Project Summary
Here, we propose to thoroughly characterize the origins of pairwise correlations in cortex using a synergistic mix
of experimental methodologies, behavior, and computation in mice and macaques.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleThe origins of neuronal correlations in cerebral cortex
Investigator
David J Heeger, Jason Neil Maclean, John H.r. Maunsell
Institute
university of chicago
Fiscal Year
Funding Opportunities Number
Project Number
TitleThe power of positivity: a novel class of voltage indicators for high-fidelity brain activity imaging
Investigator
Michael Z. Lin
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
To understand how the brain functions in health, and how sensory, motor, and cognitive functions are affected in disease, it
is crucial to be able to record the activities of large numbers of individual neurons in real time.
TitleTopological bridges between circuits, models, and behavior
Investigator
Marlene Rochelle Cohen, Chengcheng Huang, Alessandro Rinaldo, Caroline Anne Runyan
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Project summary
The plight of the neuroscientist trying to understand the brain using linear analysis methods is akin to studying
the makeup of the ocean using the bits you find with a metal detector.
TitleUltra-high Throughout Single Cell Multi-omic Analysis of Histone Modifications and Transcriptome in Mouse and Human Brains
Investigator
M Margarita Behrens, Bing Ren
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Histone modification carries rich epigenetic information that constitutes a mechanism of cellular memory.
Single cell analysis of histone modification in conjunction with transcriptome could help uncover this critical
layer of cellular memory and lead to better definition of cell types and states in
TitleUltrasonic Genetically Encoded Calcium Indicators for Whole-Brain Neuroimaging
Investigator
Mikhail Shapiro
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
A major goal of the BRAIN initiative is to develop neural imaging technologies enabling whole-brain imaging of
specific molecular signals such as neuronal calcium.
TitleUnderstanding the role of quantitative internal signals in behavioral flexibility
Investigator
Gaby Maimon
Institute
rockefeller university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
This grant focuses on how very recent experiences––over the past few seconds to minutes––allow brains to
update expectations about the world and then use these expectations to guide behavior.
TitleUse of advanced analytics to understand brain-behavior screen media activity relationships in ABCD data
Investigator
Marc N Potenza, Yihong Zhao
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Growing up in a media-saturated world, the current generation of children and adolescents spend on average 6-
9 hours each day on screen media activities (SMAs). Therefore, SMA is a topic of considerable concern in the
USA and elsewhere.
TitleA Comparative Framework for Modeling the Low-Dimensional Geometry of Neural Population States
Investigator
Eva Dyer
Institute
georgia institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Advances in neural recording technology now provide access to neural activity at high temporal resolutions, from
many brain areas, and during complex and naturalistic behavior.
TitleApplication of the principle of symmetry to neural circuitry: From building blocks to neural synchronization in the connectome
Investigator
Hernan Makse, Manuel Zimmer
Institute
city college of new york
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The broad, long-term objective of this grant is to advance a new theoretical approach to identify
synchronized building blocks of neural circuits based on group theory and its application to understand the
permutation symmetries of these circuits.
TitleCircuit dynamics of sensorimotor integration and decision making in octopus
Investigator
Galit Pelled
Institute
michigan state university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The goal of this proposal is to identify fundamental sensorimotor circuits associated with
goal-oriented gripping movement by using high-dimensional biological, analytical and robotics
technologies.
TitleCloud-based Software Framework to Simplify and Standardize Real-Time fMRI
Investigator
Jonathan D Cohen, Kenneth A Norman
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: (30 lines of text max)
We propose to create an open-source cloud-based software system for real-time fMRI neurofeedback
experiments.
TitleCombined Topological and Machine Learning Tools for Neuroscience
Investigator
Michael Hawrylycz, Partha Pratim Mitra, Yusu Wang
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Two major recent advances have raised the possibility of fundamental breakthroughs in both
basic and clinical neuroscience: the development of new tools to probe the nervous system with
single-cell resolution as well as brain-wide scope, and breakthroughs in machine learning
methods for handling com
TitleCross-frequency coupling: its role in brain function and dysfunction
Investigator
Andrei V Medvedev
Institute
georgetown university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
One of the high priority research areas listed in the BRAIN 2025 Report is a better understanding of the
brain network dynamics across time and space from human electrophysiological recordings.
TitleData Exploration and Analysis Portal for Brain Research through Advanced Imaging Neuroscience
Investigator
Chun Chieh Fan, Wesley Kurt Thompson
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Population neuroscience requires investigation of brain-behavioral relationships within epidemiological
samples studied in longitudinal designs, including a large number of assessment modalities and with subjects
enrolled at many data collection sites to achieve a large sample and br
TitleDevelopment of a scalable strategy for reconstructing cell-type determined connectome of the mammalian brain
Investigator
Dawen Cai, Meng Cui, Yan Yan, Peng Yin
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
In order to fully understand the structural substrates underlying the brain function, it is central to curate
multiple attributes of the same neurons.
TitleEstablishing Common Coordinate Framework for Quantitative Cell Census in Developing Mouse Brains
Investigator
James C Gee, Yongsoo Kim, Lydia Lup-Ming Ng
Institute
pennsylvania state univ hershey med ctr
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Brain development is characterized by a diverse set of cell types that are born and connected into rapidly growing
complex 3D structures across time.
TitleEthics of the Choice of Invasive versus Non-invasive Neurosurgery: Different Stakeholders' Perspectives, Surgical Decision-making, and Impact on Patient Sense of Control
Investigator
Cynthia M. S. Kubu
Institute
cleveland clinic lerner com-cwru
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
A fundamental ethical tenet in medicine is bodily sovereignty, inherent in which is the concept of
control.
TitleFrom ion channels to graph theory in sensorimotor learning
Investigator
Genevieve Konopka, Daniel Margoliash, Jason Neil Maclean, Todd F Roberts
Institute
university of chicago
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Mechanistically linking network connectivity and the dynamics of neural networks to variation in the behavior of
individuals is an overarching goal of neuroscience.
TitleFunctional role of the neocortico-rubro-olivo-cerebellar circuit on neocortex-induced cerebellar motor learning
Investigator
Shogo Ohmae
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The cerebellum performs information processing for motor control and various cognitive functions in
cooperation with the cerebral neocortex.
TitleHead-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving Animals
Investigator
Vladislav Verkhusha, Junjie Yao
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
To capture the normal brain functions, it is critically important to record the neural activities in freely-behaving
animals, with high resolution, high speed, and high throughput.
Last reviewed on July 02, 2025