Notices of Funding Opportunities

National Institutes of Health (NIH) BRAIN Initiative notices of funding opportunities (NOFOs), requests for applications (RFAs), program announcements (PAs), and other NIH Guide announcements are listed below. Search this page to find all notices of special interest (NOSI). Search the Closed Opportunities page to find expired opportunities.  

Learn more about NIH’s grant mechanisms.  

Learn about the Plan for Enhancing Diverse Perspectives (PEDP), a required component in most BRAIN applications.  

Learn about the NIH Data Management and Sharing Policy, which all NIH applications must follow.  

To see more NIH-funded awards, please visit NIH Grants and Funding.

For more about NIH BRAIN Initiative research and associated funding opportunities, visit the Research Overview.

Title
Release Date
Expiration Date
Funding Opportunity #
Notice of Change to Award Budget for RFA-NS-24-014 "NIH Blueprint and BRAIN Initiative Program for Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences (BP BRAIN-ENDURE) (R25 Clinical Trial Not Allowed)"
January 01 , 2027
The purpose of this notice is to inform applicants of a clarification to the Award Budget for RFA-NS-24-014 "NIH Blueprint and BRAIN Initiative Program for Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences (BP BRAIN-ENDURE) (R25 Clinical Trial Not Allowed)".
Notice of Change: Extension of RFA-NS-24-028 - BRAIN Initiative Connectivity across Scales Data Coordinating Center (BRAIN CONNECTS DCC) (U24 Clinical Trial Not Allowed)
August 22 , 2024
The purpose of this notice is to extend RFA-NS-24-028BRAIN Initiative Connectivity across Scales Data Coordinating Center (BRAIN CONNECTS DCC) (U24 Clinical Trial Not Allowed) by one additional council round. An additional receipt date, August 21, 2024, has been added and the new expiration date is August 22, 2024.
Notice of Special Interest (NOSI): Translation of BRAIN Initiative Technologies to the Marketplace
April 06 , 2027
This Notice of Special Interest (NOSI) encourages the translation of the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative-supported technologies from academic and other non-small business research sectors to the marketplace. Small Business Concerns (SBCs) are encouraged to submit Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grant applications that propose to further develop, optimize, validate and scale such technologies for commercial dissemination. Additionally, SBIR and STTR applications supporting the development and commercialization of novel technologies that fit within the mission of the BRAIN Initiative are encouraged.
Notice of Change: Post-Submission Materials for RFA-NS-24-005 - BRAIN Initiative: Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)
January 01 , 2027
Allowing post-submission materials.
Notice of Information: NINDS will increase the salary allowance for K00 awardees for NIH Blueprint and BRAIN Initiative Diversity Specialized Predoctoral to Postdoctoral Advancement in Neuroscience (D-SPAN) Award (F99/K00)
January 01 , 2027
The purpose of this notice is to inform the community that the NIH Blueprint and BRAIN Initiative are changing the funding allowance for K00 awards to RFA-NS-21-012, RFA-NS-19-011, and RFA-NS-18-007.This change will apply to all new and continuing NIH Blueprint and BRAIN Initiative F99/K00 awards. Currently, the NIH Blueprint and BRAIN Initiative provides up to $58,000 salary during the K00 phase. Effective for new and continuing K00 awards made with FY2024 funds, the NIH Blueprint and BRAIN Initiative will contribute up to $60,000 in the first year toward the salary of the career award recipient. This will be increased to $63,300 for the second year, to $66,600 for the third year, and to $69,900 for a fourth year.
Request for Information (RFI): BRAIN Initiative: Brain Behavior Quantification and Synchronization: Guidance for Opportunities in Development of Sensor Technology Hubs
January 01 , 2027

This is a request for information to gather ideas and commentary on the potential development and program planning of hubs or centers for testing sensor performance. Responses will be examined for enthusiasm and general support for the creation of several hubs for testing sensors that are developed by not only NIH awardees, but the broader engineering community.

Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)
January 01 , 2027
This Notice of Intent to Publish is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects for the following Notice of Funding Opportunity (NOFO), which is expected to be published in January 2024, with an anticipatedapplication receipt date in May 2024. The Brain Research through Advancing Innovative Neurotechnologies(BRAIN) Initiative intends to promote a new initiative by publishing a NOFO to solicit applications that would support development and preclinical testing, beginning withproof of concept,of next-generation recording and/or modulation devices for human use to further our understanding of the human central nervous system and treat nervous system disorders.
Notice of Special Interest (NOSI): Encourage Eligible NIH BRAIN Initiative Awardees to Apply for PA-23-189 Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)
November 30 , 2026
This Notice encourages eligible awardees in the BRAIN Initiative community to apply for administrative supplements in response to PA-23-189, Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed). The NIH has a strong interest in the diversity of the NIH-funded workforce (see NOT-OD-20-031) and encourages institutions to prioritize inclusion by supporting the participation of individuals from groups identified as underrepresented in the biomedical, clinical, behavioral, and social sciences.
Notice of Change to Funding Opportunity Announcement, RFA-DC-24-001, BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Basic Experimental Studies with Humans Required)
January 01 , 2027
The purpose of this Notice is to inform interested applicants that late applications will be accepted for RFA-DC-24-001 " BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Basic Experimental Studies with Humans Required)" .
Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative Connectivity across Scales Data Coordinating Center (BRAIN CONNECTS DCC) (U24 Clinical Trial Not Allowed)
January 01 , 2027
This Notice of Funding Opportunity (NOFO) solicits applications for one or more Data Coordinating Centers (DCCs) to support BRAIN CONNECTS, a networked consortium of Comprehensive Centers and Specialized Projects funded under RFA-NS-22-047, RFA-NS-22-048, and RFA-NS-22-049. The goals of these awards are to develop the research capacity and technical capabilities for comprehensive brain-wide connectivity mapping in mouse, human, and non-human primate (NHP). BRAIN CONNECTS projects will collect and process unprecedented volumes of anatomical data by scaling up cutting-edge acquisition modalities and analysis methods, to demonstrate the feasibility of collecting, reconstructing, analyzing, integrating, disseminating, and interpreting connectivity maps from entire brains. The resulting feasibility data from these awards are expected to inform NIH decisions on program continuation in a potential subsequent five-year funding period for production of brain-wide wiring diagrams. NIH expects to fund one or more BRAIN CONNECTS DCCs, which will collaborate with CONNECTS data generating projects to (1) coordinate activities of the BRAIN CONNECTS Network, (2) develop and harmonize common data processing pipelines, (3) integrate and disseminate data analytic tools and capabilities, (4) establish a unified knowledge base for connectivity data of diverse modalities, and (5) organize and implement outreach and engagement to the wider research community and the general public. Awards will be integrated into the BRAIN CONNECTS Network as a coordinated effort aimed at developing the ability to generate wiring diagrams spanning entire brains across multiple scales and species.