Integrating flexible neural probes with a giant cranial window for combined electrophysiology and 2-photon calcium imaging of cortex-hippocampal interactions

University Of California Los Angeles
Golshani, Peyman
Learning and memory retrieval may rely upon coordinated network activation in regions of the neocortex during 150-250 Hz neuronal oscillations, or ripples, in the hippocampus. Golshani’s team will implant flexible electrode arrays developed by BRAIN-funded investigators into mouse hippocampus, and will combine this technology with their large cranial window preparation. This setup should allow for long-lasting, low-noise calcium imaging of neurons across brain regions, extending from frontal to occipital cortex, bilaterally, during a memory retrieval task. The group plans to identify neurons co-activated during ripple oscillations to explore interactions between the hippocampus and neocortex, which could improve understanding of memory dysfunctions in neurodegenerative and neuropsychiatric diseases.
University Of California Los Angeles
United States
34° 4' 8.1156" N, 118° 26' 42.6516" W
Funded Status: