Project Summary/Abstract This proposal responds to RFA-MH-17-245, which requests applications focusing on the mechanisms and dose- response relationships of noninvasive neuromodulatory methods.
PROJECT SUMMARY Deep brain stimulation (DBS) has had great impact, helping patients with disorders such as Parkinson's disease and obsessive–compulsive disorder (OCD), and with great potential for other disorders such as depression and Alzheimer's disease. DBS, being a surgical procedure, bears the potential for complications that limit its deployment and adoption.
Project Abstract One of the major goals of the BRAIN initiative is to develop technologies capable of interfacing with specific neural circuits in the human brain.
Project Abstract Due to recent technological advances, it is possible to image the high-resolution structure of brain volumes at spatial extents that are much larger than was previously possible. Emerging X-ray microtomography (XRM) methods allow for the collection of whole mouse brains in a high-throughput paradigm, permitting the generation of sub-micron three-dimensional image volumes in less than a day without the alignment challenges or tissue clearing approaches of other methods.
ABSTRACT The overarching goal of this project is to secure, link, and disseminate BRAIN Initiative data, including electrophysiology, imaging, behavioral, and clinical data with all pertinent recording and imaging parameters, coming from participating sites.
PROJECT SUMMARY The wealth, depth and quality of multi-omic data generated through funding from the BRAIN initiative is unprecedented. It ranges from bulk and single cell RNA-seq, to detailed cell type- specific epigenetic analyses throughout development.
ABSTRACT The BRAIN Initiative is designed to leverage sophisticated neuromodulation, electrophysiological recording, and macroscale neuroimaging techniques in human and non-human animal models in order to develop a multilevel understanding of human brain function.
Project Summary/Abstract A fast-growing technique in human neuroscience is electrocorticography (ECOG), the only technique that allows the activity of small population of neurons in the human brain to be directly recorded. We use the term ECOG to refer to the entire range of invasive recording techniques (from subdural strips and grids to penetrating electrodes) that share the common attribute of recording neural activity from the human brain with high spatial and temporal resolution.
Project Summary Recent advances in neurotechnologies have provided us with the ability to modulate brain function by direct and indirect interventions. Deep Brain Stimulation (DBS) is one such intervention that has already been FDA-approved for certain disorders, and its use has already raised ethical questions about ways in which direct brain stimulation may affect personal identity, autonomy, authenticity and, more generally, agency. Thus far the neuroethical worries have been largely based on anecdotal clinical reports.
