-18-019 BRAIN Initiative: Optimization Transformative Technologies Large Scale Recording Modulation the Nervous System U01 Clinical Trials Allowed).  Specifically, next receipt date change October 29, 2018 to November 27, 2018. Part 1. Overview Information Key Dates Currently Reads: Application Due Date(s) 15, 2018, October 29, 2018, 1, 2019, October 29, 2019, 1, 2020, October 29, 2020 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Modified Read: Application Due Date(s) 15, 2018, November 27, 2018, 1, 2019, October 29, 2019, 1, 2020, October 29, 2020 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. other aspects this FOA remain same. Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: BRAIN-FOAs@nih.gov",,,,
"Notice of Change of Receipt Date for RFA-NS-18-020 ""BRAIN Initiative: New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)""",NOT-NS-18-087,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-18-087.html,Notices,2028-01-01,"Notice Change Receipt Date RFA-NS-18-020 BRAIN Initiative: New Technologies Novel Approaches Large-Scale Recording Modulation the Nervous System R01 Clinical Trial Allowed)"" Notice Number: NOT-NS-18-087 Key Dates Release Date: August 10, 2018 Related Announcements RFA-NS-18-020 Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) Purpose purpose this notice to inform interested applicants there be change receipt dates the Funding Opportunity Announcement FOA) RFA-NS-18-020 BRAIN Initiative: New Technologies Novel Approaches Large-Scale Recording Modulation the Nervous System R01 Clinical Trial Allowed)"".  Specifically, next receipt date change October 29, 2018 to November 27, 2018. Part 1. Overview Information Key Dates Currently Reads: Application Due Date(s) 15, 2018, October 29, 2018, 1, 2019, October 29, 2019, 1, 2020, October 29, 2020 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date.           Modified Read: Application Due Date(s) 15, 2018, November 27, 2018, 1, 2019, October 29, 2019, 1, 2020, October 29, 2020 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date.           other aspects this FOA remain same. Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: BRAIN-FOAs@nih.gov",,,,
"Notice of Change of Receipt Date for RFA-EY-18-001 ""BRAIN Initiative: New Concepts and Early - Stage Research for Large - Scale Recording and Modulation in the Nervous System (R21 Clinical Trial Not Allowed)""",NOT-NS-18-088,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-18-088.html,Notices,2028-01-01,"Notice Change Receipt Date RFA-EY-18-001 BRAIN Initiative: New Concepts Early - Stage Research Large - Scale Recording Modulation the Nervous System R21 Clinical Trial Allowed)"" Notice Number: NOT-NS-18-088 Key Dates Release Date: August 10, 2018 Related Announcements RFA-EY-18-001 Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) Purpose purpose this notice to inform interested applicants there be change receipt dates the Funding Opportunity Announcement FOA) RFA-EY-18-001 BRAIN Initiative: New Concepts Early - Stage Research Large - Scale Recording Modulation the Nervous System R21 Clinical Trial Allowed)"".  Specifically, next receipt date change October 29, 2018 to November 27, 2018. Part 1. Overview Information Key Dates Currently Reads: Application Due Date(s) 1, 2018, October 29, 2018, 1, 2019, October 29, 2019, 1, 2020, October 29, 2020 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date.           Modified Read: Application Due Date(s) 1, 2018, November 27, 2018, 1, 2019, October 29, 2019, 1, 2020, October 29, 2020 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date.           other aspects this FOA remain same. Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: BRAIN-FOAs@nih.gov",,,,
"Soliciting Feedback on the BRAIN Initiative",NOT-NS-18-075,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-18-075.html,Notices,2028-01-01,"Soliciting Feedback the BRAIN Initiative Notice Number: NOT-NS-18-075 Key Dates Release Date: July 23, 2018 Response Date: November 15, 2018 Related Announcements NOT-NS-19-041 Issued National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this Request Information RFI) to solicit input how best accomplish ambitious vision the Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative® set forth BRAIN 2025: Scientific Vision. NIH soliciting input all interested stakeholders, including members the scientific community, trainees, academic institutions, private sector, health professionals, professional societies, advocacy groups, patient communities, well other interested members the public. Background BRAIN Initiative aims develop new tools technologies understand manipulate networks cells the brain. BRAIN 2025: Scientific Vision serves the strategic plan the BRAIN Initiative NIH outlines overarching vision, seven high level scientific priorities, many specific goals. Designed be achieved over least decade, first five years BRAIN 2025 emphasizes development tools technology, the next five years shifts emphasis using tools make fundamental discoveries how brain circuits work what goes wrong disease. BRAIN Initiative well underway see  http://www.braininitiative.nih.gov ), we now approaching midpoint. this time, NIH seeking feedback the BRAIN Initiative's progress on opportunities moving forward given current state the science. NIH established new BRAIN Initiative Advisory Committee the NIH Director ACD) Working Group will provide scientific guidance the ACD how best continue accelerate ambitious vision the BRAIN Initiative. ACD-WG use responses this RFI, along information gathered through series public workshops, help inform discussions the BRAIN Initiative's progress potential updates the plan moving forward. Information Requested Please submit: Ideas new tools technologies have potential transform brain circuit research. Suggestions fundamental questions brain circuit function humans animal models could addressed new technologies. Considerations data sharing infrastructure policies. Areas topics research the ethical implications BRAIN Initiative-supported emerging neurotechnologies advancements their applications. Approaches disseminating new tools technologies well training broader neuroscience research community. Any topic relevant the strategic plan the BRAIN Initiative. to Submit Response assure consideration, responses must received November 15, 2018. Responses this RFI must submitted electronically using web-based form https://www.braininitiative.nih.gov/rfi.aspx via email BRAINFeedback@nih.gov  BRAIN RFI"" the subject line. Responses this RFI voluntary. Any personal identifiers be removed responses compiled.  Individual feedback not provided any responder. Proprietary, classified, confidential, sensitive information should be included your response. This Request Information RFI) for planning purposes only is a solicitation applications an obligation the part the United States U.S.) Government provide support any ideas identified response it. Please note the U.S. Government not pay the preparation any comment submitted for use that comment. Inquiries Please direct inquiries to: Email: BRAINFeedback@nih.gov",,,,
"Notice of Clarification for Submission of Materials Related to Communications with FDA for RFA-NS-18-021 ""BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3)""",NOT-NS-18-065,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-18-065.html,Notices,2028-01-01,"Notice Clarification Submission Materials Related Communications FDA RFA-NS-18-021 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UG3/UH3)"" Notice Number: NOT-NS-18-065 Key Dates Release Date:   June 22, 2018 Related Announcements RFA-NS-18-021 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to clarify submission materials related Communications the FDA RFA-NS-18-021 BRAIN Initiative:  Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UG3/UH3 Clinical Trial Required)"". current language reads     Section 4 Protocol Synopsis     4.6 the study an FDA-regulated intervention?     4.6.a. yes, describe availability Investigational Product IP) Investigational New Drug IND)/Investigational Device Exemption IDE) status:     Communications FDA: Large animal safety studies often required the FDA support IDE. Applicants should include large animal GLP safety study conducted the full-final device system using final manufacturing process intended support IDE. a large animal safety study not required the FDA an IDE, a test the full final system using final design manufacturing processes not required, applicants should include communication the FDA clearly stating is case the form a response a Pre-Submission. If studies proposed, ultimately needed, program staff work the investigators remove relevant milestones associated costs these activities the award   language been modified now reads:   Section 4 Protocol Synopsis   4.6 the study an FDA-regulated intervention?   4.6.a. yes, describe availability Investigational Product IP) Investigational New Drug IND)/Investigational Device Exemption IDE) status:   Communications FDA: Applicants should include minutes all pre-submission meetings, notice IDE, risk determination, email communications, other relevant documentation. material should only submitted section 4.6.a the application as post-submission material.   Large animal safety studies often required the FDA support IDE. Applicants should include large animal GLP safety study conducted the full-final device system using final manufacturing process intended support IDE. a large animal safety study not required the FDA an IDE, a test the full final system using final design manufacturing processes not required, applicants should include communication the FDA clearly stating is case the form a response a Pre-Submission. If studies proposed, ultimately needed, program staff work the investigators remove relevant milestones associated costs these activities the award. other aspects this FOA remain same. Inquiries Please direct inquiries to: Kari Ashmont, Ph.D. National Institute Neurological Disorders Stroke Telephone: 301-496-1447 Email: kari.ashmont@nih.gov        Nick Langhals, Ph.D. National Institute Neurological Disorders Stroke Telephone: 301-496-1447 Email: nick.langhals@nih.gov",,,,
"Notice of Clarification for Submission of Materials Related to Communications with FDA for RFA-NS-18-022 ""BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44)""",NOT-NS-18-066,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-18-066.html,Notices,2028-01-01,"Notice Clarification Submission Materials Related Communications FDA RFA-NS-18-022 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System U44)"" Notice Number: NOT-NS-18-066 Key Dates Release Date:   June 22, 2018 Related Announcements RFA-NS-18-022 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to clarify submission materials related Communications the FDA RFA-NS-18-022 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System U44 Clinical Trial Required)"". current language reads     Section 4 Protocol Synopsis     4.6 the study an FDA-regulated intervention?     4.6.a. yes, describe availability Investigational Product IP) Investigational New Drug IND)/Investigational Device Exemption IDE) status:     Communications FDA: Large animal safety studies often required the FDA support IDE. Applicants should include large animal GLP safety study conducted the full-final device system using final manufacturing process intended support IDE. a large animal safety study not required the FDA an IDE, a test the full final system using final design manufacturing processes not required, applicants should include communication the FDA clearly stating is case the form a response a Pre-Submission. If studies proposed, ultimately needed, program staff work the investigators remove relevant milestones associated costs these activities the award   language been modified now reads:   Section 4 Protocol Synopsis   4.6 the study an FDA-regulated intervention?   4.6.a. yes, describe availability Investigational Product IP) Investigational New Drug IND)/Investigational Device Exemption IDE) status:   Communications FDA: Applicants should include minutes all pre-submission meetings, notice IDE, risk determination, email communications, other relevant documentation. material should only submitted section 4.6.a the application as post-submission material.   Large animal safety studies often required the FDA support IDE. Applicants should include large animal GLP safety study conducted the full-final device system using final manufacturing process intended support IDE. a large animal safety study not required the FDA an IDE, a test the full final system using final design manufacturing processes not required, applicants should include communication the FDA clearly stating is case the form a response a Pre-Submission. If studies proposed, ultimately needed, program staff work the investigators remove relevant milestones associated costs these activities the award. other aspects this FOA remain same. Inquiries Please direct inquiries to: Kari Ashmont, Ph.D. National Institute Neurological Disorders Stroke Telephone: 301-496-1447 Email: kari.ashmont@nih.gov     Stephanie Fertig, M.B.A. National Institute Neurological Disorders Stroke Telephone: 301-496-1779 Email: fertigs@ninds.nih.gov     Nick Langhals, Ph.D. National Institute Neurological Disorders Stroke Telephone: 301-496-1447 Email: nick.langhals@nih.gov",,,,
"Notice of Clarification for Submission of Materials Related to Communications with FDA for RFA-NS-18-023 ""BRAIN Initiative: Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System""",NOT-NS-18-067,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-18-067.html,Notices,2028-01-01,"Notice Clarification Submission Materials Related Communications FDA RFA-NS-18-023 BRAIN Initiative: Clinical Studies Advance Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System"" Notice Number: NOT-NS-18-067 Key Dates Release Date:   June 22, 2018 Related Announcements RFA-NS-18-023 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to clarify submission materials related Communications the FDA RFA-NS-18-023 BRAIN Initiative: Clinical Studies Advance Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UH3 Clinical Trial Required)"". current language reads     Section 4 Protocol Synopsis     4.6 the study an FDA-regulated intervention?     4.6.a. yes, describe availability Investigational Product IP) Investigational New Drug IND)/Investigational Device Exemption IDE) status:     Communications FDA: Large animal safety studies often required the FDA support IDE. Applicants should include large animal GLP safety study conducted the full-final device system using final manufacturing process intended support IDE. a large animal safety study not required the FDA an IDE, a test the full final system using final design manufacturing processes not required, applicants should include communication the FDA clearly stating is case the form a response a Pre-Submission. If studies proposed, ultimately needed, program staff work the investigators remove relevant milestones associated costs these activities the award   language been modified now reads:   Section 4 Protocol Synopsis   4.6 the study an FDA-regulated intervention?   4.6.a. yes, describe availability Investigational Product IP) Investigational New Drug IND)/Investigational Device Exemption IDE) status:   Communications FDA: Applicants should include minutes all pre-submission meetings, notice IDE, risk determination, email communications, other relevant documentation. material should only submitted section 4.6.a the application as post-submission material.   Large animal safety studies often required the FDA support IDE. Applicants should include large animal GLP safety study conducted the full-final device system using final manufacturing process intended support IDE. a large animal safety study not required the FDA an IDE, a test the full final system using final design manufacturing processes not required, applicants should include communication the FDA clearly stating is case the form a response a Pre-Submission. If studies proposed, ultimately needed, program staff work the investigators remove relevant milestones associated costs these activities the award. other aspects this FOA remain same.   Inquiries Please direct inquiries to: Kari Ashmont, Ph.D. National Institute Neurological Disorders Stroke Telephone: 301-496-1447 Email: kari.ashmont@nih.gov Nick Langhals, Ph.D. National Institute Neurological Disorders Stroke Telephone: 301-496-1447 Email: nick.langhals@nih.gov",,,,
"Notice of Correction to Key Dates in RFA-NS-18-029 ""BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01 Clinical Trial Not Allowed)",NOT-NS-18-070,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-18-070.html,Notices,2028-01-01,"Notice Correction Key Dates RFA-NS-18-029 BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP U01 Clinical Trial Allowed) Notice Number: NOT-NS-18-070 Key Dates Release Date: 23, 2018 Related Announcements RFA-NS-18-029 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants a correction the Key Dates RFA-NS-18-029 BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP U01 Clinical Trial Allowed)"".  Specifically, Advisory Council Review dates January 2019 and January 2020 and Earliest Start Dates February 2019 and February 2020. Part 1. Overview Information Key Dates Currently Reads: Advisory Council Review January 2019 Earliest Start Date February 2019 Modified Read: Advisory Council Review January 2019 and January 2020 Earliest Start Date February 2019 and February 2020 other aspects this FOA remain same. Inquiries Please direct inquiries to: James Gnadt, PhD  National Institute Neurological Disorders Stroke NINDS)  Telephone: 301-496-9964  Email: BRAINCircuits@nih.gov",,,,
"Notice of Support for Administrative Supplements to Embed Ethicists into BRAIN Initiative Supported Research",NOT-MH-18-034,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-18-034.html,Notices,2028-01-01,"Notice Support Administrative Supplements Embed Ethicists BRAIN Initiative Supported Research Notice Number: NOT-MH-18-034 Key Dates Release Date: 01, 2018 Related Announcements None Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative aimed revolutionizing neuroscience through development application innovative technologies map neural circuits, monitor modulate activity, understand they contribute thoughts, sensations, emotions behavior. NIH issued variety Funding Opportunity Announcements FOAs) will support projects apply technologies understand neural circuit function the context specific circuits, resulting a diverse portfolio research the fundamental biology nervous system function.  purpose this announcement to notify research community NIH encouraging applications to PA-18-591 to integrate neuroethics perspectives approaches existing BRAIN Initiative awards. Supplement applications encouraged ongoing BRAIN Initiative projects can readily incorporate core ethical issues associated research focused the human brain resulting emerging technologies advancements research development supported the BRAIN Initiative. intent that efforts supported through administrative supplement be both complimentary integrative the transformative, breakthrough neuroscience discoveries supported through BRAIN Initiative.     an administrative supplement, work proposed needs be within scope the research is already supported. Research proposed supplement applications should clear relevance the BRAIN Initiative. proposed work cover pilot projects, resource development, personnel costs embedding neuroethics the research project. each case, work proposed should feasible complete within one-year timeframe with limited funds permitted. should also show promise becoming more substantial project might attract additional funding. Investigators should submit applications responses the parent active administrative supplement announcement https://grants.nih.gov/grants/guide/pa-files/PA-18-591.html) using electronic submission. Electronic applications strongly encouraged.. Individual requests be more 100,000 direct costs exclusive Facilities Administrative costs sub-contracts may for year only. Requests must received June 15 funding FY 2018. Inquiries Please direct inquiries to: James Churchill National Institute Mental Health NIMH) Telephone: 301-443-3621 Email: churchillj@mail.nih.gov ",,,,
"Notice of NINDS BRG, BRP, Translational Neural Devices, BRAIN Initiative: Next Generation Invasive Devices Recording, Modulation in the Human Central Nervous System, and Smart & Connected Health Program Applications Directed at the Treatment of Pain",NOT-NS-18-052,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-18-052.html,Notices,2028-01-01,"Notice NINDS BRG, BRP, Translational Neural Devices, BRAIN Initiative: Next Generation Invasive Devices Recording, Modulation the Human Central Nervous System, Smart & Connected Health Program Applications Directed the Treatment Pain Notice Number: NOT-NS-18-052 Key Dates Release Date: March 27, 2018 Related Announcements PAR-18-206 PAR-18-208 RFA-NS-18-011 RFA-NS-18-012 RFA-NS-18-021 RFA-NS-18-022 RFA-NS-18-023 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform potential applicants the National Institute Neurological Disorders Stroke NINDS) Bioengineering Research Grants BRG), Bioengineering Research Partnerships BRP), Translational Neural Devices, BRAIN Initiative: Next Generation Invasive Devices Recording Modulation the Human Central Nervous System, Smart Connected Health Funding Opportunity Announcements an area special interest.  NINDS like accelerate development devices the treatment pain. Investigators strongly encouraged contact appropriate Program Director prior submitting application. Applications be submitted to: PAR-18-206 (BRG), PAR-18-208 (BRP), RFA-NS-18-011 (Translational Neural Devices), RFA-NS-18-012 (Translational Neural Devices - SBIR), RFA-NS-18-021 (BRAIN Initiative), RFA-NS-18-022 (BRAIN Initiative), RFA-NS-18-023 (BRAIN Initiative - SBIR), and NSF-18-541 (Smart Connected Health).        Within BRG BRP programs, NINDS particularly interested bioengineering research advances technologies the potential decrease burden neurological disorders stroke, including pain. Examples areas interest include development validation invasive non-invasive devices, diagnostic/monitoring tools, advanced imaging techniques, computational models, tissue engineering, other innovative methods.     Translational Neural Devices program interested receiving applications translational studies devices treat pain. Translational Neural Devices supports translational activities small clinical studies advance development invasive non-invasive therapeutic, diagnostic devices disorders affect nervous neuromuscular systems. Program activities, including translational bench animal studies, expected lead submission an Investigational Device Exemption IDE) the U.S. Food Drug Administration FDA) Institutional Review Board IRB) application a Non-Significant Risk NSR) study. program also support subsequent small clinical trial collect safety effectiveness data required support marketing application to inform final device design.     BRAIN Initiative: Next Generation Invasive Devices Recording Modulation the Human Central Nervous System program supports translational and/or clinical studies invasive recording and/or stimulating devices treat nervous system disorders, including support the submission an Investigational Device Exemption IDE) a Significant Risk SR) study obtain Institutional Review Board IRB) approval a Non-Significant Risk NSR) study, and/or small clinical trial e.g., Early Feasibility Study). small clinical trial should provide data answer key questions the function final design a device. This final device design require most, not all, the non-clinical testing the path more advanced clinical trials market approval. BRAIN Initiative includes both brain spinal cord this program like encourage translational clinical projects invasive recording and/or stimulating devices treat pain.      Smart Connected Health program https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=504739) an interagency program between Institutes Centers the National Institutes Health NIH) the National Science Foundation NSF) supporting development technologies, analytics models supporting next generation health medical research through high-risk, high-reward advances computer information science, engineering technology, behavior, cognition, robotics imaging. NINDS interested applications next-generation multidisciplinary science encourages research pain a variety areas value health, such networking, pervasive computing, advanced analytics, sensor integration, privacy security, modeling socio-behavioral cognitive processes system process modeling. Inquiries Please direct inquiries to: Nick Langhals, Ph.D. National Institute Neurological Disorders Stroke Telephone: 301-496-1447 Email: nick.langhals@nih.gov Stephanie Fertig, M.B.A. National Institute Neurological Disorders Stroke Telephone: 301-496-1779 Email: fertigs@ninds.nih.gov Michael Oshinsky, Ph.D. National Institute Neurological Disorders Stroke Telephone: 301-496-9964 Email: michael.oshinsky@nih.gov",,,,
"Notice of Change to Receipt Dates on BRAIN Initiative:  Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)",NOT-EB-18-005,http://grants.nih.gov/grants/guide/notice-files/NOT-EB-18-005.html,Notices,2028-01-01,"Notice Change Receipt Dates BRAIN Initiative: Theories, Models Methods Analysis Complex Data the Brain R01 Clinical Trial Allowed) Notice Number: NOT-EB-18-005 Key Dates Release Date: February 07, 2018 Related Announcements RFA-EB-17-005 Issued National Institute Biomedical Imaging Bioengineering NIBIB) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this Notice to change Application Due Dates BRAIN Initiative:  Theories, Models Methods Analysis Complex Data the Brain R01 Clinical Trial Allowed) RFA-EB-17-005) Currently reads: Application Due Date(s): December 15, 2017; October 17, 2018; October 17, 2019 Revised read: Application Due Dates(s): December 15, 2017; September 4, 2018; September 3, 2019 Currently reads: Scientific Merit Review: 2018, March 2019, March 2020 Revised read: Scientific Merit Review: 2018, February 2019, February 2020 Currently reads: Advisory Council Review: August 2018, August 2019, August 2020 Revised read: Advisory Council Review: August 2018, 2019, 2020 Inquiries Please direct inquiries to: Grace C.Y. Peng, PhD National Institute Biomedical Imaging Bioengineering NIBIB) Telephone: 301-451-4778 Email: BRAINTheoriesFOA@mail.nih.gov",,,,
"BRAIN Initiative: Notice of Support for Research on the Fundamental Neurobiology of Pain Processing",NOT-NS-18-008,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-18-008.html,Notices,2028-01-01,"BRAIN Initiative: Notice Support Research the Fundamental Neurobiology Pain Processing Notice Number: NOT-NS-18-008 Key Dates Release Date: September 12, 2017 Related Announcements None Issued National Institutes Health NIH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative aimed revolutionizing neuroscience through development application innovative technologies map neural circuits, monitor modulate activity, understand they contribute thoughts, sensations, emotions behavior.  NIH issued variety Funding Opportunity Announcements FOAs) will support projects apply technologies understand neural circuit function the context specific circuits, resulting a diverse portfolio research the fundamental biology nervous system function.  purpose this announcement to notify research community NIH welcomes BRAIN Initiative applications targeting central nervous system nociceptive pain circuits, appropriate the goals requirements specific BRAIN Initiative FOAs.  Pain conditions represent important public health problem NIH continues support research pain pathologies through normal Institute Center appropriations. However, pain nociception also components normal nervous system function, the BRAIN Initiative committed understanding pain circuits along brain circuits underlying sensory, motor, cognitive emotional functions.  is expected the unique opportunities the BRAIN Initiative enable production detailed maps pain circuits, the adoption powerful new tools monitoring modulating pain circuit activity, leading significant advances the understanding pain nociception. a list past open BRAIN Initiative FOAs.  information goals requirements specific BRAIN FOAs, contact Scientific/Program staff listed the text the respective announcements.  Inquiries Please direct inquiries to: James Gnadt, PhD  National Institute Neurological Disorders Stroke NINDS)  Telephone: 301-496-9964  Email: BRAINCircuits@NIH.GOV   ",,,,
"Notice of Clarification of the Device Requirement for RFA-NS-17-005 ""BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3)""",NOT-NS-18-004,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-18-004.html,Notices,2028-01-01,"Notice Clarification the Device Requirement RFA-NS-17-005 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UG3/UH3)"" Notice Number: NOT-NS-18-004 Key Dates Release Date: August 18, 2017 Related Announcements RFA-NS-17-005 Issued National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this Notice to add language concerning device-based study requirements RFA-NS-17-005.  is expected proposed devices include ability synchronize peripheral ambulatory behavioral signals recorded brain signals. current language reads: Part 2.  Full Text Announcement Section 1. Funding Opportunity Description Objectives this FOA projects must two phases, UG3 UH3.  initial UG3 phase support nonclinical testing support filing an IDE an SR study to obtain IRB approval an NSR clinical study.  projects start the UG3 phase, the length the UG3 phase depend the maturity the project entry.  Only those UG3 projects have met specific criteria below) transition the subsequent UH3 phase after NIH administrative review.  UH3 phase support small clinical study.  Projects which only clinical phase proposed should submitted under RFA-NS-17-006, utilizes UH3 activity code. FOA milestone-driven involves NIH program staff's participation developing project plan, monitoring research progress, making go/no-go decisions.  NIH staff also provide assistance academic investigators familiarizing with clinical device development process the criteria needed advance therapeutic leads diagnostics the clinic.  expectations the program in line those industry regards advancing devices through translational development pipeline.  such, inherent high rate attrition expected within program. Scope the FOA UG3 Scope Examples studies can proposed during non-clinical phase include, are limited to: Non-GLP Good Laboratory Practice) animal studies develop surgical techniques relevant the device, define relevant therapeutic parameters, refine device design preparation subsequent GLP testing regulatory approval vitro animal testing meet FDA recognized ISO/ASTM Standards Activities become GMP Good Manufacturing Practice) compliant Activities bring development process under Design Quality Systems Control Device, software firmware design verification validation activities GLP compliant large animal model safety and/or testing an implanted device language been modified now reads: Part 2. Full Text Announcement Section 1. Funding Opportunity Description Objectives this FOA projects must two phases, UG3 UH3.  initial UG3 phase support nonclinical testing support filing an IDE an SR study to obtain IRB approval an NSR clinical study.  projects start the UG3 phase, the length the UG3 phase depend the maturity the project entry.  Only those UG3 projects have met specific criteria below) transition the subsequent UH3 phase after NIH administrative review.  UH3 phase support small clinical study.  Projects which only clinical phase proposed should submitted under RFA-NS-17-006, utilizes UH3 activity code. Proposed next generation devices strongly encouraged incorporate ability synchronize peripheral, ambulatory behavioral data signals.  signals must synchronized real time, analysis be done an online offline manner.  Data does have be stored board the device may streamed out, long it does interfere significantly the naturalistic behavior i.e., participant must be required carry around large personal computer them synchronization occur).  Behavioral signals be those captured a phone GPS, keyboard usage, accelerometer, etc.), smartwatch, related peripheral behavioral capture device. FOA milestone-driven involves NIH program staff's participation developing project plan, monitoring research progress, making go/no-go decisions.  NIH staff also provide assistance academic investigators familiarizing with clinical device development process the criteria needed advance therapeutic leads diagnostics the clinic.  expectations the program in line those industry regards advancing devices through translational development pipeline.  such, inherent high rate attrition expected within program. Scope the FOA UG3 Scope Examples studies can proposed during non-clinical phase include, are limited to: Non-GLP Good Laboratory Practice) animal studies develop surgical techniques relevant the device, define relevant therapeutic parameters, refine device design preparation subsequent GLP testing regulatory approval vitro animal testing meet FDA recognized ISO/ASTM Standards Activities become GMP Good Manufacturing Practice) compliant Activities bring development process under Design Quality Systems Control nbsp;Device, software firmware design verification validation activities Device, software, firmware design activities related synchronization naturalistic behavioral data neural recordings GLP compliant large animal model safety and/or testing an implanted device other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: nick.langhals@nih.gov",,,,
"Notice of Clarification of the Device Requirement for ""BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44)""",NOT-NS-18-006,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-18-006.html,Notices,2028-01-01,"Notice Clarification the Device Requirement BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System U44)"" Notice Number: NOT-NS-18-006 Key Dates Release Date: August 18, 2017 Related Announcements RFA-NS-17-007 Issued National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this Notice to add language concerning device-based study requirements RFA-NS-17-007. is expected proposed devices include ability synchronize peripheral ambulatory behavioral signals recorded brain signals. current language reads: Part 2.  Full Text Announcement Section 1. Funding Opportunity Description Objectives this FOA projects must two phases, Phase and Phase II, using Fast-track mechanism.  initial Phase will support non-clinical testing toward filing an IDE an SR study obtaining IRB approval an NSR clinical study.  projects start Phase I, the length Phase will depend the maturity the project entry.  Only those Phase projects have met specific criteria below) transition the subsequent Phase II after NIH administrative review.  Phase II support small clinical study. FOA milestone-driven involves NIH program staff's participation developing project plan, monitoring research progress, making go/no-go decisions.  NIH staff also provide assistance academic investigators familiarizing with clinical device development process the criteria needed advance therapeutic leads diagnostics the clinic.  expectations the program in line those industry regards advancing devices through translational development pipeline.  such, inherent high rate attrition expected within program. Scope the FOA U44 Phase Scope Examples Examples studies can proposed during non-clinical Phase include, are limited to: Non-GLP Good Laboratory Practice) animal studies develop surgical techniques relevant the device, define relevant therapeutic parameters, refine device design preparation subsequent GLP testing regulatory approval vitro animal testing meet FDA recognized ISO/ASTM Standards Activities become GMP Good Manufacturing Practice) compliant Activities bring development process under Design Quality Systems Control Device, software firmware design verification validation activities GLP compliant large animal model safety and/or testing an implanted device language been modified now reads: Part 2. Full Text Announcement Section 1. Funding Opportunity Description Objectives this FOA projects must two phases, Phase and Phase II, using Fast-track mechanism.  initial Phase will support non-clinical testing toward filing an IDE an SR study obtaining IRB approval an NSR clinical study.  projects start Phase I, the length Phase will depend the maturity the project entry.  Only those Phase projects have met specific criteria below) transition the subsequent Phase II after NIH administrative review.  Phase II support small clinical study. Proposed next generation devices strongly encouraged incorporate ability synchronize peripheral, ambulatory behavioral data signals.  signals must synchronized real time, analysis be done an online offline manner.  Data does have be stored board the device may streamed out, long it does interfere significantly the naturalistic behavior i.e., participant must be required carry around large personal computer them synchronization occur).  Behavioral signals be those captured a phone GPS, keyboard usage, accelerometer, etc.), smartwatch, related peripheral behavioral capture device. FOA milestone-driven involves NIH program staff's participation developing project plan, monitoring research progress, making go/no-go decisions.  NIH staff also provide assistance academic investigators familiarizing with clinical device development process the criteria needed advance therapeutic leads diagnostics the clinic.  expectations the program in line those industry regards advancing devices through translational development pipeline.  such, inherent high rate attrition expected within program. Scope the FOA U44 Phase Scope Examples studies can proposed during non-clinical Phase include, are limited to: Non-GLP Good Laboratory Practice) animal studies develop surgical techniques relevant the device, define relevant therapeutic parameters, refine device design preparation subsequent GLP testing regulatory approval vitro animal testing meet FDA recognized ISO/ASTM Standards Activities become GMP Good Manufacturing Practice) compliant Activities bring development process under Design Quality Systems Control Device, software firmware design verification validation activities Device, software, firmware design activities related synchronization naturalistic behavioral data neural recordings GLP compliant large animal model safety and/or testing an implanted device other aspects this FOA remain unchanged Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: nick.langhals@nih.gov",,,,
"Notice of Intent to Reissue the Funding Opportunity Announcement for BRAIN Initiative: Proof of Concept Development of Early Stage Next Generation Human Brain Imaging (R01)",NOT-EB-17-005,http://grants.nih.gov/grants/guide/notice-files/NOT-EB-17-005.html,Notices,2028-01-01,"Notice Intent Reissue Funding Opportunity Announcement BRAIN Initiative: Proof Concept Development Early Stage Next Generation Human Brain Imaging R01) Notice Number: NOT-EB-17-005 Key Dates Release Date: July 28, 2017 Estimated Publication Date Announcement: September 2017 First Estimated Application Due Date: December 2017 Earliest Estimated Award Date: September 2018  Earliest Estimated Start Date: September 2018  Related Announcements NOT-EB-17-006 Issued National Institute Biomedical Imaging Bioengineering NIBIB) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose NIH Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative intends reissue RFA-EB-17-001, Proof Concept Development Early Stage Next Generation Human Brain Imaging, modifications. funding opportunity aims support early stage development entirely new novel noninvasive human brain imaging technologies methods will lead transformative advances our understanding the human brain. FOA solicits unusually bold potentially transformative approaches supports small scale, proof concept development based exceptionally innovative, original and/or unconventional concepts.  Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published September2017 an expected application due date Winter 2017. FOA utilize R01 activity code. Details the planned FOA provided below Research Initiative Details Notice encourages investigators expertise insights this area noninvasive human brain imaging technologies methods begin consider applying this new FOA. FOA solicits unusually bold potentially transformative approaches supports small scale, proof concept development human brain imaging based exceptionally innovative, original and/or unconventional concepts. goal to accelerate early stage development promising entirely new concepts require initial stage development testing before launching full scale tool development. Applications submitted response this FOA should focus innovative approaches proof principle initial stage development breakthrough, noninvasive imaging technology measure human brain processes ways are currently unachievable via imaging technologies live persons. proposed concepts approaches expected be high-risk, high-impact, disruptive. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Shumin Wang, PhD National Institute Biomedical Imaging Bioengineering NIBIB) Telephone: 301-594-9001 Email: shumin.wang@nih.gov",,,,
"Notice of Intent to Reissue the Funding Opportunity Announcement for BRAIN Initiative: Development of Next Generation Human Brain Imaging Tools and Technologies (U01)",NOT-EB-17-006,http://grants.nih.gov/grants/guide/notice-files/NOT-EB-17-006.html,Notices,2028-01-01,"Notice Intent Reissue Funding Opportunity Announcement BRAIN Initiative: Development Next Generation Human Brain Imaging Tools Technologies U01) Notice Number: NOT-EB-17-006 Key Dates Release Date: July 28, 2017 Estimated Publication Date Announcement: September 2017 First Estimated Application Due Date: December 2017 Earliest Estimated Award Date: September 2018  Earliest Estimated Start Date: September 2018  Related Announcements NOT-EB-17-005 Issued National Institute Biomedical Imaging Bioengineering NIBIB) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose NIH Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative intends reissue RFA-EB-17-002, Development Next Generation Human Brain Imaging Tools Technologies, modifications. funding opportunity aims support full development entirely new next generation noninvasive human brain imaging tools methods will lead transformative advances our understanding the human brain. FOA seeks innovative applications are ready full-scale development breakthrough technologies the intention delivering working tools within timeframe the BRAIN Initiative. FOA represents second stage the tool/technology development effort started RFA-MH-14-217 RFA-MH-15-200. Notice being provided allow potential applicants sufficient time develop meaningful collaborations appropriate projects.  FOA expected be published September 2017 an expected application due date Winter 2017. FOA utilize U01 activity code. Details the planned FOA provided below Research Initiative Details Notice encourages investigators expertise insights this area noninvasive human brain imaging technologies methods begin consider applying this new FOA. FOA solicits applications proposing full development next generation human brain imaging breakthrough technologies would overcome existing barriers. developed, such technologies enable imaging measuring brain processes ways are currently unachievable, thereby acquiring fundamental novel insight how human brain organized functions. FOA provide needed resources support teams meet grand challenges developing novel transformative interdisciplinary approaches human brain imaging. intended outcome bold, high-impact, disruptive tools methods human neuroscience can used practically ethically healthy humans irrespective disease state. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Shumin Wang, PhD National Institute Biomedical Imaging Bioengineering NIBIB) Telephone: 301-594-9001 Email: shumin.wang@nih.gov",,,,
"Notice of Expiration of RFA-NS-17-008 "" BRAIN Initiative: SBIR Direct to Phase II Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44)""",NOT-NS-17-028,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-17-028.html,Notices,2028-01-01,"Notice Expiration RFA-NS-17-008 BRAIN Initiative: SBIR Direct Phase II Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System U44)"" Notice Number: NOT-NS-17-028 Key Dates Release Date: 24, 2017 Related Announcements RFA-NS-17-008  Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform extramural community the NINDS expiring RFA-NS-17-008 quot;BRAIN Initiative: SBIR Direct Phase II Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System U44)"" due the expiration the SBIR Direct Phase II program.  Applications not accepted the October 18, 2017 application due date. Key Dates table updated accordingly: Key Dates Application Due Date(s) December 21, 2016 5:00 PM local time applicant organization. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Expiration Date 24, 2017 Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: nick.langhals@nih.gov nbsp;",,,,
"Notice to Extend RFA-MH-17-245 ""BRAIN Initiative: Non-Invasive Neuromodulation - Mechanisms and Dose/Response Relationships for Targeted CNS Effects (R01)""",NOT-MH-16-023,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-16-023.html,Notices,2028-01-01,"Notice Extend RFA-MH-17-245 BRAIN Initiative: Non-Invasive Neuromodulation - Mechanisms Dose/Response Relationships Targeted CNS Effects R01)"" Notice Number: NOT-MH-16-023 Key Dates Release Date: September 16, 2016 Related Announcements RFA-MH-17-245 Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this Notice to extend RFA-MH-17-245 ldquo;BRAIN Initiative: Non-Invasive Neuromodulation - New Tools Techniques Spatiotemporal Precision R01)"" invites application encourage optimization existing electrical magnetic stimulation methods. Part 1. Key Dates Currently reads:  Application Due Date(s): November 23, 2016 Scientific Merit Review: March 2017 Advisory Council Review: 2017 Earliest Start Date: September 2017 Expiration Date: November 24, 2016 Modified read: Application Due Date(s): November 23, 2016 October 13, 2017 Scientific Merit Review: March 2017 March 2018 Advisory Council Review: 2017 May 2018 Earliest Start Date: September 2017 September 2018 Expiration Date: October 14, 2017 other aspects this FOA remain same. Inquiries Please direct inquiries to: Fred Friedman, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-4058 Email: ffriedma@mail.nih.gov",,,,
"Notice to Extend RFA-MH-17-240 ""BRAIN Initiative: Non-Invasive Neuromodulation - New Tools and Techniques for Spatiotemporal Precision (R01)""",NOT-MH-16-024,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-16-024.html,Notices,2028-01-01,"Notice Extend RFA-MH-17-240 BRAIN Initiative: Non-Invasive Neuromodulation - New Tools Techniques Spatiotemporal Precision R01)"" Notice Number: NOT-MH-16-024 Key Dates Release Date: September 16, 2016 Related Announcements RFA-MH-17-240 Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this Notice to extend RFA-MH-17-240 ldquo;BRAIN Initiative: Non-Invasive Neuromodulation - New Tools Techniques Spatiotemporal Precision R01)"" invites application develop test novel tools methods neuromodulation go beyond existing variations. Part 1. Key Dates Currently reads:  Application Due Date(s): November 23, 2016 Scientific Merit Review: March 2017 Advisory Council Review: 2017 Earliest Start Date: September 2017 Expiration Date: November 24, 2016 Modified read: Application Due Date(s): November 23, 2016 October 13, 2017 Scientific Merit Review: March 2017 March 2018 Advisory Council Review: 2017 May 2018 Earliest Start Date: September 2017 September 2018 Expiration Date: October 14, 2017 other aspects this FOA remain same. Inquiries Please direct inquiries to: Fred Friedman, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-4058 Email: ffriedma@mail.nih.gov",,,,
"Notice to Extend RFA-MH-17-235 ""BRAIN Initiative: Foundations of Non-Invasive Functional Human Brain Imaging and Recording-Bridging Scales and Modalities (R01)""",NOT-MH-16-025,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-16-025.html,Notices,2028-01-01,"Notice Extend RFA-MH-17-235 BRAIN Initiative: Foundations Non-Invasive Functional Human Brain Imaging Recording-Bridging Scales Modalities R01)"" Notice Number: NOT-MH-16-025 Key Dates Release Date: September 16, 2016 Related Announcements RFA-MH-17-235 Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this Notice to extend RFA-MH-17-235 ldquo;BRAIN Initiative: Foundations Non-Invasive Functional Human Brain Imaging Recording - Bridging Scales Modalities R01)"" invites application support effort will revolutionize our understanding the biological activity underlying, bioinformatic content data collected using contemporary non-invasive functional brain imaging techniques.  Part 1. Key Dates Currently reads:   Application Due Date(s): November 23, 2016 Scientific Merit Review: March 2017 Advisory Council Review: 2017 Earliest Start Date: September 2017 Expiration Date: November 24, 2016 Modified read: Application Due Date(s): November 23, 2016 October 13, 2017 Scientific Merit Review: March 2017 March 2018 Advisory Council Review: 2017 May 2018 Earliest Start Date: September 2017 September 2018 Expiration Date: October 14, 2017 other aspects this FOA remain same. Inquiries Please direct inquiries to: Jay Churchill, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-3621 Email: churchillj@mail.nih.gov",,,,
"Notice to Extend RFA-MH-17-220  ""BRAIN Initiative: Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain (R01)""",NOT-MH-16-026,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-16-026.html,Notices,2028-01-01,"Notice Extend RFA-MH-17-220 BRAIN Initiative: Development Validation Novel Tools Analyze Cell-Specific Circuit-Specific Processes the Brain R01)"" Notice Number: NOT-MH-16-026 Key Dates Release Date: September 16, 2016 Related Announcements RFA-MH-17-220 Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this Notice to extend RFA-MH-17-220 ldquo;BRAIN Initiative: Development Validation Novel Tools Analyze Cell-Specific Circuit-Specific Processes the Brain R01)"" invites application develop validate novel tools facilitate detailed analysis complex circuits provide insights cellular interactions underlie brain function. Part 1. Key Dates Currently reads: Application Due Date s): November 2, 2016 Scientific Merit Review: March 2017 Advisory Council Review: 2017 Earliest Start Date: September 2017 Expiration Date: November 3, 2016 Modified read: Application Due Date(s): November 2, 2016 October 13, 2017 Scientific Merit Review: March 2017 March 2018 Advisory Council Review: 2017 May 2018 Earliest Start Date: September 2017 September 2018 Expiration Date: October 14, 2017 other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Michelle Freund, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-1815 Email: BRAIN-info-NIMH@mail.nih.gov",,,,
"BRAIN Initiative Multi-Council Working Group Clearance of Initiative Concepts for FY2017",NOT-NS-16-041,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-16-041.html,Notices,2028-01-01,"BRAIN Initiative Multi-Council Working Group Clearance Initiative Concepts FY2017 Notice Number: NOT-NS-16-041 Key Dates Release Date: September 6, 2016 Related Announcements None     Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Center Complementary Integrative Health NCCIH) Purpose Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative an ambitious multi-agency effort announced President Obama April 2013. Specific goals NIH contributions the Initiative formulated over year-long planning process culminated the release BRAIN 2025: Scientific Vision, seminal planning document produced a working committee the Advisory Council the NIH Director. NIH continues be guided this document by input the BRAIN Multi-Council Working Group MCWG), committee includes Advisory Council members each the ten NIH Institutes Centers ICs) contributing the BRAIN Initiative.  upcoming fiscal year represents transition point the BRAIN Initiative, goals scaling efforts a number specific areas: 1.  Census Brain Cell Types 2.  Tools Cells Circuits 3.  Technologies Neural Recording Modulation 4.  Human Imaging Neuromodulation 6.  Technology Dissemination Training 7.  Small Business Awards 8.  Data Coordination 9.  Neuroethics fund ambitious goals this transition, President’s budget calls a total appropriation 195 million, has matched exceeded proposals House Senate appropriations subcommittees.  its most recent meeting August 2, 2016, MCWG provided clearance BRAIN FY 2017 initiatives.  Investigators interested particular research areas encouraged review listing cleared initiatives, includes contact information NIH Program staff each area.  Links this information be found the following url:  Multi-Council Working Group.   Interested parties also encouraged subscribe the BRAIN Update post https://brainupdate.nih.gov/), issues periodic announcements including new funding opportunities.  Inquiries Please direct inquiries to: Edmund Ned) Talley, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1917 Email: Edmund.Talley@nih.gov email strongly preferred) Gregory K. Farber, Ph.D. National Institute Mental Health NIMH) Telephone:  301-435-0778 Email: farberg@mail.nih.gov",,,,
"Request for Information (RFI):  Guidance for Opportunities in Neuroethics (NIH BRAIN Initiative)",NOT-MH-16-014,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-16-014.html,Notices,2028-01-01,"Request Information RFI): Guidance Opportunities Neuroethics NIH BRAIN Initiative) Notice Number: NOT-MH-16-014 Key Dates Release Date: 27, 2016 Response Date: July 29, 2016 Related Announcements None     Issued NIH BRAIN Initiative braininitiative.nih.gov) National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose is Request Information RFI) soliciting input identify set core ethical issues associated research involving human brain resulting advancements neurotechnology research development. Background BRAIN Initiative: Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative® aimed revolutionizing our understanding the human brain. accelerating development application innovative technologies, researchers be able produce new dynamic picture the brain that, the first time, show individual cells complex neural circuits interact both time space. work well underway http://www.braininitiative.nih.gov) the application the innovative tools technologies ultimately lead new ways treat prevent brain disorders. NIH one several federal agencies involved the BRAIN Initiative. Planning the NIH component the BRAIN initiative guided the long-term scientific plan, ldquo;BRAIN 2025: Scientific Vision,” details seven high-priority research areas calls a sustained federal commitment 4.5 billion over 12 years. address current challenges lay more stable foundation future generations researchers, NIH seeking input the community opportunities areas/topics where ethical issues related neuroscience research might considered. overall aim to integrate ethical insight progress under BRAIN Initiative, proactively consider ethical implications the research. Information Requested NIH strives maximize impact the taxpayers’ investments biomedical research. Specific this RFI, input researchers, academic institutions, professional societies other stakeholders solicited potential topics explore where BRAIN Initiative might invest resources the area neuroethics, particularly pertaining emerging neurotechnologies. While welcome input the community any areas germane neuroethics, are particularly interested feedback the following topics: Areas policy guidance might useful Principal Investigators Institutional Review Boards regarding emerging neuroethics issues associated neurotechnology research development. welcome responses point specific strengths weaknesses current policies suggestions how can expand and/or improve policies. evolving breadth neural data associated issues such as: should own data research participant, investigator, institution, public)? Storage data the cloud, via federated databases?) security concerns should access these data whom, quickly, how long, types data)? Privacy concerns protection discrimination those whose neural data shared Unintended uses data Special considerations associated novel neuromodulation neuroimaging technologies: Activation monitoring devices does it, is done) Responsibility the long-term maintenance such devices Security regarding telemetry data remote storage devices Potential culpability concerns regarding predictions neural data Informed consent issues, specifically pertaining studies using novel neurotechnologies Establishing greater uniformity the informed consent process participant perspective the consent process consent permits/hinders is possible technological advances Issues special populations such pregnant women, children, those physical and/or intellectual disabilities cognitive impairment to best integrate neuroethics, appropriate, workshops training opportunities when communicating neuroscience research findings to: Press Lay public Political leaders Scientific Community Translation new tools technologies neuroscience research contexts beyond clinic/bench: Ethics commercialization, public-private partnerships, wider application imaging technologies commercial purposes, conflicts interest use ex vivo human brain tissue; including ownership privacy issues Specific neuroethics questions could addressed using focused research approach Any issues respondents feel relevant to Submit Response Responses must submitted electronically through BRAIN-info-nimh@mail.nih.gov July 29, 2016. RFI for planning purposes only should be construed a solicitation applications an obligation the part the government. The government not pay the preparation any information submitted for government’s of information. NIH use information submitted response this RFI its discretion will provide comments any responder's submission. Responses the RFI be reflected future funding opportunity announcements. information provided be analyzed, appear reports, may shared publicly an NIH website. Respondents advised the government under obligation acknowledge receipt the information provide feedback respondents respect any information submitted. proprietary, classified, confidential, sensitive information should included your response. government reserves right use any non-proprietary technical information any resultant solicitation(s), policies procedures. Inquiries Please direct inquiries to: Email: BRAIN-info-nimh@mail.nih.gov  ",,,,
"Participation by Danish Researchers in the NIH BRAIN Initiative",NOT-MH-16-004,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-16-004.html,Notices,2028-01-01,"Participation Danish Researchers the NIH BRAIN Initiative Notice Number: NOT-MH-16-004 Key Dates Release Date:   February 22, 2016 Related Announcements None     Issued National Institutes Health NIH) National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Lundbeckfonden http://www.lundbeckfoundation.com/) Purpose Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative a multi-agency effort, a coordinated contribution 10 NIH Institutes Centers http://braininitiative.nih.gov/).  part the NIH BRAIN Initiative, NIH announces new partnership, formalized a letter agreement, Lundbeckfonden http://www.lundbeckfoundation.com/) support involvement researchers Danish institutions the BRAIN Initiative.  Both NIH Lundbeckfonden believe the ambitious goals the BRAIN Initiative best attained collaboration across disciplinary boundaries well geographic boundaries.  Supplemental Funding NIH a number BRAIN Initiative awards FY14 FY15 http://www.braininitiative.nih.gov/nih-brain-awards.htm).  Researchers Danish institutions are interested participating funded awards advised contact Program Director/Principal Investigator the NIH award inquire there mutual interest collaboration.  there interest, researcher a Danish institution apply directly Lundbeckfonden funding the work be performed Denmark.  each approved project an added Danish collaboration, funding administration the work performed Denmark shall managed the foundation the Danish host institution.  NIH consider administrative supplements support such collaborations. Matching Funding most the NIH BRAIN Initiative Funding Opportunity Announcements, foreign institutions permitted participate either submitting applications directly as subcontractors an application a domestic institution.  Researchers Danish institutions submit applications either role BRAIN Initiative awards should contact Lundbeckfonden the award submitted they interested having award potentially co-funded NIH the Lundbeckfonden.  NIH evaluate i.e., peer review) application, will a funding decision.  the project receives NIH award, Lundbeckfonden decide whether will fund – fully in part – Danish based elements the project.  NIH not share application materials summary statements directly the Lundbeckfonden, the applicant must those materials available Lundbeckfonden they want be considered co-funding.    addition providing funds, representatives the foundation join those the National Science Foundation, Food Drug Administration, Defense Advanced Research Projects Agency, Brain Canada, Australian National Health Medical Research Council, the Intelligence Advanced Research Projects Agency meetings the BRAIN Multi-Council Working Group http://braininitiative.nih.gov/Brain_multi_council_working_group.htm). Inquiries Please direct inquiries to: Gregory K. Farber, Ph.D. National Institute Mental Health NIMH) Telephone:  301-435-0778 Email:  farberg@mail.nih.gov Ned Talley, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone:  301-496-1917 Email:  talleye@mail.nih.gov Lundbeckfonden Telephone: 45 39 12 80 15 Email:  application@lundbeckfonden.com",,,,
"Notice of Change to the Application Due Date and to Allow Foreign Components for Applications to RFA-NS-16-008 ""BRAIN Initiative:  Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01)""",NOT-NS-15-044,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-15-044.html,Notices,2028-01-01,"Notice Change the Application Due Date to Allow Foreign Components Applications RFA-NS-16-008 BRAIN Initiative: Research Opportunities Using Invasive Neural Recording Stimulating Technologies the Human Brain U01)"" Notice Number: NOT-NS-15-044 Key Dates Release Date:   November 5, 2015 Related Announcements RFA-NS-16-008       Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Center Complementary Integrative Health NCCIH)  Purpose Notice to change application due date, to correct information eligible organizations RFA-NS-16-008 BRAIN Initiative:  Research Opportunities Using Invasive Neural Recording Stimulating Technologies the Human Brain U01).”  new due date be January 13, 2016.  Also changed Funding Opportunity Announcement FOA) allow applications include foreign components, such sub-contracts foreign organizations and/or activities performed foreign organizations.  Currently FOA reads: Key Dates Open Date Earliest Submission Date) November 15, 2015 Letter Intent Due Date(s) November 15, 2015 Application Due Date(s) December 15, 2015, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due this date. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. late applications be accepted this Funding Opportunity Announcement. AIDS Application Due Date(s) Not  Applicable Scientific Merit Review February 2016 Advisory Council Review 2016 Earliest Start Date June 2016 Expiration Date December 16, 2015  Foreign Institutions Non-domestic non-U.S.) Entities Foreign Institutions) not eligible apply. Non-domestic non-U.S.) components U.S. Organizations not eligible apply. Foreign components, defined the NIH Grants Policy Statement, not allowed. FOA now changed read: Key Dates Open Date Earliest Submission Date) December 13, 2015 Letter Intent Due Date(s) December 13, 2015 Application Due Date(s) January 13, 2016, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due this date. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. late applications be accepted this Funding Opportunity Announcement. AIDS Application Due Date(s) Not  Applicable Scientific Merit Review April 2016 Advisory Council Review August 2016 Earliest Start Date September 2016 Expiration Date January 14, 2016  Foreign Institutions Non-domestic non-U.S.) Entities Foreign Institutions) not eligible apply. Non-domestic non-U.S.) components U.S. Organizations not eligible apply. Foreign components, defined the NIH Grants Policy Statement,are allowed. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: James Gnadt, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: BRAIN_ResOppHu@mail.nih.gov",,,,
"Notice of Informational Webinar for PAR-15-345 ""BRAIN Initiative:  Pre-Applications for Industry Partnerships to Provide Early Access to Devices for Stimulation and Recording in the Human Central Nervous System (X02)""",NOT-NS-15-043,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-15-043.html,Notices,2028-01-01,"Notice Informational Webinar PAR-15-345 BRAIN Initiative: Pre-Applications Industry Partnerships Provide Early Access Devices Stimulation Recording the Human Central Nervous System X02)"" Notice Number: NOT-NS-15-043 Key Dates Release Date:   October 15, 2015   Related Announcements PAR-15-345 RFA-NS-16-009 RFA-NS-16-010     Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform potential applicants Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative Funding Opportunity Announcement Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System RFA-NS-16-009 RFA-NS-16-010) a webinar provide technical assistance the optional pre-application, PAR-NS-15-345 BRAIN Initiative:  Pre-Applications Industry Partnerships Provide Early Access Devices Stimulation Recording the Human Central Nervous System X02). webinar optional not required submission PAR-NS-15-345, RFA-NS-16-009, RFA-NS-16-010. Webinar Information Date: Friday, October 30, 2015 Time: 3:30 PM EDT Duration: 1 hour register the webinar, to submit questions, please email BRAIN-FOAs@nih.gov Wednesday, October 28, 2015. Inquiries Please direct inquiries to: Stephanie Fertig, MBA National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: BRAIN-FOAs@nih.gov",,,,
"Participation by Canadian Researchers in the NIH BRAIN Initiative",NOT-MH-15-020,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-15-020.html,Notices,2028-01-01,"Participation Canadian Researchers the NIH BRAIN Initiative Notice Number: NOT-MH-15-020 Key Dates Release Date:   August 6, 2015 Related Announcements None     Issued National Institute Mental Health NIMH) National Eye Institute NEI)National Institute Aging NIA) National Inistitute Alcohol Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Brain Canada Foundation Brain Canada) Purpose 10 NIH Institutes are part the NIH BRAIN Initiative announce new partnership, formalized a letter agreement, the Brain Canada Foundation Brain Canada) support involvement Canadian researchers the NIH BRAIN Initiative.  Both NIH the Brain Canada Foundation believe the ambitious goals the BRAIN Initiative best attained collaboration across disciplinary boundaries well geographic boundaries.  Brain Canada seek partners provide grant support Canadian researchers through Canada Brain Research Fund provides 1:1 match funds raised other sources. Supplemental Funding NIH a number BRAIN Initiative awards FY14 http://braininitiative.nih.gov/nih-brain-awards.htm) many are expected be in FY15.  Canadian researchers are interested participating funded awards advised contact Program Director/Principal Investigator the NIH award inquire there mutual interest collaboration.  there interest, Canadian researcher apply directly the Brain Canada Foundation funding the work be performed Canada. each approved project an added Canadian collaboration, funding administration the work performed Canada shall managed Brain Canada. Matching Funding most the NIH BRAIN Initiative Funding Opportunity Announcements, foreign institutions been permitted participate either submitting applications directly as subcontractors an application a domestic institution.  Canadian researchers submit applications either role BRAIN Initiative awards should contact Brain Canada will seek partners provide grant support through Canada Brain Research Fund. addition providing funds, representatives the Brain Canada Foundation join those the National Science Foundation, Food Drug Administration, Defense Advanced Research Projects Agency, Australian National Health Medical Research Council, the Intelligence Advanced Research Projects Agency meetings the BRAIN Multi-Council Working Group http://braininitiative.nih.gov/Brain_multi_council_working_group.htm). Inquiries Please direct inquiries to: Gregory K. Farber, Ph.D. National Institute Mental Health NIMH) Telephone:  301-435-0778 Email:  farberg@mail.nih.gov Ned Talley, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone:  301-496-1917 Email:  talleye@mail.nih.gov Inez Jabalpurwala Brain Canada Foundation Telephone: 514-989-2989 Email:  programs@braincanada.ca",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative:  Foundations of Non-Invasive Human Brain Imaging and Neuro-Recording Techniques (R01) and Participation by the Australian National Health and Medical Research Council",NOT-MH-15-022,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-15-022.html,Notices,2028-01-01,"Notice Intent Publish Funding Opportunity Announcement BRAIN Initiative: Foundations Non-Invasive Human Brain Imaging Neuro-Recording Techniques R01) Participation the Australian National Health Medical Research Council Notice Number: NOT-MH-15-022 Key Dates Release Date:   July 21, 2015 Estimated Publication Date Announcement: October 2015   First Estimated Application Due Date: December 2015  Earliest Estimated Award Date: June 2016  Earliest Estimated Start Date: June 2016 Related Announcements RFA-MH-16-750     Issued National Institutes Health NIH) National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Australian National Health Medical Research Council NHMRC) Purpose NIMH, other NIH Institutes Centers ICs) are part the BRAIN Initiative, intends promote new initiative publishing Funding Opportunity Announcement FOA) solicit applications research the foundations non-invasive human brain imaging neuro-recording techniques.  goal this FOA be support integrative, multidisciplinary efforts will revolutionize our understanding the meaning the data collected non-invasive human brain imaging functional evaluation techniques.   Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published fall 2015 an expected application due date winter 2015. FOA utilize R01 activity code. Research Initiative Details Notice encourages investigators expertise insights this area non-invasive human brain imaging neuro-recording begin consider applying this new FOA.  Studies supported this new FOA move beyond simply observing signal collected using non-invasive imaging recording techniques a level more directly informs our understanding the cellular- circuit-bases these signals. Such studies greatly improve our knowledge dynamic brain function both normal pathological conditions. addition, collaborative investigations combining expertise physics, computational information science, engineering, biology, neuroscience, clinical science, behavioral science be encouraged investigators such expertise should also begin considering applying this application. NIH Institutes Centers are part the NIH BRAIN Initiative announce new partnership, formalized a letter agreement, the Australian National Health Medical Research Council NHMRC) support involvement Australian researchers specific NIH BRAIN Initiative programs.  Both NIH the NHMRC believe the ambitious goals the BRAIN Initiative best attained collaborating across disciplinary boundaries well geographic boundaries.  Details NHMRC application procedures, funding rules, eligibility requirements be available the NHMRC website. Foreign institutions be permitted submit applications the FOA described this Notice either submitting applications directly as subcontractors an application a domestic institution.  addition providing funds, representatives the NHMRC join those the National Science Foundation, Food Drug Administration, Defense Advanced Research Projects Agency, the Intelligence Advanced Research Projects Agency meetings the BRAIN Multi-Council Working Group http://braininitiative.nih.gov/Brain_multi_council_working_group.htm). APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Gregory K. Farber, Ph.D. National Institute Mental Health NIMH) Telephone: 301-435-0778 Email: farberg@mail.nih.gov Ned Talley, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone:  301-496-1917 Email:  talleye@mail.nih.gov National Health Medical Research Council NHMRC) Telephone: 61 2 6217 9450 Email: brain@nhmrc.gov.au",,,,
"Request for Information (RFI):  BRAIN Initiative Industry Partnerships for Early Access to Neuromodulation and Recording Devices for Human Clinical Studies",NOT-NS-15-032,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-15-032.html,Notices,2028-01-01,"Request Information RFI): BRAIN Initiative Industry Partnerships Early Access Neuromodulation Recording Devices Human Clinical Studies Notice Number: NOT-NS-15-032 Key Dates Release Date: July 9, 2015 Response Date: August 7, 2015    Related Announcements None     Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Center Complementary Integrative Health NCCIH) Purpose Background BRAIN InitiativeSM Brain Research through Advancing Innovative Neurotechnologies BRAIN) InitiativeSM a multi-agency federal effort aimed revolutionizing understanding the human brain.  NIH guided its contributions this effort scientific strategic recommendations laid in landmark report, quot;BRAIN 2025: Scientific Vision,"" by input the NIH BRAIN Multi-Council Working Group MCWG, Roster).  Information meetings the MCWG available http://www.braininitiative.nih.gov/index.htm.  central focus the BRAIN Initiative development technologies recording modulating neural circuits.  bring technologies bear human brain disorders, BRAIN 2025 report recommended new quot;streamlined path developing, implementing integrating new technologies human neuroscience research, through cooperation clinical academic research teams private companies a pre-competitive space."" Towards end, NIH initiated efforts facilitate public-private partnerships manufacturers devices stimulating and/or recording neural activity humans, make devices available NIH-funded research studies.  NIH BRAIN Public-Private Partnership Program NIH intends release Funding Opportunity Announcement FOA) Fiscal Year 2016 fund research partnerships between clinical investigators manufacturers latest-generation stimulating and/or recording devices are FDA-designated Class III invasive, posing significant risk harm), conduct clinical research the CNS.  goal to spur human research mitigate cost effort required translate pre-clinical research these devices therapeutic outcomes.  types research NIH plans support IRB-approved Non Significant-Risk NSR) clinical research studies, new Significant Risk SR) clinical studies requiring amendments existing Investigational Devices Exemptions IDEs) the FDA, or SR clinical studies which new IDE require or minimal additional non-clinical testing. nbsp;Envisioned studies include exploratory research obtain proof concept new therapeutic indications, identification neural signals relevant closed loop control device therapies, research fundamental human neuroscience questions.  the RFA Fiscal Year 2016, NIH specifically interested devices existing pre-clinical safety technical data can readily leveraged enable new NSR IDE clinical research studies without need significant additional pre-clinical testing.  preparation this FOA, NIH released previous Request Information the overall goals the planned effort NOT-NS-14-054), held Workshop featuring representatives industry, clinical researchers, government regulatory funding agencies, academic technology-transfer contracting offices.  nbsp;The agenda a summary this workshop, plus links the videocast workshop proceedings, available the NIH BRAIN website http://braininitiative.nih.gov/meetings/June-2015-PPP.htm).  Template Agreements Research Partnerships facilitate research partnerships between academic institutions commercial device manufacturers, NIH drafted following template documents, were focus specific discussions the aforementioned workshop.  1.  Template Memorandum Understanding agreements between NIH specific device manufacturers.  purpose this document to describe nature the Public-Private Partnership program the signatory company's agreement participate the program.  document goes over process under Collaborative Research Agreements be reached academic researchers wishing use company's device(s) prior their submission NIH grant applications.  company signing agreement NIH expected provide description the materials devices, software, surgical tools, etc.) support company willing make available this purpose, will included exhibits the agreement will posted publicly serve a guide investigators wishing pursue agreements manufacturers specific research projects.  companies already provisional draft descriptions available, links these drafts included the webpage linked below.  Note draft descriptions tentative subject revision, have only provided the purpose giving context responses this RFI.  2.  Template Collaborative Research Agreement, be used a starting point negotiating agreements between device manufacturers academic research institutions clinical research studies. goal this document to provide standardized terms covering essential components such agreements e.g., intellectual property, data publications, reporting requirements, etc.) using language has deemed acceptable many the commercial academic parties expect negotiate agreements.  3.  Template Confidential Disclosure Agreement, be signed academic researchers discuss specific details companies regarding device capabilities their research.  Draft versions each these template documents available review http://braininitiative.nih.gov/draft_template_agreements.htm.  NIH Goals the Template Agreement Documents drafting template documents seeking feedback major stakeholders their formulation, NIH hopes accomplish following: Reduce barriers time required successful negotiation research partnerships between academic research institutions corporate manufacturers.  anticipate the template Collaborative Research Agreement speed negotiations providing common language terms serve an acceptable baseline multiple parties.  NIH recognizes different devices projects need specific terms determined a case-by-case basis, these templates not intended endorsement specific terms any particular project.  goal for terms the template be useable quot;as is"" some cases, while expediting process arrive final terms other cases providing community-vetted transparent starting point negotiations.        Provide transparent access latest-generation devices their associated capabilities new clinical studies.  Such devices be available exploratory research under controlled conditions ensure safety, are market approved therapeutic indications therefore might otherwise known the research community.  addition, devices available market often expanded capabilities can quot;unlocked"" use controlled research settings, subject appropriate regulatory approval.  Leverage manufacturers’ existing data demonstrating safety utility these devices, are very costly obtain, the purpose regulatory approval new clinical studies.  expect framework allow academic researchers test innovative ideas new therapies, to address scientific unknowns regarding mechanisms disease consequences device action, will advance goals the BRAIN Initiative understanding human brain circuits progressing towards therapies brain disorders.  addition, expect resulting research have benefits device manufacturers insofar it serves facilitate creation solid business cases larger clinical trials required take specific therapies market.  Information Requested time-sensitive RFI, issued the Institutes Centers the NIH BRAIN Initiative listed above, for feedback the general goals the specific terms the template documents described above, will serve a basis collaborative partnerships the intended RFA Fiscal Year 2016.  NIH invites input stakeholders including not limited researchers academia industry, healthcare professionals, patient advocates advocacy organizations, scientific professional organizations, federal agencies other interested members the public.  Small businesses appropriate technologies especially encouraged provide input.  feedback include is limited perspectives the following topics: Intellectual property Confidentiality Data ownership, sharing, access, privacy considerations Publications other presentations arising data generated under collaboration Liability Reporting requirements necessary patient protection regulatory oversight Potential future opportunities capitalizing this Pilot Public-Private Partnership Program   to Submit Response ensure consideration, responses must received August 7, 2015 must submitted electronically using web-based format http://braininitiative.nih.gov/rfi2-brain-initiative.htm. web format provide confirmation response submission, respondents not receive individualized feedback. Responses this RFI voluntary may submitted anonymously. Please not include any personally identifiable other information you not wish make public. Proprietary, classified, confidential sensitive information should be included your response. Comments be compiled discussion may appear related reports. Any personal identifiers names, e-mail addresses, etc.) be removed responses compiled. RFI for informational planning purposes only should be construed a solicitation as obligation the part the United States US) Government, NIH the NINDS provide support any ideas submitted response it. Please note the US Government, NIH NINDS not pay the preparation any information submitted, for use that information. Inquiries Kip Ludwig, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: brain-devices-rfi@mail.nih.gov",,,,
"Notice of Correction of the First Advisory Council Review Date for PAR-15-121 ""BRAIN Initiative: Optimization of Novel Tools and Technologies for Neuroscience Research (R44)""",NOT-NS-15-017,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-15-017.html,Notices,2028-01-01,"Notice Correction the First Advisory Council Review Date the Earliest Start Date PAR-15-121 BRAIN Initiative: Optimization Novel Tools Technologies Neuroscience Research R44)"" Notice Number: NOT-NS-15-017 Key Dates Release Date:   March 26, 2015 Related Announcements PAR-15-121 Issued National Institute Neurological Disorders Stroke NINDS)  Purpose purpose this Notice to correct First Advisory Council Review Date the Earliest Start Date PAR-15-121 quot;BRAIN Initiative: Optimization Novel Tools Technologies Neuroscience Research R44)"". corrections as follows: Part 1. Key Dates Currently reads: Advisory Council Review August, 2015 the first receipt date, then standard dates apply nbsp; Earliest Start Date September, 2015 the first receipt date, standard dates apply nbsp; nbsp; Modified read: Advisory Council Review October 2015 the first due date, then standard dates apply nbsp; Earliest Start Date November 2015 the first due date, standard dates apply nbsp; nbsp; other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Stephanie Fertig, MBA National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: fertigs@ninds.nih.gov",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for  the BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH3)",NOT-NS-15-007,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-15-007.html,Notices,2028-01-01,"Notice Intent Publish Funding Opportunity Announcement the BRAIN Initiative: Clinical Studies Advance Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UH3) Notice Number: NOT-NS-15-007 Key Dates Release Date: December 17, 2014 Estimated Publication Date Announcement: January 2015 First Estimated Application Due Date: March 2015 Earliest Estimated Award Date: September, 2015 Earliest Estimated Start Date: September 2015 Related Announcements None Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Center Complementary Alternative Medicine NCCAM) Purpose NIH BRAIN Brain Research through Advancing Innovative Neurotechnologies) Initiative intends promote new initiative publishing Funding Opportunity Announcement FOA) solicit applications Clinical Studies Advance Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. FOA expected be published January 2015 an expected application due date Spring 2015. FOA utilize UH3 mechanism support small clinical studies will advance next generation recording and/or stimulating devices treat central nervous system disorders better understand human brain. Projects appropriate this FOA must completed non-clinical testing necessary obtain Investigational Device Exemption IDE) a Significant Risk SR) clinical study obtained Institutional Review Board IRB) approval a Non-Significant Risk NSR) clinical study prior entry. addition, projects must obtain necessary approval conduct clinical study prior entry within first year the award. total duration the award not exceed 5 years. companion FOA also expected be published January 2015, will support non-clinical testing required obtain necessary approvals conduct clinical study, addition a singular clinical study. summary the planned FOA provided below. Research Initiative Details FOA related Section III the BRAIN 2025 Report, addresses goal developing innovative technologies understand human brain treat disorders'. NIH recognizes initial first-in-man studies a key point the development innovative new clinical technologies. leap animal studies humans large, initial clinical studies often necessary address critical scientific questions the function a device human subjects and/or inform final device design suitable eventual FDA market approval. Initial demonstrations novel device function humans become increasingly required encourage industry venture capital investment necessary develop final safe, reliable, efficacious device can manufactured a scale suitable regulatory approval, yet a price point sufficient sustainable commercial market given insurance reimbursement. purpose this FOA to encourage applications pursue small clinical study obtain critical information necessary advance recording and/or stimulating devices treat central nervous system disorders better understand human brain e.g., Early Feasibility Study). Clinical studies supported consist acute short-term procedures are deemed Non-Significant Risk NSR) an Institutional Review Board, Significant Risk SR) studies require Investigational Device Exemption IDE) the FDA, such chronic implants. clinical study should provide data answer key questions the function final design a device. final device design require most, not all, the non-clinical testing the path more advanced clinical trials market approval. clinical study expected provide information cannot practically obtained through additional nonclinical assessments e.g., bench top animal studies) due the novelty the device its intended use. Examples the types clinical studies can proposed include, are limited to: Optimization the device design respect the human functional anatomy Identification the most simple, reliable, cost effective device configuration more advanced clinical trials eventual market approval Basic proof-of-concept testing human subjects Studies the key physiological variables may impact function the device humans Initial assessments device safety, only conjunction obtaining enabling data device design function. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Kip Ludwig, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: brain-initiative-FY15-FOA@mail.nih.gov",,,,
"Notice of Intent to Publish a Funding Opportunity Announcement for  the BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH2/UH3)",NOT-NS-15-008,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-15-008.html,Notices,2028-01-01,"Notice Intent Publish Funding Opportunity Announcement the BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UH2/UH3) Notice Number: NOT-NS-15-008 Key Dates Release Date: December 17, 2014 Estimated Publication Date Announcement: January 2015 First Estimated Application Due Date: March 2015 Earliest Estimated Award Date: September 2015 Earliest Estimated Start Date: September 2015 Related Announcements None Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Center Complementary Alternative Medicine NCCAM) Purpose NIH BRAIN Brain Research through Advancing Innovative Neurotechnologies) Initiative intends promote new initiative publishing Funding Opportunity Announcement FOA) solicit applications Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. FOA expected be published January 2015 an expected application due date Spring 2015. FOA utilize UH2/UH3 mechanism support non-clinical testing a singular clinical study advance next generation recording and/or stimulation devices treat central nervous system disorders better understand human brain. UH2 phase support non-clinical testing necessary obtain necessary approvals a small clinical study, the UH3 phase support subsequent clinical study. companion stand-alone UH3 FOA also expected be published January, will support projects do require additional non-clinical testing obtain approval the clinical study. total duration the UH2 UH3 Phases combined not exceed 5 years. summary the planned FOA provided below. Research Initiative Details FOA related Section III the BRAIN 2025 Report, addresses goal developing innovative technologies understand human brain treat disorders'. NIH recognizes initial first-in-man studies a key point the development innovative new clinical technologies. leap animal studies humans large, initial clinical studies often necessary address critical scientific questions the function a device human subjects and/or inform final device design suitable eventual FDA market approval. Initial demonstrations novel device function humans become increasingly required encourage industry venture capital investment necessary develop final safe, reliable, efficacious device can manufactured scale suitable regulatory approval, yet a price point sufficient sustainable commercial market given insurance reimbursement. purpose this FOA to encourage applications pursue translational clinical studies obtain critical information necessary advance recording and/or stimulating devices treat central nervous system disorders better understand human brain. program utilize cooperative agreement mechanism support non-clinical testing necessary enable successful submission an Investigational Device Exemption IDE) a Significant Risk SR) study obtain Institutional Review Board IRB) approval a Non-Significant Risk NSR) study, the subsequent small clinical study e.g., Early Feasibility Study). clinical study should provide data answer key questions the function final design a device. final device design require most, not all, the non-clinical testing the path more advanced clinical trials market approval. clinical study expected provide information cannot practically obtained through additional nonclinical assessments e.g., bench top animal studies) due the novelty the device its intended use. Activities supported this program include implementation clinical prototype devices, non-clinical safety efficacy testing, design verification validation activities, pursuit regulatory approval for, implementation of, single small clinical study. projects have phases, UH2 an UH3 phase. initial UH2 phase support nonclinical testing support the submission an IDE an SR study to obtain IRB approval an NSR clinical study. projects start the UH2 phase, the length UH2 phase depend the maturity the project entry. Only those UH2 projects have met specific criteria outlined the FOA be eligible transition the second UH3 phase after NIH administrative review. UH3 phase support small clinical study. Clinical studies supported consist acute short-term NSR studies, SR studies such chronic implants. Examples the types clinical studies can proposed include, are limited to: Optimization the device design respect the human functional anatomy Identification the most simple, reliable, cost effective device configuration more advanced clinical trials eventual market approval Basic proof-of-concept testing human subjects Studies the key physiological variables may impact function the device humans Initial assessments device safety, only conjunction obtaining enabling data device design function. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Kip Ludwig, PhD, National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: brain-initiative-FY15-FOA@mail.nih.gov",,,,
"Notice to Extend the Due Date and Expiration Date for RFA-MH-14-217 ""BRAIN Initiative:  Planning for Next Generation Human Brain Imaging (R24)""",NOT-MH-14-010,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-14-010.html,Notices,2028-01-01,"Notice Extend Due Date Expiration Date RFA-MH-14-217 BRAIN Initiative: Planning Next Generation Human Brain Imaging R24)"" Notice Number: NOT-MH-14-010 Key Dates Release Date: March 5, 2014 Related Announcements RFA-MH-14-217 Issued NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Center Complementary Alternative Medicine NCCAM) National Center Advancing Translational Sciences NCATS) Office Behavioral Social Sciences Research OBSSR) Purpose purpose this Notice to inform interested applicants the Application Due Date RFA-MH-14-217 quot;BRAIN Initiative:  Planning Next Generation Human Brain Imaging R24)"" being extended March 13, 2014, March 27, 2014. Accordingly, expiration date RFA-MH-14-217 now March 28, 2014. other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Greg Farber, Ph.D. National Institute Mental Health NIMH) Telephone: 301-435-0778 Email: faberg@mail.nih.gov nbsp;",,,,
"Notice of Informational Conference Calls for Prospective Applicants to NIH BRAIN Initiative Funding Opportunity Announcements",NOT-NS-14-005,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-14-005.html,Notices,2028-01-01,"Notice Informational Conference Calls Prospective Applicants NIH BRAIN Initiative Funding Opportunity Announcements Notice Number: NOT-NS-14-005 Key Dates Release Date: January 6, 2014 Related Announcements RFA-NS-14-007 RFA-NS-14-008 RFA-NS-14-009 RFA-MH-14-215 RFA-MH-14-216 RFA-MH-14-217 Issued NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Purpose Background Information Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative a new Presidential project aimed revolutionizing our understanding the human brain. accelerating development application innovative technologies, researchers be able produce new dynamic picture the brain that, the first time, shows individual cells complex neural circuits interact both time space. is expected the application these new tools technologies ultimately lead new ways treat, cure, even prevent brain disorders. general information inquiries regarding NIH support the BRAIN Initiative, please consult following website: http://www.nih.gov/science/brain/index.htm.  December 17, 2013, NIH released six Funding Opportunity Announcements FOAs) the inaugural set projects under BRAIN Initiative links the Related Announcements section this Notice), an expected initial investment 40M be considered NIH funding Fiscal Year 2014.  Summaries the FOAs other information prospective applicants available the following website: http://www.nih.gov/science/brain/funding.htm.  Informational Conference Calls purpose this Notice to inform prospective applications the FOAs NIH be hosting series informational conference calls address technical questions regarding applications each the FOAs.  Information dates contacts each the conference calls as follows: January 10, 2014, 2:00-3:00 PM EST: RFA-MH-14-215, Transformative Approaches Cell-Type Classification the Brain call-in information, contact Andrea Beckel-Mitchener BRAIN-info-NIMH@mail.nih.gov.  January 13, 2014, 2:00-3:00 PM EST: RFA-MH-14-216, Development Validation Novel Tools Analyze Cell-Specific Circuit-Specific Processes the Brain call-in information, contact Michelle Freund BRAIN-info-NIMH@mail.nih.gov.  January 15, 2014, 1:00-2:00 PM EST: RFA-MH-14-217, Planning Next Generation Human Brain Imaging call-in information, contact Greg Farber BRAIN-info-NIMH@mail.nih.gov.  February 4, 2014, 1:00-2:30 PM EST: RFA-NS-14-007, New Technologies Novel Approaches Large-Scale Recording Modulation the Nervous System RFA-NS-14-008, Optimization Transformative Technologies Large Scale Recording Modulation the Nervous System RFA-NS-14-009, Integrated Approaches Understanding Circuit Function the Nervous System call-in information, contact Karen David NINDS-Brain-Initiative@nih.gov.  addition accessing information provided the upcoming conference calls, applicants strongly encouraged consult the Scientific/Research Contacts listed each the FOAs discuss alignment their proposed work the goals the FOA which intend apply. Inquiries Inquiries specifically regarding Notice be directed to: Edmund Talley, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301- 496-1917 Email: NINDS-Brain-Initiative@nih.gov nbsp;",,,,