Funded Awards

Understanding the brain processes underlying alcohol use and misuse are essential for the development of effective treatments for alcohol use disorder or AUD. Human brain imaging has greatly contributed to our current understanding of AUD, but much more remains to be understood.

CRCNS Research Proposal: Collaborative Research: Multimodal Dynamic Causal Learning for Neuroimaging A Project Description A.1 Introduction Many analyses of fMRI and other neuroimaging data aim to discover the underlying causal or commu- nication structures that generated that activity.1,2 An acc

The ability to predict when external events will occur, such as anticipating the actions of a predator or the availability of food, is critical for survival.

Detailed description of the proposed use of the animals, including species, strains, ages, sex, and number to be used; Dissociated, primary cultures will be prepared from the cortex of new born mice of either sex (mus musculus, Postnatal day 0-1).

Fast glutamatergic synaptic transmission is based on a precise and complex molecular organization which requires the control of the number of AMPA-type glutamate receptors (AMPARs) at the postsynaptic sites of glutamatergic synapses on dendritic spines.

A brief glimpse at a face quickly reveals rich multi-dimensional information about the person in front of us. How is this impressive computational feat accomplished? A recently revised neural framework for face processing suggests perception of face form information, i.e.

The ability to listen and identify sounds in the presence of competing background noise is a critical function of the healthy auditory system.

Project Summary To further our understanding of the function of neural circuits, there is a need for new tools that can collect simultaneous measurements from large populations of neurons involved in a common neural computation and provide precise functional modulation.

Development of a high throughput system for molecular imaging of different cell types in mouse brain tissues Mass spectrometry imaging (MSI) is a powerful tool for developing detailed molecular maps of biological tissues with high specificity and sensitivity.

ABSTRACT Understanding the biological principles of cell type diversity and organization is necessary for deciphering neural circuits underlying brain function.

Project Summary Opioids as a pain medication has been the most preferred pain treatments in order to provide quick relief from severe pain. Decades of opioid abuse have triggered negative impact on pain therapies.

Measurements of cortical field potentials are widely used throughout basic and clinical neuroscience, including in electroencephalography (EEG), electrocorticography (ECoG) and local field potential (LFP) recordings.

Project Summary [30 lines max] Timing is critical to neural processing. Nowhere is that clearer than in visual motion detection. To detect motion, neurons transmit visual information with different latencies, or delays, allowing the circuit to compare visual scenes over time.

Project Summary The goal of the proposed research is to probe object-recognition circuitry in inferotemporal cortex by specific manipulations of early visual experience.

PROJECT SUMMARY: This team initiative will provide the broad neuroscience community with a cell type-specific adeno- associated virus (AAV) armamentarium for easy and non-invasive implementation of novel and emerging molecular tools for anatomical and functional analysis of the nervous system in rod

ABSTRACT Short-term memory is an essential component of cognition. Here, we will investigate an ethologically relevant form of short-term memory that guides navigation behavior: memory of odor concentration across sniffs.

PROJECT SUMMARY/ABSTRACT The growing availability of large functional magnetic resonance imaging (fMRI) datasets has enabled new investigations into functional systems of the human brain.

Project Summary A prominent feature of biological neuronal networks is the astonishing diversity of their cell types.

Project Summary The goal of this project is to create a unified framework for understanding the relationship between neuronal gene expression and connectivity in mouse visual cortex, by using morphology as a key linking modality.