The Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative is aimed at revolutionizing neuroscience through development and application of innovative technologies to map neural circuits, monitor and modulate their activity, and understand how they contribute to thoughts, sensations, emotions and behavior. NIH has issued a variety of Funding Opportunity Announcements (FOAs) that will support projects that apply technologies to understand neural circuit function in the context of specific circuits, resulting in a diverse portfolio of research into the fundamental biology of nervous system function. The purpose of this announcement is to notify the research community that NIH is encouraging applications to PA-18-591 to integrate neuroethics perspectives and approaches into existing BRAIN Initiative awards. Supplement applications are encouraged from ongoing BRAIN Initiative projects that can readily incorporate core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements in research and development supported by The BRAIN Initiative®. The intent is that efforts supported through this administrative supplement would be both complimentary and integrative with the transformative, breakthrough neuroscience discoveries supported through The BRAIN Initiative®. As an administrative supplement, the work proposed needs to be within the scope of the research that is already supported. Research proposed in supplement applications should have clear relevance to The BRAIN Initiative®. The proposed work may cover pilot projects, resource development, or personnel costs for embedding neuroethics into the research project. In each case, the work proposed should be feasible to complete within a one-year timeframe and with the limited funds permitted. It should also show promise of becoming a more substantial project that might attract additional funding. Investigators should submit applications as responses to the parent active administrative supplement announcement (https://grants.nih.gov/grants/guide/pa-files/PA-18-591.html) using electronic submission. Electronic applications are strongly encouraged.. Individual requests can be no more than $100,000 in direct costs exclusive of Facilities and Administrative costs on sub-contracts and may be for one year only. Requests must be received by June 15 for funding in FY 2018.