Addgene, the nonprofit biorepository, now produces and distributes ready-to-use recombinant antibodies. The inaugural collection of monoclonal antibodies is part of the Neuroscience AntiBody Open Resource (NABOR), a platform that provides open access to recombinant antibodies and affinity reagents for the neuroscience community. NABOR is supported by a grant from the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative.
This is a reissue of RFA-MH-21-135. This FOA supports the development of software to visualize and analyze the data as part of programs of building the informatics infrastructure for the BRAIN Initiative. Other informatics programs include developing data standards that are needed to describe the new experiments that are being created by or used in the BRAIN Initiative ( RFA-MH-19-146 ), and creating the data infrastructures that will house the data from multiple experimental groups ( RFA-MH-19-145 ).
Over three years, the work — a collaboration between researchers at Cedars-Sinai in L.A., Boston Children’s, and the University of Toronto — led to the discovery of two new groups of brain cells: boundary and event cells.
Treatment-resistant depression (TRD) is diagnosed after an individual has tried several types of treatment for depression and their symptoms haven’t improved. The effectiveness of deep brain stimulation (DBS) as a treatment for disorders such as Parkinson’s disease has led researchers to investigate whether it could also work for psychiatric disorders such as TRD. However, depression varies significantly among individuals, and studies on DBS for TRD have also produced variable results. This points to a need to personalize DBS treatment for individuals with depression.
Labroots is excited to present the 10th Annual Neuroscience Virtual Conference, to be broadcasted live on March 10th, 2022. This distinguished, online-only, event is free to attend and will once again bring together the neuroscience community to discuss and present the newest advances in understanding the human brain, neuropsychiatric disorders, and behavioral processes as it relates to the brain function.
Reissue of:RFA-NS-18-029 and RFA-NS-20-029. This funding opportunity announcement (FOA) is designed to support teams of investigators that seek to cross boundaries of interdisciplinary collaboration to elucidate the contributions of dynamic circuit activity to a specific behavioral or neural system. Applications are encouraged to propose adventurous and challenging goals that can only be tackled by a synergistic team-based approach and have the potential to be transformative and/or to enable significant advances.
Drinking a glass of water is often sufficient to quench thirst after exercising. But while the sensation of thirst may be satiated after just a few minutes of drinking, the process of rehydration actually takes around half an hour.
Reissue of RFA-MH-19-135 The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis and manipulation of complex circuits and provide insights into cellular interactions that underlie brain function. Critical advances in the treatment of brain disorders in human populations are hindered by our lack of ability to monitor and manipulate circuitry in safe, minimally-invasive ways.
Researchers used high-resolution technologies to see how dopamine circuitry in mice is affected by addictive drugs. The results answered older structural questions, while raising new ones about plasticity and recovery in the brain.