Funded Awards

Assessing social signals, such as vocalizations, figures prominently in the outcome of aggressive encounters, including the potential to win a fight or prevent escalation resulting in physical injury.

Project Summary To advance the development of next-generation personalized therapies for long-term seizure freedom, we urgently need technologies that improve seizure diagnostics while reducing risks associated with invasive neurosurgical procedures.

PROJECT SUMMARY/ABSTRACT Functional MRI (fMRI) is the most widely-used tool to noninvasively measure brain function and has produced much of our current knowledge about the functional organization of the human brain.

PROJECT SUMMARY WINCS International LLC, in partnership with Mayo Clinic, proposes to develop and demonstrate a highly innovative next-generation clinical instrument together with custom user-friendly display and analysis software. For the first time, the Multifunctional Apparatus for Voltammetry, E

Project Summary Estimates of the total length of axonal "wiring" in the human brain are on the order of hundreds of thousands of kilometers.

Brain function is regulated by molecular signaling and metabolism, however, our ability to track neurometabolic transformations deep in the brain is very underdeveloped compared to the central role of neurometabolism in neurodegenerative disease or brain function in general.

Project Summary Primary motor cortex (M1) and the locus ceruleus (LC) both contribute in essential ways to the generation of purposive movements – with M1 and its pyramidal tract (PT) neurons involved in action planning and execution, the and LC and its noradrenergic axonal projections involved in a

This proposal responds to BRAIN Initiative RFA-NS-20-006 and aims to elucidate the neural and biophysical mechanisms of noninvasive focused ultrasound (FUS) neuromodulation.

This two-year project will advance, integrate, document, and promote the use of the Hierarchical Event Descriptor (HED) system to describe events in human neuroimaging and behavioral data from research experiments and other sources in sufficient detail to support comparative analysis of human brain

PROJECT SUMMARY/ABSTRACT Intracranial recordings in patients undergoing neurosurgical interventions provide a unique opportunity to directly access, study, and learn about both normal human brain function and neuropsychiatric disease.

Histone modifications carry rich information of cellular memory and gene regulatory mechanisms.

ABSTRACT Morphology is an essential phenotype in the characterization of cells and their states. It reflects the progression of functional cellular processes, such as morphogenesis, migration, or dendrite arborization, and can be indicative of disease.

Adeno-Associated Viruses (AAVs) are potent gene delivery vectors for neuroscience studies and gene therapy applications.

Cell Type-specific Anterograde Circuit Mapping and Functional Control by Optimizing YFV-17D Transneuronal Systems Summary To elucidate the functional organization of brain circuitry we need to delineate neuronal connectivity and control the activity of neurons with specific connectivity.

This proposal will investigate neural circuits driving negative phototaxis in an emerging model for neural circuit analysis: larvae of the primitive chordate Ciona. Ciona larvae have a number of features that make them ideally suited for this project.

Summary This proposal will investigate the neural dynamics underlying three-dimensional foraging behavior, with three overarching goals. The first is to evaluate the neural computations of foraging in dynamic environments in naturalistic settings.

Abstract Vision is an active process: we move our head and eyes to explore the sensory world.

Project Summary Divisive normalization (DN) is a well-established theory of how interactions between neurons in a circuit modulate the activity of individual neurons.

PROJECT SUMMARY How our brain achieves coherent perception by integrating information from parallel sensory pathways distributed across space and time remains a central question in neuroscience.

When learning a new task, both rats and humans exhibit suboptimal behaviors plagued with superstitious ticks and idiosyncratic biases.