Scalar Closed-Loop STN/GPi DBS Based on Evoked and Spontaneous Potentials

Duke University
RFA-NS-17-006
2017
1UH3NS103468-01
Turner, Dennis Alan
The current standard of care for advanced Parkinson’s disease (PD) with motor complications is to implant a single deep brain stimulation (DBS) lead to stimulate either the subthalamic nucleus (STN) or globus pallidus interna (GPi). However, single-site stimulation can be ineffective against balance symptoms and freezing of gait, and some patients develop additional motor complications despite DBS due to disease progression. Turner’s team will implant bilateral STN + GPi/GPe electrodes in PD patients, and assess the efficacy of either STN or GPi/GPe stimulation versus dual STN + GPi stimulation. The group will also use advanced medical device technology to compare closed-loop paradigms to conventional open-loop stimulation. This project could help people with severe PD receive improved treatment options.
Duke University
United States
36° 0' 5.1336" N, 78° 56' 17.6244" W
US
9404120
Funded Status: 
Active