A fundamental goal of the BRAIN Initiative and other neuroscience projects is to map cell types in the brain and study their changes associated with function, disease, and drug treatment.
The purpose of this proposal is to disseminate polymer microelectrode arrays and promote their integrated into neuroscience research practice. Such polymer neural interfaces are mechanically compliant to promote stability of the device-tissue interface and versatile in that both surface and penetrating electrode arrays can be produced with the same technology.
Summary Invasive neurostimulation is an established technique in the therapy of movement disorders and epilepsy, and shows promise for amelioration of psychiatric and cognitive disorders. Recently, several implantable neurostimulation hardware platforms have begun to incorporate sensing of cortical and subcortical field potential activity, with the capability for wireless streaming from the internal device to external computers over years.
Project summary Over the past five years, the Allen Institute has built two unique in-house pipelines for in vivo electro- and optical-physiology: together they form the Allen Brain Observatory. We used this observatory to freely and openly share calcium imaging data from ~60,000 cells from 221 running mice viewing standard visual stimuli; in October 2019, we will release Neuropixels electrophysiology recordings from ~100,000 cells from 100 mice under the same conditions, all registered to a common anatomical coordinate system (CCFv3).
The field of neuroscience and the BRAIN Initiative in particular are amassing a wealth of informatics resources for managing, analyzing, and sharing data.
PROJECT SUMMARY The goal of this project is to build an open-access recombinant antibody/affinity reagent resource for the neuroscience community called NABOR (Neuroscience AntiBody Open Resource).
PROJECT SUMMARY/ABSTRACT This project aims to disseminate validated technologies and resources of the National Center for Microscopy and Imaging Research (NCMIR) at UC San Diego to advance the completion of strategic goals of the BRAIN Initiative.
PROJECT SUMMARY Lack of standards for neurophysiology data and related metadata is the single greatest impediment to fully extracting return on investment from neurophysiology experiments. One of the greatest questions in science today is understanding how the brain works and gives rise to thoughts, memories, perception, and consciousness.
Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format One of the major goals of the BRAIN Initiative is to distill complex, multi-modal data into predictive frameworks via theory/modeling.
Since its invention in the early 90s, functional magnetic resonance imaging (fMRI) has revolutionized our un- derstanding of the human brain. Functional MRI may be used to observe brain function during a specific motor or cognitive task, or at “rest” (resting-state fMRI). The latter produces so-called “functional connectivity” maps that may provide a new window into human cognition. There is currently a large, world-wide effort underway to discover potential research and clinical uses of such connectivity maps.
