Rational Optimization of tACS for Targeting Thalamo-Cortical Oscillations

Univ Of North Carolina Chapel Hill
RFA-MH-16-815
2016
1R01MH111889-01
Frohlich, Flavio
Although transcranial alternating current stimulation (tACS) alters cortical alpha oscillations and associated cognitive function in humans, the relationship between tACS parameters such as frequency, amplitude, and duration, and their effects of alpha oscillations remains unclear. Frohlich and colleagues will perform a series of experiments using computational modeling, in vitro and in vivo animal models, and human subjects to elucidate the relationship between tACS parameters and functional modulation of network dynamics. This work will validate tACS targeting of cortical oscillations to enable novel studies of the functional role of alpha oscillations and may provide improved therapeutic stimulation paradigms to treat individuals with psychiatric disorders.
Univ Of North Carolina Chapel Hill
United States
35° 54' 17.6832" N, 79° 2' 48.8868" W
US
9229306
Funded Status: 
Active