Xiaotang Lu, PhD

2021 K99/R00 Awardee
Image
photo of Xiaotang Lu
Harvard University
Postdoctoral Fellow

Dr. Xiaotang Lu is a Postdoctoral Fellow working with Prof. Jeff Lichtman at Harvard University. She received her M.S. in Chemistry from Tsinghua University and Ph.D. in Materials Science and Engineering from the University of Texas at Austin. Her research interest revolves around developing new methods and tools to illustrate structures at nanoscales. In her graduate research, she synthesized novel nanomaterials for applications, including solar cells and high-capacity lithium-ion batteries. She also developed in-situ electron microscopy to study the structural and composition change of those nanomaterials during electrochemical reactions. Toward the end of her Ph.D., she became interested in connectomics, a nascent field of neuroscience that attempts to unravel the complexity of the brain using electron microscopy. In the Lichtman lab, she focuses on developing methods for preparing large brain tissues for volumetric EM imaging and extracting multiplexed information from the same sample. Her work has resulted in the invention of NATIVE (Nanobody-assisted tissue immunostaining for volumetric EM), a widely applicable immunostaining approach for intracellular targets while preserving the tissue ultrastructure for high resolution EM imaging. Through her BRAIN Initiative project, she will keep on solving bottleneck methodological problems for connectomic studies and establishing new paradigms for multimodal brain imaging.