[{"title":"A Dry Electrode for Universal Accessibility to EEG","field_investigator":"Walid Soussou","field_institution":"Quasar, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R43NS132644-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10761609\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10761609\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EElectroencephalography (EEG) measures the brain\u2019s local field potential from the surface of the scalp. This method is useful for studying cognitive processes, neurological states, and medical conditions.\u003C\/p\u003E"},{"title":"A scalable cloud-based framework for multi-modal mapping across single neuron omics, morphology and electrophysiology","field_investigator":"Bing-Xing  Huo","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133777-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725550\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725550\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary Categorizing individual neurons into different groups, or cell types, is a classical approach to studying the nervous system.\u003C\/p\u003E"},{"title":"A visualization interface for BRAIN single cell data, integrating transcriptomics, epigenomics and spatial assays","field_investigator":"Maximilian  Haeussler","field_institution":"University Of California Santa Cruz","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH132662-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10643313\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10643313\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT The BRAIN Initiative\u2019s -omics data archive NeMO contains all the BICCN single cell single cell data, more than one million files at the time of writing.\u003C\/p\u003E"},{"title":"Advancing fMRI Acquisition through Dissemination of EPTI- An Efficient Distortion-Free Multi-Contrast Imaging Technology","field_investigator":"Fuyixue  Wang","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS129893-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10572005\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10572005\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT Functional MRI (fMRI) is today the predominant tool for noninvasive imaging of brain function, which has revolutionized our understanding of the human brain.\u003C\/p\u003E"},{"title":"An optical-genetic toolbox for monitoring and controlling diverse neuromodulatory circuits governing complex behaviors in primates","field_investigator":"Karl A. Deisseroth, Eyal J Seidemann","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-115","field_project_number":"1UG3MH133047-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10650669\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10650669\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EABSTRACT Perceptually guided behavior involves a complex and dynamic interplay between external inputs and internal states that are related, for example, to alertness, motivation, expectations and attention.\u003C\/p\u003E"},{"title":"Analysis of modulation of the metabotropic glutamate receptor type 5 in a novel heritable model of drug abuse vulnerability","field_investigator":"Loren D Peeters","field_institution":"East Tennessee State University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS130827-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10754809\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10754809\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Schizophrenia is a debilitating mental illness affecting an estimated 1% of the global population.\u003C\/p\u003E"},{"title":"Beyond dopamine: dual neuromodulator regulation of motor variability and learning","field_investigator":"Drew Clinton Schreiner","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132152-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10605853\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10605853\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Learning and performing complex skills such as speech or music requires precise control of motor variability. While elevated motor variability can spur the learning of new behaviors, excessive variability can impair performance of learned skills.\u003C\/p\u003E"},{"title":"Boss: A cloud-based data archive for electron microscopy and x-ray microtomography","field_investigator":"Brock A. Wester","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH114785-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664562\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664562\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EABSTRACT The generation of scienti\ufb01cally rich, high resolution neuroimaging volumes continues to increase in extent and rate due to the advancement of new Electron Microscopy (EM) and X-ray Microtomography (XRM) imaging sys- tems and data processing methodologies.\u003C\/p\u003E"},{"title":"Bottom-Up, Top-Down, and Local Interactions in the Generation and Consolidation of Cortical Representations of Sequential Experience","field_investigator":"Bruce L Mcnaughton","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132041-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658227\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658227\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EYears of study and theory about the unique role of the hippocampus in storing new memories has led to a general idea that the hippocampus generates a unique output code for every unique experience, that is projected back to the neocortex, where it becomes coupled to attributes of the experience t\u003C\/p\u003E"},{"title":"Brain dynamics underlying long-term memory consolidation","field_investigator":"Priya  Rajasethupathy","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132047-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658311\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658311\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract The hippocampus has a well-established role in the initial formation and storage of memory. However, little is understood about brain mechanisms that support the re-organization and transfer of memories into longer-term cortical storage.\u003C\/p\u003E"},{"title":"Capturing the neural signature of the paraventricular thalamus that underlies individual variability in cue-motivated behavior","field_investigator":"Shelly Beth Flagel","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132808-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10715723\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10715723\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Individuals make choices and prioritize actions using complex processes that assign value to rewards and associated stimuli based on prior experience.\u003C\/p\u003E"},{"title":"Cell type-specific mechanisms of history-dependent perceptual biases in sensory cortex","field_investigator":"Deepa L Ramamurthy","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS129753-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739223\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739223\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Sensory representations are influenced by an animal\u2019s external context, internal state, past experiences, expectations, and future goals.\u003C\/p\u003E"},{"title":"Center for Advanced Muscle BioElectronics (CAMBER)","field_investigator":"Muhannad   Bakir, Samuel  Sober","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS126936-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10573637\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10573637\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EA central goal of neuroscience is to discover how neural circuits control the body\u2019s muscles to produce behavior.\u003C\/p\u003E"},{"title":"Characterizing Lower Extremity Neurophysiological Responses to Sensory Augmentation after Stroke","field_investigator":"Jasmine Jamilah Cash","field_institution":"Medical University Of South Carolina","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135810-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10829133\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10829133\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT After a stroke, walking ability can be compromised, which can lead to reduced quality of life and decreased ability to perform activities of daily living.\u003C\/p\u003E"},{"title":"Characterizing odor motion detection in flies","field_investigator":"Damon Alistair Clark, Thierry  Emonet","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132840-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10717167\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10717167\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EMany animals rely on their ability to navigate to the source of airborne odor plumes for survival. Studies dating back a century have shown that insects combine mechanosensory and olfactory cues to navigate, surging upwind when detecting odor but go crosswind or downwind when losing the signal.\u003C\/p\u003E"},{"title":"Circuit architecture and dynamics of the insular cortex underlying motivational behaviors","field_investigator":"Tianyi  Mao, Haining  Zhong","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS133599-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10729654\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10729654\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY The insular cortex (IC) is a multimodal hub that integrates interoceptive and exteroceptive information to control diverse aspects of animal behaviors related to cognition, emotion, and motivation.\u003C\/p\u003E"},{"title":"Circuit mechanisms of arbitration between distinct reinforcement learning systems","field_investigator":"Margaret Louise Demaegd","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132176-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608739\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608739\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Animals can exhibit goal-directed behaviors in novel environments, despite limited experience with them. How does the brain make and use inferences about the underlying statistics and generative structure of environments to guide behavior?\u003C\/p\u003E"},{"title":"Circuit-specific, chemogenetic neuromodulation in nonhuman primates.","field_investigator":"Serge E Przedborski, Charles E Schroeder","field_institution":"Nathan S. Kline Institute For Psych Res","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-115","field_project_number":"1UG3MH129381-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10651371\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10651371\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EABSTRACT \u2012 UG3\/UH3 Deep Brain Stimulation (DBS), applied to areas like the subthalamic nucleus (STN), is a standard treatment for Parkinson Disease (PD), however, DBS has inherent surgical risks as well as potential for infections and adverse side effects.\u003C\/p\u003E"},{"title":"cloudSLEAP: Maximizing accessibility to deep learning-based motion capture","field_investigator":"Talmo D. Pereira","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH132653-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10643661\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10643661\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EcloudSLEAP \u2013 PROJECT SUMMARY\/ABSTRACT Understanding how the brain produces complex behavior is a central goal of neuroscience, but quantifying behavior is technically challenging, particularly in unrestrained and naturalistic settings.\u003C\/p\u003E"},{"title":"Cognitive and Neural Strategies for Latent Feature Inference","field_investigator":"Tahra  Eissa","field_institution":"University Of Colorado","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-044","field_project_number":"1K99NS127855-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10662877\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10662877\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY The world around us has a statistical structure that we can use to improve our choices. Learning the underlying structure by identifying key features, such as the rate of change, is useful for adapting and optimizing our decision-making strategies.\u003C\/p\u003E"},{"title":"Commercial translation of high-density carbon fiber electrode arrays for multi-modal analysis of neural microcircuits","field_investigator":"Rajmohan Bhandari, Cynthia Anne Chestek, Daniel Powell, Florian Solzbacher","field_institution":"Blackrock Microsystems","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R44NS134432-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10761217\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10761217\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThe ability to measure and manipulate local brain circuit activity in living, behaving animals is essential to understanding the complexities of brain function and dysfunction.\u003C\/p\u003E"},{"title":"Contextual modulation of visual decision-making across the visual hierarchy","field_investigator":"Pamela  Reinagel","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132037-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658176\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658176\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary\/Abstract In sensory decision-making, choices are influenced by non-sensory factors such as motivation, attention, and recent trial history.\u003C\/p\u003E"},{"title":"Continuous development of nTracer2 and its deployment at NIH image repositories","field_investigator":"Dawen  Cai, Yan  Yan","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133764-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10726178\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10726178\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EAbstract In response to the BRAIN Initiative \u201cIntegration and Analysis of BRAIN Initiative Data\u201d FOA, we propose further developing nTracer2, a cloud-based platform for brain image visualization and neuron tracing in the web browser.\u003C\/p\u003E"},{"title":"CONVERGENT PROCESSING ACROSS VISUAL AND HAPTIC CIRCUITS FOR 3D SHAPE PERCEPTION","field_investigator":"Charles E Connor, Daniel Hans O\u0026#039;connor","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132848-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10720137\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10720137\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003ETHEORETICAL FRAMEWORK: Vision and touch share a critical function\u2014perception of 3D object shape.\u003C\/p\u003E"},{"title":"Cortical assembly formation through excitatory\/inhibitory circuit plasticity","field_investigator":"Brent D. Doiron, Anne-Marie Michelle Oswald","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS133598-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10729689\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10729689\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003ECortical assembly formation through excitatory\/inhibitory circuit plasticity. Project Summary Throughout the brain, sensory information is thought to be represented by the joint activity of neurons that form functionally connected assemblies.\u003C\/p\u003E"},{"title":"Cortical circuit dynamics underlying multisensory decision making","field_investigator":"Christopher R Fetsch","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132910-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721255\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721255\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary To navigate and guide locomotion in a complex 3D environment, humans and animals must make countless judgments of their direction of self-motion, or heading.\u003C\/p\u003E"},{"title":"Cross-modal sensory interactions, processing, and representation in the Drosophila brain","field_investigator":"Itai  Cohen, Noah John Cowan, Jessica  Fox, Sung Soo  Kim","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-028","field_project_number":"1U01NS131438-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10645611\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10645611\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003ERobust navigation, which is critical for an animal\u2019s survival, requires the processing of complex sensory information spanning different modalities and time scales.\u003C\/p\u003E"},{"title":"DDALAB: Identifying Latent States from Neural Recordings with Nonlinear Causal Analysis","field_investigator":"Terrence J Sejnowski","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH132664-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10643212\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10643212\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ESummary The goal of this proposal is to develop DDALAB, a software platform that will make it possible for researchers to identify latent cortical states and analyze the flow of information in large populations of neurons using Delay Differential Analysis (DDA).\u003C\/p\u003E"},{"title":"Deconstructing the sertonin system in the mouse brain","field_investigator":"Liqun  Luo, Scott Warren Linderman","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS131987-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10656870\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10656870\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY Serotonin is an evolutionarily conserved neurotransmitter that modulates the activity of excitatory and inhibitory neurons throughout the entire mammalian brain and is thus essential for diverse aspects of physiology and behavior.\u003C\/p\u003E"},{"title":"Developing novel neural network tools for accurate and interpretable dynamical modeling of neural circuits","field_investigator":"Christopher  Versteeg","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132175-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10752956\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10752956\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EAbstract In recent years, the number of neurons that we can record simultaneously has seen an exponential increase, presenting a daunting challenge: how do we analyze these complex and high-dimensional datasets to gain insight into how neural circuits perform computation?\u003C\/p\u003E"},{"title":"Dissecting modular and redundant organization of cortical circuits","field_investigator":"Shaul  Druckmann, Nuo  Li","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132025-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10657919\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10657919\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract In many cognitive processes, information is processed in a parallel manner across many brain regions.\u003C\/p\u003E"},{"title":"Dissemination of the Human Neocortical Neurosolver (HNN) software for circuit level interpretation of human MEG\/EEG","field_investigator":"Stephanie Ruggiano Jones","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS129945-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10726032\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10726032\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EHNN U24 DISSEMINATION PROJECT SUMMARY The Human Neocortical Neurosolver (HNN) neural modeling tool was developed with BRAIN Initiative funding (R01EB022889: 09\/2016\u201306\/2020) to meet the Initiative\u2019s goal to \u201cdevelop innovative technologies to understand brain circuits and ensembles of circuits th\u003C\/p\u003E"},{"title":"Distinct contributions of converging neural pathways to auditory learning","field_investigator":"Santiago  Jaramillo, James  Murray","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS131993-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10657285\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10657285\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Effective interpretation of sensory stimuli relies on the ability to discriminate stimulus features and link them to appropriate behavioral responses depending on past experience.\u003C\/p\u003E"},{"title":"Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchrony","field_investigator":"Zoe Rebecca Donaldson, Yevgenia  Kozorovitskiy, John  Rogers","field_institution":"Northwestern University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-028","field_project_number":"1U01NS131406-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10644475\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10644475\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY The vertebrate brain has evolved to enable complex social interactions, essential for survival. Brains of animals engaged in a shared social interaction exhibit inter-brain synchronization of neural activity, detectable at several levels of analysis.\u003C\/p\u003E"},{"title":"Extending ezBIDS, NiiVue and dcm2niix for user-friendly cloud-based integration and visualization","field_investigator":"Christopher  Rorden","field_institution":"University Of South Carolina At Columbia","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133701-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724895\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724895\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary\/Abstract Cloud-based analyses and easily shared data formats are revolutionizing neuroimaging. We will develop software to fill gaps created by these two trends. We will develop and refine software to visualize and analyze the data from the BRAIN Initiative.\u003C\/p\u003E"},{"title":"Functions of locus coeruleus norepinephrine neurons in decision making across multiple timescales","field_investigator":"Jeremiah Yaacov Cohen, Daniel Hans O\u0026#039;connor","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS131984-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10656752\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10656752\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003ESUMMARY Norepinephrine (NE) is a neurotransmitter released by a small number of neurons in the locus coeruleus (LC), with extensive innervation of the neocortex. Prior work in humans and other mammals led to the hypothesis that LC-NE neurons modulate multiple forms of decision making.\u003C\/p\u003E"},{"title":"Functions of the Cortical Amygdala in social behavior","field_investigator":"Antonio V Aubry","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DA058213-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10641270\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10641270\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Aggression is an evolutionarily conserved behavior that controls social hierarchies and protects valuable resources like mates, food, and territory. In most cases, aggression is a necessary, adaptive component of social behavior.\u003C\/p\u003E"},{"title":"High-throughput 3D mapping of large mammalian brains via integration of precision tissue sectioning and light sheet imaging","field_investigator":"Ji Wang, Nicholas Bruce Evans, Hsuan Lee, Jeffrey Stirman","field_institution":"Lifecanvas Technologies, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R43MH133544-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10695784\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10695784\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EWhole-brain mapping at the cellular and subcellular levels is crucial to systematically understand brain functions and disorders.\u003C\/p\u003E"},{"title":"Identifying human-specific neural progenitors and their role in neurodevelopment","field_investigator":"Sumin  Jang","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH130892-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10662868\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10662868\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Humans have highly advanced cognitive abilities and motor skills, characteristics which are reflected in the enlarged size and cell diversity of our central nervous system (CNS).\u003C\/p\u003E"},{"title":"Identifying the neural mechanisms of goal-directed decision-making in Parkinson\u0026#039;s disease using closed-loop deep brain stimulation","field_investigator":"Colin  Hoy","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132174-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608842\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608842\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003ETITLE: IDENTIFYING THE NEURAL MECHANISMS OF GOAL-DIRECTED DECISION-MAKING IN PARKINSON\u2019S DISEASE USING CLOSED-LOOP DEEP BRAIN STIMULATION PROJECT SUMMARY People with Parkinson\u2019s disease commonly suffer from non-motor symptoms, including motivation deficits, that impact quality of life more than c\u003C\/p\u003E"},{"title":"Implications of Prefrontal Cortex Development for Adolescent Reward Seeking Behavior","field_investigator":"Gabriela  Manzano Nieves","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH132082-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739548\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739548\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY As we get older, we learn to modulate our behaviors to optimize reward outcomes. These adaptive choices are orchestrated by current sensory conditions, internal cognitive states, and future expectations.\u003C\/p\u003E"},{"title":"Improving Recruitment, Engagement, and Access for Community Health Equity for BRAIN Next-Generation Human Neuroimaging Research and Beyond (REACH for BRAIN)","field_investigator":"Susie Yi Huang, Jonathan David Jackson, Francis X Shen","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH134144-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10730955\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10730955\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"\u003Cp\u003EProject Summary \/ Abstract Although BRAIN 2.0 called for the BRAIN Initiative to \u201cprioritize diversity and inclusion as a fundamental pillar,\u201d research with the human neuroimaging technologies being developed by BRAIN Initiative continues to rely on non-representative convenience samples.\u003C\/p\u003E"},{"title":"Integrating single-cell connectivity, gene expression, and function in zebra finches","field_investigator":"Justus M Kebschull","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132027-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10657971\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10657971\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY The courtship song of male zebra finches is a classical model for learning complex motor behaviors and shows important parallels to human speech and communication. Male zebra finches learn a song from an adult tutor and then reproduce this song throughout adulthood.\u003C\/p\u003E"},{"title":"Integrative Analysis of Adaptive Information Processing and Learning-Dependent Circuit Reorganization in the Auditory System","field_investigator":"Wiliam Mcintyre Debello, Mark H Ellisman, Brian J Fischer, Jose L Pena","field_institution":"Albert Einstein College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132812-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10715925\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10715925\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract Decades of research have revealed the principles of information processing that give rise to auditory spatial tuning and experience-dependent adaptive plasticity in the owl auditory system.\u003C\/p\u003E"},{"title":"Integrative circuit dissection in the behaving nonhuman primate","field_investigator":"Wyeth Daniel Bair, Farran  Briggs, Anitha  Pasupathy, Anqi  Wu","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-028","field_project_number":"1U01NS131810-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10653435\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10653435\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EIn natural vision, recognizing objects based on the retinal image is challenging and is often an ill-posed problem because a single image is compatible with multiple interpretations.\u003C\/p\u003E"},{"title":"Intersubject Synchrony in Neural and Behavioral Representations of Social Uncertainty Among Adults and Adolescents","field_investigator":"William John Mitchell","field_institution":"Temple Univ Of The Commonwealth","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134208-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10828675\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10828675\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Uncertainty is an often pervasive, stressful experience that arises when making judgments about others\u0027 beliefs, intentions, or emotions (i.e., ambiguous social situations). Excessive uncertainty can have pernicious effects upon memory, mood, and physical and mental outcomes.\u003C\/p\u003E"},{"title":"Intrinsic and Extrinsic factors regulating neurogenic competence in hypothalamic tanycytes","field_investigator":"Leighton Hosea Duncan","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135816-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10828978\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10828978\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EHypothalamic tanycytes have limited postnatal neurogenic competence, but the extrinsic and intrinsic factors that promote this are not well understood. My predoctoral research identified a defined developmental window during which neurogenic competence is lost from hypothalamic tanycytes.\u003C\/p\u003E"},{"title":"Investigating the Recruitment of Different Neuronal Subpopulations by Intracortical Micro Stimulation Using Two Photon-Microscopy","field_investigator":"Christopher  Hughes","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH130022-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10604754\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10604754\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Intracortical microstimulation (ICMS) of the sensory cortices is an emerging approach to restore sensation to people who have lost it due to neurological injury or disease.\u003C\/p\u003E"},{"title":"Investigations of cAMP-dependent brain-barrier permeability in choroid plexus","field_investigator":"Dario Xavier Figueroa Velez","field_institution":"Boston Children\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132178-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753098\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753098\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY The choroid plexus (ChP) comprises a network of cells that form a critical brain barrier that can mediate secondary damage in certain brain disorders and trauma. The Lehtinen lab has developed a suite of tools to study the ChP across development ex vivo and in vivo.\u003C\/p\u003E"},{"title":"Large-scale calcium and voltage imaging to illuminate neural mechanisms of visual experience","field_investigator":"Michelle  Redinbaugh","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134451-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753172\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753172\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary: The majority of lived experience depends on neural activity conveying sensory information about the world.\u003C\/p\u003E"},{"title":"Live spike sorting for multichannel and high-channel recordings","field_investigator":"Tim Chifong Lei, Achim Klug","field_institution":"Popneuron, LLC","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-178","field_project_number":"1R41NS132700-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10759767\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10759767\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThe goal of this project is to create two prototypes of a novel live spike sorting system which can be used by investigators to spike sort streams of neural data recorded by multi-channel, high channel and ultra-high channel probes.\u003C\/p\u003E"},{"title":"Local Circuit Control of Rapid Plasticity and Tunable Ensemble Formation in the Hippocampus","field_investigator":"Attila  Losonczy, Ivan  Soltesz","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS133381-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725714\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725714\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary\/Abstract Neural representations supporting spatial and episodic learning form, and transform rapidly in the mammalian hippocampus.\u003C\/p\u003E"},{"title":"Manipulation of neuron identity towards in-vivo circuit reprogramming in the cerebral cortex","field_investigator":"Lee O Vaasjo","field_institution":"Tulane University Of Louisiana","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134203-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10755203\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10755203\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Sub-Cerebral Projection Neurons (SCPNs) are a clinically relevant neuron class that controls voluntary movement and whose loss in Amyotrophic Lateral Sclerosis and Fronto-temporal dementia or injury (e.g., damaged by spinal cord injury) leads to paralysis.\u003C\/p\u003E"},{"title":"Mechanisms of experience-dependent plasticity in an innate social behavior circuit","field_investigator":"Emma E Boxer","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10751542\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10751542\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Many social behaviors, such as defense and aggression, are innate- requiring no prior experience to be expressed and presumably \u2018hardwired\u2019 into neural circuits.\u003C\/p\u003E"},{"title":"Mechanisms of neural circuit dynamics in working memory and decision-making","field_investigator":"Carlos D Brody, Ila R. Fiete, Mark S Goldman, Jonathan William Pillow, Hyunjune Sebastian Seung, David W Tank, Samuel Sheng-Hung Wang, Ilana  Witten","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-040","field_project_number":"1U19NS132720-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10705962\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10705962\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary\/Abstract: Overall The overarching goal of this U19 program is to determine how neural computations across brain regions produce two core cognitive processes, working memory and decision-making, and thus to derive fundamental principles of brain function.\u003C\/p\u003E"},{"title":"Models for accumulation of evidence through sequences in a navigation-based, decision-making task","field_investigator":"Lindsey Shoemaker Brown","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132179-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608293\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608293\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EDecision making is a fundamental cognitive process, and many decisions are based on gradually accumulated evidence. Thus, it is critical to understand the mechanistic basis underlying this accumulation process.\u003C\/p\u003E"},{"title":"Multiphon imaging for understanding social brain function in tadpoles","field_investigator":"Na  Ji, Lauren A O\u0026#039;connell","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132841-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10717610\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10717610\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary Mother-infant bonding is a key relationship that lays a foundation for wellness throughout life. Social recognition is an important component of this relationship, as infants imprint on the smell of their mothers and use olfaction to distinguish their mother from others.\u003C\/p\u003E"},{"title":"Multisensory integration and self-motion perception in primate vestibular cortex","field_investigator":"Alejandra  Gomez","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134455-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753017\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753017\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary In vertebrate animals, the vestibular system (primarily known as the \u201cbalance system\u201d of the brain) interprets head-movement and orientation signals to provide organisms with a sense of self-motion.\u003C\/p\u003E"},{"title":"Nanoparticle Coated Microelectrode Arrays for Electrochemically Controlled Gene Editing at the Electrode Site","field_investigator":"Nathaniel P Williams","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132145-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10604904\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10604904\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EAbstract Microelectrode arrays (MEAs) have great potential for therapeutic use in direct brain-computer interface (BCI) control of robotic prostheses to improve the lives of patients suffering from debilitating conditions related to loss of limbs or limb function.\u003C\/p\u003E"},{"title":"Neural basis of collective behavior during environmental stress","field_investigator":"Tara  Raam","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH133159-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10740543\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10740543\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Social interactions are critical to the physical and emotional health of a wide variety of species.\u003C\/p\u003E"},{"title":"Neural circuits for social modulation of a persistent negative emotional state","field_investigator":"Weizhe  Hong, Li I Zhang","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132912-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721276\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721276\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY In social species, social relationships can exert profound influences on individuals\u2019 behavioral and physiological states.\u003C\/p\u003E"},{"title":"Neural Mechanisms for Flexible Vocal Communication","field_investigator":"Arkarup  Banerjee","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132046-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658308\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658308\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary: Whether to laugh at a joke or to engage in a lively debate, we flexibly modify our vocalizations based upon social contexts. Such adaptive behavior requires real-time adjustments of motor outputs in response to rapidly changing sensory inputs.\u003C\/p\u003E"},{"title":"NexGen 7T MRI scanner for mesoscale brain imaging: Integration and Dissemination","field_investigator":"Alexander  Beckett, David Alan Feinberg, An T Vu","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS129949-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725586\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725586\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003ESUMMARY The \u0022NexGen\u0022 7 Tesla MRI scanner at UC Berkeley is a unique resource that we wish to make available for neuroscience collaborations across the globe.\u003C\/p\u003E"},{"title":"Next generation axonal quantification and classification using AI","field_investigator":"Jacob R Glaser","field_institution":"Microbrightfield, LLC","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"2R44MH128076-02","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10698843\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10698843\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThis Phase II project describes the commercial development of HyperAxon\u2122, highly innovative software for performing automated segmentation, tracing, reconstruction and quantitative analysis of all axonal fibers (with and without signs of acute axonal injury) visible in two- and three-dimensional \u003C\/p\u003E"},{"title":"O-GlcNac Modulation of GABAergic Transmission","field_investigator":"Shekinah  Phillips","field_institution":"University Of Alabama At Birmingham","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134163-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10754746\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10754746\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EChanges in the strength of GABAergic transmission is heavily influenced by posttranslational modifications and allosteric modulators like benzodiazepines and neurosteroids.\u003C\/p\u003E"},{"title":"OpenNeuro: An open archive for analysis and sharing of BRAIN Initiative data","field_investigator":"Russell A Poldrack","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH117179-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10451257\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10451257\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary\/Abstract The BRAIN Initiative is supporting a broad portfolio of neuroscience research aimed at revolutionizing our understanding of the brain.\u003C\/p\u003E"},{"title":"Oxytocin Modulation of Neural Circuit Function and Behavior","field_investigator":"Richard W Tsien","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-040","field_project_number":"2U19NS107616-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10705986\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10705986\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary Oxytocin is a peptide hormone synthesized and released from the hypothalamus for reproduction, maternal care, and social behavior, as well as various \u2018non-social\u2019 aspects of internal state and physiological processes.\u003C\/p\u003E"},{"title":"Parameterizing the relationship between motor cortical reactivation during sleep and motor skill acquisition in the freely behaving marmoset","field_investigator":"Nicholas G Hatsopoulos, Jason Neil Maclean","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132033-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658109\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658109\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary\/Abstract This project will provide a more nuanced and mechanistic model of the role of sleep in memory consolidation, particularly as it pertains to procedural motor skill acquisition in a non-human primate model.\u003C\/p\u003E"},{"title":"Peptidergic neurons in error computations and behavioral flexibility","field_investigator":"Emily L Sylwestrak","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132914-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721319\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721319\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003E\uf077PROJECT SUMMARY Survival in dynamic environments demands that behaviors are flexible and adaptive. An organism must make predictions about which actions lead to rewards, calculate how outcomes differ from those predictions (prediction errors), and adapt a behavioral strategy accordingly.\u003C\/p\u003E"},{"title":"Post-trial Access, Clinical Care, Psychosocial Support, and Scientific Progress in Experimental Deep Brain Stimulation Research","field_investigator":"Joseph J. Fins, Gabriel  Lazaro-Munoz","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH133657-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10722437\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10722437\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"\u003Cp\u003EProject Summary Public and private research funders have heavily invested in the application of implantable neurotechnologies to improve the management of treatment-resistant conditions and loss of function (e.g., deep brain stimulation (DBS) systems for recovery after traumatic brain injury (TBI\u003C\/p\u003E"},{"title":"Postnatal experience shapes gene expression and connectivity development in the cortex","field_investigator":"Alexander  Nevue","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134413-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10749679\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10749679\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Postnatal sensory experience has a profound effect on the maturation, composition, and connectivity of cortical cell types, but systematic analyses of these changes have not yet been feasible.\u003C\/p\u003E"},{"title":"Pre-motor neural circuits enable versatile and sequential limb movements","field_investigator":"Julie H Simpson","field_institution":"University Of California Santa Barbara","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132900-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721086\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721086\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract Movements are measurable outputs of the nervous system and simple movements can be combined to compose complicated behaviors. We use limb tracking and connectome analyses to map the neural circuits controlling the elemental leg movements in Drosophila grooming.\u003C\/p\u003E"},{"title":"Probing form and function of memory representations in the hippocampus of memory expert birds","field_investigator":"Emily Lambert Mackevicius","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS131256-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10641392\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10641392\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary\/Abstract Mental disorders that affect the hippocampus disrupt people\u2019s ability to form one-shot memories. My goal is to lead an independent lab, linking biological properties of hippocampal neurons to the ability to perform memory- guided cognitive behaviors.\u003C\/p\u003E"},{"title":"Processing of visual information by spatial memory circuits in the avian brain","field_investigator":"Hannah L Payne","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY034700-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10570644\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10570644\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT. Research Project: Spatial memory \u2013 memory of where an event happened or an object was located \u2013 depends on the hippocampus in a wide range of vertebrate species, including mammals and birds. In humans, most spatial memories are formed through visual experience.\u003C\/p\u003E"},{"title":"Role of coordinated multi-area reactivations during transitions between automatic and flexible behaviors.","field_investigator":"Maksim V Bazhenov, Joshua D Berke, Karunesh  Ganguly","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132913-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721280\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721280\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract Sleep occupies a large part of our lives and is widely believed to perform essential functions. During sleep, the neuronal rules of engagement and population dynamics are clearly different than waking.\u003C\/p\u003E"},{"title":"Role of cortical connections to higher-order thalamic nuclei in visual decision-making","field_investigator":"Ariana R Andrei","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY034699-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739488\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739488\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY To guide decisions, visual information must flow from primary visual cortex (V1) to prefrontal cortex (PFC), via multiple, parallel cortico-cortical and cortico-thalamo-cortical connections.\u003C\/p\u003E"},{"title":"Role of multi-regional neuronal reactivations in reward-based memories","field_investigator":"Celine  Drieu","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DA059024-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10722635\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10722635\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY The goal of this project is to provide the building blocks for an independent research program focused on the neural basis of reward-based memory across distributed brain networks.\u003C\/p\u003E"},{"title":"Scientific and Public Outreach of Cell Type Taxonomies (SPOCTT) Initiative","field_investigator":"Kaitlyn  Casimo, Jeremy A Miller","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS133077-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724950\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724950\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EProject Summary Single cell transcriptomics has transformed the field of brain cell type classification, allowing simultaneous measurement of enough molecular features from enough cells to categorize neurons quantitively and with high conservation across brain areas and species.\u003C\/p\u003E"},{"title":"Sex, Physiological State, and Genetic Background Dependent Molecular Characterization of CircuitsGoverning Parental Behavior","field_investigator":"Brandon  Logeman","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99HD108801-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10661884\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10661884\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Parental care is essential for offspring well-being and survival yet requires a significant invest from adults without immediate benefit, suggesting the existence of hard-wired mechanisms governing its control.\u003C\/p\u003E"},{"title":"State-dependent modulation of taste and temperature integration in Drosophila","field_investigator":"Fumika  Hamada","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132843-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10718009\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10718009\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY: Animals constantly detect different environmental stimuli and change their behavior or physiology based on their internal state. How animals integrate the external multiple sensory information with the internal state is largely unclear.\u003C\/p\u003E"},{"title":"The development of multimodal dynamics in a short-term memory system","field_investigator":"Gregory Patrick Davis","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134449-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753261\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753261\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT Persistent activity in neural circuits supports a variety of brain functions from motor control to navigation to perceptual decision-making.\u003C\/p\u003E"},{"title":"The Impact of Vitamin D on mTOR Signaling, Seizures, and Motor Behavior in a Mouse Model of Hyperactive mTOR Induced Epilepsy and Ataxia","field_investigator":"David  Narvaiz","field_institution":"Baylor University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134141-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10754319\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10754319\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary \/ Abstract Increased mammalian target of rapamycin (mTOR) signaling is a known cause of treatment resistant epilepsy.\u003C\/p\u003E"},{"title":"The Neuroimaging Brain Chart Software Suite","field_investigator":"Christos  Davatzikos, Yong  Fan, Ilya M Nasrallah, Haochang  Shou","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS130411-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10581015\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10581015\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EThis study proposes to refine, integrate and disseminate the NeuroImaging Brain Chart (NIBCh) software toolbox and machine learning (ML) model library, an ecosystem of software components enabling constructive integration, statistical harmonization, and ML-centric data analyses across studies.\u003C\/p\u003E"},{"title":"Time-varying spatiotemporal causal interactions in the functional brain networks","field_investigator":"Nan  Xu","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS123113-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10590411\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10590411\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EThis proposal describes a five-year career development program to prepare the candidate, Dr.\u003C\/p\u003E"},{"title":"Towards an integrated analytics solution to creating a spatially-resolved single-cell multi-omics brain atlas","field_investigator":"Panagiotis  Roussos, Guo-Cheng  Yuan","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133703-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724843\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724843\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EPROJECT SUMMARY The maintenance and function of the nervous system depends on cell-cell interactions among neuronal and non-neuronal cell populations, which occur through physically binding cell membrane surface or secreted proteins, triggering signaling cascades that activate cell-type gene regu\u003C\/p\u003E"},{"title":"Tracking Flow of Attention in Visual Circuits Across the Brain","field_investigator":"Bilal  Haider","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132288-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10665957\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10665957\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY Sensory processing is a way to understand the nervous system in action. Behavioral context strongly affects sensory processing. For example, a brief visual stimulus is easier to detect if it appears in a predictable spatial location.\u003C\/p\u003E"},{"title":"Traveling waves in neocortical circuits: Mechanisms, computational roles in sensory processing, and impact on sensory perception","field_investigator":"Todd P Coleman, Duygu  Kuzum, Lyle Edward Muller, John H Reynolds, Mark J Schnitzer","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-028","field_project_number":"1U01NS131914-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10655101\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10655101\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT An important longstanding goal in neuroscience research is to understand how large-scale spatiotemporal patterns of neural activity emerge in the brain and whether they have a direct role in shaping the brain\u2019s computational processes and thereby mammalian behavior.\u003C\/p\u003E"},{"title":"Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform","field_investigator":"Patrick Goodwill","field_institution":"Magnetic Insight, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R44EB035078-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10761613\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10761613\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EIn this SBIR grant proposal, \u201cUltra-low distortion and noise electronics to enable a clinical MPI imaging platform,\u201d we will develop the RF subsystem for a clinical magnetic particle imaging (MPI) platform to enable three classes of MPI applications: cell tracking, functional imaging, and endogen\u003C\/p\u003E"},{"title":"Understanding the Conceptual Priority Map Guiding Naturalistic Visual Attention for Autistic Individuals","field_investigator":"Amanda J Haskins","field_institution":"Dartmouth College","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135812-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10829114\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10829114\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Visual attention differences are a promising diagnostic marker for autism spectrum conditions (ASC).\u003C\/p\u003E"},{"title":"UNDERSTANDING THE CONSEQUENCES OF SLEEP LOSS IN AN AUTISM MOUSE MODEL","field_investigator":"Elizabeth  Medina","field_institution":"Washington State University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135815-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10829011\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10829011\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Poor sleep is common in neurodevelopment disorders such as autism spectrum disorder (ASD), with up to 93% of ASD individuals reporting sleep problems.\u003C\/p\u003E"},{"title":"Unified, Scalable, and Reproducible Neurostatistical Software","field_investigator":"Scott Warren Linderman, Alexander Henry Williams","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133778-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725500\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725500\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary Many advances in modern neuroscience rely on electrophysiological recordings of large neural populations (e.g. many hundreds of cells) or high-resolution measurements of animal behavior (e.g. from video).\u003C\/p\u003E"},{"title":"Validation and Optimization of Two-Photon Dendritic Voltage Imaging in Vivo","field_investigator":"Jacob  Reimer","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132045-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658307\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658307\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY Understanding information flow in cortical circuits requires understanding both the anatomical connectivity between neurons and the way in which inputs to a neuron are integrated to generate a spiking output.\u003C\/p\u003E"},{"title":"Voltage dynamics of distinct cortical ensembles in visually guided behavior","field_investigator":"Madhuvanthi  Kannan","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128890-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524557\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524557\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EABSTRACT BRAIN Initiative-funded, large-scale approaches to classify neurons based on transcriptomic, morphological and electrical properties have unveiled dozens of unique cell classes in the mouse brain.\u003C\/p\u003E"},{"title":"A BRAIN Initiative Resource: The Neuroscience Multi-omic Data Archive","field_investigator":"Anup  Mahurkar, Owen R White","field_institution":"University Of Maryland Baltimore","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH114788-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447478\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447478\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative\npromotes the development and application of technologies to describe the temporal and spatial\ndynamics of cell types and neural circuits in the brain."},{"title":"A Confocal Fluorescence Microscopy Brain Data Archive","field_investigator":"Marcel P Bruchez, Alexander J Ropelewski, Alan Michael Watson","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH114793-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10451277\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10451277\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\n Brain image data collected by the neuroscience community will continue to grow\ndramatically in the next 5-10 years as the push to image physically larger volumes, such as\nwhole brains from humans and other primates, becomes a focus."},{"title":"A Shared Neuroscience Platform for National Dissemination and Training  in Brain Organogenesis, Behavioral and Brain Disease Models, Viral Vectors, and Imaging Technologies","field_investigator":"William T Newsome, Sergiu  Pasca, Mehrdad  Shamloo, Gordon X Wang","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124026-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10439384\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10439384\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Advances in neuroscience depend on robust in vivo and in vitro models with innovative technologies to carry out\nfunctional and mechanistic studies accompanied by advanced imaging techniques."},{"title":"Aberrant Signaling from Brain Tumors Regulates Distant and Local Environments","field_investigator":"Kaysaw C Tuy","field_institution":"University Of Alabama At Birmingham","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129129-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610104\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610104\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\nPerturbations in redox signaling are associated with multiple neurological disorders, ranging from\nneurodegenerative diseases to brain tumors."},{"title":"Acoustic modulation of forebrain aggression network in miniature, transparent vocal fish","field_investigator":"Andrew H Bass","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128891-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524567\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524567\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Assessing social signals, such as vocalizations, figures prominently in the outcome of aggressive encounters,\nincluding the potential to win a fight or prevent escalation resulting in physical injury."},{"title":"Anatomical connectivity and activity in primary visual cortex of mouse","field_investigator":"Zachary Samuel Pitkow, Andreas  Tolias","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130416-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505662\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505662\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nEstimates of the total length of axonal \u0022wiring\u0022 in the human brain are on the order of hundreds of thousands\nof kilometers."},{"title":"Assessment of Behavioral Deficits in Minipig Model of Pediatric Concussion","field_investigator":"Alesa Hughson Netzley","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129171-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610655\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610655\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nTraumatic brain injury (TBI) is a leading health concern for both children and adults worldwide."},{"title":"Basic neural processing mechanisms of live human face viewing","field_investigator":"Megan  Kelley","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129174-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610114\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610114\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n  Significance. The human brain has a dedicated neural system for processing other humans. However relatively\n  little is known about the basic mechanisms of this processing."},{"title":"BCI-DEF: Brain Computer Interfaces and Disability: Developing an Inclusive Ethical Framework","field_investigator":"Karen G Hirsch, Holly K Tabor","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH130518-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10508135\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10508135\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\/Abstract\nThe objective of \u201cBrain Computer Interfaces and Disability: Developing an Inclusive Ethical Framework (BCI-\nDEF)\u201d is to use structured vignettes, video-supported interviews, and a deliberative democracy approach to\nassess and analyze diverse, critical stakeholder perspective"},{"title":"Bidirectional circuits of locus ceruleus and motor cortex neurons","field_investigator":"Gordon M Shepherd","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127119-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447235\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447235\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nPrimary motor cortex (M1) and the locus ceruleus (LC) both contribute in essential ways to the generation of\npurposive movements \u2013 with M1 and its pyramidal tract (PT) neurons involved in action planning and execution,\nthe and LC and its noradrenergic axonal projections involved in a"},{"title":"BRAIN Initiative: Hierarchical Event Descriptors (HED): a system to characterize events in neurobehavioral data","field_investigator":"Scott  Makeig, Kay A Robbins, Arnaud  Delorme","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-128","field_project_number":"1RF1MH126700-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10480619\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10480619\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"This two-year project will advance, integrate, document, and promote the use of the Hierarchical\nEvent Descriptor (HED) system to describe events in human neuroimaging and behavioral data\nfrom research experiments and other sources in sufficient detail to support comparative analysis\nof human brain "},{"title":"BRAIN Integrated Resource for Human Anatomy and Intracranial Neurophysiology","field_investigator":"Dominique  Duncan, Nader  Pouratian","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130371-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505412\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505412\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\/ABSTRACT\nIntracranial recordings in patients undergoing neurosurgical interventions provide a unique opportunity to directly\naccess, study, and learn about both normal human brain function and neuropsychiatric disease."},{"title":"CAJAL: A computational framework for the combined morphometric, transcriptomic, and physiological analysis of cells","field_investigator":"Pablo  Gonzalez Camara","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130553-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10509196\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10509196\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nMorphology is an essential phenotype in the characterization of cells and their states. It reflects the progression\nof functional cellular processes, such as morphogenesis, migration, or dendrite arborization, and can be\nindicative of disease."},{"title":"Caring for BRAIN pioneers: Understanding and enhancing family and researcher support in neural device trials","field_investigator":"Sara  Goering, Eran  Klein","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH130457-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10506303\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10506303\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project abstract\nBRAIN pioneers are people who take on significant risk as participants in first-in-human or early\nneurotechnology studies for the sake of helping to further science."},{"title":"Circuit dynamics of structuring episodic memories in humans","field_investigator":"Jie  Zheng","field_institution":"Boston Children\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS126233-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10590796\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10590796\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project summary\nOur lives unfold over time, weaving rich, dynamic, and multisensory information into a continuous experience.\nHowever, we remember this as a series of discrete events. For example, the memory of a two-hour movie\nconsists of a few memorable moments tied to the main story."},{"title":"Circuits for spontaneous behavior and phototaxis in a simple model chordate","field_investigator":"William  Smith","field_institution":"University Of California Santa Barbara","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127106-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446697\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446697\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"This proposal will investigate neural circuits driving negative phototaxis in an emerging model for neural circuit\nanalysis: larvae of the primitive chordate Ciona. Ciona larvae have a number of features that make them\nideally suited for this project."},{"title":"Computational dynamics in neural populations of freely foraging vs. restrained monkeys","field_investigator":"Dora  Angelaki","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127122-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447347\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447347\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nThis proposal will investigate the neural dynamics underlying three-dimensional foraging behavior, with three\noverarching goals. The first is to evaluate the neural computations of foraging in dynamic environments in\nnaturalistic settings."},{"title":"Computational foundations of active visual sensing","field_investigator":"Mackenzie Weygandt Mathis, Cristopher M Niell, Zachary Samuel Pitkow, Andreas  Tolias","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS126566-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10431247\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10431247\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nVision is an active process: we move our head and eyes to explore the sensory world."},{"title":"Computational Tools for assessing mechanisms and functional relevance of divisive normalization","field_investigator":"Ruben  Coen-Cagli","field_institution":"Albert Einstein College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056400-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488972\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488972\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nDivisive normalization (DN) is a well-established theory of how interactions between neurons in a circuit\nmodulate the activity of individual neurons."},{"title":"Cortical circuits for the integration of parallel short-latency auditory pathways","field_investigator":"Hiroyuki  Kato, Paul B Manis","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128873-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524362\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524362\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nHow our brain achieves coherent perception by integrating information from parallel sensory pathways\ndistributed across space and time remains a central question in neuroscience."},{"title":"CRCNS: Circuit mechanisms of priors and learning during decision making","field_investigator":"Guangyu Yang","field_institution":"Massachusetts Institute of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01MH132172-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610167\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610167\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EWhen learning a new task, both rats and humans exhibit suboptimal behaviors plagued with superstitious ticks and idiosyncratic biases.\u003C\/p\u003E"},{"title":"CRCNS: Deconstructing dynamics of motor cortex in freely moving behavior","field_investigator":"Paul Nuyujukian","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01NS130789-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610495\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610495\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EWhat operations are performed by the mammalian central nervous systems to coordinate and conduct voluntary movement? Motor systems neuroscience seeks to understand these neural mechanisms.\u003C\/p\u003E"},{"title":"CRCNS: Dynamics of thalamocortical networks during sensory discrimination","field_investigator":"Mark Allan Reimers","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01NS130919-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10612202\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10612202\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Evidence-based modeling of neuromodulatory action on network properties","field_investigator":"Yangyang Wang","field_institution":"University of Iowa","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01DA057767-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610566\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610566\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Heterogeneous effects of cognition on perception: unique leverage on circuit mechanisms","field_investigator":"Marlene Rochelle Cohen, Brent D. Doiron","field_institution":"University of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01EY034723-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608553\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608553\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Multifocal causal mapping of brain networks supporting human cognition","field_investigator":"Aapo Nummenmaa","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01DC020891-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10612128\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10612128\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ENeuroimaging methods such as functional MRI and magneto- \/ electroencephalography (MEG\/EEG) cannot directly reveal causal relationships between regional brain activity and behavior.\u003C\/p\u003E"},{"title":"CRCNS: Neural Representations of Time Across Scales in Natural and Artificial Networks","field_investigator":"Marc W Howard","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01MH132171-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610084\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610084\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Understanding Single-Neuron Computation Using Nonlinear Model Optimization","field_investigator":"Fabrizio Gabbiani, Matthias Heinkenschloss","field_institution":"Baylor College of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01NS130917-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10612187\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10612187\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EMotivation and Objectives Why are ion channels localized in subcellular dendritic compartments and is there a tight coupling of the observed localization with neuron function?\u003C\/p\u003E"},{"title":"Defining the circuit, synaptic, and molecular mechanisms linking intracellular Ca2+ release to learning using subcellularly-targeted manipulations and imaging techniques in dendrites in vivo","field_investigator":"Justin  O\u0026#039;hare","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS127815-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10502363\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10502363\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nCandidate Goals and Mission Relevance: The applicant\u2019s broad, long-term objective is to investigate how high-\n(circuit\/behavioral) and low- (subcellular\/molecular) level organizational principles of the brain cooperate to drive\nlearning."},{"title":"Dissecting circuit and cellular mechanisms for limb motor control","field_investigator":"John  Tuthill","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128785-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10522108\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10522108\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Motor neurons connect to muscles and comprise the major output of the nervous system. Patterns of\nneural activity in motor neurons cause temporally precise muscle contractions, producing coordinated\nand flexible behavior."},{"title":"Dissecting the role of cortico-basal ganglia circuit diversity in action learning from reinforcement","field_investigator":"Alice  Mosberger","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS126307-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425617\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425617\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nTo learn novel actions through reinforcement, a fundamental mechanism of motor learning, the brain needs to\ncausally link previously performed movements to their resulting outcomes."},{"title":"Dissection of Cell Type Specific Contributions to Motor Learning Circuits","field_investigator":"Lina Marcela Carmona","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS127857-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505229\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505229\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Abstract\nWhether riding your bike down a narrow path or reaching for your favorite cookie in a small box, many of our\ndaily actions require skilled and accurate movements. However, to achieve proficiency, these motor skills must\nfirst be learned through the process of motor learning."},{"title":"Dissection of spatiotemporal activity from large-scale, multi-modal, multi-resolution hippocampal-neocortical recordings.","field_investigator":"Gyorgy  Buzsaki, Zhe Sage Chen","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056394-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488900\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488900\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ ABSTRACT\nAdvances in neurotechnologies are producing large and complex datasets at unprecedented rate."},{"title":"Dissemination of FlyWire, A Whole-Brain Connectomics Resource","field_investigator":"Mala  Murthy","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS126935-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10439970\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10439970\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"This proposal will disseminate FlyWire, a Drosophila whole brain connectomics resource. We\nused advances in AI to segment all neurons from a whole brain EM volume called FAFB."},{"title":"Dissemination of MAPseq and BARseq for high-throughput brain mapping","field_investigator":"Anthony M Zador","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS126938-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10440138\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10440138\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The goal of this project is to disseminate MAPseq and BARseq to the broader neuroscience\ncommunity. These are novel methods developed in my laboratory based on high-throughput DNA\nsequencing for determining neuronal circuitry."},{"title":"Distributed Neural Activity Patterns Underlying Practice-Based Learning","field_investigator":"Kimberly  Reinhold","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH127471-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447345\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447345\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY \/ ABSTRACT\nTo survive, animals must learn appropriate associations between sensory cues and motor actions through a\nprocess of trial and error."},{"title":"Early-Life Stress Drives Increased Heroin Vulnerability: Role of D3 Receptors","field_investigator":"Brianna Elyse George","field_institution":"Wake Forest University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129177-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541392\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541392\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nStress and addiction are intricately linked neural processes. Acute stress can serve as a stimulus for relapse to\ncompulsive drug seeking following abstinence, and chronic stress can induce escalated drug intake to multiple\nclasses of drugs."},{"title":"Elucidating Principles of Sensorimotor Control using Deep Learning","field_investigator":"Shreya  Saxena","field_institution":"University Of Florida","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056377-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488409\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488409\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nHow do distributed neural circuits drive purposeful movements from the complex musculoskeletal system?"},{"title":"Empirical Power Analysis Tool for fMRI","field_investigator":"Stephanie  Noble","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH130894-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10503064\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10503064\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nFunctional magnetic resonance imaging (fMRI) research has transformed our understanding of human brain\nfunction and disease and is flourishing under unprecedented international funding, including dedicated support\nfrom the BRAIN Initiative."},{"title":"Enabling precise cell-type-specific dissection of orientation and memory circuits in retrosplenial cortex","field_investigator":"Omar Jamil Ahmed","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127101-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446099\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446099\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nIn humans, damage to a brain region called the retrosplenial cortex leads to pronounced spatial disorientation\nand severe retrograde and anterograde memory deficits."},{"title":"Feedback and feedforward gating of sensory signaling through timing in the thalamocortical loop","field_investigator":"Garrett B. Stanley","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128896-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524608\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524608\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Feedback and feedforward gating of sensory signaling through timing in the thalamocortical loop\nNearly all sensory experience begins in the periphery, generating sensory signals travelling through the thalamus\nbefore reaching neocortex."},{"title":"Fostering Ethical Neurotechnology Academia-Industry Partnerships: A Stakeholder Engagement and Toolkit Development Project","field_investigator":"Tristan  Mcintosh","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH130519-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10508408\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10508408\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\nNeurotechnologies used to treat brain disorders and diseases can drastically change brain function and behavior,\nmonitor brain activity, and collect and transmit personal health data."},{"title":"From synapses to neural representations: The role of neuromodulatory circuits in shaping contextual memories in the hippocampus","field_investigator":"Mark E J Sheffield","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127123-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447353\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447353\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary: Memory enables animals to acquire, store, and recall knowledge of the world\nthrough experience and use this knowledge to maximize reward and avoid danger."},{"title":"Functional connectivity of a brain-scale neural circuit for motion perception","field_investigator":"Eva Aimable Naumann","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128895-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524593\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524593\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nThe transformation of visual cues into appropriate behavior requires the collaboration of diverse neurons across\ndistant brain areas."},{"title":"Functional dissection of cerebellar output circuits that orchestrate limb motor control","field_investigator":"Eiman  Azim, Albert  Chen","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128898-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524627\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524627\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe cerebellum is essential for coordinating motor behavior through rapid adjustments of ongoing movements.\nTo refine movement, the cerebellum processes motor and sensory information, and transmits output that\nultimately modulates motor neuron activity to ensure successful execution."},{"title":"Functional interrogation of the mouse somatosensory thalamic interneuron in sensory perception and rhythmic states","field_investigator":"Jane  Yi","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH130023-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10467357\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10467357\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\/SUMMARY\nThe mouse somatosensory thalamus participates in fundamental processes including sensory processing, sleep\nand pathological rhythmic behaviors like seizure. Local thalamic interneurons have been considerably\noverlooked due to their sparsity in the total neuronal population."},{"title":"Functional Mapping of the Suprachiasmatic Nucleus","field_investigator":"Karen Jill Tonsfeldt","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS119291-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10448026\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10448026\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nThis proposal aims to delineate the electrical and molecular diversity of the suprachiasmatic nucleus (SCN) and\nprovide new evidence for receptor-expressing subtypes of SCN neurons using novel nanowire arrays that allow\nsingle cell recording at 1024 contacts simultaneously."},{"title":"Gene regulatory networks influencing neuron-microglia interactions in fetal brain development.","field_investigator":"Claudia Z Han","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH129983-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425902\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425902\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nThe prenatal period is a sensitive and critical time for brain development characterized by waves of neurogenesis,\nneuronal migration, and formation of neural networks."},{"title":"Hierarchy of the vocalization motor patterning circuits","field_investigator":"Kevin  Yackle","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127104-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446346\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446346\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"How are complex behaviors that require the coordination of multiple muscle systems produced? How does the\nbrain suddenly turn them \u201con\u201d?\n Vocalizations are seemingly simple, yet to occur, ~100 muscles must be coordinated, such as those for\narticulation (laryngeal and tongue) and breathing."},{"title":"Hippocampo-cortical contributions to world building in freely behaving macaques","field_investigator":"Kari  Hoffman","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127128-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447412\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447412\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nWhen learning in complex, realistic, or even real worlds, we have the benefit of using different\nstrategies adaptively. For most primate brains, adaptive means adjusting as a function of where we\nare, who we are with, and what things of use are in view or in reach."},{"title":"Hormonal regulation of sensory processing during parental care","field_investigator":"Kristina O. Smiley","field_institution":"University Of Massachusetts Amherst","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99HD108800-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425599\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425599\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\n Does the way we hear sounds change when we become parents?"},{"title":"Identifying prefrontal signatures of successful and dysfunctional attention","field_investigator":"Brielle  Ferguson","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH128892-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10349347\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10349347\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\n Attention is comprised of several component processes, including sustained attention, selective\nattention, and attentional flexibility."},{"title":"Implementation and dissemination of cloud-based retrospective hemodynamic analysis tools to enhance HCP data interpretation","field_investigator":"Blaise Debonneval Frederick","field_institution":"Mclean Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130637-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10509534\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10509534\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Summary\nFunctional Magnetic Resonance Imaging data has been a mainstay of neuroscience research for more than two\ndecades, as it allows rapid, continuous, noninvasive monitoring of neuronal function."},{"title":"Improving the robustness of neuroimaging through exploitation of variability in processing pipelines","field_investigator":"Gregory  Kiar, Michael Peter Milham","field_institution":"Child Mind Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130859-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516830\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516830\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nReproducible findings are essential to scientific advancement. Unfortunately, when fields lack consensus\nstandards for methods, or their implementations, reproducibility tends to be more of an ideal than a reality."},{"title":"Integrated functional and structural analysis of an entire column in mouse primary visual cortex","field_investigator":"Reza  Abbasi Asl","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH128672-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505417\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505417\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\nNeurons in the visual cortex form an intricate connectivity structure and topographic arrangement. The\nstructural and morphological organization of the neurons is known to constrain its functional properties."},{"title":"Integration of social and nonsocial information in the primate brain","field_investigator":"Joseph  Simon","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS125826-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541330\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541330\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nPrimate species frequently use social information to inform their decisions, for instance, to help make inferences\nabout potential threats or rewards in the environment."},{"title":"Investigating descending control of walking","field_investigator":"Helen Horan Yang","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS129759-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10568039\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10568039\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nCircuits in the brain control motor output to generate the precise behaviors required for survival. Dysfunction of\nthese circuits results in devastating movement disorders such as Parkinson\u2019s disease and amyotrophic lateral\nsclerosis."},{"title":"Investigating the microcircuit determinants of neural population activity through comparative analysis of latent dynamics across cortical areas in the mouse","field_investigator":"Audrey  Sederberg","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130413-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505552\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505552\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nA key goal in neuroscience is determining how microcircuit structure predicts circuit function. An intriguing idea,\nsupported by some theoretical models, is that variation in microcircuit composition supports functional\nspecialization."},{"title":"Investigating the pathomechanisms underlying Charcot-Marie-Tooth Disease","field_investigator":"Julia Alexis Jones","field_institution":"Scripps Research Institute, The","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129169-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541701\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541701\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nCharcot-Marie-Tooth (CMT) disease is a genetically and clinically heterogeneous group of\ninherited peripheral neuropathies that is characterized by damage to long motor and sensory\naxons."},{"title":"Investigating the Role of Microglia in Methamphetamine Use Disorder","field_investigator":"Samara Jo Vilca","field_institution":"University Of Miami School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS130871-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610124\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610124\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\nSubstance use disorder is a chronic relapsing disease that is characterized by repeated drug use despite\nnegative consequences."},{"title":"Locus coeruelus-prefrontal interactions for flexible decision-making","field_investigator":"Joshua I Gold","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128974-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10532047\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10532047\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nHigher brain functions include the ability to learn expectations about the world, update those expectations\nappropriately when given new sensory information, and use those continually updating expectations to guide\nbehavior."},{"title":"Long-term consequences of visual working memory","field_investigator":"Megan Teresa Debettencourt","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-044","field_project_number":"1K99MH128893-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523326\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523326\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThe ability to remember information, whether after short or long delays, is a fundamental human ability."},{"title":"Machine learning analyses of single-cell multi-modal data for understanding cell-type functional genomics and gene regulation","field_investigator":"Daifeng  Wang","field_institution":"University Of Wisconsin-Madison","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH128695-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505191\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505191\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nUnderstanding cell-type-specific gene functions, expression dynamics, and regulatory\nmechanisms in complex brains is still challenging."},{"title":"Mechanisms of Transplanted Cortical Interneuron Survival and Function","field_investigator":"Benjamin  Rakela","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY033976-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425147\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425147\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nCortical interneurons (cINs) are inhibitory cells that are born in surplus far from the cortex. During prenatal\ntimepoints, cIN precursors migrate into the mouse visual cortex (V1) where only a fraction are selected to\nsurvive."},{"title":"Mesh electronics for understanding space encoding in the amphibian brain","field_investigator":"Lisa  Giocomo, Guosong  Hong, Lauren A O\u0026#039;connell","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127103-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446284\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446284\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nMany animals rely on spatial cognition for daily survival in order to recognize familiar places and process movements\nthrough or between locations. A variety of space-encoding cells in the hippocampus are important for spatial behaviors\nin mammals."},{"title":"Modeling the development of orientation selectivity, maps, and the associated recurrent circuit","field_investigator":"Kenneth D Miller","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056397-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488978\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488978\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nMuch evidence suggests that the development of orientation selectivity and maps in primary visual cortex (V1)\nis instructed by spontaneous patterns of input activity, without the necessity of visual experience."},{"title":"Molecular and circuit mechanisms of nausea-associated behaviors","field_investigator":"Chuchu  Zhang","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS129758-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10569466\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10569466\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project summary\nNausea is an unpleasant sensation of visceral malaise often accompanied by an involuntary urge to vomit.\nNausea responses to toxin ingestion and infection are evolutionarily beneficial survival behaviors that\navoid or expel toxins which may cause peripheral tissue damage."},{"title":"Molecular and sensory foundations of vestibular reflex circuit assembly in the larval zebrafish","field_investigator":"Dena  Goldblatt","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129179-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541342\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541342\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY: Behavioral dysfunction in neurodevelopmental diseases often arises from aberrant\nneural circuit assembly. However, the developmental logic that dictates circuit organization, function, and\nultimately behavior remains unresolved due to the complexity of most circuits."},{"title":"Motor Recovery through Plasticity-Inducing Cortical Stimulation","field_investigator":"Steven C. Cramer, Jeffrey G Ojemann","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS121565-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10357993\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10357993\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Limited recovery of function after stroke remains a major problem for millions. Disability persists in\nmany, especially when hand function is limited. Existing therapies are limited and many have difficulties with\nactivities of daily living, even after rehabilitation."},{"title":"Multimodal dissociation of posterior cingulate cortex contributions to episodic memory","field_investigator":"Seth Ryan Koslov","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH130027-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10467220\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10467220\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nEpisodic memory is the ability to recall details about prior experiences. Researchers have historically relied on\ncontrolled item-recognition paradigms, in complement to autobiographical recall tasks, to investigate the\nbiological substrates of episodic memory."},{"title":"Network based neuro-modulation for mesial temporal lobe epilepsy","field_investigator":"Behnaam  Aazhang, Sandipan Pati  Bankim Behari Pati, Nitin  Tandon, Gregory A Worrell","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS119834-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10113342\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10113342\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":""},{"title":"Neural basis of facial individual recognition in paper wasps","field_investigator":"Michael J Sheehan","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128868-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524286\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524286\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The neural circuits of animals, including humans, are the combined product of adaptation by natural selection\nand the evolutionary history of a species."},{"title":"Neural circuit control of fluid and solute clearance during sleep","field_investigator":"Patrick James Drew, Hajime  Hirase, Douglas H Kelley, Laura Diane Lewis, Maiken  Nedergaard","field_institution":"University Of Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS128613-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516497\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516497\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Program abstract: This proposal aims to identify the neural circuit mechanisms that control periarterial\ncerebrospinal fluid (CSF) pumping and glymphatic clearance of fluid and solutes."},{"title":"Neural circuit mechanisms for multisensory associative learning","field_investigator":"Roudabeh  Behnia, Ashok  Litwin-Kumar","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128874-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524400\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524400\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe brain uses sensory representations to assess risk and predict reward in order to adjust behavior. Per\u00ad\nception is a multisensory process. To make reliable predictions, it is advantageous for the brain to combine\nmore than one sensory modality to represent the world."},{"title":"Neural coding of natural stimuli in freely moving macaque","field_investigator":"Valentin  Dragoi","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128894-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524592\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524592\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Despite the fact that visual perception represents such a fundamental aspect of our everyday life, our knowledge\nof the underlying neural coding of natural stimuli is woefully lacking."},{"title":"Neural mechanisms of behavioral coordination in Hydra","field_investigator":"Alison  Hanson","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS127851-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505359\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505359\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nHow do animals coordinate their many parts to generate coherent, adaptive behavior?"},{"title":"Neural mechanisms of taste and metabolic state integration in the brainstem","field_investigator":"Nilay  Yapici","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128872-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524319\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524319\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nThe taste of food is a critical factor that determines whether an organism will accept or reject a food source."},{"title":"NEURODEVELOPMENTAL FUNCTION OF HCFC1","field_investigator":"Victoria L Castro","field_institution":"University Of Texas El Paso","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS125690-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541351\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541351\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nMutation of HCFC1 causes a multiple congenital anomaly syndrome characterized by inborn errors of cobalamin\nmetabolism, intractable epilepsy, intellectual disability, and motor dysfunction."},{"title":"Neurodevelopmental role of a tRNA methyltransferase underlying intellectual disability","field_investigator":"Kimberly Rose R. Madhwani","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129128-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10540878\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10540878\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nGene regulation at multiple levels is critical for nervous system development and function."},{"title":"New Methodologies for Connectomics","field_investigator":"Xiaotang  Lu","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH128891-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10345620\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10345620\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT ABSTRACT\nThe nervous systems of animals are comprised of neurons connected by a large number of synapses.\nThe resulting neural networks underlie animal behavior and contribute to the storage of learned\ninformation in many species."},{"title":"Odor trail tracking: a new paradigm to unveil algorithms and neural circuits underlying active sensation and continuous decision making","field_investigator":"Catherine  Dulac, Venkatesh N Murthy, Massimo  Vergassola","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128865-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524245\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524245\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nAnimals actively sample sensory information, which they combine with prior knowledge to make\ndecisions in a sensorimotor feedback loop."},{"title":"Pinpointing the Cerebellum\u0026#039;s Contribution to Social Reward Processing","field_investigator":"Haroon Skander Popal","field_institution":"Temple Univ Of The Commonwealth","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129182-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541308\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541308\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nThe cerebellum has long been thought to solely process motor information. Yet, there is a growing literature\nthat points to a role of the cerebellum in processes across multiple domains."},{"title":"PREFRONTAL CIRCUITS OF WORKING MEMORY","field_investigator":"Christos  Constantinidis, Boris V Zemelman","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127100-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446082\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446082\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nWorking memory, the ability to maintain and manipulate in formation in memory over a period of seconds, is a\ncritical component of higher cognitive functions."},{"title":"Probing Neural Circuits of Zebrafish Sleep with Electrophysiology and Calcium Imaging","field_investigator":"David Aaron Prober, Thai V. Truong","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS126800-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10436734\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10436734\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nThe zebrafish has emerged as a useful model system to discover and characterize genetic and neuronal circuits\nthat regulate vertebrate sleep."},{"title":"Real-time mapping and adaptive testing for neural population hypotheses","field_investigator":"John  Pearson","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056376-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10486197\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10486197\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\n Recent advances in neural recording technologies have made it possible to study increasingly large and di-\nverse subsets of neurons, producing a growing interest in the collective computational properties of neural pop-\nulations."},{"title":"Revealing the mechanisms of primate face recognition with synthetic stimulus sets optimized to compare computational models","field_investigator":"Winrich  Freiwald, Nikolaus  Kriegeskorte","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128897-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524626\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524626\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nNeuroscience is entering a new era, where large-scale neural network models can be tested with unprecedent-\nedly rich measurements of neural activity."},{"title":"Role of Endocannabinoid System in Seizure Sensitivity in Eclampsia","field_investigator":"Maria  Jones-Muhammad","field_institution":"University Of Mississippi Med Ctr","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129125-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541023\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541023\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nPreeclampsia, a hypertensive disorder of pregnancy, can advance to eclampsia, when the mother\ndisplays novel seizures. The mechanisms that cause some preeclampsia patients to advance to\neclampsia are unknown."},{"title":"Role of neuronal ensembles in cortical plasticity during learning and development","field_investigator":"Alejandro  Akrouh","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY033974-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523350\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523350\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\n The brain undergoes extensive synaptic plasticity and circuit refinement during development. Similar\nchanges recur throughout life during learning in a more narrowly constrained manner."},{"title":"Secondary analysis of resting state MEG data using the Human Neocortical Neurosolver software tool for cellular and circuit-level interpretation","field_investigator":"Stephanie Ruggiano Jones","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130415-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505661\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505661\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe neuroscience community is experiencing a revolution in its ability to share and analyze vast amounts of\nhuman brain imaging data, with support from the BRAIN Initiative and other substantial data-sharing efforts."},{"title":"Sensory-motor strategies for odor-guided navigation","field_investigator":"Ian Gordon Davison","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128975-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10531982\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10531982\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nAnimals interact with the world through dynamic, iterative sensory-motor processes that guide their\nongoing movement."},{"title":"Statistical machine learning tools for understanding neural ensemble representations and dynamics","field_investigator":"Uri Tzvi Eden, Loren M Frank, Alan David Kaplan","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130623-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10510107\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10510107\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The brain is a massively interconnected network of specialized circuits."},{"title":"Thalamus in the middle: computations in multi-regional neural circuits","field_investigator":"Adam G Carter, Jayaram  Chandrashekar, Jorge H Jaramillo, Karel  Svoboda, Bosiljka  Tasic","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS123714-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294397\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294397\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary, Overall (Thalamus in the middle: computations in multi-regional neural\ncircuits)\nThis collaborative project aims to uncover the logic of signal routing from subcortical areas to the frontal cortex\nthrough the thalamus."},{"title":"The Disadvantage Exposome as a Driver of Alzheimer\u2019s Disease Pathology","field_investigator":"Margo  Heston","field_institution":"University Of Wisconsin-Madison","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS130922-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610660\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610660\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"1 PROJECT SUMMARY\n 2 Alzheimer\u0027s disease (AD) is the most common form of dementia worldwide, incurring a projected healthcare\n 3 burden of $1 trillion in the United States alone by 2060."},{"title":"The Heart and the Mind: An Integrative Approach to Brain-Body Interactions in the Zebrafish","field_investigator":"Florian  Engert, Mark C Fishman, Adrienne L Fairhall, Jeff W Lichtman, Joshua T Vogelstein","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"2U19NS104653-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10525427\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10525427\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The heart and the mind: an integrative approach to brain-body interactions in the\nzebrafish\nOur current U19 has focused primarily on Exteroception, which can be defined as the accumulated sensory experience\noriginating from events in the outside world."},{"title":"The interaction of cortical and subcortical processing in natural sensory behavior","field_investigator":"Cristopher M Niell, Michael  Wehr","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127305-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10455297\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10455297\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nOur brains have evolved to extract relevant sensory information from rich and complex natural environments in\norder to drive appropriate behavior."},{"title":"The Neural Circuit Basis of Olfactory Navigation in Adult Drosophila","field_investigator":"Katherine  Nagel","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127129-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447440\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447440\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nIn order to forage effectively for food, the brain must integrate innate and learned information about the\nvalue of different food odors and use this information to select navigational motor programs."},{"title":"The Neural Code and Dynamics of the Reading Network","field_investigator":"Nitin  Tandon","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS128921-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10526168\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10526168\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Reading involves complex transformations of word forms, with visual input mapped to lexical, semantic and\nphonological systems in less than a second."},{"title":"The Spatial and Temporal Scale of Neuromodulation in Mouse Sensory Cortex","field_investigator":"Jacob  Reimer","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128901-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524638\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524638\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The neuromodulators acetylcholine (ACh) and norepinephrine (NE) are associated with an\nactivated cortical brain state characterized by an increase in the reliability of cortical responses\nto external stimuli and enhanced performance on behavioral tasks."},{"title":"Tracking the emergence of internal models","field_investigator":"Elizabeth A Buffalo, Adrienne L Fairhall","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS126485-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10429372\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10429372\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nCentral to human and animal cognition is the idea of internal models: an internal repository of\nknowledge about the structure of the world and its affordances that enables prediction and\nplanning. The existence of such models is fundamental to experience."},{"title":"Ultrafast high-contrast voltage imaging in freely moving animals","field_investigator":"Jerome  Mertz","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127098-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10445419\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10445419\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nWe propose to develop a targeted illumination confocal (TICO) microscope to enable high speed,\nlarge-scale voltage imaging in the brain. This microscope will be based on the combination of two\nkey strategies. The first strategy is high-speed confocal microscopy based on line scanning."},{"title":"Understanding feedforward and feedback signaling between neuronal populations","field_investigator":"Adam  Kohn, Christian  Machens, Byron M. Yu","field_institution":"Albert Einstein College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127107-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446820\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446820\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nMost perceptual, cognitive, and motor functions rely on neuronal activity distributed across multiple networks,\noften located in different brain areas."},{"title":"Understanding how cortex supports flexible sensory representations","field_investigator":"Katherine Charlotte Wood","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DC019504-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10448054\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10448054\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nLearning is a fundamental function of the brain: sensory representations must be flexible to adjust to changes in\nenvironmental demands and experience, thus allowing us to adapt to the world around us."},{"title":"Virtual observatory of the cortex: organelles, cells, circuits, and dynamics","field_investigator":"Forrest Christie Collman, Nuno  Macarico Da Costa, R Clay Reid, Hyunjune Sebastian Seung","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120053-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10440183\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10440183\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"We propose to create VOrtex, a Virtual Observatory for the Cortex: Spanning the Scales of Organelles, Cells,\nCircuits, and Dynamics."},{"title":"Wearable RF-EEG Cap for closed loopTMS\/fMRI\/EEG Applications","field_investigator":"Lucia Isabel Navarro De Lara","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EB032749-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10520726\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10520726\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nFunctional MRI (fMRI) is the prevailing method for both basic research and clinical functional neuroimaging in\nhumans."},{"title":"Whole-Brain Functional Imaging and Analysis of Zebrafish Sleep","field_investigator":"Geoffrey J Goodhill, David Aaron Prober, Thai V. Truong","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS126562-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10430595\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10430595\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nSleep occupies a third of our lives and sleep-related ailments cost an estimated $100 billion per year, yet the\nmechanisms governing its regulation remain poorly understood."},{"title":"A community-driven development of the brain imaging data standard (BIDS) to describe macroscopic brain connections","field_investigator":"Franco  Pestilli","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-128","field_project_number":"1R01MH126699-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10253558\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10253558\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\n The Brain Imaging Data Structure (BIDS) is a BRAIN initiative (R24 MH114705)\ncommunity-driven standard meant to maximize neuroimaging data sharing, and facilitate analysis tool\ndevelopment."},{"title":"A Computational Framework for Distributed Registration of Massive Neuroscience Images","field_investigator":"Matthew  Mccormick","field_institution":"Kitware, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH126732-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10259930\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10259930\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nNeuroscience stands at the precipice of a new depth of understanding about how the brain works thanks to recent\nadvances in imaging data acquisition technologies such as light-sheet \ufb02uorescence microscopy (LSFM)."},{"title":"A harmonized vendor-agnostic environment for multi-site functional MRI studies","field_investigator":"Jon-Fredrik  Nielsen, Maxim  Zaitsev","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120056-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10306940\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10306940\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Since its invention in the early 90s, functional magnetic resonance imaging (fMRI) has revolutionized our un-\nderstanding of the human brain. Functional MRI may be used to observe brain function during a speci\ufb01c motor\nor cognitive task, or at \u201crest\u201d (resting-state fMRI)."},{"title":"A multi-plane 3-photon microscope for volume imaging in NHP cortex","field_investigator":"Jack  Waters","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS121766-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10205806\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10205806\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT ABSTRACT\nRecent advances in microscopy permit volume imaging - the near-simultaneous imaging of many neurons in a circuit -\nwith 2-photon (2P) excitation, yielding new insights into the circuits underlying relatively simple behaviors."},{"title":"A Tool for Synapse-level Circuit Analysis of Human Cerebral Cortex Specimens.","field_investigator":"Jeff W Lichtman","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH123386-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10271724\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10271724\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nThe goal of this work is to facilitate synaptic level analysis of neurons and their interconnecting microcircuits in\nneurosurgical cerebral cortex biopsies from human patients."},{"title":"A web-based framework for multi-modal visualization and annotation of neuroanatomical data","field_investigator":"David  Kleinfeld, Samuel Sheng-Hung Wang","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH128776-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10365435\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10365435\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\/ABSTRACT\nModern experimental approaches allow researchers to collect a variety of whole-brain data from the same animal\nvia different anatomical labels, including tracers, genetic markers, and fiducial marks from recording electrodes.\nUnfortunately, viewing and analysis methods have "},{"title":"Acute Modulation of Stereotyped High Frequency Oscillations with a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy","field_investigator":"Nuri Firat Ince","field_institution":"University Of Houston","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS117944-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10290984\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10290984\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary:\nHigh frequency oscillations (HFOs) of intracranial EEG (iEEG) have the potential to identify the surgical resection\narea\/seizure onset zone (SOZ) in patients with drug resistant epilepsy."},{"title":"Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format","field_investigator":"Anton  Arkhipov, Emad  Tajkhorshid","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124001-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10306896\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10306896\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format\nOne of the major goals of the BRAIN Initiative is to distill complex, multi-modal data into predictive frameworks\nvia theory\/modeling."},{"title":"Advancing Standardization of Neurophysiology Data Through Dissemination of NWB","field_investigator":"Benjamin K Dichter, Oliver  Ruebel","field_institution":"University Of Calif-Lawrenc Berkeley Lab","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120057-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10116139\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10116139\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nLack of standards for neurophysiology data and related metadata is the single greatest impediment to fully\nextracting return on investment from neurophysiology experiments."},{"title":"An Alignment Framework For Mapping Brain Dynamics and Substrates of Human Cognition Across Species","field_investigator":"Ting  Xu","field_institution":"Child Mind Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH128696-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10360863\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10360863\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nThe non-human primate (NHP) model is critical to the advancement of translational neuroscience, as it allows\nresearchers to link observations regarding macroscale brain dynamics and cognition in the human to underlying\nmeso- and microscale phenomena that cannot be fully investigated in huma"},{"title":"An integrated single-neuronal, population-, local network- and stimulation-based prefrontal investigation of human social cognition","field_investigator":"Ziv  Williams","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS121616-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10200517\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10200517\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"An integrated single-neuronal, population-, local network- and stimulation-based\nprefrontal investigation of human social cognition\nThis proposal aims to undertake a comprehensive single-cellular, population-, local circuit- and stimulation-\nbased evaluation of the role that the dorsal prefrontal co"},{"title":"Anticipating ethical challenges and disparities in the dissemination of novel neurotechnologies","field_investigator":"Winston  Chiong, Daniel P. Dohan","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1R01MH126997-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10283140\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10283140\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"PROJECT SUMMARY\/ABSTRACT\nA central goal for the second half of the BRAIN Initiative is to develop new circuit-based treatments for\nbrain diseases."},{"title":"Behavioral Analysis and Modeling Core","field_investigator":"Jonathan William Pillow","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS123716-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294672\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294672\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\/Abstract, Core D: Behavioral Analysis and Modeling\nThis proposal\u2019s overarching goal is to understand how internal states influence decisions and to identify the\nunderlying neural mechanisms."},{"title":"Big-Data Electron-microscopy for Novel Community Hypotheses: Measuring And Retrieving Knowledge (BENCHMARK)","field_investigator":"William R Gray Roncal","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-128","field_project_number":"1R01MH126684-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10252257\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10252257\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nIn an effort to better understand structural organization and anatomy of nervous systems at\nunprecedented spatial resolution, recent efforts, including BRAIN Initiative funded projects, have\ncollected increasingly larger datasets using Electron Microscopy (EM) and X-Ray\nMicrotomograp"},{"title":"BRAIN Initiative: Assessing development of event-related cortical network dynamics","field_investigator":"Scott  Makeig, Michael Peter Milham, Arnaud  Delorme","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125934-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10190670\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10190670\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe Child Mind Institute\u2019s Healthy Brain Network (HBN) is an ongoing initiative focused on creating and\nsharing a biobank of brain and behavioral data now being collected from 10,000 New York City area children\nand adolescents (ages 5-21)."},{"title":"BRAIN Viral Vector Services and Distribution Core","field_investigator":"Kimberly  Ritola","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124025-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10308224\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10308224\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The BRAIN Viral Vector Service and Distribution Core will serve as a resource for the maintenance,\npropagation, and distribution of viral vectors that are used by neuroscientists for neural circuit\nidentification and manipulation, as well as for preclinical translational studies."},{"title":"BRAINShare: Sharing Data in BRAIN Initiative Studies","field_investigator":"Amy L Mcguire, Sameer Anil Sheth","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1R01MH126937-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10281874\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10281874\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"PROJECT SUMMARY\nData sharing is essential to promote equity and maximize the impact of the significant investment in the BRAIN\nInitiative."},{"title":"Capturing large-scale locus coeruleus single neuron activity in behaving rats with nanoelectronic threads (NETs), an ultra-flexible multi-electrode probe","field_investigator":"Nelson  Totah","field_institution":"University Of Helsinki","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS123876-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300345\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300345\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary \/ Abstract\nSystems neuroscience has viewed the brainstem noradrenergic nucleus, Locus Coeruleus (LC), as the\nsource of a global arousal signal, which modulates cognitive functions by altering operations throughout\nthe entire central nervous system."},{"title":"Changing the neuromodulation game: ultrasound fenestration of the blood brain barrier for noninvasive viral transfection of primate CNS neurons","field_investigator":"Arnaud Y Falchier, Charles E Schroeder","field_institution":"Nathan S. Kline Institute For Psych Res","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS122272-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10235811\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10235811\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nGenetic technologies have revolutionized the way scientists can dissect out brain circuitry by inserting G\nprotein-coupled receptors that enable selective modulation of neurons in target structures."},{"title":"Circuit basis of social behavior decision-making in a subcortical network","field_investigator":"David J Anderson","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123916-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300937\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300937\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\n This proposal responds to an FOA (RFA-NS-18-030) calling for 1) \u201cnovel approaches to understand neural\ncircuitry associated with well-defined social behaviors;\u201d 2) Distributed circuits that contribute to the coordination\nof motivational states and reward behavior;\u201d 3) \u201cEmpi"},{"title":"Circuits underlying threat and safety","field_investigator":"Donald B Arnold, Scott E Fraser, Nancy  Kopell, Carl  Kesselman","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS122082-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10218722\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10218722\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Classical conditioning has been studied in many different animal models, and even in humans. However, the\nlarval zebrafish with its transparent brain offers a unique opportunity to observe large scale changes in\nsynaptic structure that accompany this form of learning."},{"title":"Combined Mechanistic and Input-Output Modeling of the Hippocampus During Spatial Navigation","field_investigator":"Dong  Song","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055665-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263699\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263699\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT ABSTRACT\nLarge-scale realistic model of neuronal network is a powerful tool for studying neural dynamics and cognitive\nfunctions. It integrates multi-scale neurobiological mechanisms\/processes identified through diverse hypotheses\nand experimental data into a single platform."},{"title":"Comparative Neuroanatomy at single-neuron resolution","field_investigator":"Roger L Clem, Peter  Rudebeck","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS122050-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10216577\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10216577\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project summary\nAlthough single neurons occasionally project to a single downstream target, it is more often the case that their\naxons collateralize and project to multiple distinct anatomical areas."},{"title":"Computational neuroscience of language processing in the human brain","field_investigator":"Evelina  Fedorenko, Robert Mark Richardson","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS121471-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10199330\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10199330\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":""},{"title":"Connecting late-life depression and cognition with statistical physics based connectomics and sparse Frechet regression","field_investigator":"Alex  Leow, Yichao  Wu, Liang  Zhan","field_institution":"University Of Illinois At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125928-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10190424\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10190424\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Recently, several lines of evidence have supported that synaptic dysfunction represents one of\nthe earliest brain changes in Alzheimer\u2019s disease (AD), leading to hyper-excitation in neuronal\ncircuits."},{"title":"Converting Value into Action: Computations in Corticostriatal Circuits for Flexible Decision Making","field_investigator":"Linda  Amarante","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127780-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10314166\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10314166\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nTo flexibly execute behavior, choices are made based on previous outcomes that will maximize reward.\nCrucially, learning the value of each action to obtain a reward is thought to drive this decision making process.\nIn a value-based decision making framework, these values are first co"},{"title":"Coordinating Structure and Function for Neuronal Computations Mediating Context-Dependent Behavior","field_investigator":"Bijan  Pesaran","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS122123-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10225166\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10225166\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThis proposal explores an emergent computational framework for understanding the neural population codes\nthat support flexible, context-dependent behavior. The current state of the field is based on two competing\nviews."},{"title":"Cortical basis of complex motor sequences in humans for neural interfaces","field_investigator":"Jaimie M Henderson, Krishna V Shenoy","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS123101-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10289711\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10289711\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"PROJECT SUMMARY\nIntracortical brain-computer interfaces (iBCIs) can restore lost function for people with severe\nspeech and motor impairment (SSMI) due to neurological injury or disease. Despite tremendous\nrecent progress, iBCI performance remains well below that of able-bodied people."},{"title":"Cortical information integration as a model for pain perception and behavior","field_investigator":"Zhe Sage Chen, Jing  Wang","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121776-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10205303\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10205303\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Sensory processing requires the interaction between external inputs and an internal brain state. Pain is a unique\nsensory experience that is triggered by external signals, but is also strongly shaped by internal cognitive and\nemotional variables."},{"title":"Cortical visual processing for navigation","field_investigator":"Michael  Goard, Cristopher M Niell, Spencer Lavere Smith","field_institution":"University Of California Santa Barbara","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121919-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10208550\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10208550\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project summary\nVision plays a key role in our ability to navigate through the environment, from identifying landmarks and obstacles\nto determining location and heading."},{"title":"CRCNS: A mechanistic theory of serotonergic modulation of cortical processing","field_investigator":"Luca Mazzucato, Cristopher M Niell","field_institution":"University of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01DA055439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396147\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396147\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ESerotonergic neuromodulation is a crucial factor in regulating several aspects of brain function, from mood disorders to appetite, reward and motivation, and in maintaining balance of sensory perception. However, the network mechanisms by which it modulates brain dynamics are elusive.\u003C\/p\u003E"},{"title":"CRCNS: Computational Modeling of Microvascular Effects in Cortical Laminar fMRI","field_investigator":"Jonathan Rizzo Polimeni","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01EB032746-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10398277\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10398277\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EToday, the most widespread tool for measuring whole-brain activity noninvasively is functional magnetic resonance imaging (fMRI).\u003C\/p\u003E"},{"title":"CRCNS: Computational principles of mental simulation in the entorhinal and parietal cortex","field_investigator":"Mehrdad Jazayeri, Ila R. Fiete","field_institution":"Massachusetts Institute of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01MH129046-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396142\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396142\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EHumans make rich inferences about the relationships between entities in the world from scarce information. For example, we can find a novel destination after seeing a few street numbers, or find a page in a dictionary by glancing at a few words in other pages.\u003C\/p\u003E"},{"title":"CRCNS: Crossbeam Transcranial Ultrasound Technology to Stimulate the Deep Brain","field_investigator":"Kim Butts-Pauly","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01EB032743-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10397709\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10397709\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ENumerous neuroscience and clinical applications exist for a noninvasive neuromodulation technology that can reach deep in the brain with high resolution. One compelling clinical application is the treatment of drug addiction, a major public health challenge in the US.\u003C\/p\u003E"},{"title":"CRCNS: Diverse effects of GABAergic inputs on a basal ganglia output center","field_investigator":"Jonathan E. Rubin, Aryn hilary Gittis","field_institution":"University of Pittsburgh at Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01NS125814-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10395793\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10395793\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThe basal ganglia are a collection of subcortical nuclei studied for their contributions to movement, action selection, habit formation, and reward learning as well as their dysfunction in movement disorders.\u003C\/p\u003E"},{"title":"CRCNS: Functional Brain Networks with Tensioned Stability for Optimal Processing","field_investigator":"Paul Laurienti, Erik Bollt","field_institution":"Wake Forest University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01AA029926-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10395742\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10395742\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EUnderstanding the brain processes underlying alcohol use and misuse are essential for the development of effective treatments for alcohol use disorder or AUD. Human brain imaging has greatly contributed to our current understanding of AUD, but much more remains to be understood.\u003C\/p\u003E"},{"title":"CRCNS: Integrating gray and white matter data to understand the organization of human visual cortex","field_investigator":"Jonathan A Winawer, Noah C Benson","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01EY033628-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396141\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396141\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Multimodal Dynamic Causal Learning for Neuroimaging","field_investigator":"Sergey Plis","field_institution":"Georgia State University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01MH129047-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396137\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396137\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ECRCNS Research Proposal: Collaborative Research: Multimodal Dynamic Causal Learning for Neuroimaging A Project Description A.1 Introduction Many analyses of fMRI and other neuroimaging data aim to discover the underlying causal or commu- nication structures that generated that activity.1,2 An acc\u003C\/p\u003E"},{"title":"CRCNS: Multiple clocks for the encoding of time in corticostriatal circuits","field_investigator":"Sotiris Masmanidis, Dean V Buonomano","field_institution":"University of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01NS125877-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396146\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396146\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThe ability to predict when external events will occur, such as anticipating the actions of a predator or the availability of food, is critical for survival.\u003C\/p\u003E"},{"title":"CRCNS: Multiple Time Scale Memory Consolidation in Neural Networks","field_investigator":"Alex D Reyes, Stefano Fusi","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01MH129031-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10395852\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10395852\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EDetailed description of the proposed use of the animals, including species, strains, ages, sex, and number to be used; Dissociated, primary cultures will be prepared from the cortex of new born mice of either sex (mus musculus, Postnatal day 0-1).\u003C\/p\u003E"},{"title":"CRCNS: Regulation of assembly and disassembly of the postsynaptic density during synaptic plasticity and its effect on AMPAR trapping","field_investigator":"Terrence J Sejnowski, Mary B Kennedy","field_institution":"Salk Institute for Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01MH129066-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10397182\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10397182\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EFast glutamatergic synaptic transmission is based on a precise and complex molecular organization which requires the control of the number of AMPA-type glutamate receptors (AMPARs) at the postsynaptic sites of glutamatergic synapses on dendritic spines.\u003C\/p\u003E"},{"title":"CRCNS: Resolving human face perception with novel MEG source localization methods","field_investigator":"Dimitrios Pantazis","field_institution":"Massachusetts Institute of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01EY033638-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10397180\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10397180\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EA brief glimpse at a face quickly reveals rich multi-dimensional information about the person in front of us. How is this impressive computational feat accomplished? A recently revised neural framework for face processing suggests perception of face form information, i.e.\u003C\/p\u003E"},{"title":"CRCNS: The Role of Statistical Structure for Natural Sound Recognition in Noise","field_investigator":"Monty A Escabi","field_institution":"University of Connecticut Storrs","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01DC020097-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396135\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396135\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThe ability to listen and identify sounds in the presence of competing background noise is a critical function of the healthy auditory system.\u003C\/p\u003E"},{"title":"Decoding and Selective Modulation of Human Memory During Awake\/Sleep Cycles","field_investigator":"Itzhak  Fried","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS123128-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10289993\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10289993\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nEpisodic memories integrate the content of human experience in space and time and constitute the core of one\u0027s\nidentity."},{"title":"Defining motor neuron diversity from embryo to adulthood and generating tools for in vivo and in vitro access","field_investigator":"Tulsi  Patel","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS121136-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10369830\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10369830\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\n In order to understand neurological diseases, it is essential to identify the affected neuronal cell types,\ncreate model systems that accurately recapitulate normal function and disease phenotypes, and develop tools\nthat allow cellular manipulations."},{"title":"Defining Targets for Tic Detection and Suppression in Tourette Syndrome Deep Brain Stimulation","field_investigator":"Christopher R Butson, Aysegul  Gunduz, Michael S Okun","field_institution":"University Of Florida","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS119844-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10290544\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10290544\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nTourette syndrome (TS) is a continuous lifelong condition that is highly prevalent, socially disabling, and in some severe\ncases, physically injurious."},{"title":"Developing cell type-specific enhancers and connectivity mapping pipelines for marmosets","field_investigator":"Guoping  Feng, Partha Pratim Mitra","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH126869-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10271630\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10271630\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\n Although genetic tools have dramatically advanced our understanding of brain function, they have\nlargely been confined to mice."},{"title":"Discovering the molecular genetic principles of cell type organization through neurobiology-guided computational analysis of single cell multi-omics data sets","field_investigator":"Z Josh Huang","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125921-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10189902\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10189902\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nUnderstanding the biological principles of cell type diversity and organization is necessary for deciphering\nneural circuits underlying brain function."},{"title":"Disentangling hippocampal and cortical contributions to episodic memory","field_investigator":"Alexa  Tompary","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH126427-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10188803\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10188803\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThis application describes a 5-year plan to investigate the neural dynamics that underpin distortion in memory,\nintegrating computational modeling approaches with functional neuroimaging (fMRI) and non-invasive brain\nstimulation techniques (TMS)."},{"title":"Dissecting active neural circuits regulating sensory and affective pain","field_investigator":"Akihiko  Ozawa","field_institution":"Florida Atlantic University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS121875-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10206401\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10206401\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nOpioids as a pain medication has been the most preferred pain treatments in order to provide quick relief from\nsevere pain. Decades of opioid abuse have triggered negative impact on pain therapies."},{"title":"Dissecting sodium appetite circuits in the mammalian brain","field_investigator":"Yuki  Oka","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123918-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300953\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300953\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nInternal sodium balance is critical for many physiological functions, including osmoregulation and action\npotentials. Deciphering the mechanisms that control sodium intake is essential for understanding the\nprinciples of appetite regulation and sodium homeostasis in the body."},{"title":"Dissecting the role of neuronal-astroglial interactions in sleep homeostasis","field_investigator":"Ashley Miranda Ingiosi","field_institution":"Washington State University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS119293-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10299917\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10299917\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nInsufficient sleep, sleep disorders, and resulting problems with health and cognition are increasingly common\nin the United States."},{"title":"Dissecting the roles of timing in a canonical neural computation","field_investigator":"Damon Alistair Clark","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121773-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10205535\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10205535\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary [30 lines max]\nTiming is critical to neural processing. Nowhere is that clearer than in visual motion detection. To detect\nmotion, neurons transmit visual information with different latencies, or delays, allowing the circuit to compare\nvisual scenes over time."},{"title":"Effects of abnormal early experience on IT circuitry","field_investigator":"Margaret S Livingstone","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123778-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10296415\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10296415\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe goal of the proposed research is to probe object-recognition circuitry in inferotemporal cortex by specific\nmanipulations of early visual experience."},{"title":"Enhancing the spatial control of non-invasive brain stimulation by magnetic temporal interference","field_investigator":"John Gustaf Wilhelm Samuelsson ","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127789-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316652\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316652\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nElectromagnetic brain stimulation is a safe and proven way of controlling neural activity non-invasively with no\nimplanted hardware or injected biochemical agents."},{"title":"Ethical and Policy Aspects of Cortical Visual Prosthetics Research: An Empirical Neuroethics Study","field_investigator":"Peter David Zuk","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"7F32MH127776-02","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10507898\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10507898\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nBrain-computer interfaces (BCIs) have emerged as a promising modality for restoring physiological functions\nsuch as mobility, communication, and visual perception."},{"title":"Ethologically relevant short term memory in the olfactory bulb","field_investigator":"Matthew C Smear","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS123903-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300826\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300826\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nShort-term memory is an essential component of cognition. Here, we will investigate an ethologically\nrelevant form of short-term memory that guides navigation behavior: memory of odor concentration across\nsniffs."},{"title":"Flexible normalization in ferret V1: computational modeling and 2-photon imaging","field_investigator":"Theoden I Netoff, Cheryl A. Olman, Gordon Brawn Smith","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123842-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10299683\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10299683\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nThe remarkable efficiency of human perception derives from the fact that we do not process each stimulus as a\nnovel event. Instead, past experiences and scene context inform internal, working models of the world that\nallow us to generate predictions for our physical environment."},{"title":"fMRI physiological signatures of aging and Alzheimer\u0026#039;s Disease","field_investigator":"Catherine Elizabeth Chang","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125931-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10361105\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10361105\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\/ABSTRACT\nThe growing availability of large functional magnetic resonance imaging (fMRI) datasets has enabled new\ninvestigations into functional systems of the human brain."},{"title":"From diverse dynamics to diverse computation via neural cell types","field_investigator":"Stefan  Mihalas, Eric Todd Shea-Brown","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055669-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263658\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263658\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nA prominent feature of biological neuronal networks is the astonishing diversity of their cell types."},{"title":"From synapses to genes through morphology: an integrated characterization of cell types based on connectomics and transcriptomics data","field_investigator":"Forrest Christie Collman, Nuno  Macarico Da Costa, R Clay Reid","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125932-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10360840\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10360840\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe goal of this project is to create a unified framework for understanding the relationship between\nneuronal gene expression and connectivity in mouse visual cortex, by using morphology as a key\nlinking modality."},{"title":"Functional and cell-type specific axonal pathways in the primate brain","field_investigator":"R Clay Reid","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH126864-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10272370\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10272370\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nOver the past decade, there have been transformative advances in three areas of mammalian neuroscience.\nFirst, our ability to record from large populations of neurons has dramatically increased with the advent of new\nelectrode technologies and improved multiphoton imaging."},{"title":"Genetic and neural mechanisms underlying emerging social behavior in zebrafish","field_investigator":"Florian  Engert, Mark C Fishman","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS124017-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10306905\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10306905\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Genetic and neural mechanisms underlying emerging social behavior in zebrafish\nOur goal is to understand emerging collective behaviors of groups, such as schooling and shoaling in fish.\nOur approach is to dissect basic sensorimotor transformations in the zebrafish, which we believe play a\nfundamenta"},{"title":"Harmonizing and Archiving of Large-scale Infant Neuroimaging Data","field_investigator":"Gang  Li","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123202-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10189251\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10189251\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Abstract\nThe first postnatal years are an exceptionally dynamic and critical period of structural and functional development\nof the human brain. Many neurodevelopmental disorders are the consequence of abnormal brain development\nduring this stage."},{"title":"Hemogenetic imaging technology for circuit-specific analysis of primate brain function","field_investigator":"Alan  Jasanoff","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH126868-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10271639\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10271639\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Primate brains contain cortical areas that exhibit selective engagement in high-level sensory or behavioral\noperations. The functional specialization of these regions is thought to be central to primate-specific cognitive\nfaculties and to associated disorders."},{"title":"Heritability and cognitive implications of structural-functional connectome coupling","field_investigator":"Amy  Kuceyeski","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123232-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10189014\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10189014\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The human brain is an unimaginably complicated system of interconnected neurons that is capable of complex\nthought, emotion and behavior."},{"title":"High-resolution synaptic and functional connectivity mapping of a neural circuit architecture underlying a behavioral sequence","field_investigator":"Andrew Michael Seeds","field_institution":"University Of Puerto Rico Med Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121911-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10208363\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10208363\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The ability to generate complex motor behaviors by assembling sequences of movements is essential for\npurposeful actions and survival. Defects in the brain regions thought to drive such movement selection can lead\nto behaviors becoming abnormally repetitive (e.g. autism spectrum disorder)."},{"title":"Hippocampal neural dynamics driving affiliation and attachment","field_investigator":"Zoe Rebecca Donaldson, Peyman  Golshani, Weizhe  Hong, Michael Moshe Yartsev","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS122124-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10225059\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10225059\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract:\nAttachment powerfully shapes our development and remains a primary driver of health and well-being in\nadulthood; disruption of attachments is highly traumatic."},{"title":"Imaging Dynamics in Anxiogenic Serotonin Circuitry","field_investigator":"Emily Clarissa Wright","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH125597-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316027\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316027\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nSerotonin has been long been recognized as an important modulator of mood and behavior, yet it projection-\nspecific dynamics are little understood."},{"title":"Influence of task complexity and sensory feedback on cortical control of grasp force","field_investigator":"Jennifer L. Collinger","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS123125-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10289762\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10289762\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"ABSTRACT\nHumans can skillfully control their grasp during actions as complex and dynamic as swinging a tennis racket,\nand as simple and static as holding a briefcase. Both tasks require the use of sensory feedback to achieve\nand maintain an appropriate grasp force."},{"title":"Integrative analysis of genomics and imaging data from the BRAIN Initiative and other public data sources","field_investigator":"Mark Bender Gerstein, Avram J Holmes","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123245-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10190025\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10190025\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Constructing an integrated picture of human brain function requires understanding how the effects of molecular\nand genetic factors propagate upwards, through many intervening layers of structure and interaction, to\ninfluence behavioral, psychiatric and cognitive traits."},{"title":"Integrative analysis of multiomic datasets for discovery of molecular underpinnings of large-scale human brain networks","field_investigator":"Mikail  Rubinov","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125933-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10361057\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10361057\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"SUMMARY\nBrain-mapping initiatives are acquiring increasingly large and comprehensive neuroimaging and multiomic\u2014\ne.g. genomic and transcriptomic\u2014datasets."},{"title":"Investigating Functional Ependymal Cell Heterogeneity in the Ventricular System","field_investigator":"Stephanie  Redmond","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS121273-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10189131\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10189131\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract:\nGlial cells collectively outnumber neurons in the vertebrate brain, but mechanistic understanding of their\nmolecular subtypes and functions is lacking."},{"title":"iSonogenetics for incisionless cell-type-specific neuromodulation of non-human primate brains","field_investigator":"Hong  Chen, Ilya E. Monosov","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH126861-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10270569\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10270569\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\/ABSTRACT\nCritical advances in the treatment of human brain disorders are hindered by our inability to specifically target\ndysfunctional circuitry in a safe and noninvasive manner."},{"title":"Linking Fast Timescale Neuron-Astrocyte Communication to Neural Circuit Function and Behavior","field_investigator":"Axel  Nimmerjahn","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS123719-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294804\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294804\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary: Project 2 - Linking Fast Timescale Neuron-Astrocyte Communication to Neural\nCircuit Function and Behavior\nA fundamental yet unresolved question in neuroscience is how non-neuronal cells communicate with the\nsurrounding neurons, influence their function, and potentially affect animal"},{"title":"Linking function, structure, and molecular identity of lateral habenula neurons","field_investigator":"Steven  Shabel","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS121873-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10206846\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10206846\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT:\nThe lateral habenula (LHb) impacts motivated behavior through dense direct and indirect projections to midbrain\ndopaminergic and serotonergic neurons."},{"title":"Long-range neuronal projections: circuit blueprint or stochastic targeting?  Rigorous classification of brain-wide axonal reconstructions","field_investigator":"Giorgio A Ascoli","field_institution":"George Mason University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH128693-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10360723\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10360723\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT (PROJECT SUMMARY)\nThe classification of neurons in the mammalian brain has long been a focus of intensive investigation in\nneuroscience."},{"title":"Map Manager: Longitudinal image analysis with online editing and sharing.","field_investigator":"Robert Harry Cudmore","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH123206-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10365810\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10365810\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The increasing availability and ease of use of confocal, two-photon, and light-sheet microscopes coupled with\nrapid developments in fluorescent protein reporters have made 3D and functional imaging and its analysis a\ncentral component of modern Neuroscience research."},{"title":"Mapping Algorithmic State Space in the Human Brain","field_investigator":"Sameer Anil Sheth","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS121472-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10199622\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10199622\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Abstract\nHumans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of this\ncognitive flexibility is our ability to respond correctly to novel contextual situations on the first attempt, without\nprior rehearsal."},{"title":"MAPPING RETINOTECTAL CIRCUITS FOR VISUAL-EVOKED INNATE BEHAVIORS","field_investigator":"Xin  Duan, Massimo  Scanziani","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123912-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300917\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300917\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\n The precise assembly of neural circuits ensures accurate neurological function and behavior."},{"title":"Mapping thalamo-striatal neuronal circuits underlying motivational drive","field_investigator":"Sofia Beas","field_institution":"National Institute of Mental Health ","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH126429-01","field_link":"","field_funded_status":"Active","field_grant_mechanism":"Training Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EMotivational drive is an adaptive process that helps individuals overcome obstacles to obtain essential needs and hence ensure survival. Motivation is composed of two major components.\u003C\/p\u003E"},{"title":"Mechanism and Modulation of the homeostatic setpoint for protein feeding","field_investigator":"Qili  Liu","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123890-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300667\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300667\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nAll animals share motivated behaviors to fulfill their basic needs for survival, including food, water,\nsleep, and social interactions, etc. The homeostatic regulatory system energizes behaviors to defend a\ntarget level for these needs (the homeostatic setpoint)."},{"title":"Mechanisms of basal forebrain control over sensory processing","field_investigator":"Elizabeth Hanson Moss","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DC019505-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10187890\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10187890\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nA key problem in neuroscience is understanding how internal and external information are integrated in the brain to produce\nsensory experiences, cognition, and behavioral responses."},{"title":"Midbrain circuits for perceptual decision-making","field_investigator":"Martha E Bickford, Michele A Basso, Jianhua  Cang, Alev  Erisir, Per Benjamin Sederberg","field_institution":"University Of Virginia","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS122040-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10216482\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10216482\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\n Perceptual decision-making is a fundamental cognitive ability that is vital to healthy, daily functioning and is\nimpaired in many diseases."},{"title":"Molecular identity, cellular physiology, and in vivo functions of nucleus accumbens astrocytes","field_investigator":"Kay Elizabeth Linker","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH125598-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316907\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316907\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary \/ Abstract\n Astrocytes are pervasive throughout the CNS and are the most abundant non-neuronal cell type. They\nare an essential component of neural circuits, and increasing evidence demonstrates they are specialized for\nspecific brain regions."},{"title":"mRNA Alternative Splicing Regulatory Networks in the Specification of Cortical Interneuron Subtypes","field_investigator":"Melissa Mckenzie Campbell","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH126430-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10188959\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10188959\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nAlternative splicing of pre-mRNAs is extensively employed by the nervous system to expand the transcriptomic\nmanifold."},{"title":"Multi-feature, Multi-scale Atlas","field_investigator":"Paul S Katz","field_institution":"University Of Massachusetts Amherst","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U01NS123972-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10302203\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10302203\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"SUMMARY \/ ABSTRACT \u2013 Project 1. Multi-feature, Multi-scale Atlas\nProject 1 of the Berghia Brain Project is to create a multi-scale, multi-feature atlas of the Berghia brain and\nperipheral neural plexus."},{"title":"Multiscale computational frameworks for integrating large-scale cortical dynamics, connectivity, and behavior","field_investigator":"Tatiana  Engel","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055666-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263628\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263628\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\nA central problem in neuroscience is to understand how activity arises from neural circuits to drive animal\nbehaviors. Solving this problem requires integrating information from multiple experimental modalities and\norganization levels of the nervous system."},{"title":"Multiscale theory of synapse function with model reduction by machine learning","field_investigator":"Eric D Mjolsness","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055668-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263653\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263653\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\n This project constructs a unifying model that links synaptic morphodynamics, the fundamental process of\nlearning and memory in the brain, to the underlying molecular signaling pathways that regulate it."},{"title":"NABOR: A Sustainable, High-quality Neuroscience Antibody Open Resource","field_investigator":"Melina  Fan","field_institution":"Addgene, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS119916-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10114049\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10114049\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nThe goal of this project is to build an open-access recombinant antibody\/affinity reagent resource for the\nneuroscience community called NABOR (Neuroscience AntiBody Open Resource)."},{"title":"National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination Resource","field_investigator":"Mark H Ellisman","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120055-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10116087\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10116087\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"PROJECT SUMMARY\/ABSTRACT\nThis project aims to disseminate validated technologies and resources of the National Center for Microscopy\nand Imaging Research (NCMIR) at UC San Diego to advance the completion of strategic goals of the BRAIN\nInitiative."},{"title":"Neural dynamics of somatosensory guidance of dexterous movement in intact and stroke-injured networks","field_investigator":"Preeya  Khanna","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS124748-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10349317\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10349317\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\n Stroke-causing illness, disability, and early death is set to double worldwide within the next 15 years."},{"title":"Neural mechanisms of multisensory auditory-olfactory integration in the auditory cortex","field_investigator":"Nathan  Vogler","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127788-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316690\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316690\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nLiving organisms interact with complex environments that are inherently multisensory. Within these\nenvironments, the brain must integrate information from multiple sensory modalities, including the auditory and\nolfactory systems, for perception and behavior."},{"title":"Neural Mechanisms of Social Communication in Parrots","field_investigator":"Jesse Heymann Goldberg","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS121898-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10207958\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10207958\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nWhen Confucius said, \u201cTell me who are your friends, and I\u2019ll tell you who you are,\u201d he was noticing that how we\nbehave and communicate is shaped by who we choose to hang out with every day. We constantly mimic the\nmannerisms and behaviors of friends and loved ones."},{"title":"NeuroJSON - A Scalable, Searchable and Verifiable Neuroimaging Data Platform","field_investigator":"Qianqian  Fang","field_institution":"Northeastern University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124027-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10308329\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10308329\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Traditional file-based neuroimaging data management and integration strategies have shown\nincreasing limitations in accommodating the meteoric growth in both the scale and complexity of today\u2019s\nneuroimaging data."},{"title":"NIPreps: integrating neuroimaging preprocessing workflows across modalities, populations, and species","field_investigator":"Oscar  Esteban, Michael Peter Milham, Russell A Poldrack, Ariel Shalom Rokem, Theodore  Satterthwaite","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH121867-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10260312\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10260312\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nDespite the rapid advances in the neuroimaging research workflow over the last decade, the enormous\nvariability between and within data types and specimens impedes integrated analyses."},{"title":"OpenScope: A Platform for High-Throughput and Reproducible Neurophysiology Open to External Scientists to Test Impactful Theories of Brain Function","field_investigator":"Christof  Koch, Jerome Anthony-Jean Lecoq","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS113646-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9967446\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9967446\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Project summary\nOver the past five years, the Allen Institute has built two unique in-house pipelines for in vivo electro- and\noptical-physiology: together they form the Allen Brain Observatory."},{"title":"Principles of sensorimotor processing in zebrafish thermosensation","field_investigator":"Martin  Haesemeyer","field_institution":"Ohio State University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123887-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300619\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300619\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"SUMMARY\nIt is our long-term goal to understand computations that underlie sensori-motor transformations in the context\nof thermoregulatory behaviors. Generating appropriate behaviors in response to sensory stimuli is critical for\nthe survival of any animal."},{"title":"Project 2","field_investigator":"Anna  Devor","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS123717-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294713\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294713\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nWe propose to investigate the role of neuromodulation in the phenomenon of \u201cwhole-cortex\u201d activity of\nthe pial neurovascular circuit."},{"title":"Redefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine Learning","field_investigator":"Peter V. Kochunov, Paul M Thompson","field_institution":"University Of Maryland Baltimore","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123163-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10186960\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10186960\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Abstract\nThis application will combine the strengths of two large scale NIH-funded initiatives to understand disorder-\nrelated patterns in the human brain: Connectomes Related to Human Disease (CRHD) and Enhancing\nNeuroimaging Genetics through Meta-Analysis (ENIGMA)."},{"title":"Representation and modulation of social information in the ant chemosensory system","field_investigator":"Daniel  Kronauer","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123899-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300789\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300789\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nSocial insects show robust and complex behaviors, and have served as important study systems in ethology\nfor decades."},{"title":"Resolving Spatiotemporal Determinants of Cell Specification in Corticogenesis with Latent Space Methods","field_investigator":"Genevieve Lauren Stein-O\u0026#039;brien","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS122085-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10188106\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10188106\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nHigh-throughput profiling of hundreds of thousands of cells in the central nervous system (CNS) is currently\nunderway."},{"title":"Resource Core 3 - Teaching\/Training\/Dissemination Core (TTDC)","field_investigator":"Maisie Ky Lo","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS118284-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10047731\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10047731\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Resource Core 3 - Teaching\/Training\/Dissemination Core (TTDC)\n Leads: Maisie Lo PhD and Kristin Overton PhD\nSummary\n The TTDC\u2019s teaching mission specifically leverages our educational infrastructure for advancing the\napplication of modern neurotechnology methods in short (3-day) or extended-format ("},{"title":"Revealing neural circuits underlying zebrafish behavior using mesoscopic light field microscopy","field_investigator":"Oliver Strides Cossairt, Geoffrey J Goodhill","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS123913-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300922\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300922\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nA critical step towards understanding how neural circuits drive behavior is the ability to record the activity of all\nneurons in an organism while it interacts with its environment in an unconstrained manner."},{"title":"Robust modeling of within- and across-area population dynamics using recurrent neural networks","field_investigator":"Lee  Miller, Chethan  Pandarinath","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055667-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263644\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263644\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Over the past several decades, the ability to record from large populations of neurons (e.g., multi-electrode\narrays, neuropixels, calcium imaging) has increased exponentially, promising new avenues for understanding\nthe brain."},{"title":"Scalable tools for consistent identification of neuronal cell types in mouse and human","field_investigator":"Staci A Sorensen, Uygar  Sumbul","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH128778-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10365216\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10365216\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe proposed work will address a critical gap in our understanding of neuronal phenotypes and cell types by\ndeveloping machine learning algorithms and cloud-based software for the integration of multiple modality\ncharacterizations large and growing datasets of cortical neurons in mou"},{"title":"Secondary analysis of functional MRI and resting state connectivity in white matter","field_investigator":"John C Gore, Bennett A. Landman","field_institution":"Vanderbilt University Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123201-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10190338\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10190338\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Abstract \/ Summary\nThis proposal aims to perform novel, secondary analyses on large archives of publicly-available fMRI\nstudies in order to quantify the functional characteristics of white matter (WM) and their changes during\nnormal aging and in the progression to Alzheimer\u2019s Disease (AD)."},{"title":"Sensory motor transformations in human cortex","field_investigator":"Richard A Andersen","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS123127-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10289879\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10289879\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Abstract: The long-term objective of this application is to understand cortical processing of sensory to\nmotor transformations within the human cerebral cortex. A vast number of computations must be\nperformed to achieve sensory-guided motor control."},{"title":"Sex hormone regulation of Lateral Habenula circuitry for reward and aversion encoding","field_investigator":"Brandy A. Briones","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127772-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10313129\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10313129\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n This proposal seeks to investigate sex hormone effects on reward and aversion-related behaviors through\nmapping of Lateral Habenula (LHb) circuits."},{"title":"Stability and Robustness of Hippocampal Representations of Space","field_investigator":"John C Doyle, Carlos  Lois, Evgueniy Vassilev Lubenov, Athanassios  Siapas","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS121918-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10208522\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10208522\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nHow does the brain balance the need to preserve prior knowledge with the necessity to continuously learn\nnew information? The tradeo\ufb00 between stability and plasticity is inherent in both biological and arti\ufb01cial\nlearning systems constrained by \ufb01nite resources and capacity."},{"title":"Stimulation of novel spinal respiratory circuit to restore breathing in ventilator-dependent patients with SCI.","field_investigator":"Daniel  Lu","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS119772-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10112480\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10112480\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nRespiratory failure after spinal cord injury (SCI) impairs the health of the injured patients, and respiratory failure\nis the leading cause of death in patients with SCI."},{"title":"Structural variation in neuronal circuits as a basis for functional and behavioral individuality","field_investigator":"Bassem A Hassan, Wei-Chung Allen Lee, Benjamin  De Bivort","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS121874-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10206473\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10206473\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nA fundamental gap in our knowledge of the nervous system is understanding how variations in wiring and\nconnectivity of neuronal circuits relate to variability in neural computations and behavior."},{"title":"Structure and function of spontaneous network activity during circuit formation","field_investigator":"Arnaldo  Carreira-Rosario","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS119295-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10103918\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10103918\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nTowards the end of nervous system development, neural circuits are extremely plastic. Small perturbations\nduring this time can cause lifelong circuit and behavioral changes."},{"title":"Thalamocortical Responsive Neurostimulation for the Treatment of Lennox-Gastaut Syndrome","field_investigator":"Martha J Morrell","field_institution":"Neuropace, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS109557-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9958791\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9958791\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary \/ Abstract\n Lennox-Gastaut Syndrome (LGS) is a devastating form of childhood onset epilepsy with cognitive\ndysfunction and very frequent generalized onset seizures (GOS) often leading to injury."},{"title":"The encoding of uncertainty in the Drosophila compass system","field_investigator":"Jan  Drugowitsch, Rachel  Wilson","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS123819-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10298651\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10298651\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nStrategic behaviors often take account of uncertainty. For example, if we are presented with two conflicting\npieces of information, we give less weight to the more uncertain source of information \u2013 i.e., the source of\ninformation that leads to lower accuracy overall."},{"title":"The laminar organization of \u0026#039;index\u0026#039; versus \u0026#039;attribute\u0026#039; coding in neocortex","field_investigator":"Bruce L Mcnaughton","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121764-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10205913\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10205913\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"We propose a circuit-level principal underlying how brains acquire \u0027episodic\u0027 memories and reprocess\nthem into compact, efficient \u0027schemas\u0027: The attributes or \u0027contents\u0027 of experience are represented primarily in\nthe deeper layers of neocortex (NC), whereas the superficial layers are dedicated to en"},{"title":"The origins of neuronal correlations in cerebral cortex","field_investigator":"David J Heeger, Jason Neil Maclean, John H.r. Maunsell","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121772-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10205571\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10205571\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nHere, we propose to thoroughly characterize the origins of pairwise correlations in cortex using a synergistic mix\nof experimental methodologies, behavior, and computation in mice and macaques."},{"title":"The representation and modulation of sensory information in the learning and memory center of the Drosophila brain","field_investigator":"Andrew M Davidson","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH125582-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10314793\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10314793\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The brain uses the combined physiology of many cells to transform incoming sensory signals into internal\nrepresentations."},{"title":"The role of astrocyte-neuron signaling in closing a critical period required for motor circuit structure, function, and behavior","field_investigator":"Sarah D Ackerman","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS121137-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10188928\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10188928\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nSignificance: Neural circuit assembly requires activity-dependent refinement of circuit architecture (e.g.\nplasticity) to produce stereotyped behavior."},{"title":"Topological bridges between circuits, models, and behavior","field_investigator":"Marlene Rochelle Cohen, Chengcheng  Huang, Alessandro  Rinaldo, Caroline Anne Runyan","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121913-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10208403\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10208403\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project summary\nThe plight of the neuroscientist trying to understand the brain using linear analysis methods is akin to studying\nthe makeup of the ocean using the bits you find with a metal detector."},{"title":"Toward functional molecular neuroimaging using vasoactive probes in human subjects","field_investigator":"Alan  Jasanoff","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB031641-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10253338\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10253338\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"We propose to develop a probe technology for monitoring human brain function with molecular precision;\nin conjunction with magnetic resonance imaging (MRI) or other imaging modalities, the probes will provide a\ncombination of sensitivity and resolution that could permit unprecedented noninvasive stu"},{"title":"Understanding the regulation of neuron cell number and arbor size","field_investigator":"Jennifer A Malin","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY032269-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10104237\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10104237\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nHow the brain generates the correct number of neurons and how these neurons determine the size of their\narbors to innervate the receptor field is a critical question in neurobiology."},{"title":"Understanding the role of quantitative internal signals in behavioral flexibility","field_investigator":"Gaby  Maimon","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121904-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10208212\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10208212\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary \/ Abstract\nThis grant focuses on how very recent experiences\u2013\u2013over the past few seconds to minutes\u2013\u2013allow brains to\nupdate expectations about the world and then use these expectations to guide behavior."},{"title":"Use of advanced analytics to understand brain-behavior screen media activity relationships in ABCD data","field_investigator":"Marc N Potenza, Yihong  Zhao","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH128614-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10358692\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10358692\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\nGrowing up in a media-saturated world, the current generation of children and adolescents spend on average 6-\n9 hours each day on screen media activities (SMAs). Therefore, SMA is a topic of considerable concern in the\nUSA and elsewhere."},{"title":"Using large scale electrophysiology to study the role of midbrain dopamine neurons underlying motivated behaviors","field_investigator":"Kurt M Fraser","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127792-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316450\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316450\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nA core feature of a number of psychiatric illnesses is the disordered estimation of the predictive relationship\nbetween a given cue and an outcome. This failure to appraise and generate appropriate behavioral responses\nis true for cues that both are rewarding and aversive."},{"title":"Waking up the nervous system: Molecular characterization of neuronal leader cells and their role in brain development","field_investigator":"Nicole Ann Aponte-Santiago","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127777-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10315708\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10315708\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nLearning how spontaneous neuronal activity shapes embryonic brain development is critical for understanding\nneurodevelopmental processes, with implications in neurological or neuropsychiatric disorders."},{"title":"4D Transcranial Acoustoelectric Imaging for High Resolution Functional Mapping of Neuronal Currents","field_investigator":"Russell S Witte","field_institution":"University Of Arizona","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB029834-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007275\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007275\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"ABSTRACT\nThe overarching goal of this project is to optimize, validate and implement a revolutionary and safe modality\nfor noninvasive functional imaging of neural currents deep in the human brain through the skull at\nunprecedented spatial and temporal resolution."},{"title":"A Community Framework for Data-driven Brain Transcriptomic Cell Type Definition, Ontology, and Nomenclature","field_investigator":"Michael  Hawrylycz, Ed  Lein, Christopher J Mungall, Helen Elizabeth Parkinson, Richard H Scheuermann","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-146","field_project_number":"1RF1MH123220-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012886\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012886\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary: A Data-driven Framework for Brain Transcriptomic Cell Type Definition, Ontology, and\nNomenclature\nDefining the complete census of neuronal and non-neuronal cell types in the brain is a major priority for the NIH BRAIN\nInitiative, since cellular complexity is a major barrier to under"},{"title":"A Comparative Framework for Modeling the Low-Dimensional Geometry of Neural Population States","field_investigator":"Eva  Dyer","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB029852-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007243\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007243\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nAdvances in neural recording technology now provide access to neural activity at high temporal resolutions, from\nmany brain areas, and during complex and naturalistic behavior."},{"title":"A neuroethological model of sensorimotor processing in animal-animal interactions","field_investigator":"Joseph  Parker","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS118470-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053664\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053664\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project\u0026nbsp;Summary\u0026nbsp;\nAnimals\u0026nbsp; interact\u0026nbsp; with\u0026nbsp; members\u0026nbsp; of\u0026nbsp; their\u0026nbsp; own\u0026nbsp; or\u0026nbsp; other\u0026nbsp; species\u0026nbsp; in\u0026nbsp; the\u0026nbsp; context\u0026nbsp; of\u0026nbsp; social\u0026nbsp; and\u0026nbsp; defensive\u0026nbsp;\nbehaviors,\u0026nbsp;predator-\u00adprey\u0026nbsp;relationships\u0026nbsp;and\u0026nbsp;symbiose"},{"title":"A new theory of population coding in the cerebellum","field_investigator":"Reza  Shadmehr","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028156-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10005617\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10005617\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"A theory of population coding in the cerebellum\nIn order to move accurately, the brain relies on internal models that predict the sensory consequences of motor\ncommands."},{"title":"A novel approach to analyzing functional connectomics and combinatorial control in a tractable small-brain closed-loop system","field_investigator":"John H Byrne, Hillel J Chiel, Elizabeth C Cropper, Cynthia Anne Chestek, Avy  Susswein, Peter John Thomas","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118606-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10058915\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10058915\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"SUMMARY\nAdaptive behaviors emerge from neuronal networks by dynamically regulating functional connectomes."},{"title":"Accelerating Dissemination of Implantable Neurotechnology for Clinical Research","field_investigator":"David Allenson Borton, Timothy  Denison, Philip Andrew Starr, Gregory A Worrell","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS113637-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9967390\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9967390\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Summary\nInvasive neurostimulation is an established technique in the therapy of movement disorders and epilepsy, and\nshows promise for amelioration of psychiatric and cognitive disorders."},{"title":"Active sensing at the sensory surface: glomerular signals for olfactory navigation by freely-moving mice","field_investigator":"Matthew C Smear","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS116731-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9978630\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9978630\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Our senses aren\u2019t passive. Rather, we actively seek relevant information via sampling movements.\nHowever, experiments in sensory systems often restrict sampling movements to simplify stimulus delivery\nand allow large scale imaging and electrophysiology."},{"title":"Activity-dependent mechanisms for memory circuit maturation.","field_investigator":"Sarah  Leinwand","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99DC018779-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9952093\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9952093\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nAdult behavior is the product of neural circuits that have been sculpted during development by\ngenetic programs and experience in the form of neural activity."},{"title":"Adaptive Neurostimulation to Restore Sleep in Parkinson\u0026#039;s Disease: An Investigation of STN LFP Biomarkers In Sleep Dysregulation and Repair","field_investigator":"Aviva  Abosch, Casey Harrison Halpern, Clete A Kushida, John A Thompson","field_institution":"University Of Nebraska Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS113769-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9960743\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9960743\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nParkinson\u2019s disease (PD) is a neurodegenerative disorder that leads to both motor and non-motor symptoms.\nWhile there is as yet no cure for PD, medical and surgical therapies have been developed that effectively target\nthe motor symptoms of PD."},{"title":"An Ethical Approach to Detecting Covert Consciousness","field_investigator":"Michael J Young","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123001-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9990274\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9990274\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nAlarming shortcomings of the bedside behavioral examination in reliably detecting consciousness generate\nprofound dilemmas for clinicians and families facing decisions about continuation of life-sustaining therapy, pain\ncontrol, prognostication, and resource allocation in patients wi"},{"title":"An integrated platform for studying sensory networks in the vertebrate brain","field_investigator":"Ethan Kime Scott","field_institution":"University Of Queensland","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118406-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10051317\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10051317\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"7. Project Summary\/Abstract\nHuman experience is shaped by our senses, which receive diverse inputs from our\nenvironment. These varied inputs, however, all contribute to a single integrated\nrepresentation in our minds of the outside world."},{"title":"Application of the principle of symmetry to neural circuitry: From building blocks to neural synchronization in the connectome","field_investigator":"Hernan  Makse, Manuel  Zimmer","field_institution":"City College Of New York","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028157-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10006982\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10006982\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\n The broad, long-term objective of this grant is to advance a new theoretical approach to identify\nsynchronized building blocks of neural circuits based on group theory and its application to understand the\npermutation symmetries of these circuits."},{"title":"Bidirectional Interactions of Cortex and Basal Ganglia During Action Selection","field_investigator":"Allison Elizabeth Girasole","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125596-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10156658\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10156658\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nSelecting future actions based on previous experiences is key to an animal\u0027s survival. This process, known as\naction selection, depends on the proper function of cortical and subcortical basal ganglia circuits."},{"title":"Biophysical modeling of the functional MRI signal through parametric variations in neuronal activation and blood vessel anatomy using realistic synthetic microvascular networks","field_investigator":"Grant  Hartung","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125599-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10156061\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10156061\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The most widespread tool for measuring brain activity noninvasively in humans is functional magnetic resonance\nimaging (fMRI), which typically tracks changes in blood flow and oxygenation using the blood-oxygenation-level-\ndependent (BOLD) signal."},{"title":"Brain States and Flexible Behavior","field_investigator":"Santiago  Jaramillo, David  Mccormick, Cristopher M Niell","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118461-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053588\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053588\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nTo survive in dynamic environments, the nervous system must be able to generate flexible behavior \u2014\nseamlessly weaving together past experience with the present context to achieve future goals."},{"title":"Brainstem circuits of corticospinal neurons","field_investigator":"Gordon M Shepherd","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS116713-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9977340\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9977340\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nCorticospinal axonal projections are critical for mammalian motor control."},{"title":"Cell type selective viral tools to interrogate and correct non-human primate and human brain circuitry","field_investigator":"Franck K Kalume, Ed  Lein, Boaz Pirie Levi, Jonathan T Ting","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH120095-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10025520\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10025520\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Abstract:\nMany cell types together assemble the functional circuitry of the human brain. For over a century, neuroscientists\nhave categorized brain cell types by their features, including shape, position, physiology, molecules, and\nfunction."},{"title":"Central neuronal circuitry for homeostatic thermoregulation modulated by brain temperature","field_investigator":"Lily Y Jan","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS116588-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9970898\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9970898\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\n Maintenance of body temperature at the optimal level is crucial for survival, and it requires homeostatic\nfeedback regulation based on monitoring the temperature of internal organs as well as the environment.\nHomeostatic thermoregulation in response to changes of brain temp"},{"title":"Characterizing the structure of motor cortex activity across multiple behaviors for improved brain-machine interfaces","field_investigator":"Karen Elizabeth Schroeder","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS115919-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9952827\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9952827\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Abstract. Candidate and career goals: I am an engineer by training, with a strong background in\nneural engineering and the development of motor brain-machine interfaces (BMIs). My career goal is to establish\nan independent nonhuman primate (NHP) laboratory with two primary aims."},{"title":"Circuit and cellular mechanisms underlying hierarchical recruitment of motor neurons.","field_investigator":"Brandon J Mark","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125443-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10137601\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10137601\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n A fundamentally important motor pattern for terrestrial animals is walking. Walking requires precise\ncontrol of large numbers of motor neurons."},{"title":"Circuit dynamics of sensorimotor integration and decision making in octopus","field_investigator":"Galit  Pelled","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-029","field_project_number":"1UF1NS115817-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9949982\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9949982\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\n The goal of this proposal is to identify fundamental sensorimotor circuits associated with\ngoal-oriented gripping movement by using high-dimensional biological, analytical and robotics\ntechnologies."},{"title":"Cloud-based Software Framework to Simplify and Standardize Real-Time fMRI","field_investigator":"Jonathan D Cohen, Kenneth A Norman","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH125318-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10123207\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10123207\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary: (30 lines of text max)\n We propose to create an open-source cloud-based software system for real-time fMRI neurofeedback\nexperiments."},{"title":"Combined Topological and Machine Learning Tools for Neuroscience","field_investigator":"Michael  Hawrylycz, Partha Pratim Mitra, Yusu  Wang","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH125317-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10123310\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10123310\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Two major recent advances have raised the possibility of fundamental breakthroughs in both\nbasic and clinical neuroscience: the development of new tools to probe the nervous system with\nsingle-cell resolution as well as brain-wide scope, and breakthroughs in machine learning\nmethods for handling com"},{"title":"Connecting neural circuit architecture and experience-driven probabilistic computations","field_investigator":"Zachary Peter Kilpatrick","field_institution":"University Of Colorado","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB029847-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007281\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007281\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary: Organisms\u0027 actions and decisions are guided by experience. Models of such behavior often\nappeal to the formalism of probabilistic inference, in which expectations about the world build up sequentially\ndue to past observations."},{"title":"Context-dependent neural processing of leg proprioception in Drosophila","field_investigator":"Sweta  Agrawal","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS117657-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10039477\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10039477\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Proprioception is critical for effective motor control: dysfunctions of the proprioceptive system can impair\nbalance, motor coordination, and motor learning."},{"title":"Cortical circuitry supporting flexible audiovisual interactions and behaviors","field_investigator":"Andrea Rayne Hasenstaub","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS116598-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9971394\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9971394\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nInteractions between the auditory and visual systems are among the most well-established cases of\ncrossmodal interplay, yet the overwhelming bulk of the sensory physiology literature reflects studies examining\nprocessing confined to a single modality and we understand comparatively l"},{"title":"Cortical-Basal Ganglia Speech Networks","field_investigator":"Robert Mark Richardson","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS117836-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10044852\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10044852\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"PROJECT SUMMARY\nActions are not mediated solely by cortical processes but rely on communication within basal ganglia-\nthalamocortical loops. Speech is one example, although how the basal ganglia participate in this uniquely\nhuman behavior is not clear, due to a lack of empirical data."},{"title":"Corticostriatal contributions to motor exploration and reinforcement","field_investigator":"Timothy James Gardner, Carlos  Lois, Richard D. Mooney, John  Pearson","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118424-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053204\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053204\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nComplex motor sequences are fundamental to many highly skilled behaviors, ranging from athletics to musical\nand vocal expression."},{"title":"Corticostriatal mechanisms of causal inference and temporal credit assignment.","field_investigator":"Hyojung  Seo","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118463-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053605\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053605\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Learning desired actions from experience requires evaluating alternative actions by integrating the\nconsequences assigned to each action over time."},{"title":"Coupling between circadian rhythms and redox signaling in stem cell differentiation and adult neurogenesis","field_investigator":"Daniel Maxim Iascone","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125600-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10155930\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10155930\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nCircadian rhythms are necessary to coordinate the timing of key behavioral and physiological processes in\nmammals [1-3]."},{"title":"Cross-frequency coupling: its role in brain function and dysfunction","field_investigator":"Andrei V Medvedev","field_institution":"Georgetown University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123192-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10008042\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10008042\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Abstract\n One of the high priority research areas listed in the BRAIN 2025 Report is a better understanding of the\nbrain network dynamics across time and space from human electrophysiological recordings."},{"title":"Crossing space and time: uncovering the nonlinear dynamics of multimodal and multiscale brain activity","field_investigator":"Shella D Keilholz, Garrett B. Stanley","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB029857-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007011\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007011\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The brain is a complex dynamical system, with a hierarchy of spatial and temporal scales ranging from microns\nand milliseconds to centimeters and years. Activity at any given scale contributes to activity at the scales above\nit and can influence activity at smaller scales."},{"title":"Data Exploration and Analysis Portal for Brain Research through Advanced Imaging Neuroscience","field_investigator":"Chun Chieh  Fan, Wesley Kurt Thompson","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH120025-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10011169\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10011169\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nPopulation neuroscience requires investigation of brain-behavioral relationships within epidemiological\nsamples studied in longitudinal designs, including a large number of assessment modalities and with subjects\nenrolled at many data collection sites to achieve a large sample and br"},{"title":"DataJoint Pipelines for Neurophysiology","field_investigator":"Dimitri  Yatsenko","field_institution":"Vathes Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS116470-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9967639\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9967639\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The field of neuroscience and the BRAIN Initiative in particular are amassing a wealth of informatics resources for managing, analyzing, and sharing data."},{"title":"Decision-related information at single-neuron resolution in human motor cortex and its implications for neuroprosthetics","field_investigator":"Sharlene  Flesher","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-813","field_project_number":"1K99NS112412-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9977403\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9977403\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary \/ Abstract\nThe long-term goal of my research is to gain a holistic understanding of how movement commands are\ngenerated- including their relationship to sensory feedback and movement context- in order to restore movement\nto those who have lost it."},{"title":"Defining the role of a prefrontal-midbrain circuit in exploratory behavior","field_investigator":"Victoria L Corbit","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125546-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10146550\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10146550\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\nInvestigating how neural circuits mediate natural behavior is a critical to our understanding of the brain.\nExploratory behaviors are necessary for rodent survival in the natural world and ubiquitous in freely-moving\nrodent experiments."},{"title":"Determining computational principles governing neural circuits responsible for feedback and movement control of D. melanogaster flight","field_investigator":"Itai  Cohen","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS116595-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9971313\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9971313\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nA principle aim of the NINDS is to determine how motor control is successfully implemented by\nthe nervous system. Locomotion and balance are complex motor functions that are largely\ncontrolled by complex microcircuits that reside outside the brain."},{"title":"Developing A Mouse Chronic Pain Scale by 3D Imaging and Measurement of Mouse Spontaneous Behaviors","field_investigator":"Long  Ding, Wenqin  Luo, Hyun Soo  Park","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS118411-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10051598\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10051598\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nRodent models are highly valuable for elucidating the molecular and cellular mechanisms of chronic pain.\nBecause rodents cannot articulate their sensation, \u201cpain-like\u201d behaviors have been used as the proxy.\nHowever, sensitivity and specificity of many existing methods for measuring r"},{"title":"Development of the Human Dynamic Neurochemical Connectome Scanner","field_investigator":"Ciprian  Catana","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB029826-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007205\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007205\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary\nWe seek support to develop and build the next generation 7-Tesla magnetic resonance (MR)-compatible\npositron emission tomography (PET) brain scanner with dramatically improved spatiotemporal resolution\n(HSTR-BrainPET)."},{"title":"Dissecting the neural circuit for discrete cue representation in the Dentate Gyrus","field_investigator":"Sebnem Nur Tuncdemir","field_institution":"New York State Psychiatric Institute Dba Research Foundation For Mental Hygiene, Inc","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH122226-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10125693\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10125693\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The goal of this project is to provide the building blocks for an independent research program focused on\nthe mechanisms by which neural networks incorporate multisensory cues into episodic memories.\nDiscrimination of different contexts composed of distinct constellations of multisensory cues is a h"},{"title":"Distributional reinforcement learning in the brain.","field_investigator":"Jan  Drugowitsch, Naoshige  Uchida","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS116753-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9978224\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9978224\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe field of artificial intelligence (AI) has recently made remarkable advances that resulted in new and\nimproved algorithms and network architectures that proved efficient empirically in silico."},{"title":"Dopamine neuronal microcircuits controlling methamphetamine seeking behavior","field_investigator":"Sergio  Dominguez Lopez","field_institution":"Oklahoma Medical Research Foundation","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99DA049719-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9977578\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9977578\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nThis proposal is being submitted to support the transition of Dr. Dominguez-Lopez from mentored trainee to\nan independent investigator in the neurobiology of drug addiction, specifically studying the dopamine\nmicrocircuits controlling drug-seeking behavior. Dr."},{"title":"Dynamic Striatal Astrocyte-Neuron Interactions: An Integrated Experimental and Computational Study","field_investigator":"Marsa  Taheri","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123010-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991579\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991579\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\n Astrocytes comprise up to half of mammalian brain cells."},{"title":"Ethics of the Choice of Invasive versus Non-invasive Neurosurgery: Different Stakeholders\u0026#039; Perspectives, Surgical Decision-making, and Impact on Patient Sense of Control","field_investigator":"Cynthia M. S. Kubu","field_institution":"Cleveland Clinic Lerner Com-Cwru","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1RF1MH123407-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10026287\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10026287\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"ABSTRACT\nA fundamental ethical tenet in medicine is bodily sovereignty, inherent in which is the concept of\ncontrol."},{"title":"From ion channels to graph theory in sensorimotor learning","field_investigator":"Genevieve  Konopka, Daniel  Margoliash, Jason Neil Maclean, Todd F Roberts","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-029","field_project_number":"1UF1NS115821-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9950584\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9950584\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nMechanistically linking network connectivity and the dynamics of neural networks to variation in the behavior of\nindividuals is an overarching goal of neuroscience."},{"title":"Functional role of the neocortico-rubro-olivo-cerebellar circuit on neocortex-induced cerebellar motor learning","field_investigator":"Shogo  Ohmae","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS118445-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053429\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053429\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nThe cerebellum performs information processing for motor control and various cognitive functions in\ncooperation with the cerebral neocortex."},{"title":"Genetic access and connectional assays of mouse inhibitory cortical cell types","field_investigator":"Edward M Callaway","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS116885-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9985641\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9985641\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe function of the nervous system is dependent on complex interactions between networks of neurons\ncomposed of multiple neuron types."},{"title":"Genetic access to cortical cell types with epigenetic assays and high-throughput, low-cost enhancer screening","field_investigator":"Edward M Callaway","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH123394-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10025622\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10025622\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nThe function of the nervous system is dependent on complex interactions between networks of neurons\ncomposed of multiple neuron types."},{"title":"Genetic mechanisms specifying astrocyte functional diversity and their role in sleep","field_investigator":"Margaret  Ho","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS117654-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10039993\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10039993\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nAstrocytes are evolutionarily conserved and constitute a substantial proportion of the cells in the brain, yet our\nunderstanding of their identities and functions is far less comprehensive than for neurons."},{"title":"Graspy: A python package for rigorous statistical analysis of populations of attributed connectomes","field_investigator":"Carey  Priebe, Joshua T Vogelstein","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH123233-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012519\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012519\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\nOverview: We will extend and develop implementations of foundational methods for analyzing populations of\nattributed connectomes."},{"title":"Highly Portable and Cloud-Enabled Neuroimaging Research: Confronting Ethics Challenges in Field Research with New Populations","field_investigator":"Frances Patricia Lawrenz, Francis X Shen, Susan M. Wolf","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1RF1MH123698-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10035136\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10035136\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary \/ Abstract\n This 4-year Neuroethics R01 based at the University of Minnesota (UMN) will convene a national\nWorking Group of top neuroethics, neurolaw, and neuroscience experts to conduct empirical research and\ngenerate evidence-based consensus recommendations for the ethical conduct "},{"title":"Hormonal regulation of value-based decision-making","field_investigator":"Carla  Golden","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125448-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10140910\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10140910\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nIndividuals decide between alternatives based on their perceived value of the reward associated with each\noption."},{"title":"How do parvalbumin interneuron-generated gamma oscillations organize prefrontal networks to promote behavioral adaptation?","field_investigator":"Vikaas Singh Sohal","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS116594-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9971310\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9971310\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nRhythmic fluctuations of electrical activity in the brain are frequently observed during cognitive tasks. In many\ncases these oscillations are synchronized across brain regions."},{"title":"Identifying mediators of sex hormone uptake and signaling","field_investigator":"Nicole Yishi Leung","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125593-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10158076\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10158076\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nSex hormones are critical for sexual differentiation of the brain and body and diverse physiological processes\nacross our lifespan."},{"title":"Improving Brain Organoid Models by Mediating Metabolic Dysregulation","field_investigator":"Madeline  Andrews","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH125329-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10104263\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10104263\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThere is currently an unmet need for accurate model systems of the human brain to study its cellular and\nmolecular features."},{"title":"Innovative biostatistical approaches to network level analyses of connectome-behavior relationships","field_investigator":"Muriah D Wheelock","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99EB029343-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10055480\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10055480\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nDetermining the mechanisms by which the human brain generates cognition, perception, and emotion hinges\nupon quantifying the relationships between coordinated brain activity and behavior."},{"title":"Inter-System Closed-Loop Control of Locomotor and Bladder Function in Individuals with Acute Spinal Cord Injury","field_investigator":"Claudia  Angeli, Maxwell  Boakye","field_institution":"University Of Louisville","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS116238-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9962062\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9962062\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"SUMMARY ABSTRACT\nMore than 1.2 million people in the United States have a spinal cord injury (SCI), and each year there are 10,000\nnew cases."},{"title":"Investigation of the Cortical Communication (CORTICOM) System","field_investigator":"Nathan E Crone, Nicolas Franciscus Ramsey","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS114439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9879474\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9879474\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"For many years brain-computer interfaces (BCI\u0027s) have been explored as a means of restoring communication\nto patients with Locked-In Syndrome (LIS), a devastating and often irreversible neurological condition in which\ncognition is intact but nearly all motor output from the brain is interrupted, eff"},{"title":"Large-scale monitoring of circuits for adaptation and novelty detection in primary visual cortex","field_investigator":"Jordan Marie Ross","field_institution":"Georgia State University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125445-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10139328\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10139328\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\n In a world filled with sensory information, the ability to filter out repetitive or redundant stimuli while still\nmaintaining the ability to detect change in the environment is critical to biological success."},{"title":"Large-scale recordings in Primate Prefrontal Cortex: Mechanisms of Value and Attention","field_investigator":"Tirin  Moore, Krishna V Shenoy, Joni D Wallis","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS116623-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9972475\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9972475\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Prefrontal cortex (PFC) is critical for a range of high-level cognitive functions, such as attention and decision-\nmaking. Studying these processes is difficult, since they are covert, dynamic and under the control of the\nsubject, rather than the experimenter."},{"title":"Lateral habenula circuit in reward\/conflict mediation","field_investigator":"Christian Emmanuell Bravo-Rivera","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH123495-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9952906\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9952906\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nReward is often present in risky environments, requiring individuals to weigh the benefits of rewards against\nthe associated risks. There are several psychiatric disorders in which patients are unable to choose an\nappropriate response during risky reward opportunities."},{"title":"Linking Hippocampal Replay Content to Learning and Decision-Making","field_investigator":"Michael Edward Coulter","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123003-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9990114\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9990114\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY \/ ABSTRACT\nMemory is an integral component of human cognition, and when memory processes go awry, the result is\ndevastating neurological disorders of memory loss including Alzheimer\u0027s disease and other forms of dementia.\nOne essential role of normal memory processes is to use previou"},{"title":"Linking interneuron-mediated circuit regulation with sleep-dependent plasticity and memory storage in the hippocampus","field_investigator":"Sara J Aton","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118440-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053374\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053374\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project summary: Synaptic plasticity in brain structures like the hippocampus has been hypothesized to\nunderlie an essential brain function - consolidating transient experiences into long-lasting memories."},{"title":"Linking molecular and anatomical features of brain cell identity through computational data integration","field_investigator":"Joshua  Welch","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123199-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10009608\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10009608\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Linking molecular and anatomical features of brain cell identity through computational data integration\nAbstract\nThe brain contains diverse cell types that vary widely in characteristic properties and function in complex,\ninterconnected circuits."},{"title":"Mapping human brain perivascular space in lifespan using human connectome project data","field_investigator":"Jeiran  Choupan","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123223-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012731\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012731\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\nPerivascular spaces are a critical component of the glia-lymphatic circuit, facilitating the clearance of soluble\nwaste."},{"title":"Mapping the neural circuitry underlying walking","field_investigator":"Sumaira  Zamurrad","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123012-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991417\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991417\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nWalking is an essential and conserved behavior across the animal kingdom."},{"title":"Markerless Tracking of 3D Posture to Reveal the Sensory Origins of Body Schema","field_investigator":"Kyle Scott Severson","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH122995-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9987939\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9987939\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The goal of this proposed research is to reveal the sensory origins underlying the body schema\nrepresentation. Body schema is the brain\u0027s internal model of the body\u0027s spatial configuration."},{"title":"Massively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain","field_investigator":"Danny Jj Wang, Lihong  Wang","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB029823-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007184\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007184\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"ABSTRACT (30 Lines)\nThe BRAIN initiative (RFA-EB-19-002) has called for the development of entirely new or next-generation\nnoninvasive human brain imaging tools and methods that will lead to transformative advances in our\nunderstanding of the human brain."},{"title":"Measuring Electrical Activity from the Human Brain to Predict Memory Formation and Behavior Across the Lifespan","field_investigator":"Elizabeth  Johnson","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS115918-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9952838\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9952838\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nMemory is core to human cognition, undergoes protracted developmental maturation and age-related decline,\nand is disrupted in numerous neurological and neuropsychiatric disorders."},{"title":"Metastable dynamics in cortical circuits","field_investigator":"Braden  Brinkman, Alfredo  Fontanini, Giancarlo  La Camera, Arianna  Maffei, Il Memming Park, Jin  Wang","field_institution":"State University New York Stony Brook","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-029","field_project_number":"1UF1NS115779-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9949119\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9949119\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\n Cortical circuits generate dynamic patterns of activity. One of the great challenges of modern neuroscience is to\ndetermine the circuit architectures that generate such dynamics patterns, and understand their genesis and functional\nsignificance."},{"title":"Modeling the structure-function relation in a reconstructed cortical tissue","field_investigator":"Anton  Arkhipov, Stefan  Mihalas","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB029813-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10005712\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10005712\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\n How is connectivity between neurons related to patterns of activity exhibited by these neurons in vivo? This\nquestion of structure-function relations in brain circuits is of fundamental importance."},{"title":"Multimodal study of infra-slow propagating brain activity","field_investigator":"Xiao  Liu","field_institution":"Pennsylvania State University, The","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123247-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012212\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012212\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\nThe highly-organized intrinsic brain activity, as measured by resting-state functional magnetic resonance imaging\n(rsfMRI), is being widely used to measure functional brain connectivity in both healthy subjects and patient\ngroups, despite the underlying neural mechanisms remain large"},{"title":"Multiplexing working memory and timing: Encoding retrospective and prospective information in transient neural trajectories.","field_investigator":"Dean V Buonomano, Peyman  Golshani","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS116589-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9971022\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9971022\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nA general principle of brain function is the ability to store information about the past to better predict and prepare for the\nfuture."},{"title":"Multiscale imaging of marmoset cortex during visual object recognition and learning","field_investigator":"Elias  Issa","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS116739-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9978313\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9978313\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"SUMMARY\/ABSTRACT\nAnthropoid primates (monkeys, apes, and humans) are distinguished from their phylogenetically nearest\nrelatives (lemurs, tree shrews, and rodents) by an elaboration of the cerebral cortex including changes in\ncellular composition of the cortical circuit."},{"title":"Neural basis of causal inference: representations, circuits, and dynamics","field_investigator":"Gregory C Deangelis","field_institution":"University Of Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS118246-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10047607\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10047607\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe same pattern of neural activity can correspond to multiple events in the world. Signals sweeping across\nthe retina, for instance, might be generated by a moving object or by the animal\u0027s self-motion."}]