Electrophysiological Biomarkers to Optimize DBS for Depression

Emory University
RFA-NS-17-006
2017
1UH3NS103550-01
Mayberg, Helen S
Deep brain stimulation of subcallosal cingulate (DBS-SCC) white matter is an emerging new therapy for treatment resistant depression (TRD). An important next step is to develop biomarkers for guiding lead placement and titrating stimulation parameters during ongoing care. Mayberg’s team will develop and test electrophysiological biomarkers for device configuration in individuals receiving DBS-SCC for TRD. They aim to optimize and standardize treatment based on functional anatomy and electrophysiological variables, replacing current methods that rely on? depression severity scores and psychiatric assessments. If successful, this work will impact future clinical trial design and provide a new approach to long-term management of symptoms in patients receiving this treatment.
Emory University
United States
33° 47' 33.072" N, 84° 19' 26.3964" W
US
9405277
Funded Status: 
Active