Neural Recording and Modulation

The NIH BRAIN Initiative supports the development and optimization of new tools and technologies for modulation and recording of cellular or near cellular resolution signals of the central nervous system and the biology and biophysics underlying those technologies.  

These technologies include electrodes, micro/miniscopes, molecular probes for neurotransmitters, magnetothermal tools, bioluminescent recorders, and voltage indicators, as well as supplemental components for these base technologies like custom application specific integrated circuits (ASICs), adaptive optics, and signal processing techniques.  

The primary goal of this research is to develop new tools that enable new capabilities for in vivo experiments, at or near cellular resolution, in animal models. Neural activity is defined broadly to include electrical activity, neurotransmitter and neuropeptide signaling, as well as plasticity and intracellular signaling events. The technologies funded through these funding opportunities represent diverse modalities including optical, electrical, magnetic, acoustic and genetic recording/manipulation. 

Funding Opportunities

  • New Concepts and Early - Stage Research for Large - Scale Recording and Modulation in the Nervous System (RFA-EY-23-001; R21 Clinical Trial Not Allowed)  

  • New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (RFA-NS-24-004; R01 Clinical Trial Not Allowed) 

  • Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (RFA-NS-24-005; U01 Clinical Trials Not Allowed)   

  • BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (RFA-NS-24-031; R18 - Clinical Trial Not Allowed)

Related Information

Brain Behavior Quantification and Synchronization program


For questions related to funding opportunities or program areas, please find contact information below. For public inquiries, please use our Contact Us form.

Yvonne Bennett, Ph.D.
National Institute of Mental Health (NIMH)  

Megan Frankowski, Ph.D. 
National Institute of Neurological Disorders and Stroke  (NINDS