Project Summary Mechanistically linking network connectivity and the dynamics of neural networks to variation in the behavior of individuals is an overarching goal of neuroscience. Here we address this goal using techniques from network science to calculate functional networks that summarize pair-wise and higher order interactions between all recorded neurons.
Project Summary Navigating within an odor plume is a complex task due to unpredictable changes in odor concentration. The algorithms used by organisms to navigate the odor plume remain mysterious and how the brain solves this complex sensorimotor task key to escaping, mating and eating is unknown (1). The problem is challenging because it requires parallel monitoring of: 1) brain activity in multiple brain regions in the freely moving animal, 2) odor plume dynamics, 3) sniffing and 4) animal motion.
PROJECT SUMMARY / ABSTRACT Our current understanding of primate motion perception is often lauded as one of the great achievements of computational systems neuroscience. Due to its early successes in explicating the fundamentals of neural coding and relations between brain activity and perception, and further constrained by the practical limitations of the macaque model, it has remained rooted in conventional experimental approaches.
Project Summary / Abstract How do cortical populations represent sensory input and support perceptual decision making? It has long been known that the responses of individual neurons to the repeated presentation of a stimulus are highly variable. Nonetheless, the pattern of activity across a population encodes enough information to support precise perceptual decisions. This implies that hidden in the distribution of population responses there are invariant features, yet to be identified, which robustly encode the sensory stimulus from one trial to the next.
PROJECT SUMMARY Pattern separation is the process by which the brain distinguishes between similar or overlapping features of the external world. This fundamental computation is performed by multilayered circuits – including the dentate gyrus, cerebellar cortex, and insect mushroom body – that expand and diversify neural representations. Diversity in “space” (i.e.
Project Summary/Abstract Maintenance of body temperature at the optimal level is crucial for survival, and it requires homeostatic feedback regulation based on monitoring the temperature of internal organs as well as the environment. Homeostatic thermoregulation in response to changes of brain temperature relies on the temperature- sensitive neurons in the preoptic area of the anterior hypothalamus (POA).
Abstract A general principle of brain function is the ability to store information about the past to better predict and prepare for the future. Working memory and timing are two computational features that evolved to allow the brain to use recent information about the past to accomplish short-term goals. Working memory refers to the ability to transiently store information in a flexible manner, while timing refers to the ability to generate well timed motor responses, modulate attention in time, and predict when external events will occur.
Project Summary/Abstract In order to control specific behavioral responses, transcriptionally distinct cell types assembled into dynamic brain circuits integrate environmental information with internal states and generate purposeful motor actions. While tools have been developed to independently measure the activity dynamics, connectivity and transcriptional profiles of individual neurons, it remains challenging to integrate this diverse information into a coherent model of behavior.
PROJECT SUMMARY Rhythmic fluctuations of electrical activity in the brain are frequently observed during cognitive tasks. In many cases these oscillations are synchronized across brain regions. Synchronization in the gamma-frequency (~30- 100 Hz) range has been hypothesized to promote communication between brain regions, thereby facilitating cognitive functions. Conversely, deficits in gamma synchrony have been hypothesized to contribute to cognitive deficits at the heart of schizophrenia, Alzheimer’s disease, and related disorders.
PROJECT SUMMARY A principle aim of the NINDS is to determine how motor control is successfully implemented by the nervous system. Locomotion and balance are complex motor functions that are largely controlled by complex microcircuits that reside outside the brain. Understanding how such microcircuits function is critical to being able to treat diseases related to age, congenital disorders, and trauma in which these circuits are impaired.
