Abstract: In this proposed research project, we seek to develop an advanced brain SPECT system that offers a unique hyperspectral imaging capability substantiated by an excellent energy resolution (e.g.,
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
1 mm resolution single-photon spectral imaging of the brain
Investigator
Ling-Jian Meng, Scott Dean Metzler
Institute
university of illinois at urbana-champaign
Fiscal Year
Funding Opportunities Number
Project Number
Title
3D Printed Configurable and Themoresponsive Intracortical Electrode Array Platform
Investigator
Huanan Zhang
Institute
university of utah
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY: Long-term neural recording using implantable devices has provided important discoveries that have shaped our understanding of how the neural circuitry of the brain works and, more recently, has been used experimentally to treat such disorders as paralysis that provide hope for ma
Title
A Dry Electrode for Universal Accessibility to EEG
Investigator
Walid Soussou
Institute
quasar, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Electroencephalography (EEG) measures the brain’s local field potential from the surface of the scalp. This method is useful for studying cognitive processes, neurological states, and medical conditions.
Title
A germline- and promoter-independent strategy to gain access to all cell types in the brain
Investigator
Huaiyu Hu, Yingxi Lin, Baisong Lu
Institute
wake forest university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project summary The heterogeneity from the vast number of cell types in the brain presents a major challenge in our understanding of how brain works and in our treatment of neurological disorders.
Title
A multi-foci objective lens for large scale brain activity recording
Investigator
Chris Xu
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract The goal of this project is to develop a novel bifocal catadioptric objective that will allow large-scale recording of neural circuits in vivo.
Title
A scalable cloud-based framework for multi-modal mapping across single neuron omics, morphology and electrophysiology
Investigator
Bing-Xing Huo
Institute
broad institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Categorizing individual neurons into different groups, or cell types, is a classical approach to studying the nervous system.
Title
A transformative method for functional brain imaging with Speckle Contrast Optical Spectroscopy
Investigator
David A Boas, Xiaojun Cheng
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
Abstract Advances in non-invasive monitoring of human brain function under normal and pathological conditions will lead to breakthroughs in our understanding of the brain in health and disease, and lead to the development of devices available for everyday use, with applications such as monitoring
Title
A visualization interface for BRAIN single cell data, integrating transcriptomics, epigenomics and spatial assays
Investigator
Maximilian Haeussler
Institute
university of california santa cruz
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT The BRAIN Initiative’s -omics data archive NeMO contains all the BICCN single cell single cell data, more than one million files at the time of writing.
Title
Advancing fMRI Acquisition through Dissemination of EPTI- An Efficient Distortion-Free Multi-Contrast Imaging Technology
Investigator
Fuyixue Wang
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT Functional MRI (fMRI) is today the predominant tool for noninvasive imaging of brain function, which has revolutionized our understanding of the human brain.
Title
All holographic two-photon electrophysiology
Investigator
Hillel Adesnik
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Achieving a detailed understanding of the neural codes of sensation, action, and cognition will require technologies that can both sample and perturb neural activity with millisecond precision and cellular resolution across large populations of neurons.
Title
An Autonomous Rapidly Adaptive Multiphoton Microscope for Neural Recording and Stimulation
Investigator
Mark A Foster
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT Multiphoton microscopy of cells labeled with genetically encoded calcium indicators (GECIs) enables detection and correlation of fine neuronal structure to functional activity with cellular resolution.
Title
An Integrated Biomarker Approach to Personalized, Adaptive Deep Brain Stimulation in Parkinson Disease
Investigator
Dennis Alan Turner
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
DBS therapy for Parkinson Disease [PD], the primary, FDA-approved surgical approach, has proven efficacious in clinical trials.
Title
An optical-genetic toolbox for monitoring and controlling diverse neuromodulatory circuits governing complex behaviors in primates
Investigator
Karl A. Deisseroth, Eyal J Seidemann
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT Perceptually guided behavior involves a complex and dynamic interplay between external inputs and internal states that are related, for example, to alertness, motivation, expectations and attention.
Title
Analysis of modulation of the metabotropic glutamate receptor type 5 in a novel heritable model of drug abuse vulnerability
Investigator
Loren D Peeters
Institute
east tennessee state university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Schizophrenia is a debilitating mental illness affecting an estimated 1% of the global population.
Title
Beyond dopamine: dual neuromodulator regulation of motor variability and learning
Investigator
Drew Clinton Schreiner
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Learning and performing complex skills such as speech or music requires precise control of motor variability. While elevated motor variability can spur the learning of new behaviors, excessive variability can impair performance of learned skills.
Title
Biophysical Mechanisms of Cortical MicroStimulation
Investigator
Sydney S Cash, Mark Thomas Harnett
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Direct local electrical stimulation (DLES) is an increasingly important therapeutic tool for treating brain disorders such as Parkinson’s, epilepsy, and OCD.
Title
Boss: A cloud-based data archive for electron microscopy and x-ray microtomography
Investigator
Brock A. Wester
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT The generation of scientifically rich, high resolution neuroimaging volumes continues to increase in extent and rate due to the advancement of new Electron Microscopy (EM) and X-ray Microtomography (XRM) imaging sys- tems and data processing methodologies.
Title
Bottom-Up, Top-Down, and Local Interactions in the Generation and Consolidation of Cortical Representations of Sequential Experience
Investigator
Bruce L Mcnaughton
Institute
university of california-irvine
Fiscal Year
Funding Opportunities Number
Project Number
Years of study and theory about the unique role of the hippocampus in storing new memories has led to a general idea that the hippocampus generates a unique output code for every unique experience, that is projected back to the neocortex, where it becomes coupled to attributes of the experience t
Title
BRAIN CONNECTS: A Center for High-throughput Integrative Mouse Connectomics
Investigator
Jeff W Lichtman
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract The proposed project will demonstrate the feasibility of generating a complete synapse-level brain map (connectome) by developing a serial-section electron microscopy pipeline that could scale to a whole mouse brain.
Title
BRAIN CONNECTS: Center for a pipeline of high throughput integrated volumetric electron microscopy for whole mouse brain connectomics
Investigator
Forrest Christie Collman, Nuno Macarico Da Costa
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: Center for whole mouse brain connectomics using high-throughput integrated volumetric electron microscopy (HIVE) Two fundamental components of the structural basis of brain function are cell type composition and the wiring diagram between those cells.