A Comprehensive Center for Mouse Brain Cell Atlas

Cold Spring Harbor Laboratory
RFA-MH-17-225
2017
1U19MH114821-01
Huang, Z Josh

Identifying individual cell types in the brain is a monumental task that is complicated by the limitations of current molecular technologies. To measure genetic diversity in the whole mouse brain, Huang and Arlotta will lead a team using next-generation droplet-based single-cell transcriptome sequencing along with other highly sensitive single-cell techniques that allow for high-throughput data collection. They plan to map these data onto the spatial locations of forebrain neurons with the help of high-resolution microscopy and genetically driven cell markers. These efforts will provide the scientific community with unprecedented detail about neurons’ molecular and spatial characteristics that can be used to develop additional tools for cell-specific manipulations.

Cold Spring Harbor Laboratory
United States
40° 51' 28.998" N, 73° 28' 0.9552" W
US
9415770
Funded Status: 
Complete