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Researchers supported by the National Institutes of Health Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative have developed a way to genetically insert a type of light receptor into neurons. The new technique enables the researchers to suppress the neuron’s activity using pulses of light. While researchers have previously used light to control the activation of neurons, the ability to inhibit the activity of neurons represents a powerful tool that can be used to better understand the workings of neural circuits in the brain.

In the diagnosis of disease, doctors often need to take tissue samples and process them for examination under a microscope. Millions of such biopsies are performed in the U.S. every year. But these pose many challenges. Biopsies may damage healthy tissue. Conventional histology techniques used to examine the samples can require extensive processing and take days.

NIH-funded study identifies brain cells that form boundaries between discrete events.

Treatment-resistant depression (TRD) is diagnosed after an individual has tried several types of treatment for depression and their symptoms haven’t improved. The effectiveness of deep brain stimulation (DBS) as a treatment for disorders such as Parkinson’s disease has led researchers to investigate whether it could also work for psychiatric disorders such as TRD. However, depression varies significantly among individuals, and studies on DBS for TRD have also produced variable results. This points to a need to personalize DBS treatment for individuals with depression.

Study sheds light on potential for long-term, at-home use of deep brain stimulation as a treatment for neuropsychiatric disorders

Atlas and cell census represent the initial products of the BRAIN Initiative Cell Census Network

By Joshua Gordon, M.D., Ph.D., and Walter Koroshetz, M.D., director of the National Institute of Neurological Disorders and Stroke 

The NIH-led Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative continues to teach us about the world’s most sophisticated computer: the human brain. This striking image offers a spectacular case in point, thanks to a new tool called Visual Neuronal Dynamics (VND).