Circuit Diagrams

Project Abstract In this Phase I

ABSTRACT Many clinical situations, including stroke, expose the brain to insufficient cerebral blood flow (CBF) that cannot maintain normal cerebral metabolic rate of oxygen consumption (CMRO2) requirements, thereby leading to cerebral ischemic/hypoxic stresses and neurological disorders. Effective interventions are dependent on the findings of CBF/CMRO2 improvement and eventually neural recovery. Rodents (mice and rats) make up 95% of research animals.

Abstract The proposed work aims at the development of an enhanced organoid-based in vitro pre-clinical drug screening platform for neurological and neurodegenerative brain diseases.

Abstract Preclinical small animal imaging makes valuable contributions to improving our understanding of human brain. Multi-modal imaging approaches to combine functional Magnetic Resonance Imaging (fMRI) with Intracranial Electroencephalogram (iEEG) provides an unparalleled view of the global network activity across cortical areas, revealing information at high temporal and spatial scales about functional connectivity and their intrinsic oscillatory properties, which is of vital importance in many branches of neuroscience and medicine.

PROJECT SUMMARY Examining how behavior arises from the complex interconnected activity of the brain is a cornerstone of neuroscience research. A recent technological advance in neurotechnology is enabling studies where the parallel activity of thousands of neurons can be studied in rodent brains. The Neuropixels probe, allowing 384 channels of electrophysiological data to be observed from the brain, is now a valuable tool for next-generation experiments.

PROJECT SUMMARY Over the last century, extracellular recording technologies have progressed from handmade needle electrodes and vacuum tube amplifiers to microfabricated devices containing hundreds of recording sites and on-chip digitization circuits. This technological arc has facilitated Nobel-prize winning discoveries such as the unitary nature of action potentials, the computations underlying mammalian vision, and the neural basis of spatial learning, among many other notable findings.

This Phase I SBIR will further develop, validate, and initiate commercialization of the miniature ultrasound beamforming array (MUBA) system for transcranial focused ultrasound (tFUS). The MUBA system will allow preclinical researchers to reversibly and non-invasively modulate neural activity in intact brain circuits with unparalleled precision.

Project Abstract/Summary The objective of this psychological technology SBIR/

Project summary This SBIR proposal aims to address current challenges in data-driven neuroscience by implementing DataJoint SciOps: a commercial service to help research labs implement computational workflows for data-intensive science experiments.

PROJECT SUMMARY This project seeks to develop a multi-probe ultrathin endomicroscope to enable high-resolution imaging and photo-stimulation at multiple sites within currently inaccessible regions of the brain. The instrument will be amenable to scientific studies in model animals and a stepping stone for future medical instrumentation targeted at diagnosis and disease treatment in humans. The company addresses the critical need in the scientific and medical fields for endoscopes that are minimally invasive, with a cross section in the order of 100μm.