[{"title":"A Dry Electrode for Universal Accessibility to EEG","field_investigator":"Walid Soussou","field_institution":"Quasar, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R43NS132644-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10761609\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10761609\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EElectroencephalography (EEG) measures the brain\u2019s local field potential from the surface of the scalp. This method is useful for studying cognitive processes, neurological states, and medical conditions.\u003C\/p\u003E"},{"title":"A scalable cloud-based framework for multi-modal mapping across single neuron omics, morphology and electrophysiology","field_investigator":"Bing-Xing  Huo","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133777-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725550\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725550\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary Categorizing individual neurons into different groups, or cell types, is a classical approach to studying the nervous system.\u003C\/p\u003E"},{"title":"A visualization interface for BRAIN single cell data, integrating transcriptomics, epigenomics and spatial assays","field_investigator":"Maximilian  Haeussler","field_institution":"University Of California Santa Cruz","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH132662-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10643313\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10643313\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT The BRAIN Initiative\u2019s -omics data archive NeMO contains all the BICCN single cell single cell data, more than one million files at the time of writing.\u003C\/p\u003E"},{"title":"Advancing fMRI Acquisition through Dissemination of EPTI- An Efficient Distortion-Free Multi-Contrast Imaging Technology","field_investigator":"Fuyixue  Wang","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS129893-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10572005\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10572005\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT Functional MRI (fMRI) is today the predominant tool for noninvasive imaging of brain function, which has revolutionized our understanding of the human brain.\u003C\/p\u003E"},{"title":"An optical-genetic toolbox for monitoring and controlling diverse neuromodulatory circuits governing complex behaviors in primates","field_investigator":"Karl A. Deisseroth, Eyal J Seidemann","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-115","field_project_number":"1UG3MH133047-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10650669\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10650669\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EABSTRACT Perceptually guided behavior involves a complex and dynamic interplay between external inputs and internal states that are related, for example, to alertness, motivation, expectations and attention.\u003C\/p\u003E"},{"title":"Analysis of modulation of the metabotropic glutamate receptor type 5 in a novel heritable model of drug abuse vulnerability","field_investigator":"Loren D Peeters","field_institution":"East Tennessee State University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS130827-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10754809\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10754809\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Schizophrenia is a debilitating mental illness affecting an estimated 1% of the global population.\u003C\/p\u003E"},{"title":"Beyond dopamine: dual neuromodulator regulation of motor variability and learning","field_investigator":"Drew Clinton Schreiner","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132152-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10605853\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10605853\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Learning and performing complex skills such as speech or music requires precise control of motor variability. While elevated motor variability can spur the learning of new behaviors, excessive variability can impair performance of learned skills.\u003C\/p\u003E"},{"title":"Biophysical Mechanisms of Cortical MicroStimulation","field_investigator":"Sydney S Cash, Mark Thomas Harnett","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS132784-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10711723\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10711723\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EDirect local electrical stimulation (DLES) is an increasingly important therapeutic tool for treating brain disorders such as Parkinson\u2019s, epilepsy, and OCD.\u003C\/p\u003E"},{"title":"Boss: A cloud-based data archive for electron microscopy and x-ray microtomography","field_investigator":"Brock A. Wester","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH114785-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664562\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664562\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EABSTRACT The generation of scienti\ufb01cally rich, high resolution neuroimaging volumes continues to increase in extent and rate due to the advancement of new Electron Microscopy (EM) and X-ray Microtomography (XRM) imaging sys- tems and data processing methodologies.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: A Center for High-throughput Integrative Mouse Connectomics","field_investigator":"Jeff W Lichtman","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-048","field_project_number":"1UM1NS132250-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10665380\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10665380\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary\/Abstract The proposed project will demonstrate the feasibility of generating a complete synapse-level brain map (connectome) by developing a serial-section electron microscopy pipeline that could scale to a whole mouse brain.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Center for a pipeline of high throughput integrated volumetric electron microscopy for whole mouse brain connectomics","field_investigator":"Forrest Christie Collman, Nuno  Macarico Da Costa","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-048","field_project_number":"1UM1NS132253-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10665386\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10665386\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary: Center for whole mouse brain connectomics using high-throughput integrated volumetric electron microscopy (HIVE) Two fundamental components of the structural basis of brain function are cell type composition and the wiring diagram between those cells.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Center for Mesoscale Connectomics","field_investigator":"Taner  Akkin, Damien A Fair, Sarah Rachel Heilbronner, Christophe  Lenglet, Kamil  Ugurbil, Essa  Yacoub, Jan  Zimmermann","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-047","field_project_number":"1UM1NS132207-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664257\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664257\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EPROJECT SUMMARY To understand complex neural pathways and networks and their remarkable ability to generate human behaviors, it is critical to precisely map brain connectomics in vivo.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Comprehensive regional projection map of marmoset with single axon and cell type resolution","field_investigator":"Guoping  Feng, Partha Pratim Mitra, Xiao  Wang","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-047","field_project_number":"1UM1NS132173-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664170\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664170\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\u003Cp\u003ESUMMARY This ambitious proposal will establish an integrated experimental-computational platform to create the first comprehensive brain-wide mesoscale connectivity map in a non-human primate, the common marmoset (Callithrix jacchus),.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Mapping brain-wide connectivity of neuronal types using barcoded connectomics","field_investigator":"Xiaoyin  Chen, Justus M Kebschull, Ian R Wickersham","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132161-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10663723\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10663723\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary Mapping the brain-wide connections of neurons provides a foundation for understanding the structure and functions of a brain.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Mapping Connectivity of the Human Brainstem in a Nuclear Coordinate System","field_investigator":"Bruce  Fischl, Patrick R Hof, Hui  Wang","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132181-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664289\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664289\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary\/Abstract (30 lines of text limit) The ~1 billion neurons that form the human brainstem are organized at multiple scales, ranging from their cell type-specific patterns of dendritic arborization, to local circuits embedded within large-scale projection systems spanning the brainste\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Multi-beam transmission electron microscopy of iteratively milled semi-thick tissue sections","field_investigator":"Andreas  Schaefer, Adrian Andreas Wanner","field_institution":"Paul Scherrer Institut Psi","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132317-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10669305\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10669305\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary\/Abstract Volume electron microscopy is the only technique to-date that provides both sufficient resolution (100 \u03bcm) for the dense reconstruction of neuronal wiring diagrams.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: PatchLink, scalable tools for integrating connectomes, projectomes, and transcriptomes","field_investigator":"Tim M Jarsky, Staci A Sorensen, Uygar  Sumbul","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132267-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10665493\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10665493\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary \/ Abstract Upcoming brain-wide descriptions of synaptic connectivity are poised to transform our understanding of brain circuitry in the same way single-cell genomics has revolutionized our understanding of cell type diversity.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Rapid and Cost\u2010effective Connectomics with Intelligent Image Acquisition, Reconstruction, and Querying","field_investigator":"Jeff W Lichtman, Hanspeter  Pfister, Aravinthan D. Samuel, Nir  Shavit, Brock A. Wester","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132158-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10663654\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10663654\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003ESUMMARY High-throughput connectomics is needed to generate the TB-, PB- and EB-scale wiring diagrams of mammalian brains, but is limited to the few research institutes (e.g., Janelia, Allen, Max Planck) with suf\ufb01cient infrastructure.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Synaptic resolution whole-brain circuit mapping of molecularly defined cell types using a barcoded rabies virus","field_investigator":"Andreas  Tolias, Anthony M Zador","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132353-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10672786\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10672786\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EABSTRACT Single-cell transcriptomics has revolutionized our understanding of neuronal diversity and enabled high-throughput characterization of molecular cell types across brain areas and species.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)","field_investigator":"Suzanne N Haber, Elizabeth M. C. Hillman, Anastasia  Yendiki","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-047","field_project_number":"1UM1NS132358-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10672681\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10672681\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject summary: This project will develop and validate a comprehensive toolset of novel technologies for imaging axonal projections across scales, and will deploy this toolset to map a complex system of cortico- subcortical projections in the macaque and human brain.\u003C\/p\u003E"},{"title":"Cell type-specific mechanisms of history-dependent perceptual biases in sensory cortex","field_investigator":"Deepa L Ramamurthy","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS129753-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739223\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739223\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Sensory representations are influenced by an animal\u2019s external context, internal state, past experiences, expectations, and future goals.\u003C\/p\u003E"},{"title":"Center for Advanced Muscle BioElectronics (CAMBER)","field_investigator":"Muhannad   Bakir, Samuel  Sober","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS126936-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10573637\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10573637\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EA central goal of neuroscience is to discover how neural circuits control the body\u2019s muscles to produce behavior.\u003C\/p\u003E"},{"title":"Characterizing Lower Extremity Neurophysiological Responses to Sensory Augmentation after Stroke","field_investigator":"Jasmine Jamilah Cash","field_institution":"Medical University Of South Carolina","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135810-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10829133\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10829133\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT After a stroke, walking ability can be compromised, which can lead to reduced quality of life and decreased ability to perform activities of daily living.\u003C\/p\u003E"},{"title":"Circuit mechanisms of arbitration between distinct reinforcement learning systems","field_investigator":"Margaret Louise Demaegd","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132176-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608739\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608739\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Animals can exhibit goal-directed behaviors in novel environments, despite limited experience with them. How does the brain make and use inferences about the underlying statistics and generative structure of environments to guide behavior?\u003C\/p\u003E"},{"title":"Circuit-specific, chemogenetic neuromodulation in nonhuman primates.","field_investigator":"Serge E Przedborski, Charles E Schroeder","field_institution":"Nathan S. Kline Institute For Psych Res","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-115","field_project_number":"1UG3MH129381-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10651371\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10651371\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EABSTRACT \u2012 UG3\/UH3 Deep Brain Stimulation (DBS), applied to areas like the subthalamic nucleus (STN), is a standard treatment for Parkinson Disease (PD), however, DBS has inherent surgical risks as well as potential for infections and adverse side effects.\u003C\/p\u003E"},{"title":"cloudSLEAP: Maximizing accessibility to deep learning-based motion capture","field_investigator":"Talmo D. Pereira","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH132653-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10643661\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10643661\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EcloudSLEAP \u2013 PROJECT SUMMARY\/ABSTRACT Understanding how the brain produces complex behavior is a central goal of neuroscience, but quantifying behavior is technically challenging, particularly in unrestrained and naturalistic settings.\u003C\/p\u003E"},{"title":"Cognitive and Neural Strategies for Latent Feature Inference","field_investigator":"Tahra  Eissa","field_institution":"University Of Colorado","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-044","field_project_number":"1K99NS127855-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10662877\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10662877\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY The world around us has a statistical structure that we can use to improve our choices. Learning the underlying structure by identifying key features, such as the rate of change, is useful for adapting and optimizing our decision-making strategies.\u003C\/p\u003E"},{"title":"Commercial translation of high-density carbon fiber electrode arrays for multi-modal analysis of neural microcircuits","field_investigator":"Rajmohan Bhandari, Cynthia Anne Chestek, Daniel Powell, Florian Solzbacher","field_institution":"Blackrock Microsystems","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R44NS134432-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10761217\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10761217\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThe ability to measure and manipulate local brain circuit activity in living, behaving animals is essential to understanding the complexities of brain function and dysfunction.\u003C\/p\u003E"},{"title":"Continuous development of nTracer2 and its deployment at NIH image repositories","field_investigator":"Dawen  Cai, Yan  Yan","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133764-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10726178\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10726178\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EAbstract In response to the BRAIN Initiative \u201cIntegration and Analysis of BRAIN Initiative Data\u201d FOA, we propose further developing nTracer2, a cloud-based platform for brain image visualization and neuron tracing in the web browser.\u003C\/p\u003E"},{"title":"DDALAB: Identifying Latent States from Neural Recordings with Nonlinear Causal Analysis","field_investigator":"Terrence J Sejnowski","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH132664-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10643212\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10643212\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ESummary The goal of this proposal is to develop DDALAB, a software platform that will make it possible for researchers to identify latent cortical states and analyze the flow of information in large populations of neurons using Delay Differential Analysis (DDA).\u003C\/p\u003E"},{"title":"Developing novel neural network tools for accurate and interpretable dynamical modeling of neural circuits","field_investigator":"Christopher  Versteeg","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132175-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10752956\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10752956\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EAbstract In recent years, the number of neurons that we can record simultaneously has seen an exponential increase, presenting a daunting challenge: how do we analyze these complex and high-dimensional datasets to gain insight into how neural circuits perform computation?\u003C\/p\u003E"},{"title":"Development and In Vivo Validation of a Theoretical Framework and Practical Methods to Improve Safety and Efficacy of Neuromodulation Electrodes","field_investigator":"Kip A Ludwig","field_institution":"University Of Wisconsin-Madison","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS129955-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10572029\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10572029\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EDespite widespread clinical use, the theoretical framework by which to understand safety of electrical stimulation through implanted electrodes is surprisingly limited.\u003C\/p\u003E"},{"title":"Dissemination of the Human Neocortical Neurosolver (HNN) software for circuit level interpretation of human MEG\/EEG","field_investigator":"Stephanie Ruggiano Jones","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS129945-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10726032\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10726032\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EHNN U24 DISSEMINATION PROJECT SUMMARY The Human Neocortical Neurosolver (HNN) neural modeling tool was developed with BRAIN Initiative funding (R01EB022889: 09\/2016\u201306\/2020) to meet the Initiative\u2019s goal to \u201cdevelop innovative technologies to understand brain circuits and ensembles of circuits th\u003C\/p\u003E"},{"title":"ENABLING SUBMILLISECOND-TIMESCALE TWO-PHOTON RECORDING OF VOLTAGE DYNAMICS IN THREE DIMENSIONS IN VIVO","field_investigator":"Laurent  Bourdieu, Francois  St-Pierre","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS133971-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739579\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739579\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Because neurons integrate and process information via modulation of their membrane potential, the ability to monitor voltage is critical to understanding how single and groups of neurons compute.\u003C\/p\u003E"},{"title":"Extending ezBIDS, NiiVue and dcm2niix for user-friendly cloud-based integration and visualization","field_investigator":"Christopher  Rorden","field_institution":"University Of South Carolina At Columbia","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133701-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724895\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724895\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary\/Abstract Cloud-based analyses and easily shared data formats are revolutionizing neuroimaging. We will develop software to fill gaps created by these two trends. We will develop and refine software to visualize and analyze the data from the BRAIN Initiative.\u003C\/p\u003E"},{"title":"Functions of the Cortical Amygdala in social behavior","field_investigator":"Antonio V Aubry","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DA058213-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10641270\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10641270\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Aggression is an evolutionarily conserved behavior that controls social hierarchies and protects valuable resources like mates, food, and territory. In most cases, aggression is a necessary, adaptive component of social behavior.\u003C\/p\u003E"},{"title":"High-throughput 3D mapping of large mammalian brains via integration of precision tissue sectioning and light sheet imaging","field_investigator":"Ji Wang, Nicholas Bruce Evans, Hsuan Lee, Jeffrey Stirman","field_institution":"Lifecanvas Technologies, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R43MH133544-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10695784\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10695784\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EWhole-brain mapping at the cellular and subcellular levels is crucial to systematically understand brain functions and disorders.\u003C\/p\u003E"},{"title":"Identifying human-specific neural progenitors and their role in neurodevelopment","field_investigator":"Sumin  Jang","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH130892-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10662868\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10662868\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Humans have highly advanced cognitive abilities and motor skills, characteristics which are reflected in the enlarged size and cell diversity of our central nervous system (CNS).\u003C\/p\u003E"},{"title":"Identifying the neural mechanisms of goal-directed decision-making in Parkinson\u0026#039;s disease using closed-loop deep brain stimulation","field_investigator":"Colin  Hoy","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132174-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608842\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608842\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003ETITLE: IDENTIFYING THE NEURAL MECHANISMS OF GOAL-DIRECTED DECISION-MAKING IN PARKINSON\u2019S DISEASE USING CLOSED-LOOP DEEP BRAIN STIMULATION PROJECT SUMMARY People with Parkinson\u2019s disease commonly suffer from non-motor symptoms, including motivation deficits, that impact quality of life more than c\u003C\/p\u003E"},{"title":"Implications of Prefrontal Cortex Development for Adolescent Reward Seeking Behavior","field_investigator":"Gabriela  Manzano Nieves","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH132082-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739548\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739548\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY As we get older, we learn to modulate our behaviors to optimize reward outcomes. These adaptive choices are orchestrated by current sensory conditions, internal cognitive states, and future expectations.\u003C\/p\u003E"},{"title":"Improving Recruitment, Engagement, and Access for Community Health Equity for BRAIN Next-Generation Human Neuroimaging Research and Beyond (REACH for BRAIN)","field_investigator":"Susie Yi Huang, Jonathan David Jackson, Francis X Shen","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH134144-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10730955\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10730955\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"\u003Cp\u003EProject Summary \/ Abstract Although BRAIN 2.0 called for the BRAIN Initiative to \u201cprioritize diversity and inclusion as a fundamental pillar,\u201d research with the human neuroimaging technologies being developed by BRAIN Initiative continues to rely on non-representative convenience samples.\u003C\/p\u003E"},{"title":"Intersubject Synchrony in Neural and Behavioral Representations of Social Uncertainty Among Adults and Adolescents","field_investigator":"William John Mitchell","field_institution":"Temple Univ Of The Commonwealth","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134208-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10828675\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10828675\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Uncertainty is an often pervasive, stressful experience that arises when making judgments about others\u0027 beliefs, intentions, or emotions (i.e., ambiguous social situations). Excessive uncertainty can have pernicious effects upon memory, mood, and physical and mental outcomes.\u003C\/p\u003E"},{"title":"Intrinsic and Extrinsic factors regulating neurogenic competence in hypothalamic tanycytes","field_investigator":"Leighton Hosea Duncan","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135816-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10828978\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10828978\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EHypothalamic tanycytes have limited postnatal neurogenic competence, but the extrinsic and intrinsic factors that promote this are not well understood. My predoctoral research identified a defined developmental window during which neurogenic competence is lost from hypothalamic tanycytes.\u003C\/p\u003E"},{"title":"Investigating the Recruitment of Different Neuronal Subpopulations by Intracortical Micro Stimulation Using Two Photon-Microscopy","field_investigator":"Christopher  Hughes","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH130022-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10604754\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10604754\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Intracortical microstimulation (ICMS) of the sensory cortices is an emerging approach to restore sensation to people who have lost it due to neurological injury or disease.\u003C\/p\u003E"},{"title":"Investigations of cAMP-dependent brain-barrier permeability in choroid plexus","field_investigator":"Dario Xavier Figueroa Velez","field_institution":"Boston Children\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132178-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753098\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753098\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY The choroid plexus (ChP) comprises a network of cells that form a critical brain barrier that can mediate secondary damage in certain brain disorders and trauma. The Lehtinen lab has developed a suite of tools to study the ChP across development ex vivo and in vivo.\u003C\/p\u003E"},{"title":"Large-scale calcium and voltage imaging to illuminate neural mechanisms of visual experience","field_investigator":"Michelle  Redinbaugh","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134451-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753172\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753172\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary: The majority of lived experience depends on neural activity conveying sensory information about the world.\u003C\/p\u003E"},{"title":"Live spike sorting for multichannel and high-channel recordings","field_investigator":"Tim Chifong Lei, Achim Klug","field_institution":"Popneuron, LLC","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-178","field_project_number":"1R41NS132700-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10759767\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10759767\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThe goal of this project is to create two prototypes of a novel live spike sorting system which can be used by investigators to spike sort streams of neural data recorded by multi-channel, high channel and ultra-high channel probes.\u003C\/p\u003E"},{"title":"Manipulation of neuron identity towards in-vivo circuit reprogramming in the cerebral cortex","field_investigator":"Lee O Vaasjo","field_institution":"Tulane University Of Louisiana","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134203-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10755203\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10755203\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Sub-Cerebral Projection Neurons (SCPNs) are a clinically relevant neuron class that controls voluntary movement and whose loss in Amyotrophic Lateral Sclerosis and Fronto-temporal dementia or injury (e.g., damaged by spinal cord injury) leads to paralysis.\u003C\/p\u003E"},{"title":"Mechanisms of experience-dependent plasticity in an innate social behavior circuit","field_investigator":"Emma E Boxer","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10751542\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10751542\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Many social behaviors, such as defense and aggression, are innate- requiring no prior experience to be expressed and presumably \u2018hardwired\u2019 into neural circuits.\u003C\/p\u003E"},{"title":"Mechanisms of neural circuit dynamics in working memory and decision-making","field_investigator":"Carlos D Brody, Ila R. Fiete, Mark S Goldman, Jonathan William Pillow, Hyunjune Sebastian Seung, David W Tank, Samuel Sheng-Hung Wang, Ilana  Witten","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-040","field_project_number":"1U19NS132720-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10705962\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10705962\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary\/Abstract: Overall The overarching goal of this U19 program is to determine how neural computations across brain regions produce two core cognitive processes, working memory and decision-making, and thus to derive fundamental principles of brain function.\u003C\/p\u003E"},{"title":"Models for accumulation of evidence through sequences in a navigation-based, decision-making task","field_investigator":"Lindsey Shoemaker Brown","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132179-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608293\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608293\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EDecision making is a fundamental cognitive process, and many decisions are based on gradually accumulated evidence. Thus, it is critical to understand the mechanistic basis underlying this accumulation process.\u003C\/p\u003E"},{"title":"Multiplex Imaging of Brain Activity and Plasticity with Optimized FRET\/FLIM-based Sensors","field_investigator":"Daniel A Dombeck, Oliver  Griesbeck, Ryohei  Yasuda","field_institution":"Northwestern University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128655-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516813\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516813\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EProject Summary Plasticity is a fundamental aspect of neuronal circuits across all species. It is at the base of learning and memory, sensory adaption, and many disease-related processes such as addiction, chronic pain or regeneration.\u003C\/p\u003E"},{"title":"Multisensory integration and self-motion perception in primate vestibular cortex","field_investigator":"Alejandra  Gomez","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134455-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753017\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753017\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary In vertebrate animals, the vestibular system (primarily known as the \u201cbalance system\u201d of the brain) interprets head-movement and orientation signals to provide organisms with a sense of self-motion.\u003C\/p\u003E"},{"title":"Nanoparticle Coated Microelectrode Arrays for Electrochemically Controlled Gene Editing at the Electrode Site","field_investigator":"Nathaniel P Williams","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132145-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10604904\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10604904\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EAbstract Microelectrode arrays (MEAs) have great potential for therapeutic use in direct brain-computer interface (BCI) control of robotic prostheses to improve the lives of patients suffering from debilitating conditions related to loss of limbs or limb function.\u003C\/p\u003E"},{"title":"Neural basis of collective behavior during environmental stress","field_investigator":"Tara  Raam","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH133159-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10740543\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10740543\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Social interactions are critical to the physical and emotional health of a wide variety of species.\u003C\/p\u003E"},{"title":"Neuronal and Network Mechanisms of Electrocortical Stimulation","field_investigator":"Marc W. Slutzky","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS125026-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724958\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724958\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EElectrocortical stimulation (ECS) has been used for functional mapping for many decades to identify brain areas that are \u201ccritical\u201d for speech and language (i.e., that impair function when stimulated) prior to epilepsy or tumor surgery.\u003C\/p\u003E"},{"title":"Neuropixels Opto: Integrated Silicon Probes for Cell-Type-Specific Electrophysiology","field_investigator":"Joshua H Siegle, Karel  Svoboda","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS133760-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731991\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731991\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY Within every brain region, neurons can be classified into dozens or hundreds of different cell types, each with unique functional roles and unique impacts on disease states.\u003C\/p\u003E"},{"title":"NexGen 7T MRI scanner for mesoscale brain imaging: Integration and Dissemination","field_investigator":"Alexander  Beckett, David Alan Feinberg, An T Vu","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS129949-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725586\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725586\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003ESUMMARY The \u0022NexGen\u0022 7 Tesla MRI scanner at UC Berkeley is a unique resource that we wish to make available for neuroscience collaborations across the globe.\u003C\/p\u003E"},{"title":"Next generation axonal quantification and classification using AI","field_investigator":"Jacob R Glaser","field_institution":"Microbrightfield, LLC","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"2R44MH128076-02","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10698843\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10698843\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThis Phase II project describes the commercial development of HyperAxon\u2122, highly innovative software for performing automated segmentation, tracing, reconstruction and quantitative analysis of all axonal fibers (with and without signs of acute axonal injury) visible in two- and three-dimensional \u003C\/p\u003E"},{"title":"Next Generation Opto-GPCRs for Neuromodulatory Control","field_investigator":"Andre  Berndt, Michael R Bruchas, Moran  Shalev-Benami, Ofer  Yizhar","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128537-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10515612\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10515612\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EProject Summary\/Abstract: The field of optogenetics \u2014 utilizing light to engage biological systems \u2014 is widely used for the dissection of neural circuits, cellular signaling and manipulating neurophysiological systems in awake, behaving animals.\u003C\/p\u003E"},{"title":"O-GlcNac Modulation of GABAergic Transmission","field_investigator":"Shekinah  Phillips","field_institution":"University Of Alabama At Birmingham","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134163-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10754746\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10754746\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EChanges in the strength of GABAergic transmission is heavily influenced by posttranslational modifications and allosteric modulators like benzodiazepines and neurosteroids.\u003C\/p\u003E"},{"title":"OpenNeuro: An open archive for analysis and sharing of BRAIN Initiative data","field_investigator":"Russell A Poldrack","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH117179-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10451257\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10451257\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary\/Abstract The BRAIN Initiative is supporting a broad portfolio of neuroscience research aimed at revolutionizing our understanding of the brain.\u003C\/p\u003E"},{"title":"Optimizing ultraflexible electrodes and integrated electronics for high-resolution, large-scale intraspinal recording and modulation","field_investigator":"Lan  Luan, Chong  Xie","field_institution":"Rice University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS131086-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10617092\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10617092\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EElectrophysiology is a critical technology in neuroscience as a direct measure of neuronal functions. It has become routine for scientists to record and stimulate neuron populations in different brain regions in awake behaving animals, correlating activity with behavior.\u003C\/p\u003E"},{"title":"Oxytocin Modulation of Neural Circuit Function and Behavior","field_investigator":"Richard W Tsien","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-040","field_project_number":"2U19NS107616-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10705986\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10705986\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary Oxytocin is a peptide hormone synthesized and released from the hypothalamus for reproduction, maternal care, and social behavior, as well as various \u2018non-social\u2019 aspects of internal state and physiological processes.\u003C\/p\u003E"},{"title":"Post-trial Access, Clinical Care, Psychosocial Support, and Scientific Progress in Experimental Deep Brain Stimulation Research","field_investigator":"Joseph J. Fins, Gabriel  Lazaro-Munoz","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH133657-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10722437\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10722437\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"\u003Cp\u003EProject Summary Public and private research funders have heavily invested in the application of implantable neurotechnologies to improve the management of treatment-resistant conditions and loss of function (e.g., deep brain stimulation (DBS) systems for recovery after traumatic brain injury (TBI\u003C\/p\u003E"},{"title":"Postnatal experience shapes gene expression and connectivity development in the cortex","field_investigator":"Alexander  Nevue","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134413-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10749679\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10749679\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Postnatal sensory experience has a profound effect on the maturation, composition, and connectivity of cortical cell types, but systematic analyses of these changes have not yet been feasible.\u003C\/p\u003E"},{"title":"Probing form and function of memory representations in the hippocampus of memory expert birds","field_investigator":"Emily Lambert Mackevicius","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS131256-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10641392\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10641392\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary\/Abstract Mental disorders that affect the hippocampus disrupt people\u2019s ability to form one-shot memories. My goal is to lead an independent lab, linking biological properties of hippocampal neurons to the ability to perform memory- guided cognitive behaviors.\u003C\/p\u003E"},{"title":"Processing of visual information by spatial memory circuits in the avian brain","field_investigator":"Hannah L Payne","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY034700-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10570644\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10570644\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT. Research Project: Spatial memory \u2013 memory of where an event happened or an object was located \u2013 depends on the hippocampus in a wide range of vertebrate species, including mammals and birds. In humans, most spatial memories are formed through visual experience.\u003C\/p\u003E"},{"title":"Psych-DS: A FAIR data standard for behavioral datasets","field_investigator":"Melissa  Kline","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-145","field_project_number":"1RF1MH132747-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10645923\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10645923\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ESummary: Behavioral data is central to biomedical research, including both synchronous measures (e.g. brain activation and button-presses from a reading task in an fMRI scan), and those performed independently (e.g.\u003C\/p\u003E"},{"title":"Role of cortical connections to higher-order thalamic nuclei in visual decision-making","field_investigator":"Ariana R Andrei","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY034699-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739488\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739488\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY To guide decisions, visual information must flow from primary visual cortex (V1) to prefrontal cortex (PFC), via multiple, parallel cortico-cortical and cortico-thalamo-cortical connections.\u003C\/p\u003E"},{"title":"Role of multi-regional neuronal reactivations in reward-based memories","field_investigator":"Celine  Drieu","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DA059024-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10722635\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10722635\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY The goal of this project is to provide the building blocks for an independent research program focused on the neural basis of reward-based memory across distributed brain networks.\u003C\/p\u003E"},{"title":"Scientific and Public Outreach of Cell Type Taxonomies (SPOCTT) Initiative","field_investigator":"Kaitlyn  Casimo, Jeremy A Miller","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS133077-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724950\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724950\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EProject Summary Single cell transcriptomics has transformed the field of brain cell type classification, allowing simultaneous measurement of enough molecular features from enough cells to categorize neurons quantitively and with high conservation across brain areas and species.\u003C\/p\u003E"},{"title":"Sex, Physiological State, and Genetic Background Dependent Molecular Characterization of CircuitsGoverning Parental Behavior","field_investigator":"Brandon  Logeman","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99HD108801-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10661884\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10661884\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Parental care is essential for offspring well-being and survival yet requires a significant invest from adults without immediate benefit, suggesting the existence of hard-wired mechanisms governing its control.\u003C\/p\u003E"},{"title":"Systematic characterization of spinal cord stimulation effects on dorsal horn populations","field_investigator":"Andrei D Sdrulla","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS124557-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10558269\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10558269\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EThere is a substantial need to understand the fundamental biological mechanisms of neuromodulation therapies in order to improve clinical delivery and outcomes (RFA-NS-20-006).\u003C\/p\u003E"},{"title":"The development of multimodal dynamics in a short-term memory system","field_investigator":"Gregory Patrick Davis","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134449-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753261\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753261\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT Persistent activity in neural circuits supports a variety of brain functions from motor control to navigation to perceptual decision-making.\u003C\/p\u003E"},{"title":"The Impact of Vitamin D on mTOR Signaling, Seizures, and Motor Behavior in a Mouse Model of Hyperactive mTOR Induced Epilepsy and Ataxia","field_investigator":"David  Narvaiz","field_institution":"Baylor University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134141-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10754319\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10754319\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary \/ Abstract Increased mammalian target of rapamycin (mTOR) signaling is a known cause of treatment resistant epilepsy.\u003C\/p\u003E"},{"title":"The Neuroimaging Brain Chart Software Suite","field_investigator":"Christos  Davatzikos, Yong  Fan, Ilya M Nasrallah, Haochang  Shou","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS130411-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10581015\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10581015\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EThis study proposes to refine, integrate and disseminate the NeuroImaging Brain Chart (NIBCh) software toolbox and machine learning (ML) model library, an ecosystem of software components enabling constructive integration, statistical harmonization, and ML-centric data analyses across studies.\u003C\/p\u003E"},{"title":"Time-varying spatiotemporal causal interactions in the functional brain networks","field_investigator":"Nan  Xu","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS123113-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10590411\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10590411\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EThis proposal describes a five-year career development program to prepare the candidate, Dr.\u003C\/p\u003E"},{"title":"Towards an integrated analytics solution to creating a spatially-resolved single-cell multi-omics brain atlas","field_investigator":"Panagiotis  Roussos, Guo-Cheng  Yuan","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133703-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724843\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724843\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EPROJECT SUMMARY The maintenance and function of the nervous system depends on cell-cell interactions among neuronal and non-neuronal cell populations, which occur through physically binding cell membrane surface or secreted proteins, triggering signaling cascades that activate cell-type gene regu\u003C\/p\u003E"},{"title":"Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform","field_investigator":"Patrick Goodwill","field_institution":"Magnetic Insight, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R44EB035078-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10761613\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10761613\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EIn this SBIR grant proposal, \u201cUltra-low distortion and noise electronics to enable a clinical MPI imaging platform,\u201d we will develop the RF subsystem for a clinical magnetic particle imaging (MPI) platform to enable three classes of MPI applications: cell tracking, functional imaging, and endogen\u003C\/p\u003E"},{"title":"Understanding the Conceptual Priority Map Guiding Naturalistic Visual Attention for Autistic Individuals","field_investigator":"Amanda J Haskins","field_institution":"Dartmouth College","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135812-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10829114\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10829114\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Visual attention differences are a promising diagnostic marker for autism spectrum conditions (ASC).\u003C\/p\u003E"},{"title":"UNDERSTANDING THE CONSEQUENCES OF SLEEP LOSS IN AN AUTISM MOUSE MODEL","field_investigator":"Elizabeth  Medina","field_institution":"Washington State University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135815-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10829011\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10829011\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Poor sleep is common in neurodevelopment disorders such as autism spectrum disorder (ASD), with up to 93% of ASD individuals reporting sleep problems.\u003C\/p\u003E"},{"title":"Unified, Scalable, and Reproducible Neurostatistical Software","field_investigator":"Scott Warren Linderman, Alexander Henry Williams","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133778-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725500\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725500\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary Many advances in modern neuroscience rely on electrophysiological recordings of large neural populations (e.g. many hundreds of cells) or high-resolution measurements of animal behavior (e.g. from video).\u003C\/p\u003E"},{"title":"A BRAIN Initiative Resource: The Neuroscience Multi-omic Data Archive","field_investigator":"Anup  Mahurkar, Owen R White","field_institution":"University Of Maryland Baltimore","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH114788-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447478\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447478\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative\npromotes the development and application of technologies to describe the temporal and spatial\ndynamics of cell types and neural circuits in the brain."},{"title":"A Confocal Fluorescence Microscopy Brain Data Archive","field_investigator":"Marcel P Bruchez, Alexander J Ropelewski, Alan Michael Watson","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH114793-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10451277\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10451277\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\n Brain image data collected by the neuroscience community will continue to grow\ndramatically in the next 5-10 years as the push to image physically larger volumes, such as\nwhole brains from humans and other primates, becomes a focus."},{"title":"A Shared Neuroscience Platform for National Dissemination and Training  in Brain Organogenesis, Behavioral and Brain Disease Models, Viral Vectors, and Imaging Technologies","field_investigator":"William T Newsome, Sergiu  Pasca, Mehrdad  Shamloo, Gordon X Wang","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124026-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10439384\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10439384\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Advances in neuroscience depend on robust in vivo and in vitro models with innovative technologies to carry out\nfunctional and mechanistic studies accompanied by advanced imaging techniques."},{"title":"Aberrant Signaling from Brain Tumors Regulates Distant and Local Environments","field_investigator":"Kaysaw C Tuy","field_institution":"University Of Alabama At Birmingham","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129129-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610104\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610104\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\nPerturbations in redox signaling are associated with multiple neurological disorders, ranging from\nneurodegenerative diseases to brain tumors."},{"title":"An Ecosystem of Technology and Protocols for Adaptive Neuromodulation Research in Humans","field_investigator":"Peter  Brunner, Kai  Miller, Gregory A Worrell","field_institution":"Mayo Clinic Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128612-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516471\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516471\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\/Abstract\n Neurological and psychiatric disorders affect millions of people in the United States and worldwide, and produce\na third of all health care costs."},{"title":"Anatomical connectivity and activity in primary visual cortex of mouse","field_investigator":"Zachary Samuel Pitkow, Andreas  Tolias","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130416-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505662\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505662\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nEstimates of the total length of axonal \u0022wiring\u0022 in the human brain are on the order of hundreds of thousands\nof kilometers."},{"title":"Assessment of Behavioral Deficits in Minipig Model of Pediatric Concussion","field_investigator":"Alesa Hughson Netzley","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129171-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610655\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610655\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nTraumatic brain injury (TBI) is a leading health concern for both children and adults worldwide."},{"title":"Basic neural processing mechanisms of live human face viewing","field_investigator":"Megan  Kelley","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129174-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610114\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610114\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n  Significance. The human brain has a dedicated neural system for processing other humans. However relatively\n  little is known about the basic mechanisms of this processing."},{"title":"BCI-DEF: Brain Computer Interfaces and Disability: Developing an Inclusive Ethical Framework","field_investigator":"Karen G Hirsch, Holly K Tabor","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH130518-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10508135\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10508135\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\/Abstract\nThe objective of \u201cBrain Computer Interfaces and Disability: Developing an Inclusive Ethical Framework (BCI-\nDEF)\u201d is to use structured vignettes, video-supported interviews, and a deliberative democracy approach to\nassess and analyze diverse, critical stakeholder perspective"},{"title":"Biophysical and Neural Basis of Focused Ultrasound Stimulation","field_investigator":"Charles F Caskey, Li Min  Chen","field_institution":"Vanderbilt University Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS126144-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10415733\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10415733\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"This proposal responds to BRAIN Initiative RFA-NS-20-006 and aims to elucidate the neural and biophysical mechanisms of noninvasive focused ultrasound (FUS) neuromodulation."},{"title":"BRAIN Initiative: Hierarchical Event Descriptors (HED): a system to characterize events in neurobehavioral data","field_investigator":"Scott  Makeig, Kay A Robbins, Arnaud  Delorme","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-128","field_project_number":"1RF1MH126700-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10480619\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10480619\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"This two-year project will advance, integrate, document, and promote the use of the Hierarchical\nEvent Descriptor (HED) system to describe events in human neuroimaging and behavioral data\nfrom research experiments and other sources in sufficient detail to support comparative analysis\nof human brain "},{"title":"BRAIN Integrated Resource for Human Anatomy and Intracranial Neurophysiology","field_investigator":"Dominique  Duncan, Nader  Pouratian","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130371-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505412\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505412\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\/ABSTRACT\nIntracranial recordings in patients undergoing neurosurgical interventions provide a unique opportunity to directly\naccess, study, and learn about both normal human brain function and neuropsychiatric disease."},{"title":"CAJAL: A computational framework for the combined morphometric, transcriptomic, and physiological analysis of cells","field_investigator":"Pablo  Gonzalez Camara","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130553-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10509196\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10509196\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nMorphology is an essential phenotype in the characterization of cells and their states. It reflects the progression\nof functional cellular processes, such as morphogenesis, migration, or dendrite arborization, and can be\nindicative of disease."},{"title":"Caring for BRAIN pioneers: Understanding and enhancing family and researcher support in neural device trials","field_investigator":"Sara  Goering, Eran  Klein","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH130457-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10506303\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10506303\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project abstract\nBRAIN pioneers are people who take on significant risk as participants in first-in-human or early\nneurotechnology studies for the sake of helping to further science."},{"title":"Circuit dynamics of structuring episodic memories in humans","field_investigator":"Jie  Zheng","field_institution":"Boston Children\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS126233-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10590796\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10590796\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project summary\nOur lives unfold over time, weaving rich, dynamic, and multisensory information into a continuous experience.\nHowever, we remember this as a series of discrete events. For example, the memory of a two-hour movie\nconsists of a few memorable moments tied to the main story."},{"title":"Computational Tools for assessing mechanisms and functional relevance of divisive normalization","field_investigator":"Ruben  Coen-Cagli","field_institution":"Albert Einstein College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056400-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488972\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488972\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nDivisive normalization (DN) is a well-established theory of how interactions between neurons in a circuit\nmodulate the activity of individual neurons."},{"title":"CRCNS: Circuit mechanisms of priors and learning during decision making","field_investigator":"Guangyu Yang","field_institution":"Massachusetts Institute of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01MH132172-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610167\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610167\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EWhen learning a new task, both rats and humans exhibit suboptimal behaviors plagued with superstitious ticks and idiosyncratic biases.\u003C\/p\u003E"},{"title":"CRCNS: Deconstructing dynamics of motor cortex in freely moving behavior","field_investigator":"Paul Nuyujukian","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01NS130789-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610495\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610495\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EWhat operations are performed by the mammalian central nervous systems to coordinate and conduct voluntary movement? Motor systems neuroscience seeks to understand these neural mechanisms.\u003C\/p\u003E"},{"title":"CRCNS: Dynamics of thalamocortical networks during sensory discrimination","field_investigator":"Mark Allan Reimers","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01NS130919-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10612202\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10612202\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Evidence-based modeling of neuromodulatory action on network properties","field_investigator":"Yangyang Wang","field_institution":"University of Iowa","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01DA057767-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610566\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610566\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Heterogeneous effects of cognition on perception: unique leverage on circuit mechanisms","field_investigator":"Marlene Rochelle Cohen, Brent D. Doiron","field_institution":"University of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01EY034723-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608553\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608553\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Multifocal causal mapping of brain networks supporting human cognition","field_investigator":"Aapo Nummenmaa","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01DC020891-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10612128\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10612128\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ENeuroimaging methods such as functional MRI and magneto- \/ electroencephalography (MEG\/EEG) cannot directly reveal causal relationships between regional brain activity and behavior.\u003C\/p\u003E"},{"title":"CRCNS: Neural Representations of Time Across Scales in Natural and Artificial Networks","field_investigator":"Marc W Howard","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01MH132171-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610084\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610084\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Understanding Single-Neuron Computation Using Nonlinear Model Optimization","field_investigator":"Fabrizio Gabbiani, Matthias Heinkenschloss","field_institution":"Baylor College of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01NS130917-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10612187\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10612187\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EMotivation and Objectives Why are ion channels localized in subcellular dendritic compartments and is there a tight coupling of the observed localization with neuron function?\u003C\/p\u003E"},{"title":"Deciphering the genomic mechanisms underlying the physiology of human brain stimulation","field_investigator":"Genevieve  Konopka, Bradley C Lega","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS126143-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10559426\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10559426\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The underlying mechanisms of brain stimulation in humans are poorly understood, especially at the level of gene expression."},{"title":"Deep and fast imaging using adaptive excitation sources","field_investigator":"Chris  Xu","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128660-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516870\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516870\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\n Optical recordings of activity are critical to probe neural systems because they provide high-resolution,\nnon-invasive measurements, ranging from single neurons to entire populations in intact nervous systems, and\nare readily combined with genetic methods to provide cell type-specific reco"},{"title":"Defining the circuit, synaptic, and molecular mechanisms linking intracellular Ca2+ release to learning using subcellularly-targeted manipulations and imaging techniques in dendrites in vivo","field_investigator":"Justin  O\u0026#039;hare","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS127815-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10502363\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10502363\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nCandidate Goals and Mission Relevance: The applicant\u2019s broad, long-term objective is to investigate how high-\n(circuit\/behavioral) and low- (subcellular\/molecular) level organizational principles of the brain cooperate to drive\nlearning."},{"title":"Dissecting the role of cortico-basal ganglia circuit diversity in action learning from reinforcement","field_investigator":"Alice  Mosberger","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS126307-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425617\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425617\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nTo learn novel actions through reinforcement, a fundamental mechanism of motor learning, the brain needs to\ncausally link previously performed movements to their resulting outcomes."},{"title":"Dissection of Cell Type Specific Contributions to Motor Learning Circuits","field_investigator":"Lina Marcela Carmona","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS127857-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505229\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505229\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Abstract\nWhether riding your bike down a narrow path or reaching for your favorite cookie in a small box, many of our\ndaily actions require skilled and accurate movements. However, to achieve proficiency, these motor skills must\nfirst be learned through the process of motor learning."},{"title":"Dissection of spatiotemporal activity from large-scale, multi-modal, multi-resolution hippocampal-neocortical recordings.","field_investigator":"Gyorgy  Buzsaki, Zhe Sage Chen","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056394-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488900\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488900\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ ABSTRACT\nAdvances in neurotechnologies are producing large and complex datasets at unprecedented rate."},{"title":"Dissemination of FlyWire, A Whole-Brain Connectomics Resource","field_investigator":"Mala  Murthy","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS126935-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10439970\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10439970\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"This proposal will disseminate FlyWire, a Drosophila whole brain connectomics resource. We\nused advances in AI to segment all neurons from a whole brain EM volume called FAFB."},{"title":"Dissemination of MAPseq and BARseq for high-throughput brain mapping","field_investigator":"Anthony M Zador","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS126938-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10440138\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10440138\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The goal of this project is to disseminate MAPseq and BARseq to the broader neuroscience\ncommunity. These are novel methods developed in my laboratory based on high-throughput DNA\nsequencing for determining neuronal circuitry."},{"title":"Distributed Neural Activity Patterns Underlying Practice-Based Learning","field_investigator":"Kimberly  Reinhold","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH127471-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447345\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447345\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY \/ ABSTRACT\nTo survive, animals must learn appropriate associations between sensory cues and motor actions through a\nprocess of trial and error."},{"title":"Early-Life Stress Drives Increased Heroin Vulnerability: Role of D3 Receptors","field_investigator":"Brianna Elyse George","field_institution":"Wake Forest University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129177-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541392\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541392\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nStress and addiction are intricately linked neural processes. Acute stress can serve as a stimulus for relapse to\ncompulsive drug seeking following abstinence, and chronic stress can induce escalated drug intake to multiple\nclasses of drugs."},{"title":"Efficient Two-Photon Voltage Imaging of Neuronal Populations at Behavioral Timescales","field_investigator":"Jerry L Chen, Vincent A Pieribone, Michelle Yen-Ling Sander","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128665-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516906\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516906\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nUnderstanding how information is processed in the mammalian neocortex has been a longstanding\nquestion in neuroscience. While the action potential is the fundamental bit of information, how these\nspikes encode representations and drive behavior remains unclear."},{"title":"Elucidating Principles of Sensorimotor Control using Deep Learning","field_investigator":"Shreya  Saxena","field_institution":"University Of Florida","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056377-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488409\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488409\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nHow do distributed neural circuits drive purposeful movements from the complex musculoskeletal system?"},{"title":"Empirical Power Analysis Tool for fMRI","field_investigator":"Stephanie  Noble","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH130894-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10503064\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10503064\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nFunctional magnetic resonance imaging (fMRI) research has transformed our understanding of human brain\nfunction and disease and is flourishing under unprecedented international funding, including dedicated support\nfrom the BRAIN Initiative."},{"title":"Fostering Ethical Neurotechnology Academia-Industry Partnerships: A Stakeholder Engagement and Toolkit Development Project","field_investigator":"Tristan  Mcintosh","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH130519-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10508408\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10508408\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\nNeurotechnologies used to treat brain disorders and diseases can drastically change brain function and behavior,\nmonitor brain activity, and collect and transmit personal health data."},{"title":"Functional interrogation of the mouse somatosensory thalamic interneuron in sensory perception and rhythmic states","field_investigator":"Jane  Yi","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH130023-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10467357\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10467357\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\/SUMMARY\nThe mouse somatosensory thalamus participates in fundamental processes including sensory processing, sleep\nand pathological rhythmic behaviors like seizure. Local thalamic interneurons have been considerably\noverlooked due to their sparsity in the total neuronal population."},{"title":"Functional Mapping of the Suprachiasmatic Nucleus","field_investigator":"Karen Jill Tonsfeldt","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS119291-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10448026\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10448026\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nThis proposal aims to delineate the electrical and molecular diversity of the suprachiasmatic nucleus (SCN) and\nprovide new evidence for receptor-expressing subtypes of SCN neurons using novel nanowire arrays that allow\nsingle cell recording at 1024 contacts simultaneously."},{"title":"Gene regulatory networks influencing neuron-microglia interactions in fetal brain development.","field_investigator":"Claudia Z Han","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH129983-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425902\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425902\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nThe prenatal period is a sensitive and critical time for brain development characterized by waves of neurogenesis,\nneuronal migration, and formation of neural networks."},{"title":"Hormonal regulation of sensory processing during parental care","field_investigator":"Kristina O. Smiley","field_institution":"University Of Massachusetts Amherst","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99HD108800-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425599\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425599\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\n Does the way we hear sounds change when we become parents?"},{"title":"Identifying prefrontal signatures of successful and dysfunctional attention","field_investigator":"Brielle  Ferguson","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH128892-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10349347\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10349347\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\n Attention is comprised of several component processes, including sustained attention, selective\nattention, and attentional flexibility."},{"title":"Implementation and dissemination of cloud-based retrospective hemodynamic analysis tools to enhance HCP data interpretation","field_investigator":"Blaise Debonneval Frederick","field_institution":"Mclean Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130637-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10509534\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10509534\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Summary\nFunctional Magnetic Resonance Imaging data has been a mainstay of neuroscience research for more than two\ndecades, as it allows rapid, continuous, noninvasive monitoring of neuronal function."},{"title":"Improving the robustness of neuroimaging through exploitation of variability in processing pipelines","field_investigator":"Gregory  Kiar, Michael Peter Milham","field_institution":"Child Mind Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130859-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516830\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516830\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nReproducible findings are essential to scientific advancement. Unfortunately, when fields lack consensus\nstandards for methods, or their implementations, reproducibility tends to be more of an ideal than a reality."},{"title":"Integrated functional and structural analysis of an entire column in mouse primary visual cortex","field_investigator":"Reza  Abbasi Asl","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH128672-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505417\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505417\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\nNeurons in the visual cortex form an intricate connectivity structure and topographic arrangement. The\nstructural and morphological organization of the neurons is known to constrain its functional properties."},{"title":"Integration of social and nonsocial information in the primate brain","field_investigator":"Joseph  Simon","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS125826-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541330\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541330\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nPrimate species frequently use social information to inform their decisions, for instance, to help make inferences\nabout potential threats or rewards in the environment."},{"title":"Investigating descending control of walking","field_investigator":"Helen Horan Yang","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS129759-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10568039\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10568039\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nCircuits in the brain control motor output to generate the precise behaviors required for survival. Dysfunction of\nthese circuits results in devastating movement disorders such as Parkinson\u2019s disease and amyotrophic lateral\nsclerosis."},{"title":"Investigating the microcircuit determinants of neural population activity through comparative analysis of latent dynamics across cortical areas in the mouse","field_investigator":"Audrey  Sederberg","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130413-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505552\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505552\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nA key goal in neuroscience is determining how microcircuit structure predicts circuit function. An intriguing idea,\nsupported by some theoretical models, is that variation in microcircuit composition supports functional\nspecialization."},{"title":"Investigating the pathomechanisms underlying Charcot-Marie-Tooth Disease","field_investigator":"Julia Alexis Jones","field_institution":"Scripps Research Institute, The","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129169-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541701\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541701\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nCharcot-Marie-Tooth (CMT) disease is a genetically and clinically heterogeneous group of\ninherited peripheral neuropathies that is characterized by damage to long motor and sensory\naxons."},{"title":"Investigating the Role of Microglia in Methamphetamine Use Disorder","field_investigator":"Samara Jo Vilca","field_institution":"University Of Miami School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS130871-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610124\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610124\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\nSubstance use disorder is a chronic relapsing disease that is characterized by repeated drug use despite\nnegative consequences."},{"title":"Long-term consequences of visual working memory","field_investigator":"Megan Teresa Debettencourt","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-044","field_project_number":"1K99MH128893-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523326\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523326\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThe ability to remember information, whether after short or long delays, is a fundamental human ability."},{"title":"Machine learning analyses of single-cell multi-modal data for understanding cell-type functional genomics and gene regulation","field_investigator":"Daifeng  Wang","field_institution":"University Of Wisconsin-Madison","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH128695-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505191\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505191\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nUnderstanding cell-type-specific gene functions, expression dynamics, and regulatory\nmechanisms in complex brains is still challenging."},{"title":"Mechanisms of Transplanted Cortical Interneuron Survival and Function","field_investigator":"Benjamin  Rakela","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY033976-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425147\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425147\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nCortical interneurons (cINs) are inhibitory cells that are born in surplus far from the cortex. During prenatal\ntimepoints, cIN precursors migrate into the mouse visual cortex (V1) where only a fraction are selected to\nsurvive."},{"title":"Modeling the development of orientation selectivity, maps, and the associated recurrent circuit","field_investigator":"Kenneth D Miller","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056397-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488978\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488978\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nMuch evidence suggests that the development of orientation selectivity and maps in primary visual cortex (V1)\nis instructed by spontaneous patterns of input activity, without the necessity of visual experience."},{"title":"Modulation of Cerebellar Activity by Electrical and Focused Ultrasound Stimulation","field_investigator":"Eric J Lang, Omer  Oralkan, Mesut  Sahin","field_institution":"New Jersey Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS122741-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10429656\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10429656\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The cerebellum has been overlooked for its potential for neuromodulation for decades."},{"title":"Molecular and circuit mechanisms of nausea-associated behaviors","field_investigator":"Chuchu  Zhang","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS129758-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10569466\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10569466\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project summary\nNausea is an unpleasant sensation of visceral malaise often accompanied by an involuntary urge to vomit.\nNausea responses to toxin ingestion and infection are evolutionarily beneficial survival behaviors that\navoid or expel toxins which may cause peripheral tissue damage."},{"title":"Molecular and sensory foundations of vestibular reflex circuit assembly in the larval zebrafish","field_investigator":"Dena  Goldblatt","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129179-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541342\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541342\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY: Behavioral dysfunction in neurodevelopmental diseases often arises from aberrant\nneural circuit assembly. However, the developmental logic that dictates circuit organization, function, and\nultimately behavior remains unresolved due to the complexity of most circuits."},{"title":"Motor Recovery through Plasticity-Inducing Cortical Stimulation","field_investigator":"Steven C. Cramer, Jeffrey G Ojemann","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS121565-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10357993\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10357993\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Limited recovery of function after stroke remains a major problem for millions. Disability persists in\nmany, especially when hand function is limited. Existing therapies are limited and many have difficulties with\nactivities of daily living, even after rehabilitation."},{"title":"Multimodal dissociation of posterior cingulate cortex contributions to episodic memory","field_investigator":"Seth Ryan Koslov","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH130027-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10467220\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10467220\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nEpisodic memory is the ability to recall details about prior experiences. Researchers have historically relied on\ncontrolled item-recognition paradigms, in complement to autobiographical recall tasks, to investigate the\nbiological substrates of episodic memory."},{"title":"Network based neuro-modulation for mesial temporal lobe epilepsy","field_investigator":"Behnaam  Aazhang, Sandipan Pati  Bankim Behari Pati, Nitin  Tandon, Gregory A Worrell","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS119834-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10113342\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10113342\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":""},{"title":"Neural circuit control of fluid and solute clearance during sleep","field_investigator":"Patrick James Drew, Hajime  Hirase, Douglas H Kelley, Laura Diane Lewis, Maiken  Nedergaard","field_institution":"University Of Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS128613-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516497\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516497\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Program abstract: This proposal aims to identify the neural circuit mechanisms that control periarterial\ncerebrospinal fluid (CSF) pumping and glymphatic clearance of fluid and solutes."},{"title":"Neural mechanisms of behavioral coordination in Hydra","field_investigator":"Alison  Hanson","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS127851-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505359\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505359\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nHow do animals coordinate their many parts to generate coherent, adaptive behavior?"},{"title":"NEURODEVELOPMENTAL FUNCTION OF HCFC1","field_investigator":"Victoria L Castro","field_institution":"University Of Texas El Paso","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS125690-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541351\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541351\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nMutation of HCFC1 causes a multiple congenital anomaly syndrome characterized by inborn errors of cobalamin\nmetabolism, intractable epilepsy, intellectual disability, and motor dysfunction."},{"title":"Neurodevelopmental role of a tRNA methyltransferase underlying intellectual disability","field_investigator":"Kimberly Rose R. Madhwani","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129128-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10540878\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10540878\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nGene regulation at multiple levels is critical for nervous system development and function."},{"title":"New Methodologies for Connectomics","field_investigator":"Xiaotang  Lu","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH128891-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10345620\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10345620\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT ABSTRACT\nThe nervous systems of animals are comprised of neurons connected by a large number of synapses.\nThe resulting neural networks underlie animal behavior and contribute to the storage of learned\ninformation in many species."},{"title":"Open-source miniaturized two-photon microscopes for large field-of-view and volumetric imaging","field_investigator":"Daniel  Aharoni, Hugh T Blair, Anne Kathryn Churchland, Peyman  Golshani, Alcino J. Silva, Alipasha  Vaziri","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128664-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516900\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516900\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract:\nSingle-photon (1P) epifluorescence miniaturized microscopy coupled with genetically encoded calcium sensors\nhas allowed investigators to record the activity of large populations of identified neurons over days to weeks in\nfreely behaving animals, answering fundamental questions in neurosci"},{"title":"Optical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation","field_investigator":"Xue  Han","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS129520-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10558965\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10558965\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Optical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation Deep brain stimulation (DBS) directly stimulates brain tissue via implanted electrodes."},{"title":"Pinpointing the Cerebellum\u0026#039;s Contribution to Social Reward Processing","field_investigator":"Haroon Skander Popal","field_institution":"Temple Univ Of The Commonwealth","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129182-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541308\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541308\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nThe cerebellum has long been thought to solely process motor information. Yet, there is a growing literature\nthat points to a role of the cerebellum in processes across multiple domains."},{"title":"Real-time mapping and adaptive testing for neural population hypotheses","field_investigator":"John  Pearson","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056376-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10486197\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10486197\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\n Recent advances in neural recording technologies have made it possible to study increasingly large and di-\nverse subsets of neurons, producing a growing interest in the collective computational properties of neural pop-\nulations."},{"title":"Role of Endocannabinoid System in Seizure Sensitivity in Eclampsia","field_investigator":"Maria  Jones-Muhammad","field_institution":"University Of Mississippi Med Ctr","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129125-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541023\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541023\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nPreeclampsia, a hypertensive disorder of pregnancy, can advance to eclampsia, when the mother\ndisplays novel seizures. The mechanisms that cause some preeclampsia patients to advance to\neclampsia are unknown."},{"title":"Role of neuronal ensembles in cortical plasticity during learning and development","field_investigator":"Alejandro  Akrouh","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY033974-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523350\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523350\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\n The brain undergoes extensive synaptic plasticity and circuit refinement during development. Similar\nchanges recur throughout life during learning in a more narrowly constrained manner."},{"title":"Secondary analysis of resting state MEG data using the Human Neocortical Neurosolver software tool for cellular and circuit-level interpretation","field_investigator":"Stephanie Ruggiano Jones","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130415-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505661\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505661\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe neuroscience community is experiencing a revolution in its ability to share and analyze vast amounts of\nhuman brain imaging data, with support from the BRAIN Initiative and other substantial data-sharing efforts."},{"title":"Statistical machine learning tools for understanding neural ensemble representations and dynamics","field_investigator":"Uri Tzvi Eden, Loren M Frank, Alan David Kaplan","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130623-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10510107\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10510107\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The brain is a massively interconnected network of specialized circuits."},{"title":"Thalamus in the middle: computations in multi-regional neural circuits","field_investigator":"Adam G Carter, Jayaram  Chandrashekar, Jorge H Jaramillo, Karel  Svoboda, Bosiljka  Tasic","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS123714-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294397\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294397\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary, Overall (Thalamus in the middle: computations in multi-regional neural\ncircuits)\nThis collaborative project aims to uncover the logic of signal routing from subcortical areas to the frontal cortex\nthrough the thalamus."},{"title":"The Disadvantage Exposome as a Driver of Alzheimer\u2019s Disease Pathology","field_investigator":"Margo  Heston","field_institution":"University Of Wisconsin-Madison","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS130922-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610660\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610660\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"1 PROJECT SUMMARY\n 2 Alzheimer\u0027s disease (AD) is the most common form of dementia worldwide, incurring a projected healthcare\n 3 burden of $1 trillion in the United States alone by 2060."},{"title":"The Heart and the Mind: An Integrative Approach to Brain-Body Interactions in the Zebrafish","field_investigator":"Florian  Engert, Mark C Fishman, Adrienne L Fairhall, Jeff W Lichtman, Joshua T Vogelstein","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"2U19NS104653-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10525427\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10525427\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The heart and the mind: an integrative approach to brain-body interactions in the\nzebrafish\nOur current U19 has focused primarily on Exteroception, which can be defined as the accumulated sensory experience\noriginating from events in the outside world."},{"title":"Tools for gene editing in marmosets","field_investigator":"Richard L Huganir, Christopher A Ross, James H. Segars, Xiaoqin  Wang","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-21-006","field_project_number":"1U01DA056556-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10508541\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10508541\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Tools for Gene Editing in Marmosets\nSUMMARY\n The goal of this proposal is to create an efficient new set of tools and techniques for the generation of\ngenetically modified marmosets suitable for use as models of brain physiology and function."},{"title":"Understanding how cortex supports flexible sensory representations","field_investigator":"Katherine Charlotte Wood","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DC019504-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10448054\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10448054\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nLearning is a fundamental function of the brain: sensory representations must be flexible to adjust to changes in\nenvironmental demands and experience, thus allowing us to adapt to the world around us."},{"title":"Virtual observatory of the cortex: organelles, cells, circuits, and dynamics","field_investigator":"Forrest Christie Collman, Nuno  Macarico Da Costa, R Clay Reid, Hyunjune Sebastian Seung","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120053-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10440183\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10440183\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"We propose to create VOrtex, a Virtual Observatory for the Cortex: Spanning the Scales of Organelles, Cells,\nCircuits, and Dynamics."},{"title":"Wearable RF-EEG Cap for closed loopTMS\/fMRI\/EEG Applications","field_investigator":"Lucia Isabel Navarro De Lara","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EB032749-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10520726\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10520726\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nFunctional MRI (fMRI) is the prevailing method for both basic research and clinical functional neuroimaging in\nhumans."},{"title":"A community-driven development of the brain imaging data standard (BIDS) to describe macroscopic brain connections","field_investigator":"Franco  Pestilli","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-128","field_project_number":"1R01MH126699-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10253558\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10253558\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\n The Brain Imaging Data Structure (BIDS) is a BRAIN initiative (R24 MH114705)\ncommunity-driven standard meant to maximize neuroimaging data sharing, and facilitate analysis tool\ndevelopment."},{"title":"A Computational Framework for Distributed Registration of Massive Neuroscience Images","field_investigator":"Matthew  Mccormick","field_institution":"Kitware, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH126732-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10259930\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10259930\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nNeuroscience stands at the precipice of a new depth of understanding about how the brain works thanks to recent\nadvances in imaging data acquisition technologies such as light-sheet \ufb02uorescence microscopy (LSFM)."},{"title":"A Genetic Engineering Toolbox for Marmosets (GETMarm): Development and optimization of genome editing and assisted reproduction techniques for marmoset models","field_investigator":"Guoping  Feng","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-21-006","field_project_number":"1U01DA054181-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10286437\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10286437\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\n While mice are essential models for many areas of neuroscience, there are also many aspects of\nhigher brain function and dysfunction that cannot be adequately modeled in rodents. Thus, there is a need for\nnew genetic models that have brain structure and function closer to humans."},{"title":"A harmonized vendor-agnostic environment for multi-site functional MRI studies","field_investigator":"Jon-Fredrik  Nielsen, Maxim  Zaitsev","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120056-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10306940\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10306940\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Since its invention in the early 90s, functional magnetic resonance imaging (fMRI) has revolutionized our un-\nderstanding of the human brain. Functional MRI may be used to observe brain function during a speci\ufb01c motor\nor cognitive task, or at \u201crest\u201d (resting-state fMRI)."},{"title":"A web-based framework for multi-modal visualization and annotation of neuroanatomical data","field_investigator":"David  Kleinfeld, Samuel Sheng-Hung Wang","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH128776-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10365435\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10365435\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\/ABSTRACT\nModern experimental approaches allow researchers to collect a variety of whole-brain data from the same animal\nvia different anatomical labels, including tracers, genetic markers, and fiducial marks from recording electrodes.\nUnfortunately, viewing and analysis methods have "},{"title":"Acute Modulation of Stereotyped High Frequency Oscillations with a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy","field_investigator":"Nuri Firat Ince","field_institution":"University Of Houston","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS117944-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10290984\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10290984\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary:\nHigh frequency oscillations (HFOs) of intracranial EEG (iEEG) have the potential to identify the surgical resection\narea\/seizure onset zone (SOZ) in patients with drug resistant epilepsy."},{"title":"Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format","field_investigator":"Anton  Arkhipov, Emad  Tajkhorshid","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124001-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10306896\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10306896\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format\nOne of the major goals of the BRAIN Initiative is to distill complex, multi-modal data into predictive frameworks\nvia theory\/modeling."},{"title":"Advancing brain health research through male germline editing in marmosets","field_investigator":"Brian Peter Hermann, Jenny  Hsieh, John R Mccarrey, Christopher  Navara","field_institution":"University Of Texas San Antonio","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-21-006","field_project_number":"1U01DA054170-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10285904\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10285904\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\/ABSTRACT\nNeuropsychiatric disorders represent a leading cause of disability, affecting nearly 19% of the US population.\nOnly 9% of neuropsychiatric drugs entering clinical trials reach the market, which is one of the lowest success\nrates across all therapeutic areas."},{"title":"Advancing Standardization of Neurophysiology Data Through Dissemination of NWB","field_investigator":"Benjamin K Dichter, Oliver  Ruebel","field_institution":"University Of Calif-Lawrenc Berkeley Lab","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120057-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10116139\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10116139\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nLack of standards for neurophysiology data and related metadata is the single greatest impediment to fully\nextracting return on investment from neurophysiology experiments."},{"title":"An Alignment Framework For Mapping Brain Dynamics and Substrates of Human Cognition Across Species","field_investigator":"Ting  Xu","field_institution":"Child Mind Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH128696-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10360863\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10360863\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nThe non-human primate (NHP) model is critical to the advancement of translational neuroscience, as it allows\nresearchers to link observations regarding macroscale brain dynamics and cognition in the human to underlying\nmeso- and microscale phenomena that cannot be fully investigated in huma"},{"title":"Anticipating ethical challenges and disparities in the dissemination of novel neurotechnologies","field_investigator":"Winston  Chiong, Daniel P. Dohan","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1R01MH126997-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10283140\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10283140\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"PROJECT SUMMARY\/ABSTRACT\nA central goal for the second half of the BRAIN Initiative is to develop new circuit-based treatments for\nbrain diseases."},{"title":"Behavioral Analysis and Modeling Core","field_investigator":"Jonathan William Pillow","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS123716-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294672\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294672\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\/Abstract, Core D: Behavioral Analysis and Modeling\nThis proposal\u2019s overarching goal is to understand how internal states influence decisions and to identify the\nunderlying neural mechanisms."},{"title":"Big-Data Electron-microscopy for Novel Community Hypotheses: Measuring And Retrieving Knowledge (BENCHMARK)","field_investigator":"William R Gray Roncal","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-128","field_project_number":"1R01MH126684-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10252257\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10252257\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nIn an effort to better understand structural organization and anatomy of nervous systems at\nunprecedented spatial resolution, recent efforts, including BRAIN Initiative funded projects, have\ncollected increasingly larger datasets using Electron Microscopy (EM) and X-Ray\nMicrotomograp"},{"title":"BRAIN Initiative: Assessing development of event-related cortical network dynamics","field_investigator":"Scott  Makeig, Michael Peter Milham, Arnaud  Delorme","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125934-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10190670\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10190670\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe Child Mind Institute\u2019s Healthy Brain Network (HBN) is an ongoing initiative focused on creating and\nsharing a biobank of brain and behavioral data now being collected from 10,000 New York City area children\nand adolescents (ages 5-21)."},{"title":"BRAIN Viral Vector Services and Distribution Core","field_investigator":"Kimberly  Ritola","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124025-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10308224\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10308224\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The BRAIN Viral Vector Service and Distribution Core will serve as a resource for the maintenance,\npropagation, and distribution of viral vectors that are used by neuroscientists for neural circuit\nidentification and manipulation, as well as for preclinical translational studies."},{"title":"BRAINShare: Sharing Data in BRAIN Initiative Studies","field_investigator":"Amy L Mcguire, Sameer Anil Sheth","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1R01MH126937-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10281874\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10281874\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"PROJECT SUMMARY\nData sharing is essential to promote equity and maximize the impact of the significant investment in the BRAIN\nInitiative."},{"title":"Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment","field_investigator":"Anton  Arkhipov, Li-Huei  Tsai","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS122742-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10275301\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10275301\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment\nPatterned sensory stimulation (PSS) is a non-invasive technique for manipulating brain activity and states,\ntypically employing periodic light flicker or auditory tones presented at regular intervals."},{"title":"Cellular and Neural Network Mechanism of Transcranial Electric Stimulation","field_investigator":"Dominique M Durand","field_institution":"Case Western Reserve University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS124592-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10338804\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10338804\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Unveiling mechanisms of neural stimulation technologies is an important goal of the Brain Initiative (RFA-NS-20-006)."},{"title":"Cellular Mechanisms of Transcranial Magnetic Stimulation in Cerebellar Cortex","field_investigator":"Padmavathi Sundaram Patel","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS112183-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10178967\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10178967\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract: Our goal is to develop a cellular level understanding of how transcranial magnetic stimulation (TMS)\nmay activate neurons in the human cerebellum (Cb) using (i) electrophysiological measurements in an in vitro\nturtle Cb, (ii) computational modeling of the induced electric (E) fields in the"},{"title":"Characterization of in vivo neuronal and inter-neuronal responses to transcranial focused ultrasound","field_investigator":"Bin  He","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS124564-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10337754\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10337754\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Non-invasive neuromodulation approaches have been developed to enable the modulation of neural tissue without necessitating invasive surgical procedures."},{"title":"Circuit and Cognitive Mechanisms of Striatal Deep Brain Stimulation","field_investigator":"Alik S Widge","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS120851-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10339086\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10339086\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Neurostimulation, including invasive methods like deep brain stimulation (DBS), is an increasingly important approach to treating mental illness. It offers the possibility of directly targeting the circuit dysfunctions that produce mental disorders."},{"title":"Combined Mechanistic and Input-Output Modeling of the Hippocampus During Spatial Navigation","field_investigator":"Dong  Song","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055665-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263699\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263699\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT ABSTRACT\nLarge-scale realistic model of neuronal network is a powerful tool for studying neural dynamics and cognitive\nfunctions. It integrates multi-scale neurobiological mechanisms\/processes identified through diverse hypotheses\nand experimental data into a single platform."},{"title":"Connecting late-life depression and cognition with statistical physics based connectomics and sparse Frechet regression","field_investigator":"Alex  Leow, Yichao  Wu, Liang  Zhan","field_institution":"University Of Illinois At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125928-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10190424\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10190424\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Recently, several lines of evidence have supported that synaptic dysfunction represents one of\nthe earliest brain changes in Alzheimer\u2019s disease (AD), leading to hyper-excitation in neuronal\ncircuits."},{"title":"Control of the time course of dopamine release through optimized electrical brain stimulation.","field_investigator":"Stephen Leigh Cowen, Michael L Heien, Timothy  Lewis","field_institution":"University Of Arizona","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS123424-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10285860\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10285860\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nElectrical stimulation of deep brain structures is an essential tool for the causal investigation of neural systems\nthat regulate learning and decision making."},{"title":"Converting Value into Action: Computations in Corticostriatal Circuits for Flexible Decision Making","field_investigator":"Linda  Amarante","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127780-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10314166\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10314166\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nTo flexibly execute behavior, choices are made based on previous outcomes that will maximize reward.\nCrucially, learning the value of each action to obtain a reward is thought to drive this decision making process.\nIn a value-based decision making framework, these values are first co"},{"title":"Correlating molecular behavioral phenotypes in a marmoset model of Huntingtons disease","field_investigator":"Ali H Brivanlou","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-21-006","field_project_number":"1U01DA054182-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10287090\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10287090\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\nThe common marmoset provides a very relevant primate model for understanding the organization of the human\nnervous system and the diseases that affect it."},{"title":"CRCNS: A mechanistic theory of serotonergic modulation of cortical processing","field_investigator":"Luca Mazzucato, Cristopher M Niell","field_institution":"University of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01DA055439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396147\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396147\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ESerotonergic neuromodulation is a crucial factor in regulating several aspects of brain function, from mood disorders to appetite, reward and motivation, and in maintaining balance of sensory perception. However, the network mechanisms by which it modulates brain dynamics are elusive.\u003C\/p\u003E"},{"title":"CRCNS: Computational Modeling of Microvascular Effects in Cortical Laminar fMRI","field_investigator":"Jonathan Rizzo Polimeni","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01EB032746-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10398277\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10398277\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EToday, the most widespread tool for measuring whole-brain activity noninvasively is functional magnetic resonance imaging (fMRI).\u003C\/p\u003E"},{"title":"CRCNS: Computational principles of mental simulation in the entorhinal and parietal cortex","field_investigator":"Mehrdad Jazayeri, Ila R. Fiete","field_institution":"Massachusetts Institute of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01MH129046-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396142\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396142\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EHumans make rich inferences about the relationships between entities in the world from scarce information. For example, we can find a novel destination after seeing a few street numbers, or find a page in a dictionary by glancing at a few words in other pages.\u003C\/p\u003E"},{"title":"CRCNS: Crossbeam Transcranial Ultrasound Technology to Stimulate the Deep Brain","field_investigator":"Kim Butts-Pauly","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01EB032743-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10397709\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10397709\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ENumerous neuroscience and clinical applications exist for a noninvasive neuromodulation technology that can reach deep in the brain with high resolution. One compelling clinical application is the treatment of drug addiction, a major public health challenge in the US.\u003C\/p\u003E"},{"title":"CRCNS: Diverse effects of GABAergic inputs on a basal ganglia output center","field_investigator":"Jonathan E. Rubin, Aryn hilary Gittis","field_institution":"University of Pittsburgh at Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01NS125814-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10395793\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10395793\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThe basal ganglia are a collection of subcortical nuclei studied for their contributions to movement, action selection, habit formation, and reward learning as well as their dysfunction in movement disorders.\u003C\/p\u003E"},{"title":"CRCNS: Functional Brain Networks with Tensioned Stability for Optimal Processing","field_investigator":"Paul Laurienti, Erik Bollt","field_institution":"Wake Forest University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01AA029926-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10395742\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10395742\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EUnderstanding the brain processes underlying alcohol use and misuse are essential for the development of effective treatments for alcohol use disorder or AUD. Human brain imaging has greatly contributed to our current understanding of AUD, but much more remains to be understood.\u003C\/p\u003E"},{"title":"CRCNS: Integrating gray and white matter data to understand the organization of human visual cortex","field_investigator":"Jonathan A Winawer, Noah C Benson","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01EY033628-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396141\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396141\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Multimodal Dynamic Causal Learning for Neuroimaging","field_investigator":"Sergey Plis","field_institution":"Georgia State University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01MH129047-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396137\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396137\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ECRCNS Research Proposal: Collaborative Research: Multimodal Dynamic Causal Learning for Neuroimaging A Project Description A.1 Introduction Many analyses of fMRI and other neuroimaging data aim to discover the underlying causal or commu- nication structures that generated that activity.1,2 An acc\u003C\/p\u003E"},{"title":"CRCNS: Multiple clocks for the encoding of time in corticostriatal circuits","field_investigator":"Sotiris Masmanidis, Dean V Buonomano","field_institution":"University of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01NS125877-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396146\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396146\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThe ability to predict when external events will occur, such as anticipating the actions of a predator or the availability of food, is critical for survival.\u003C\/p\u003E"},{"title":"CRCNS: Multiple Time Scale Memory Consolidation in Neural Networks","field_investigator":"Alex D Reyes, Stefano Fusi","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01MH129031-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10395852\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10395852\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EDetailed description of the proposed use of the animals, including species, strains, ages, sex, and number to be used; Dissociated, primary cultures will be prepared from the cortex of new born mice of either sex (mus musculus, Postnatal day 0-1).\u003C\/p\u003E"},{"title":"CRCNS: Regulation of assembly and disassembly of the postsynaptic density during synaptic plasticity and its effect on AMPAR trapping","field_investigator":"Terrence J Sejnowski, Mary B Kennedy","field_institution":"Salk Institute for Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01MH129066-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10397182\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10397182\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EFast glutamatergic synaptic transmission is based on a precise and complex molecular organization which requires the control of the number of AMPA-type glutamate receptors (AMPARs) at the postsynaptic sites of glutamatergic synapses on dendritic spines.\u003C\/p\u003E"},{"title":"CRCNS: Resolving human face perception with novel MEG source localization methods","field_investigator":"Dimitrios Pantazis","field_institution":"Massachusetts Institute of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01EY033638-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10397180\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10397180\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EA brief glimpse at a face quickly reveals rich multi-dimensional information about the person in front of us. How is this impressive computational feat accomplished? A recently revised neural framework for face processing suggests perception of face form information, i.e.\u003C\/p\u003E"},{"title":"CRCNS: The Role of Statistical Structure for Natural Sound Recognition in Noise","field_investigator":"Monty A Escabi","field_institution":"University of Connecticut Storrs","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01DC020097-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396135\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396135\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThe ability to listen and identify sounds in the presence of competing background noise is a critical function of the healthy auditory system.\u003C\/p\u003E"},{"title":"Defining motor neuron diversity from embryo to adulthood and generating tools for in vivo and in vitro access","field_investigator":"Tulsi  Patel","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS121136-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10369830\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10369830\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\n In order to understand neurological diseases, it is essential to identify the affected neuronal cell types,\ncreate model systems that accurately recapitulate normal function and disease phenotypes, and develop tools\nthat allow cellular manipulations."},{"title":"Defining Targets for Tic Detection and Suppression in Tourette Syndrome Deep Brain Stimulation","field_investigator":"Christopher R Butson, Aysegul  Gunduz, Michael S Okun","field_institution":"University Of Florida","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS119844-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10290544\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10290544\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nTourette syndrome (TS) is a continuous lifelong condition that is highly prevalent, socially disabling, and in some severe\ncases, physically injurious."},{"title":"Discovering the molecular genetic principles of cell type organization through neurobiology-guided computational analysis of single cell multi-omics data sets","field_investigator":"Z Josh Huang","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125921-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10189902\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10189902\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nUnderstanding the biological principles of cell type diversity and organization is necessary for deciphering\nneural circuits underlying brain function."},{"title":"Disentangling hippocampal and cortical contributions to episodic memory","field_investigator":"Alexa  Tompary","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH126427-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10188803\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10188803\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThis application describes a 5-year plan to investigate the neural dynamics that underpin distortion in memory,\nintegrating computational modeling approaches with functional neuroimaging (fMRI) and non-invasive brain\nstimulation techniques (TMS)."},{"title":"Dissecting neocortical field potential dynamics using optical voltage imaging in genetically targeted cell-types","field_investigator":"Mark J Schnitzer, Ivan  Soltesz","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS124590-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10338619\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10338619\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Measurements of cortical field potentials are widely used throughout basic and clinical neuroscience, including in electroencephalography (EEG), electrocorticography (ECoG) and local field potential (LFP) recordings."},{"title":"Dissecting the role of neuronal-astroglial interactions in sleep homeostasis","field_investigator":"Ashley Miranda Ingiosi","field_institution":"Washington State University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS119293-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10299917\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10299917\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nInsufficient sleep, sleep disorders, and resulting problems with health and cognition are increasingly common\nin the United States."},{"title":"Enhancing the spatial control of non-invasive brain stimulation by magnetic temporal interference","field_investigator":"John Gustaf Wilhelm Samuelsson ","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127789-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316652\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316652\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nElectromagnetic brain stimulation is a safe and proven way of controlling neural activity non-invasively with no\nimplanted hardware or injected biochemical agents."},{"title":"Ethical and Policy Aspects of Cortical Visual Prosthetics Research: An Empirical Neuroethics Study","field_investigator":"Peter David Zuk","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"7F32MH127776-02","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10507898\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10507898\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nBrain-computer interfaces (BCIs) have emerged as a promising modality for restoring physiological functions\nsuch as mobility, communication, and visual perception."},{"title":"fMRI physiological signatures of aging and Alzheimer\u0026#039;s Disease","field_investigator":"Catherine Elizabeth Chang","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125931-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10361105\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10361105\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\/ABSTRACT\nThe growing availability of large functional magnetic resonance imaging (fMRI) datasets has enabled new\ninvestigations into functional systems of the human brain."},{"title":"From diverse dynamics to diverse computation via neural cell types","field_investigator":"Stefan  Mihalas, Eric Todd Shea-Brown","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055669-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263658\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263658\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nA prominent feature of biological neuronal networks is the astonishing diversity of their cell types."},{"title":"From synapses to genes through morphology: an integrated characterization of cell types based on connectomics and transcriptomics data","field_investigator":"Forrest Christie Collman, Nuno  Macarico Da Costa, R Clay Reid","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125932-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10360840\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10360840\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe goal of this project is to create a unified framework for understanding the relationship between\nneuronal gene expression and connectivity in mouse visual cortex, by using morphology as a key\nlinking modality."},{"title":"Harmonizing and Archiving of Large-scale Infant Neuroimaging Data","field_investigator":"Gang  Li","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123202-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10189251\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10189251\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Abstract\nThe first postnatal years are an exceptionally dynamic and critical period of structural and functional development\nof the human brain. Many neurodevelopmental disorders are the consequence of abnormal brain development\nduring this stage."},{"title":"Heritability and cognitive implications of structural-functional connectome coupling","field_investigator":"Amy  Kuceyeski","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123232-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10189014\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10189014\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The human brain is an unimaginably complicated system of interconnected neurons that is capable of complex\nthought, emotion and behavior."},{"title":"Imaging Dynamics in Anxiogenic Serotonin Circuitry","field_investigator":"Emily Clarissa Wright","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH125597-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316027\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316027\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nSerotonin has been long been recognized as an important modulator of mood and behavior, yet it projection-\nspecific dynamics are little understood."},{"title":"Integrative analysis of genomics and imaging data from the BRAIN Initiative and other public data sources","field_investigator":"Mark Bender Gerstein, Avram J Holmes","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123245-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10190025\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10190025\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Constructing an integrated picture of human brain function requires understanding how the effects of molecular\nand genetic factors propagate upwards, through many intervening layers of structure and interaction, to\ninfluence behavioral, psychiatric and cognitive traits."},{"title":"Integrative analysis of multiomic datasets for discovery of molecular underpinnings of large-scale human brain networks","field_investigator":"Mikail  Rubinov","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125933-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10361057\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10361057\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"SUMMARY\nBrain-mapping initiatives are acquiring increasingly large and comprehensive neuroimaging and multiomic\u2014\ne.g. genomic and transcriptomic\u2014datasets."},{"title":"Interrogating the propagation of electrical stimulation across scales in vivo","field_investigator":"Daniel James Denman","field_institution":"University Of Colorado Denver","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS120850-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10175648\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10175648\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nIntracranial electrical brain stimulation (EBS) remains a central method in the clinic as well as for research in\nseveral animal model systems. However, little is actually known about the ensembles of neurons activated by\ntypical and clinical intracranial EBS protocols."},{"title":"Investigating Functional Ependymal Cell Heterogeneity in the Ventricular System","field_investigator":"Stephanie  Redmond","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS121273-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10189131\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10189131\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract:\nGlial cells collectively outnumber neurons in the vertebrate brain, but mechanistic understanding of their\nmolecular subtypes and functions is lacking."},{"title":"Linking Fast Timescale Neuron-Astrocyte Communication to Neural Circuit Function and Behavior","field_investigator":"Axel  Nimmerjahn","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS123719-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294804\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294804\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary: Project 2 - Linking Fast Timescale Neuron-Astrocyte Communication to Neural\nCircuit Function and Behavior\nA fundamental yet unresolved question in neuroscience is how non-neuronal cells communicate with the\nsurrounding neurons, influence their function, and potentially affect animal"},{"title":"Long-range neuronal projections: circuit blueprint or stochastic targeting?  Rigorous classification of brain-wide axonal reconstructions","field_investigator":"Giorgio A Ascoli","field_institution":"George Mason University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH128693-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10360723\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10360723\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT (PROJECT SUMMARY)\nThe classification of neurons in the mammalian brain has long been a focus of intensive investigation in\nneuroscience."},{"title":"Map Manager: Longitudinal image analysis with online editing and sharing.","field_investigator":"Robert Harry Cudmore","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH123206-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10365810\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10365810\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The increasing availability and ease of use of confocal, two-photon, and light-sheet microscopes coupled with\nrapid developments in fluorescent protein reporters have made 3D and functional imaging and its analysis a\ncentral component of modern Neuroscience research."},{"title":"Mapping thalamo-striatal neuronal circuits underlying motivational drive","field_investigator":"Sofia Beas","field_institution":"National Institute of Mental Health ","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH126429-01","field_link":"","field_funded_status":"Active","field_grant_mechanism":"Training Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EMotivational drive is an adaptive process that helps individuals overcome obstacles to obtain essential needs and hence ensure survival. Motivation is composed of two major components.\u003C\/p\u003E"},{"title":"Mechanisms of basal forebrain control over sensory processing","field_investigator":"Elizabeth Hanson Moss","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DC019505-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10187890\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10187890\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nA key problem in neuroscience is understanding how internal and external information are integrated in the brain to produce\nsensory experiences, cognition, and behavioral responses."},{"title":"Molecular identity, cellular physiology, and in vivo functions of nucleus accumbens astrocytes","field_investigator":"Kay Elizabeth Linker","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH125598-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316907\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316907\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary \/ Abstract\n Astrocytes are pervasive throughout the CNS and are the most abundant non-neuronal cell type. They\nare an essential component of neural circuits, and increasing evidence demonstrates they are specialized for\nspecific brain regions."},{"title":"mRNA Alternative Splicing Regulatory Networks in the Specification of Cortical Interneuron Subtypes","field_investigator":"Melissa Mckenzie Campbell","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH126430-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10188959\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10188959\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nAlternative splicing of pre-mRNAs is extensively employed by the nervous system to expand the transcriptomic\nmanifold."},{"title":"Multi-feature, Multi-scale Atlas","field_investigator":"Paul S Katz","field_institution":"University Of Massachusetts Amherst","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U01NS123972-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10302203\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10302203\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"SUMMARY \/ ABSTRACT \u2013 Project 1. Multi-feature, Multi-scale Atlas\nProject 1 of the Berghia Brain Project is to create a multi-scale, multi-feature atlas of the Berghia brain and\nperipheral neural plexus."},{"title":"Multiscale computational frameworks for integrating large-scale cortical dynamics, connectivity, and behavior","field_investigator":"Tatiana  Engel","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055666-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263628\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263628\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\nA central problem in neuroscience is to understand how activity arises from neural circuits to drive animal\nbehaviors. Solving this problem requires integrating information from multiple experimental modalities and\norganization levels of the nervous system."},{"title":"Multiscale theory of synapse function with model reduction by machine learning","field_investigator":"Eric D Mjolsness","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055668-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263653\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263653\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\n This project constructs a unifying model that links synaptic morphodynamics, the fundamental process of\nlearning and memory in the brain, to the underlying molecular signaling pathways that regulate it."},{"title":"NABOR: A Sustainable, High-quality Neuroscience Antibody Open Resource","field_investigator":"Melina  Fan","field_institution":"Addgene, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS119916-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10114049\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10114049\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nThe goal of this project is to build an open-access recombinant antibody\/affinity reagent resource for the\nneuroscience community called NABOR (Neuroscience AntiBody Open Resource)."},{"title":"National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination Resource","field_investigator":"Mark H Ellisman","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120055-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10116087\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10116087\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"PROJECT SUMMARY\/ABSTRACT\nThis project aims to disseminate validated technologies and resources of the National Center for Microscopy\nand Imaging Research (NCMIR) at UC San Diego to advance the completion of strategic goals of the BRAIN\nInitiative."},{"title":"Neural dynamics of somatosensory guidance of dexterous movement in intact and stroke-injured networks","field_investigator":"Preeya  Khanna","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS124748-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10349317\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10349317\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\n Stroke-causing illness, disability, and early death is set to double worldwide within the next 15 years."},{"title":"Neural mechanisms of multisensory auditory-olfactory integration in the auditory cortex","field_investigator":"Nathan  Vogler","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127788-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316690\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316690\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nLiving organisms interact with complex environments that are inherently multisensory. Within these\nenvironments, the brain must integrate information from multiple sensory modalities, including the auditory and\nolfactory systems, for perception and behavior."},{"title":"Neural Mechanisms of Transcranial Current Stimulation","field_investigator":"Bart  Krekelberg, Pierre- Olivier  Polack","field_institution":"Rutgers The State Univ Of Nj Newark","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS120289-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10274328\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10274328\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nTranscranial current stimulation (TCS) creates small electrical fields in the brain through electrodes placed on\nthe scalp."},{"title":"NeuroJSON - A Scalable, Searchable and Verifiable Neuroimaging Data Platform","field_investigator":"Qianqian  Fang","field_institution":"Northeastern University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124027-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10308329\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10308329\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Traditional file-based neuroimaging data management and integration strategies have shown\nincreasing limitations in accommodating the meteoric growth in both the scale and complexity of today\u2019s\nneuroimaging data."},{"title":"NIPreps: integrating neuroimaging preprocessing workflows across modalities, populations, and species","field_investigator":"Oscar  Esteban, Michael Peter Milham, Russell A Poldrack, Ariel Shalom Rokem, Theodore  Satterthwaite","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH121867-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10260312\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10260312\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nDespite the rapid advances in the neuroimaging research workflow over the last decade, the enormous\nvariability between and within data types and specimens impedes integrated analyses."},{"title":"OpenScope: A Platform for High-Throughput and Reproducible Neurophysiology Open to External Scientists to Test Impactful Theories of Brain Function","field_investigator":"Christof  Koch, Jerome Anthony-Jean Lecoq","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS113646-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9967446\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9967446\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Project summary\nOver the past five years, the Allen Institute has built two unique in-house pipelines for in vivo electro- and\noptical-physiology: together they form the Allen Brain Observatory."},{"title":"Project 2","field_investigator":"Anna  Devor","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS123717-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294713\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294713\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nWe propose to investigate the role of neuromodulation in the phenomenon of \u201cwhole-cortex\u201d activity of\nthe pial neurovascular circuit."},{"title":"Redefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine Learning","field_investigator":"Peter V. Kochunov, Paul M Thompson","field_institution":"University Of Maryland Baltimore","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123163-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10186960\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10186960\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Abstract\nThis application will combine the strengths of two large scale NIH-funded initiatives to understand disorder-\nrelated patterns in the human brain: Connectomes Related to Human Disease (CRHD) and Enhancing\nNeuroimaging Genetics through Meta-Analysis (ENIGMA)."},{"title":"Resolving Spatiotemporal Determinants of Cell Specification in Corticogenesis with Latent Space Methods","field_investigator":"Genevieve Lauren Stein-O\u0026#039;brien","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS122085-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10188106\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10188106\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nHigh-throughput profiling of hundreds of thousands of cells in the central nervous system (CNS) is currently\nunderway."},{"title":"Resource Core 3 - Teaching\/Training\/Dissemination Core (TTDC)","field_investigator":"Maisie Ky Lo","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS118284-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10047731\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10047731\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Resource Core 3 - Teaching\/Training\/Dissemination Core (TTDC)\n Leads: Maisie Lo PhD and Kristin Overton PhD\nSummary\n The TTDC\u2019s teaching mission specifically leverages our educational infrastructure for advancing the\napplication of modern neurotechnology methods in short (3-day) or extended-format ("},{"title":"Robust modeling of within- and across-area population dynamics using recurrent neural networks","field_investigator":"Lee  Miller, Chethan  Pandarinath","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055667-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263644\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263644\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Over the past several decades, the ability to record from large populations of neurons (e.g., multi-electrode\narrays, neuropixels, calcium imaging) has increased exponentially, promising new avenues for understanding\nthe brain."},{"title":"Scalable tools for consistent identification of neuronal cell types in mouse and human","field_investigator":"Staci A Sorensen, Uygar  Sumbul","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH128778-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10365216\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10365216\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe proposed work will address a critical gap in our understanding of neuronal phenotypes and cell types by\ndeveloping machine learning algorithms and cloud-based software for the integration of multiple modality\ncharacterizations large and growing datasets of cortical neurons in mou"},{"title":"Secondary analysis of functional MRI and resting state connectivity in white matter","field_investigator":"John C Gore, Bennett A. Landman","field_institution":"Vanderbilt University Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123201-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10190338\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10190338\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Abstract \/ Summary\nThis proposal aims to perform novel, secondary analyses on large archives of publicly-available fMRI\nstudies in order to quantify the functional characteristics of white matter (WM) and their changes during\nnormal aging and in the progression to Alzheimer\u2019s Disease (AD)."},{"title":"Sex hormone regulation of Lateral Habenula circuitry for reward and aversion encoding","field_investigator":"Brandy A. Briones","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127772-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10313129\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10313129\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n This proposal seeks to investigate sex hormone effects on reward and aversion-related behaviors through\nmapping of Lateral Habenula (LHb) circuits."},{"title":"Stimulation of novel spinal respiratory circuit to restore breathing in ventilator-dependent patients with SCI.","field_investigator":"Daniel  Lu","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS119772-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10112480\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10112480\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nRespiratory failure after spinal cord injury (SCI) impairs the health of the injured patients, and respiratory failure\nis the leading cause of death in patients with SCI."},{"title":"Structure and function of spontaneous network activity during circuit formation","field_investigator":"Arnaldo  Carreira-Rosario","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS119295-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10103918\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10103918\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nTowards the end of nervous system development, neural circuits are extremely plastic. Small perturbations\nduring this time can cause lifelong circuit and behavioral changes."},{"title":"Thalamocortical Responsive Neurostimulation for the Treatment of Lennox-Gastaut Syndrome","field_investigator":"Martha J Morrell","field_institution":"Neuropace, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS109557-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9958791\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9958791\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary \/ Abstract\n Lennox-Gastaut Syndrome (LGS) is a devastating form of childhood onset epilepsy with cognitive\ndysfunction and very frequent generalized onset seizures (GOS) often leading to injury."},{"title":"The representation and modulation of sensory information in the learning and memory center of the Drosophila brain","field_investigator":"Andrew M Davidson","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH125582-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10314793\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10314793\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The brain uses the combined physiology of many cells to transform incoming sensory signals into internal\nrepresentations."},{"title":"The role of astrocyte-neuron signaling in closing a critical period required for motor circuit structure, function, and behavior","field_investigator":"Sarah D Ackerman","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS121137-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10188928\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10188928\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nSignificance: Neural circuit assembly requires activity-dependent refinement of circuit architecture (e.g.\nplasticity) to produce stereotyped behavior."},{"title":"Toward functional molecular neuroimaging using vasoactive probes in human subjects","field_investigator":"Alan  Jasanoff","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB031641-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10253338\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10253338\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"We propose to develop a probe technology for monitoring human brain function with molecular precision;\nin conjunction with magnetic resonance imaging (MRI) or other imaging modalities, the probes will provide a\ncombination of sensitivity and resolution that could permit unprecedented noninvasive stu"},{"title":"Understanding the regulation of neuron cell number and arbor size","field_investigator":"Jennifer A Malin","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY032269-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10104237\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10104237\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nHow the brain generates the correct number of neurons and how these neurons determine the size of their\narbors to innervate the receptor field is a critical question in neurobiology."},{"title":"Use of advanced analytics to understand brain-behavior screen media activity relationships in ABCD data","field_investigator":"Marc N Potenza, Yihong  Zhao","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH128614-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10358692\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10358692\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\nGrowing up in a media-saturated world, the current generation of children and adolescents spend on average 6-\n9 hours each day on screen media activities (SMAs). Therefore, SMA is a topic of considerable concern in the\nUSA and elsewhere."},{"title":"Using large scale electrophysiology to study the role of midbrain dopamine neurons underlying motivated behaviors","field_investigator":"Kurt M Fraser","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127792-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316450\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316450\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nA core feature of a number of psychiatric illnesses is the disordered estimation of the predictive relationship\nbetween a given cue and an outcome. This failure to appraise and generate appropriate behavioral responses\nis true for cues that both are rewarding and aversive."},{"title":"Waking up the nervous system: Molecular characterization of neuronal leader cells and their role in brain development","field_investigator":"Nicole Ann Aponte-Santiago","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127777-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10315708\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10315708\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nLearning how spontaneous neuronal activity shapes embryonic brain development is critical for understanding\nneurodevelopmental processes, with implications in neurological or neuropsychiatric disorders."},{"title":"4D Transcranial Acoustoelectric Imaging for High Resolution Functional Mapping of Neuronal Currents","field_investigator":"Russell S Witte","field_institution":"University Of Arizona","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB029834-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007275\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007275\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"ABSTRACT\nThe overarching goal of this project is to optimize, validate and implement a revolutionary and safe modality\nfor noninvasive functional imaging of neural currents deep in the human brain through the skull at\nunprecedented spatial and temporal resolution."},{"title":"A Community Framework for Data-driven Brain Transcriptomic Cell Type Definition, Ontology, and Nomenclature","field_investigator":"Michael  Hawrylycz, Ed  Lein, Christopher J Mungall, Helen Elizabeth Parkinson, Richard H Scheuermann","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-146","field_project_number":"1RF1MH123220-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012886\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012886\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary: A Data-driven Framework for Brain Transcriptomic Cell Type Definition, Ontology, and\nNomenclature\nDefining the complete census of neuronal and non-neuronal cell types in the brain is a major priority for the NIH BRAIN\nInitiative, since cellular complexity is a major barrier to under"},{"title":"A Comparative Framework for Modeling the Low-Dimensional Geometry of Neural Population States","field_investigator":"Eva  Dyer","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB029852-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007243\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007243\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nAdvances in neural recording technology now provide access to neural activity at high temporal resolutions, from\nmany brain areas, and during complex and naturalistic behavior."},{"title":"A new theory of population coding in the cerebellum","field_investigator":"Reza  Shadmehr","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028156-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10005617\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10005617\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"A theory of population coding in the cerebellum\nIn order to move accurately, the brain relies on internal models that predict the sensory consequences of motor\ncommands."},{"title":"Accelerating Dissemination of Implantable Neurotechnology for Clinical Research","field_investigator":"David Allenson Borton, Timothy  Denison, Philip Andrew Starr, Gregory A Worrell","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS113637-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9967390\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9967390\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Summary\nInvasive neurostimulation is an established technique in the therapy of movement disorders and epilepsy, and\nshows promise for amelioration of psychiatric and cognitive disorders."},{"title":"Activity-dependent mechanisms for memory circuit maturation.","field_investigator":"Sarah  Leinwand","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99DC018779-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9952093\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9952093\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nAdult behavior is the product of neural circuits that have been sculpted during development by\ngenetic programs and experience in the form of neural activity."},{"title":"Adaptive Neurostimulation to Restore Sleep in Parkinson\u0026#039;s Disease: An Investigation of STN LFP Biomarkers In Sleep Dysregulation and Repair","field_investigator":"Aviva  Abosch, Casey Harrison Halpern, Clete A Kushida, John A Thompson","field_institution":"University Of Nebraska Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS113769-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9960743\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9960743\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nParkinson\u2019s disease (PD) is a neurodegenerative disorder that leads to both motor and non-motor symptoms.\nWhile there is as yet no cure for PD, medical and surgical therapies have been developed that effectively target\nthe motor symptoms of PD."},{"title":"An Ethical Approach to Detecting Covert Consciousness","field_investigator":"Michael J Young","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123001-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9990274\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9990274\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nAlarming shortcomings of the bedside behavioral examination in reliably detecting consciousness generate\nprofound dilemmas for clinicians and families facing decisions about continuation of life-sustaining therapy, pain\ncontrol, prognostication, and resource allocation in patients wi"},{"title":"Application of the principle of symmetry to neural circuitry: From building blocks to neural synchronization in the connectome","field_investigator":"Hernan  Makse, Manuel  Zimmer","field_institution":"City College Of New York","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028157-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10006982\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10006982\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\n The broad, long-term objective of this grant is to advance a new theoretical approach to identify\nsynchronized building blocks of neural circuits based on group theory and its application to understand the\npermutation symmetries of these circuits."},{"title":"Bidirectional Interactions of Cortex and Basal Ganglia During Action Selection","field_investigator":"Allison Elizabeth Girasole","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125596-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10156658\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10156658\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nSelecting future actions based on previous experiences is key to an animal\u0027s survival. This process, known as\naction selection, depends on the proper function of cortical and subcortical basal ganglia circuits."},{"title":"Biology and Biophysics of the Cortical Response to Transcranial Magnetic Stimulation","field_investigator":"Angel V Peterchev, Marc A Sommer","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS117405-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10031284\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10031284\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"The use of transcranial magnetic stimulation (TMS) as a therapeutic intervention is FDA-cleared for treating\ndepression, obsessive-compulsive disorder, and migraine, and shows promise for a host of other brain disorders.\nThe appeal of TMS is its safety, non-invasiveness, and well-established capacit"},{"title":"Biophysical modeling of the functional MRI signal through parametric variations in neuronal activation and blood vessel anatomy using realistic synthetic microvascular networks","field_investigator":"Grant  Hartung","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125599-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10156061\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10156061\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The most widespread tool for measuring brain activity noninvasively in humans is functional magnetic resonance\nimaging (fMRI), which typically tracks changes in blood flow and oxygenation using the blood-oxygenation-level-\ndependent (BOLD) signal."},{"title":"Characterizing the structure of motor cortex activity across multiple behaviors for improved brain-machine interfaces","field_investigator":"Karen Elizabeth Schroeder","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS115919-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9952827\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9952827\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Abstract. Candidate and career goals: I am an engineer by training, with a strong background in\nneural engineering and the development of motor brain-machine interfaces (BMIs). My career goal is to establish\nan independent nonhuman primate (NHP) laboratory with two primary aims."},{"title":"Circuit and cellular mechanisms underlying hierarchical recruitment of motor neurons.","field_investigator":"Brandon J Mark","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125443-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10137601\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10137601\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n A fundamentally important motor pattern for terrestrial animals is walking. Walking requires precise\ncontrol of large numbers of motor neurons."},{"title":"Cloud-based Software Framework to Simplify and Standardize Real-Time fMRI","field_investigator":"Jonathan D Cohen, Kenneth A Norman","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH125318-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10123207\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10123207\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary: (30 lines of text max)\n We propose to create an open-source cloud-based software system for real-time fMRI neurofeedback\nexperiments."},{"title":"Combined Topological and Machine Learning Tools for Neuroscience","field_investigator":"Michael  Hawrylycz, Partha Pratim Mitra, Yusu  Wang","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH125317-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10123310\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10123310\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Two major recent advances have raised the possibility of fundamental breakthroughs in both\nbasic and clinical neuroscience: the development of new tools to probe the nervous system with\nsingle-cell resolution as well as brain-wide scope, and breakthroughs in machine learning\nmethods for handling com"},{"title":"Connecting neural circuit architecture and experience-driven probabilistic computations","field_investigator":"Zachary Peter Kilpatrick","field_institution":"University Of Colorado","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB029847-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007281\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007281\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary: Organisms\u0027 actions and decisions are guided by experience. Models of such behavior often\nappeal to the formalism of probabilistic inference, in which expectations about the world build up sequentially\ndue to past observations."},{"title":"Context-dependent neural processing of leg proprioception in Drosophila","field_investigator":"Sweta  Agrawal","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS117657-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10039477\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10039477\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Proprioception is critical for effective motor control: dysfunctions of the proprioceptive system can impair\nbalance, motor coordination, and motor learning."},{"title":"Coupling between circadian rhythms and redox signaling in stem cell differentiation and adult neurogenesis","field_investigator":"Daniel Maxim Iascone","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125600-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10155930\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10155930\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nCircadian rhythms are necessary to coordinate the timing of key behavioral and physiological processes in\nmammals [1-3]."},{"title":"Cross-frequency coupling: its role in brain function and dysfunction","field_investigator":"Andrei V Medvedev","field_institution":"Georgetown University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123192-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10008042\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10008042\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Abstract\n One of the high priority research areas listed in the BRAIN 2025 Report is a better understanding of the\nbrain network dynamics across time and space from human electrophysiological recordings."},{"title":"Crossing space and time: uncovering the nonlinear dynamics of multimodal and multiscale brain activity","field_investigator":"Shella D Keilholz, Garrett B. Stanley","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB029857-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007011\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007011\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The brain is a complex dynamical system, with a hierarchy of spatial and temporal scales ranging from microns\nand milliseconds to centimeters and years. Activity at any given scale contributes to activity at the scales above\nit and can influence activity at smaller scales."},{"title":"Data Exploration and Analysis Portal for Brain Research through Advanced Imaging Neuroscience","field_investigator":"Chun Chieh  Fan, Wesley Kurt Thompson","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH120025-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10011169\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10011169\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nPopulation neuroscience requires investigation of brain-behavioral relationships within epidemiological\nsamples studied in longitudinal designs, including a large number of assessment modalities and with subjects\nenrolled at many data collection sites to achieve a large sample and br"},{"title":"DataJoint Pipelines for Neurophysiology","field_investigator":"Dimitri  Yatsenko","field_institution":"Vathes Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS116470-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9967639\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9967639\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The field of neuroscience and the BRAIN Initiative in particular are amassing a wealth of informatics resources for managing, analyzing, and sharing data."},{"title":"Decision-related information at single-neuron resolution in human motor cortex and its implications for neuroprosthetics","field_investigator":"Sharlene  Flesher","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-813","field_project_number":"1K99NS112412-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9977403\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9977403\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary \/ Abstract\nThe long-term goal of my research is to gain a holistic understanding of how movement commands are\ngenerated- including their relationship to sensory feedback and movement context- in order to restore movement\nto those who have lost it."},{"title":"Defining the role of a prefrontal-midbrain circuit in exploratory behavior","field_investigator":"Victoria L Corbit","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125546-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10146550\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10146550\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\nInvestigating how neural circuits mediate natural behavior is a critical to our understanding of the brain.\nExploratory behaviors are necessary for rodent survival in the natural world and ubiquitous in freely-moving\nrodent experiments."},{"title":"Development of the Human Dynamic Neurochemical Connectome Scanner","field_investigator":"Ciprian  Catana","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB029826-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007205\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007205\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary\nWe seek support to develop and build the next generation 7-Tesla magnetic resonance (MR)-compatible\npositron emission tomography (PET) brain scanner with dramatically improved spatiotemporal resolution\n(HSTR-BrainPET)."},{"title":"Dissecting the neural circuit for discrete cue representation in the Dentate Gyrus","field_investigator":"Sebnem Nur Tuncdemir","field_institution":"New York State Psychiatric Institute Dba Research Foundation For Mental Hygiene, Inc","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH122226-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10125693\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10125693\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The goal of this project is to provide the building blocks for an independent research program focused on\nthe mechanisms by which neural networks incorporate multisensory cues into episodic memories.\nDiscrimination of different contexts composed of distinct constellations of multisensory cues is a h"},{"title":"Dopamine neuronal microcircuits controlling methamphetamine seeking behavior","field_investigator":"Sergio  Dominguez Lopez","field_institution":"Oklahoma Medical Research Foundation","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99DA049719-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9977578\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9977578\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nThis proposal is being submitted to support the transition of Dr. Dominguez-Lopez from mentored trainee to\nan independent investigator in the neurobiology of drug addiction, specifically studying the dopamine\nmicrocircuits controlling drug-seeking behavior. Dr."},{"title":"Dynamic Striatal Astrocyte-Neuron Interactions: An Integrated Experimental and Computational Study","field_investigator":"Marsa  Taheri","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123010-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991579\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991579\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\n Astrocytes comprise up to half of mammalian brain cells."},{"title":"Elucidating electrical stimulation induced non-neuronal activity using emerging in vivo imaging technology and electrophysiology","field_investigator":"Takashi Daniel Yoshida Kozai","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS115707-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10132019\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10132019\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\n Electrical microstimulation has become a mainstay of fundamental neuroscience exploration and an\nincreasingly prevalent clinical therapy."},{"title":"Ethics of the Choice of Invasive versus Non-invasive Neurosurgery: Different Stakeholders\u0026#039; Perspectives, Surgical Decision-making, and Impact on Patient Sense of Control","field_investigator":"Cynthia M. S. Kubu","field_institution":"Cleveland Clinic Lerner Com-Cwru","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1RF1MH123407-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10026287\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10026287\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"ABSTRACT\nA fundamental ethical tenet in medicine is bodily sovereignty, inherent in which is the concept of\ncontrol."},{"title":"Genetic mechanisms specifying astrocyte functional diversity and their role in sleep","field_investigator":"Margaret  Ho","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS117654-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10039993\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10039993\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nAstrocytes are evolutionarily conserved and constitute a substantial proportion of the cells in the brain, yet our\nunderstanding of their identities and functions is far less comprehensive than for neurons."},{"title":"Graspy: A python package for rigorous statistical analysis of populations of attributed connectomes","field_investigator":"Carey  Priebe, Joshua T Vogelstein","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH123233-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012519\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012519\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\nOverview: We will extend and develop implementations of foundational methods for analyzing populations of\nattributed connectomes."},{"title":"Highly Portable and Cloud-Enabled Neuroimaging Research: Confronting Ethics Challenges in Field Research with New Populations","field_investigator":"Frances Patricia Lawrenz, Francis X Shen, Susan M. Wolf","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1RF1MH123698-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10035136\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10035136\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary \/ Abstract\n This 4-year Neuroethics R01 based at the University of Minnesota (UMN) will convene a national\nWorking Group of top neuroethics, neurolaw, and neuroscience experts to conduct empirical research and\ngenerate evidence-based consensus recommendations for the ethical conduct "},{"title":"Hormonal regulation of value-based decision-making","field_investigator":"Carla  Golden","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125448-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10140910\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10140910\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nIndividuals decide between alternatives based on their perceived value of the reward associated with each\noption."},{"title":"Identifying mediators of sex hormone uptake and signaling","field_investigator":"Nicole Yishi Leung","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125593-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10158076\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10158076\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nSex hormones are critical for sexual differentiation of the brain and body and diverse physiological processes\nacross our lifespan."},{"title":"Improving Brain Organoid Models by Mediating Metabolic Dysregulation","field_investigator":"Madeline  Andrews","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH125329-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10104263\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10104263\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThere is currently an unmet need for accurate model systems of the human brain to study its cellular and\nmolecular features."},{"title":"Innovative biostatistical approaches to network level analyses of connectome-behavior relationships","field_investigator":"Muriah D Wheelock","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99EB029343-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10055480\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10055480\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nDetermining the mechanisms by which the human brain generates cognition, perception, and emotion hinges\nupon quantifying the relationships between coordinated brain activity and behavior."},{"title":"Inter-System Closed-Loop Control of Locomotor and Bladder Function in Individuals with Acute Spinal Cord Injury","field_investigator":"Claudia  Angeli, Maxwell  Boakye","field_institution":"University Of Louisville","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS116238-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9962062\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9962062\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"SUMMARY ABSTRACT\nMore than 1.2 million people in the United States have a spinal cord injury (SCI), and each year there are 10,000\nnew cases."},{"title":"Investigation of the Cortical Communication (CORTICOM) System","field_investigator":"Nathan E Crone, Nicolas Franciscus Ramsey","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS114439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9879474\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9879474\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"For many years brain-computer interfaces (BCI\u0027s) have been explored as a means of restoring communication\nto patients with Locked-In Syndrome (LIS), a devastating and often irreversible neurological condition in which\ncognition is intact but nearly all motor output from the brain is interrupted, eff"},{"title":"kHz frequency Spinal Cord Stimulation: Novel Temperature-Based Mechanisms of Action","field_investigator":"Marom  Bikson","field_institution":"City College Of New York","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS112996-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9960245\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9960245\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project(Summary(\/(Abstract!\nThere is a need to understand the mechanisms of neural stimulation technologies (RFA-NS-18-018). The impact\nof such research increases with both the clinical relevance of a neuromodulation technology and the extent\nmechanisms are unknown."},{"title":"Large-scale monitoring of circuits for adaptation and novelty detection in primary visual cortex","field_investigator":"Jordan Marie Ross","field_institution":"Georgia State University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125445-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10139328\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10139328\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\n In a world filled with sensory information, the ability to filter out repetitive or redundant stimuli while still\nmaintaining the ability to detect change in the environment is critical to biological success."},{"title":"Lateral habenula circuit in reward\/conflict mediation","field_investigator":"Christian Emmanuell Bravo-Rivera","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH123495-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9952906\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9952906\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nReward is often present in risky environments, requiring individuals to weigh the benefits of rewards against\nthe associated risks. There are several psychiatric disorders in which patients are unable to choose an\nappropriate response during risky reward opportunities."},{"title":"Linking Hippocampal Replay Content to Learning and Decision-Making","field_investigator":"Michael Edward Coulter","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123003-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9990114\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9990114\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY \/ ABSTRACT\nMemory is an integral component of human cognition, and when memory processes go awry, the result is\ndevastating neurological disorders of memory loss including Alzheimer\u0027s disease and other forms of dementia.\nOne essential role of normal memory processes is to use previou"},{"title":"Linking molecular and anatomical features of brain cell identity through computational data integration","field_investigator":"Joshua  Welch","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123199-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10009608\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10009608\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Linking molecular and anatomical features of brain cell identity through computational data integration\nAbstract\nThe brain contains diverse cell types that vary widely in characteristic properties and function in complex,\ninterconnected circuits."},{"title":"Mapping human brain perivascular space in lifespan using human connectome project data","field_investigator":"Jeiran  Choupan","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123223-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012731\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012731\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\nPerivascular spaces are a critical component of the glia-lymphatic circuit, facilitating the clearance of soluble\nwaste."},{"title":"Mapping the neural circuitry underlying walking","field_investigator":"Sumaira  Zamurrad","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123012-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991417\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991417\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nWalking is an essential and conserved behavior across the animal kingdom."},{"title":"Markerless Tracking of 3D Posture to Reveal the Sensory Origins of Body Schema","field_investigator":"Kyle Scott Severson","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH122995-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9987939\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9987939\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The goal of this proposed research is to reveal the sensory origins underlying the body schema\nrepresentation. Body schema is the brain\u0027s internal model of the body\u0027s spatial configuration."},{"title":"Massively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain","field_investigator":"Danny Jj Wang, Lihong  Wang","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB029823-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007184\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007184\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"ABSTRACT (30 Lines)\nThe BRAIN initiative (RFA-EB-19-002) has called for the development of entirely new or next-generation\nnoninvasive human brain imaging tools and methods that will lead to transformative advances in our\nunderstanding of the human brain."},{"title":"Measuring Electrical Activity from the Human Brain to Predict Memory Formation and Behavior Across the Lifespan","field_investigator":"Elizabeth  Johnson","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS115918-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9952838\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9952838\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nMemory is core to human cognition, undergoes protracted developmental maturation and age-related decline,\nand is disrupted in numerous neurological and neuropsychiatric disorders."},{"title":"Modeling the structure-function relation in a reconstructed cortical tissue","field_investigator":"Anton  Arkhipov, Stefan  Mihalas","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB029813-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10005712\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10005712\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\n How is connectivity between neurons related to patterns of activity exhibited by these neurons in vivo? This\nquestion of structure-function relations in brain circuits is of fundamental importance."},{"title":"Multi-modal, large-scale characterization of cellular and cell-type-specific effects with electric stimulation in rodent and human brain","field_investigator":"Soo Yeun  Lee","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS120300-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10132674\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10132674\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Abstract\nThe application of electric stimulation (ES) to the brain has been widely used to perturb the physiological and\npathological dynamics of neuronal circuits, with established applications including therapeutic interventions for\nneurological disorders such as epilepsy, dementia, and Pa"},{"title":"Multimodal study of infra-slow propagating brain activity","field_investigator":"Xiao  Liu","field_institution":"Pennsylvania State University, The","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123247-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012212\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012212\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\nThe highly-organized intrinsic brain activity, as measured by resting-state functional magnetic resonance imaging\n(rsfMRI), is being widely used to measure functional brain connectivity in both healthy subjects and patient\ngroups, despite the underlying neural mechanisms remain large"},{"title":"Neural basis of causal inference: representations, circuits, and dynamics","field_investigator":"Gregory C Deangelis","field_institution":"University Of Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS118246-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10047607\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10047607\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe same pattern of neural activity can correspond to multiple events in the world. Signals sweeping across\nthe retina, for instance, might be generated by a moving object or by the animal\u0027s self-motion."},{"title":"Neural circuitry for observational learning of maternal behavior","field_investigator":"Amy  Lemessurier","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123016-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991218\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991218\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nBehaviors essential for survival, including parenting behaviors, are driven by neural circuits that arise from\ncombinations of genetics and experience-dependent learning."},{"title":"Neurobiology of Social Behavior: Circuit Analysis in Early Life","field_investigator":"Maya  Opendak","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH124434-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10039031\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10039031\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n My long-termcareer goal is to establish a research laboratory that dissects functional microcircuits supporting\nflexible social behavior in typical and perturbed development."},{"title":"NeuroEthics  of Non-Therapeutic Invasive Human Neurophysiologic Research","field_investigator":"Ashley L Feinsinger, Nader  Pouratian","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1RF1MH121373-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10038224\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10038224\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\/Abstract\nThe BRAIN Initiative has made a significant investment in invasive human neuroscientific studies that take\nadvantage of unique neurosurgical opportunities to study basic human neuroscience without therapeutic intent.\nThese non-therapeutic studies are of particular ethical in"},{"title":"NeuroExplorer: Ultra-high Performance Human Brain PET Imager for Highly-resolved In Vivo Imaging of Neurochemistry","field_investigator":"Richard E. Carson, Hongdi  Li, Jinyi  Qi","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB029811-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10005604\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10005604\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Research applications of brain Positron Emission Tomography (PET) have been in place for over 40 years.\nThe combination of quantitative PET systems with novel radiotracers has led to a numerous imaging para-\ndigms to understand normal brain physiology including neurotransmitter dynamics and receptor"},{"title":"Neurostimulation by Ultrasound: Physical, Biophysical, and Neural Mechanisms","field_investigator":"Stephen A Baccus, Kim  Butts-Pauly, Butrus T Khuri-Yakub, Merritt C Maduke","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS112152-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9957860\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9957860\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\n The goal of this project is to understand the neurobiological underpinnings of the effects of ultrasound\n(US) on neural activity. US can modify action potential activity in neurons in vitro and in vivo without damaging\nneural tissue."},{"title":"Nobrainer: A robust and validated neural network tool suite for imagers","field_investigator":"Satrajit Sujit Ghosh","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH121885-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10021957\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10021957\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"There is an increasing need for efficient and robust software to process, integrate, and offer insight across the\ndiversity of population imaging efforts underway across the BRAIN Initiative and other projects."},{"title":"Non-invasive Radio Frequency Stimulation of Neurons and Networks","field_investigator":"Gyorgy  Buzsaki, Daniel K Sodickson","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS113782-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10030860\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10030860\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Abstract\nNonivasive stimulation of the brain in health and disease is an important goal of the Brain Initiative. Current\nmethods include Transcranial Magnetic Stimulation (TMS), Transcranial Electric Stimulation (TES) and\nTranscranial Focused Ultrasound Stimulation (TFUS)."},{"title":"Non-invasive, Deep Brain, and Focal Neuromodulation in Nonhuman Primates","field_investigator":"Taylor D Webb","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123019-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991119\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991119\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The ability to non-invasively perturb speci\ufb01c regions deep in the human brain would enable researchers and clinicians\nto study the causal relationships between speci\ufb01c brain structures and behavior."},{"title":"Open-source software for multi-scale mapping of the human brain","field_investigator":"Bruce  Fischl, Juan Eugenio Iglesias Gonzalez","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH123195-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10008355\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10008355\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary (maximum 30 lines)\nThe BRAIN initiative seeks to develop and apply technologies in order to understand of how brain cells interact\nin both time and space to give rise to brain function."},{"title":"Optimizing oscillatory epidural electrical stimulation to selectively increase task-related population dynamics in motor areas","field_investigator":"Karunesh  Ganguly, Jeffrey A Roberts","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS117406-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10031331\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10031331\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nStroke is the leading cause of motor disability in the United States. While brain stimulation to enhance motor\nfunction after stroke has shown promise in small studies, two recent large stroke trials did not find evidence for\nsignificant benefits."},{"title":"Prefrontal contributions to contextual representation","field_investigator":"Cybelle Marguerite Smith","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123002-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9990118\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9990118\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Abstract\/Summary\nThis application describes a 3-year training plan that will enable me, a cognitive neuroscientist with prior\ntraining in electroencephalography (EEG), to conduct research on contextual memory representation using\nneuroimaging (fMRI) and computational modeling."},{"title":"Real-time manipulations to understand and improve memory processes","field_investigator":"Anna Kathleen Gillespie","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99AG068425-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9953551\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9953551\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nThe hippocampus is critical for capturing rich, multimodal representations of experience and facilitating\nthe long-term storage and later recall of these experiences."},{"title":"Relating structure and function in synapse-level wiring diagrams","field_investigator":"Ashok  Litwin-Kumar","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB029858-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10006999\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10006999\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project summary:\nModern electron-microscopy (EM) imaging and analysis methods now permit the comprehensive reconstruction\nof all neurons and synapses in large volumes of brain tissue or the entire brains of individual organisms. However,\nrelating this structure to function is difficult."},{"title":"Restoring Sight to the Blind: Neural Imaging with Retinal Prostheses","field_investigator":"Noelle  Stiles","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99EY031987-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10041440\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10041440\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary \u2013 Restoring Sight to the Blind: Neural Imaging with Retinal Prostheses\n Retinal prostheses restore sight to the blind by electrically stimulating still viable cells in the\nretina."},{"title":"Significance of excitatory and inhibitory synaptic integration by interneurons for local circuit dynamics and behavior","field_investigator":"Brandon David Turner","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123017-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991142\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991142\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Localized structuring of neuronal output by inhibitory microcircuits is a fundamental component of\nneuronal information processing."},{"title":"Studying how the hippocampal-prefrontal-hypothalamic circuit encodes social dominance","field_investigator":"Nancy  Padilla Coreano","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH124435-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10041744\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10041744\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nSocial deficits are common in psychiatric disorders and available treatments are limited. Our lack of basic\nknowledge on how the brain controls social behaviors makes it challenging to develop therapeutics for social\ndeficits."},{"title":"The behavioral microstructure of a memory-guided food-caching behavior and its relationship to hippocampal replay","field_investigator":"Selmaan  Chettih","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123015-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991327\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991327\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThe hippocampus is a critical site for rapid memory formation and retrieval, with extensively documented\nfunctions representing spatial and navigational variables, yet less is known of the means by which it guides\nbehavior."},{"title":"The experience of human subjects with brain organoid research","field_investigator":"Kate E. Macduffie","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH125328-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10101989\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10101989\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nEfforts to understand the mechanisms of brain-based disease have been hindered by the limited\nability of animal models to reflect the full complexity of human brain and behavior."},{"title":"The Neuroscience of Everyday World- A novel wearable system for continuous measurement of brain function","field_investigator":"David A Boas, Swathi  Kiran","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB029856-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007021\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007021\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Innovations in human neuroimaging tools have driven profound advances in our understanding\nof brain function under well-controlled and constrained conditions."},{"title":"The planning of new compositional action sequences guided by interpretation of ambiguous sensory data in a novel drawing task","field_investigator":"Lucas Y. Tian","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125573-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10151223\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10151223\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nAnimals exhibit a remarkable array of creative, adaptive, and flexible behaviors."},{"title":"Tracking Changes in High-Dimensional Circuit Behaviors over Long-Term Neural Recordings","field_investigator":"Alexander Henry Williams","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH122998-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9989472\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9989472\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary \/ Abstract\nRecent breakthroughs in neural recording technologies suggest the possibility of understanding the\ncollective dynamics of large-scale brain circuits."},{"title":"Using multiple species, stimuli, and tasks to study the neural basis of visually guided behavior","field_investigator":"Amy Meesun Ni","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-813","field_project_number":"1K99NS118117-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10040904\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10040904\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n The visual system must constantly extract behaviorally relevant stimulus information from an abundance of\nirrelevant inputs from the environment, using cognitive phenomena such as attention and learning to guide this\ncontinuously adapting process."},{"title":"Using perceptual decision-making to understand the role of selective inhibitory activity in cortical computation","field_investigator":"James Patrick Roach","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123011-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991423\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991423\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Cortical circuits perform computations to generate appropriate behaviors based upon diverse\nsensory inputs. These computations are central to an animal maintaining its health and long-\nterm survival."},{"title":"4D Transcranial Acoustoelectric Imaging for High Resolution Functional Mapping of Neuronal Currents","field_investigator":"Russell S Witte","field_institution":"University Of Arizona","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-004","field_project_number":"1U01EB028662-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9837231\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9837231\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"ABSTRACT\nThe overarching goal of this project is to develop, validate and implement a new modality for noninvasive\nfunctional imaging of neural currents deep in the human brain through the skull at unprecedented spatial and\ntemporal resolution."},{"title":"A data science toolbox for analysis of Human Connectome Project diffusion MRI","field_investigator":"Ariel Shalom Rokem","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH121868-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9886761\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9886761\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\nThe connections between different brain regions play an important role in normal brain function. This project\nproposes to create an end-to-end pipeline for analysis of human white matter connections using \u201ctractometry\u201d\nmethods."},{"title":"A Technology Resource for Polymer Microelectrode Arrays","field_investigator":"Ellis  Meng, Dong  Song","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS113647-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9845414\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9845414\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The purpose of this proposal is to disseminate polymer microelectrode arrays and promote their\nintegrated into neuroscience research practice."},{"title":"A unified framework to study history dependence in the nervous system","field_investigator":"Fidel  Santamaria","field_institution":"University Of Texas San Antonio","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB026939-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9775830\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9775830\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The brain uses its own previous activity to adapt to an ever-changing environment. This history\ndependent adaptation takes place at all scales of organization of the nervous system."},{"title":"A wearable functional-brain-imaging system with full-head coverage and enhanced spatiotemporal-resolution to study complex neural circuits in human subjects","field_investigator":"Peter D. D. Schwindt","field_institution":"Sandia Corp-Sandia National Laboratories","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-004","field_project_number":"1U01EB028656-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9837083\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9837083\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\/ABSTRACT\nTo develop maps at multiple scales of neuronal circuits in the human brain and study the brain dynamics, there\nis a need for non-invasive functional brain imaging with high spatiotemporal resolution operating in natural\nenvironments."},{"title":"Accurate and reliable computational dosimetry and targeting for transcranial magnetic stimulation","field_investigator":"Luis Javier Gomez","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH120046-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9751045\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9751045\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Transcranial magnetic stimulation (TMS) is a noninvasive technique used for neuroscience research and\ntreatment of psychiatric and neurological disorders. During TMS, a current-carrying coil placed on the scalp\ninduces an electric field that modulates targeted neuronal circuits."},{"title":"An open software solution to integrate non-invasive brain stimulation with functional imaging data","field_investigator":"Alexander  Opitz","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH117428-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9793745\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9793745\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Abstract\nNoninvasive tools capable of selectively manipulating neural systems in the human brain are needed to\nadvance our neuroscientific understanding of brain function and develop novel non-pharmacologic\npsychotherapeutics and are a major focus of Brain Initiative funding."},{"title":"BCI2000: Software Resource for Adaptive Neurotechnology Research","field_investigator":"Peter  Brunner, Gerwin  Schalk","field_institution":"Wadsworth Center","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-005","field_project_number":"1U24NS109103-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9645884\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9645884\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The central nervous system (CNS) changes throughout life, and its interactions with the world produce activity-\ndependent plasticity that enables it to acquire and maintain useful behaviors."},{"title":"Bilateral Closed Loop Deep Brain Stimulation for Freezing of Gait using Neural and Kinematic Feedback","field_investigator":"Helen  Bronte-Stewart","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS107709-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9729333\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9729333\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Gait impairment and Freezing of gait (FOG), lead to falls, injury (even death), loss of independent living, and are\ncommon in neurodegenerative diseases such as Parkinson\u2019s Disease (PD), affecting over 7 million people\nworldwide."},{"title":"BRAIN INITIATIVE RESOURCE: DEVELOPMENT OF A HUMAN NEUROELECTROMAGNETIC DATA ARCHIVE AND TOOLS RESOURCE (NEMAR)","field_investigator":"Amitava  Majumdar, Scott  Makeig, Russell A Poldrack, Arnaud  Delorme","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-145","field_project_number":"1R24MH120037-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795341\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795341\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"To take advantage of recent and ongoing advances in intensive and large-scale computational methods,\nand to preserve the scientific data created by publicly funded research projects, data archives must be\ncreated as well as standards for specifying, identifying, and annotating deposited data."},{"title":"Bridging structure, dynamics, and information processing in brain networks","field_investigator":"Hannah  Choi","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99EY030840-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9804370\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9804370\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The mammalian brain is believed to be optimally designed for robust and adaptable computation of the\nsensory inputs from the world, with respect to both its hardware (network structure) and software (network\ndynamics)."},{"title":"Cellular mechanisms of hippocampal network neuroplasticity generated by brain stimulation","field_investigator":"John F Disterhoft, Joel L Voss","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS113804-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9867989\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9867989\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Summary\/Abstract\nThe distributed brain network of the hippocampus supports memory and related cognitive abilities. Disruptions\nof this network occur in many neurological disorders such as epilepsy, brain injury, and neurodegenerative\ndisease."},{"title":"Circuit Dynamics for encoding and remembering sequence of events","field_investigator":"Anna  Jafarpour","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH120048-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9753679\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9753679\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"We experience the world as a continuous sequence of events, but we remember the events as segmented\nepisodes (e.g., my sister\u2019s wedding). During encoding, we associate a sequence of relevant events and segment\ndeviant events."},{"title":"Cognitive Restoration: Neuroethics and Disability Rights","field_investigator":"Joseph J. Fins","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1RF1MH121378-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9861790\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9861790\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\nApproximately, 40% of TBI patients discharged from the hospital will develop long-term disability with 70%\nexperiencing chronic cognitive impairments that disrupt vocational, social, and emotional functioning."},{"title":"Cortical dynamics underlying visual working memory","field_investigator":"Arbora  Resulaj","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99EY030415-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754448\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754448\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Playing a game of chess, driving a car, or even reading this sentence all require that the brain retain and integrate information over short periods of time. This retaining and integration of information is accomplished by working memory."},{"title":"Cortico-striatal representations of multisensory decision-making","field_investigator":"Xiaonan  Sun","field_institution":"Feinstein Institute For Medical Research","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120888-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9834241\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9834241\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Perceptual decision-making is a complex cognitive function critical for health, reproductive success, and\nsurvival. In this process, an informed choice based on sensory evidence is made through engagement of\ncircuits across the brain."},{"title":"Cracking the Olfactory Code","field_investigator":"Dmitry  Rinberg","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS112953-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9814744\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9814744\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary (Overall: Cracking the Olfactory Code)\n Sensation drives perception, which informs decisions and actions. Olfaction is the main sense used by\nmost animals to interact with the environment."},{"title":"CRCNS: Neurocomputational Study of Reward-Related Decision-Making \u0026amp; Uncertainty","field_investigator":"Angela Yu","field_institution":"University of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-19-002","field_project_number":"1R01DA050373-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9916054\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9916054\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EHumans and animals often make decisions under uncertainty, whereby each decision affects not only the immediate reward gain but also longer-term information gain.\u003C\/p\u003E"},{"title":"CRCNS: Optimization of closed-loop control of gamma oscillations","field_investigator":"Satish S Nair","field_institution":"University of Missouri - Columbia","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-19-002","field_project_number":"1R01MH122023-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9914633\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9914633\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThroughout the brain, specialized systems carry out different but complementary functions, sometimes independently but often in cooperation. However, we do not understand how their activity is dynamically coordinated, and dysregulation of this is associated with many mental health conditions.\u003C\/p\u003E"},{"title":"DANDI: Distributed Archives for Neurophysiology Data Integration","field_investigator":"Satrajit Sujit Ghosh, Yaroslav O Halchenko","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-145","field_project_number":"1R24MH117295-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795271\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795271\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Neuroscientific data contain information from an incredible diversity of species, are generated by a plethora of\ndevices, and encapsulate the results of scientific thinking and decision making."},{"title":"Deep brain live imaging of cAMP and protein kinase A activities underlying synaptic- and circuit-level mechanisms during learned behaviors","field_investigator":"Shana M Augustin","field_institution":"National Institute on Alcohol Abuse and Alcoholism","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99AA027740-01A1","field_link":"","field_funded_status":"Active","field_grant_mechanism":"Training Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003ENeuromodulation is crucial for information processing throughout the brain. Neuromodulators influence neuronal function by acting through G protein-coupled receptors (GPCRs) to alter neuronal excitability and synaptic transmission, which can then affect circuit functions.\u003C\/p\u003E"},{"title":"Determining the role of muscle afferent signals in cortical proprioceptive representation","field_investigator":"Kyle  Blum","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120893-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9834054\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9834054\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThe overall premise of this proposal is to understand how the transformation of the signals from proprioceptive\nafferents within muscles leads to the representation of movements in somatosensory cortex."},{"title":"Developing novel chemo-optogenetic tools for in vivo applications","field_investigator":"Pui Ying  Lam","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS112599-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9805989\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9805989\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Optogenetics and chemo-optogenetics are powerful tools for modulating cell activities with light."},{"title":"Dissecting distributed representations by advanced population activity analysis methods and modeling","field_investigator":"Shaul  Druckmann","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028171-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9776022\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9776022\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nA central goal of systems neuroscience is to relate behavior to its underlying circuit dynamics. This task is\ncomplicated by the complex and circuitous paths along which information flows as it is encoded and processed\nin the many steps between sensory inputs and motor outputs."},{"title":"Dissecting the inhibitory architecture governing basal ganglia output","field_investigator":"Rebekah C Evans","field_institution":"National Institute of Neurological Disorders and Stroke","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS112417-01","field_link":"","field_funded_status":"Active","field_grant_mechanism":"Training Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EThe initiation and maintenance of organized movement through the basal ganglia is strongly influenced by its feed-forward and feedback inhibitory architecture. The substantia nigra pars compacta (SNc) and pedunculopontine nucleus (PPN) contribute to the overall output of the basal ganglia.\u003C\/p\u003E"},{"title":"Dual Lead Thalamic DBR-DBS Interface for Closed Loop Control of Severe Essential Tremor","field_investigator":"Kelly D Foote, Karim G Oweiss","field_institution":"University Of Florida","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS109845-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9663679\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9663679\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Abstract\n Essential Tremor (ET) is a progressive disease that leads to significant disability and\nmarkedly diminished quality of life."},{"title":"Effects of standard fMRI calibrations on the diverse microvascular blood flow and oxygenation responses in cortical layers","field_investigator":"Ikbal  Sencan-Egilmez","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH120053-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754481\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754481\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"This proposed project focuses on quantifying the spatial and temporal diversity in cortical oxygen metabolism and neurovascular coupling, and informing next generation of biophysical models of the Blood Oxygen Level Dependent (BOLD) functional Magnetic Resonance Imaging (fMRI) measurements by integr"},{"title":"Efficiency and Safety of Microstimulation Via Different Electrode Materials","field_investigator":"Xinyan Tracy Cui","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS110564-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9713886\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9713886\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Microstimulation has been an invaluable tool for neuroscience researchers to infer functional connections\nbetween brain structures or causal links between structure and behavior."},{"title":"Efficient resource allocation and information retention in working memory circuits","field_investigator":"Shinung  Ching, Lawrence H Snyder","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028154-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9774513\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9774513\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nShort-term working memory is critical for all cognition. It is important to fluid intelligence by definition and is\ndisordered in many psychiatric conditions. It is also an ideal model system for studying the link between the\ndynamics and functions of neural circuits."},{"title":"Expanding access to open-source data acquisition software for next-generation silicon probes","field_investigator":"Joshua H Siegle","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-005","field_project_number":"1U24NS109043-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9645567\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9645567\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"We plan to provide software support services for Neuropixels probes, a groundbreaking new tool for recording\nelectrical signals from the brain."},{"title":"Functional implications of a patch\/matrix-like compartmental organization in the mouse inferior colliculus","field_investigator":"Alexandria Marie Lesicko","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120890-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9834188\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9834188\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nA major unresolved question in systems neuroscience is whether specialized anatomical structures support\nspecific functions in behavior. Therefore, this proposal will bridge the gap between anatomical circuit diagrams\nand their predicted functional roles."},{"title":"Generating a formal set of collaborative standards for sharing behavioral data and task designs to enable reproducibility in neuroscience","field_investigator":"Stephen Anthony Edwards, Adam  Kepecs","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-146","field_project_number":"1RF1MH120034-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795228\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795228\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Abstract\nThe goal of this project is to develop an archival data format and a formal task specification\nlanguage to serve as standards for describing behavioral experiments."},{"title":"High-density microgrid development for human neural interface devices","field_investigator":"Daniel R Cleary","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120886-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9834280\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9834280\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Abstract\nBrain-computer interfaces (BCI) offer hope to treat otherwise intractable neurological disease. However, the\ncurrent state of BCI is still short of the potential; solutions to fundamental biological and engineering problems\nmust be found before BCIs can be broadly used for patient care."},{"title":"Input-specific imaging and manipulation of synaptic plasticity underlying social memory","field_investigator":"Mary L Phillips","field_institution":"Max Planck Florida Corporation","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120872-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9832833\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9832833\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary \/ Abstract\nAscertaining the neural basis of behavior has been a cornerstone goal since the conception of neurobiology.\nWhile activity recording and loss-of-function studies have shed light on brain regions involved and necessary for\nthe expression of certain behaviors, they are unabl"},{"title":"Integrated Biophysical and Neural Model of Electrical Stimulation Effects","field_investigator":"Maksim V Bazhenov, Eric  Halgren","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS109553-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9800559\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9800559\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Abstract\nElectrical stimulation is widely used to activate and\/or disrupt neuronal activity."},{"title":"Intercellular TWEAK\/Fn14 Cytokine Signaling in Sensory-Dependent Circuit Refinement","field_investigator":"Lucas M Cheadle","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH120051-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754316\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754316\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"During postnatal brain development, newly assembled neural circuits are refined through the strengthening of a subset of synaptic connections and the concurrent elimination of others."},{"title":"Interneurons differentially regulate discrete pathways from ventral hippocampus","field_investigator":"Jennifer  Donegan","field_institution":"University Of Texas Hlth Science Center","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH121355-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9806339\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9806339\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Hippocampal microcircuits are comprised of excitatory pyramidal cells, which integrate information and innervate\ndownstream brain regions, and inhibitory interneurons, which function locally to regulate pyramidal cell activity\nand synchronicity."},{"title":"Interrogating Biophysical Mechanisms of Magnetogenetic Cell Stimulation at Radio Frequencies","field_investigator":"Chunlei  Liu","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS110554-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9712554\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9712554\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Abstract\nMagnetogenetics is a recently proposed method for stimulating cells using electromagnetic fields. In one\napproach, radio-frequency (RF) electromagnetic fields are applied to stimulate membrane channel proteins such\nas TRPV1 and TRPV4 that are attached to ferritins."},{"title":"Investigating the molecular, cellular and circuit effects of transcranial magnetic stimulation","field_investigator":"Arnaud Y Falchier, Alexander  Opitz, Andreas  Vlachos","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS109498-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9793736\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9793736\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Abstract\nTranscranial magnetic stimulation (TMS) is a non-invasive brain stimulation method which can alter brain\nactivity in humans in a safe manner."},{"title":"Investigating the response of CNS neurons to electric and magnetic stimulation","field_investigator":"Shelley  Fried","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS110575-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9716798\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9716798\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Our long-term goals are to better understand the response of neurons to artificial stimulation, and, to use this\nknowledge to develop new and more effective strategies for stimulating non- or improperly-functioning neurons\nof the CNS."},{"title":"Leveraging ethical dissension among capacity, beneficence and justice in clinical trials of neurotherapeutics in the severely disabled: lessons from schizophrenia","field_investigator":"Rachel A Davis, Judith Morse Gault, Elyn R. Saks","field_institution":"University Of Colorado Denver","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1RF1MH121362-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9863120\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9863120\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\/Abstract\nEthical concerns raised from both current and historically controversial psychosurgeries are driving disparities in\naccessibility to emerging BRAIN Initiative technology for those with severe, disabling, chronic mental illness like\nindividuals with treatment-refractory schiz"},{"title":"Mapping cerebellar granule cell function with novel genetic and optical tools","field_investigator":"Gerard Joey Broussard","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120887-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9834274\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9834274\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nRecent evidence from multiple laboratories in both human and animal models supports a role for the granule cell (GrC)\npathway of the cerebellum in representing a wide range of sensory, motor, and internal information."},{"title":"Mapping the neuronal circuitry underlying indirect striatal to hypothalamicconnectivity and its role in feeding","field_investigator":"Miriam E Bocarsly","field_institution":"National Institute on Alcohol Abuse and Alcoholism","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99AA027750-01","field_link":"","field_funded_status":"Active","field_grant_mechanism":"Training Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EFood consumption is fundamental to species survival and understanding the neuronal circuitry underlying feeding behaviors is of the utmost importance. Amassing evidence supports the idea that control of caloric intake is complex and involves calculations of hedonic value, reward and motivation.\u003C\/p\u003E"},{"title":"Mechanism underlying Nerve Conduction Block by High Frequency (kHz) Biphasic Stimulation","field_investigator":"Changfeng  Tai","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS109198-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795292\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795292\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Summary\nBased on the gate-control theory of pain, traditional spinal cord stimulation (SCS) to treat chronic back\/leg pain\nutilizes 40-60 Hz stimulation that activates spinal dorsal columns to elicit paresthesia over a patient\u2019s painful\nregion."},{"title":"Mechanisms of Active Sensing in Drosophila","field_investigator":"Marie  Suver","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS114179-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9871513\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9871513\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The goal of this project is to study the cellular basis of active sensation. A crucial function of all nervous systems is to distinguish between sensory stimuli originating from the external world and that generated by our own movements."},{"title":"Mechanisms of Information Routing in Primate Fronto-striatal Circuits","field_investigator":"Thilo  Womelsdorf","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028161-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9775812\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9775812\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY \/ ABSTRACT\n This project focuses on developing new analysis tools to investigate the mechanisms of information\nrouting in primate fronto-striatal circuits during goal-directed behavior."},{"title":"Mechanisms underlying large-scale coordination of cortical activity during perceptual decisions","field_investigator":"Lucas  Pinto","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH120047-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754327\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754327\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"It has become increasingly clear that both spontaneous and trained behaviors engage activity throughout the cortex. However, at least in the case of perceptual decisions, task complexity critically modulates the underlying large- and mesoscale cortical dynamics."},{"title":"Motion Sequencing for All: pipelining, distribution and training to enable broad adoption of a next-generation platform for behavioral and neurobehavioral analysis","field_investigator":"Sandeep R Datta","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-005","field_project_number":"1U24NS109520-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9654850\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9654850\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Understanding the function of the nervous system requires a sophisticated understanding of its main\noutput, behavior."},{"title":"Multi-region \u0026#039;Network of Networks\u0026#039; Recurrent Neural Network Models of Adaptive and Maladaptive Learning","field_investigator":"Kanaka  Rajan","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028166-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9775964\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9775964\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The massive neural activity data collected through transformative new technologies present an incredible\nopportunity in facilitating the mission of the BRAIN Initiative and the wider neuroscience community: to\nunderstand brain function."},{"title":"Neural signatures of learning complex environments in the amygdala-prefrontal network","field_investigator":"David  Barack","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99DA048748-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754494\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754494\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The ability to learn and think about complex situations is central to a range of human cognitive\nfunctions, including navigation, reasoning, and decision making."},{"title":"Neuromodulation approaches for restoring dexterous control following cortical stroke.","field_investigator":"Preeya  Khanna","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120891-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9834150\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9834150\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\n Stroke-causing illness, disability, and early death is set to double worldwide within the next 15 years.\nDespite physical therapy, about 50% of stroke survivors have impaired hand function, which strongly impacts\nactivities of daily living and independence; novel treatment methods a"},{"title":"New methods and theories to interrogate organizational principles from single cell to neuronal networks","field_investigator":"Mara  Dierssen, Bing  Ye","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028159-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9775774\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9775774\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nUnderstanding how individual neurons contribute to network functions is fundamental to neuroscience. Recent\nyears have seen exciting progresses in the reconstructions of single-neuron morphologies and wiring diagrams\nat the level of individual synapses."},{"title":"Pediatric Deep Brain Stimulation: Neuroethics and Decision Making","field_investigator":"Jennifer  Blumenthal-Barby, Gabriel  Lazaro-Munoz, Eric A. Storch","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1RF1MH121371-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9862214\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9862214\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"PROJECT SUMMARY\n Deep brain stimulation (DBS) and adaptive DBS systems are currently used in children with dystonia,\nepilepsy, and Tourette Syndrome, and its use is expanding to other neuropsychiatric conditions."},{"title":"Proprioceptive Coding of Jaw Movement during Orofacial Behavior","field_investigator":"William Paul Olson","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120873-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9832792\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9832792\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nIntegration of sensory information with motor commands allows movement to be adaptable. For example,\nmany survival-critical orofacial behaviors (chewing, drinking, breathing, etc.) involve updating movement\ntrajectories based on interaction with objects (e.g."},{"title":"Quantifying causality for neuroscience","field_investigator":"Konrad P. Kording","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028162-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9775861\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9775861\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract:\nCausality is central to neuroscience. For example, we might ask about the causal effect of a neuron on another\nneuron, or its influence on perception, action, or cognition. Moreover, any medical approaches aim at\nproducing a causal effect \u2013 effecting improvements for patients."},{"title":"Relating functional MRI to neuronal activity: accounting for effects of microarchitecture","field_investigator":"Anna I Blazejewska","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH120054-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754470\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754470\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The central goal of the BRAIN Initiative is to understand the structure and function of human brain circuits."},{"title":"Responsive Neurostimulation for Loss of Control Eating","field_investigator":"Casey Harrison Halpern, James D Lock, Robert C Malenka, Tara L Skarpaas (Crowder)","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-006","field_project_number":"1UH3NS103446-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588174\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588174\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Abstract\nBackground\/Description."},{"title":"Responsive Neurostimulation for Post-Traumatic Stress Disorder","field_investigator":"Jean-Philippe  Langevin","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS107673-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9730252\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9730252\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\/Abstract\nPost-traumatic stress disorder (PTSD) refractory to treatment is marked by failure of fear extinction and its\nbiological substrate, amygdala reactivity to trauma reminders13,14."},{"title":"Revealing the transcriptional and developmental mechanisms of interneuron identity","field_investigator":"Megan  Crow","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH120050-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754408\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754408\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Cortical GABAergic interneurons are critical components of neural circuitry, and their dysfunction has been\nlinked to neurodevelopmental diseases."},{"title":"Single Neuron Analyzer for Multi-modal, Cross-dataset (Epi)genomic Cell Type Datasets","field_investigator":"Eran A Mukamel","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH120015-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795063\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795063\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\nOur project will create a computational resource, the Single Neuron Analyzer, to support the neuroscience\ncommunity\u2019s efforts to build a reproducible, comprehensive, data-driven atlas of brain cell types."},{"title":"Spinal Circuits for the Control of Dextrous Movement","field_investigator":"Martyn D Goulding","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS112959-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9815384\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9815384\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary: Overall\nLocal networks within the spinal cord represent an essential computational layer for the control of limb-driven\nmotor behaviors, integrating descending and sensory inputs to coordinate dexterous motor output."},{"title":"Spinal Effects of Cortical Stimulation: Mechanisms and Functional Impact","field_investigator":"Jonathan Saul Carp, Yu  Wang, Jonathan Rickel Wolpaw","field_institution":"Wadsworth Center","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS110577-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9868054\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9868054\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Summary\/Abstract\n Because activity-dependent plasticity is ubiquitous in the CNS, brain stimulation may have long-term effects on\nareas to which the stimulated area connects. These effects have received little attention."},{"title":"Subcellular Mapping and Post-Synaptic Impacts of Striatal Dopamine Release During Behavior","field_investigator":"Mai-Anh  Vu","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120894-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9833927\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9833927\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nThe basal ganglia are a group of deep brain nuclei that play a central role in motivating, selecting, and learning\nactions."},{"title":"Technology development for closed-loop deep brain stimulation to treat refractory neuropathic pain","field_investigator":"Edward  Chang, Philip Andrew Starr","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS109556-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9655963\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9655963\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nMany pain syndromes are notoriously refractory to almost all treatment and pose significant costs to patients\nand society. Deep brain stimulation (DBS) for refractory pain disorders showed early promise but\ndemonstration of long-term efficacy is lacking."},{"title":"The glial mechanism for electrical brain stimulation","field_investigator":"Hai-Long  Wang, Gregory A Worrell, Long-Jun  Wu","field_institution":"Mayo Clinic Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS112144-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795519\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795519\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT:\nElectrical brain stimulation (EBS) is a FDA-approved neuromodulation therapy applied to several\nneurological disorders. However, the molecular basis of its efficacy remains unclear."},{"title":"The Neural Mechanism of Interval Timing in Drosophila","field_investigator":"Ashley Danielle Smart","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120865-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9832447\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9832447\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n There is no dedicated sensory organ for time, and yet our brains are able to use time to anticipate the\nenvironment and adapt."}]