Circuit Diagrams

BRAIN Initiative: Data Archives for the BRAIN Initiative (R24 Clinical Trial Optional)

This Notice of Funding Opportunity (NOFO) solicits applications to develop web-accessible data archives to capture, store, and curate data related to BRAIN Initiative activities.

BRAIN Initiative: Production and distribution facilities for brain cell type-specific access reagents (U24 Clinical Trial Not Allowed)

This BRAIN Initiative Notice of Funding Opportunity (NOFO) is to support scaled reagent production and distribution facilities involving technologies to access brain cell types.

BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R21 Clinical Trial Optional)

Guided by the goals established in BRAIN 2025: A Scientific Vision and reinforced by the Advisory Council to the Director Working Group on BRAIN 2.0 Neuroethics Subgroup, this Notice of Funding Opportunity (

BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R01 Clinical Trial Optional)

BRAIN Initiative: Marmoset Coordination Center (U24 Clinical Trials Not Allowed)

This Notice of Funding Opportunity (NOFO) solicits applications to create a Marmoset Coordination Center. The awardee will be responsible for two separate but related activities. The first activity will be to become the repository for genomic, pedigree, and event records (date of birth, medical, reproductive history) for captive marmosets.

BRAIN Initiative: Marmoset Colonies for Neuroscience Research (U24 Clinical Trials Not Allowed)

The common marmoset (Callithrix jacchus) has emerged as a promising nonhuman primate model system to understand the primate brain. This has come about both from the realization that the behavior of the common marmoset is similar in some ways to human behavior and from recent demonstration of germline transmission of exogenous genetic information.

Live spike sorting for multichannel and high-channel recordings

The goal of this project is to create two prototypes of a novel live spike sorting system which can be used by investigators to spike sort streams of neural data recorded by multi-channel, high channel and ultra-high channel probes. In most in-vivo extracellular recording conditions, an electrode can pick up neural spikes from several nearby neurons resulting in so-called “multi-unit” activity in the recording trace.

Commercial translation of high-density carbon fiber electrode arrays for multi-modal analysis of neural microcircuits

The ability to measure and manipulate local brain circuit activity in living, behaving animals is essential to understanding the complexities of brain function and dysfunction.

BRAIN Initiative Connectivity across Scales Data Coordinating Center (BRAIN CONNECTS DCC) (U24 Clinical Trial Not Allowed)

This Notice of Funding Opportunity (NOFO) solicits applications for one or more Data Coordinating Centers (DCCs) to support BRAIN CONNECTS, a networked consortium of Comprehensive Cente

A Dry Electrode for Universal Accessibility to EEG

Electroencephalography (EEG) measures the brain’s local field potential from the surface of the scalp. This method is useful for studying cognitive processes, neurological states, and medical conditions. Its relative low- cost, ease-of use, and non-invasiveness increase its utility in brain monitoring for both research and medical applications. Unfortunately, the process of acquiring EEG is often not inclusive of all research subjects. EEG typically requires scalp abrasion and application of conductive gels to create a low impedance contact between exposed skin and the electrode tips.

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