Researchers develop a wider spectrum for dLight1 sensor, allowing multiplex imaging of neurotransmitters
Most of us will be familiar with the sort of stress that leads to sleepless nights. In new research on mice, scientists have now identified the brain circuit involved in such experiences; moreover, this part of the brain also seems to be linked to a stress-induced weakening of the immune system.
Immune cells play an unexpected role in fine-tuning the brain’s neural circuits, according to research published in September, 2020 in Neuron. The immune cells that reside there, known as microglia, not only protect the brain from infection and inflammation, they also help physically sculpt circuits in the developing brain. The new work demonstrates that microglia also direct neurons to modify their own connectivity in response to sensory cues.