Resources

Program
  • Cell Census Network (BICCN)
Resource Type
  • Research Tool
Priority Area
  • Cell Type
Summary

This Blueprint-funded Resource supports the design, creation, and characterization of Cre-recombinase-expressing ("Cre-Driver") mouse lines on the C57B1/6 background, which can be used to drive expression of reporter genes and conditional-ready alleles in the mouse nervous system. A MATLAB toolbox used in the paper that can be used to plug in other cell-type transcriptomes to infer their spatial distribution in the mouse brain.

Program
  • Cell Census Network (BICCN)
Resource Type
  • Research Tool
Priority Area
  • Cell Type
Summary

clusterExperiment, an open source R package, provides functions for executing, evaluating and visualizing many different clusterings of experimental data, including data from single cell RNA-Seq studies.

Program
  • Cell Census Network (BICCN)
Resource Type
  • Research Tool
Priority Area
  • Cell Type
Summary

FastProject analyzes a gene expression matrix and produces a dynamic output report in which two-dimensional projections of the data can be explored. Annotated gene sets (referred to as 'signatures') are incorporated so that features in the projections can be understood in relation to the biological processes they might represent. FastProject provides a novel method of scoring each cell against a gene signature so as to minimize the effect of missed transcripts as well as a method to rank signature-projection pairings so that meaningful associations can be quickly identified.

Contact
Email
info@biccn.org
Program
  • Cell Census Network (BICCN)
Resource Type
  • Research Tool
Priority Area
  • Cell Type
Summary

NIH's Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative - Cell Census Network (BICCN) aims to provide researchers and the public with a comprehensive reference of the diverse cell types in human, mouse, and marmoset brain. A network of integrated centers and laboratories including U01, U19 data centers, R24 data archives, and a U24 Brain Cell Data Center (BCDC) are working collaboratively to share these data with the community.  This site is the entry portal to the data, tools, and knowledge for this program.

Program
  • Cell Census Network (BICCN)
  • Understanding Circuits
  • Technology Development
Resource Type
  • Research Tool
Priority Area
  • Cell Type
  • Circuit Diagrams
  • Human Neuroscience
  • Integrated Approaches
  • Interventional Tools
  • Monitor Neural Activity
  • Theory & Data Analysis Tools
Summary

The BRAIN Initiative supports the development of a diverse portfolio of biomolecular tools and emphasizes their rapid and broad dissemination to the research community. Browse the Addgene collection of plasmids created with support from the BRAIN Initiative.