PROJECT SUMMARY/ABSTRACT
The growing availability of large functional magnetic resonance imaging (fMRI) datasets has enabled new
investigations into functional systems of the human brain.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitlefMRI physiological signatures of aging and Alzheimer's Disease
Investigator
Catherine Elizabeth Chang
Institute
vanderbilt university
Fiscal Year
Funding Opportunities Number
Project Number
TitleFrom diverse dynamics to diverse computation via neural cell types
Investigator
Stefan Mihalas, Eric Todd Shea-Brown
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A prominent feature of biological neuronal networks is the astonishing diversity of their cell types.
TitleFrom synapses to genes through morphology: an integrated characterization of cell types based on connectomics and transcriptomics data
Investigator
Forrest Christie Collman, Nuno Macarico Da Costa, R Clay Reid
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The goal of this project is to create a unified framework for understanding the relationship between
neuronal gene expression and connectivity in mouse visual cortex, by using morphology as a key
linking modality.
TitleFunctional and cell-type specific axonal pathways in the primate brain
Investigator
R Clay Reid
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Over the past decade, there have been transformative advances in three areas of mammalian neuroscience.
First, our ability to record from large populations of neurons has dramatically increased with the advent of new
electrode technologies and improved multiphoton imaging.
TitleGenetic and neural mechanisms underlying emerging social behavior in zebrafish
Investigator
Florian Engert, Mark C Fishman
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
Genetic and neural mechanisms underlying emerging social behavior in zebrafish
Our goal is to understand emerging collective behaviors of groups, such as schooling and shoaling in fish.
Our approach is to dissect basic sensorimotor transformations in the zebrafish, which we believe play a
fundamenta
TitleHarmonizing and Archiving of Large-scale Infant Neuroimaging Data
Investigator
Gang Li
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
The first postnatal years are an exceptionally dynamic and critical period of structural and functional development
of the human brain. Many neurodevelopmental disorders are the consequence of abnormal brain development
during this stage.
TitleHemogenetic imaging technology for circuit-specific analysis of primate brain function
Investigator
Alan Jasanoff
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Primate brains contain cortical areas that exhibit selective engagement in high-level sensory or behavioral
operations. The functional specialization of these regions is thought to be central to primate-specific cognitive
faculties and to associated disorders.
TitleHeritability and cognitive implications of structural-functional connectome coupling
Investigator
Amy Kuceyeski
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
The human brain is an unimaginably complicated system of interconnected neurons that is capable of complex
thought, emotion and behavior.
TitleHigh Frequency Wearable and Transparent Electrostrictive Row-Column Arrays for Whole Brain Functional Imaging
Investigator
Roger J Zemp
Institute
university of alberta
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract Section
Enter the text here that is the new abstract information for your application.
TitleHigh-content single-cell epigenetic technologies scalable to the human brain
Investigator
Andrew Adey
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT ABSTRACT
To meet the goal of the BRAIN Initiative Cell Census Network to catalogue and produce molecular profiles of
every cell type in the human brain; order-of-magnitude improvements in single-cell assay throughput and
coverage are required.
TitleHigh-density optical tomography of cerebral blood flow and metabolism in small animals
Investigator
Guoqiang Yu
Institute
biopticstechnology, llc
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Many clinical situations, including stroke, expose the brain to insufficient cerebral blood flow (CBF) that cannot
maintain normal cerebral metabolic rate of oxygen consumption (CMRO2) requirements, thereby leading to
cerebral ischemic/hypoxic stresses and neurological disorders.
TitleHigh-resolution synaptic and functional connectivity mapping of a neural circuit architecture underlying a behavioral sequence
Investigator
Andrew Michael Seeds
Institute
university of puerto rico med sciences
Fiscal Year
Funding Opportunities Number
Project Number
The ability to generate complex motor behaviors by assembling sequences of movements is essential for
purposeful actions and survival. Defects in the brain regions thought to drive such movement selection can lead
to behaviors becoming abnormally repetitive (e.g. autism spectrum disorder).
TitleHighly scalable and sensitive spatial transcriptomic and epigenomic sequencing of brain tissues from human and non-human primate
Investigator
Rong Fan, Nenad Sestan
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
The human nervous system is possibly the most complex biological tissue, organized into multiple functionally
distinct regions and comprised of over 200 billion neural and non-neural cells, requiring novel scalable tools to
profile cell types and relationships in the tissue context with high
TitleHippocampal neural dynamics driving affiliation and attachment
Investigator
Zoe Rebecca Donaldson, Peyman Golshani, Weizhe Hong, Michael Moshe Yartsev
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Abstract:
Attachment powerfully shapes our development and remains a primary driver of health and well-being in
adulthood; disruption of attachments is highly traumatic.
TitleImaging Dynamics in Anxiogenic Serotonin Circuitry
Investigator
Emily Clarissa Wright
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Serotonin has been long been recognized as an important modulator of mood and behavior, yet it projection-
specific dynamics are little understood.
TitleInfluence of task complexity and sensory feedback on cortical control of grasp force
Investigator
Jennifer L. Collinger
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Humans can skillfully control their grasp during actions as complex and dynamic as swinging a tennis racket,
and as simple and static as holding a briefcase. Both tasks require the use of sensory feedback to achieve
and maintain an appropriate grasp force.
TitleIntegration of High Definition Display Technologies with Platinum Nanorod Microelectrodes for Large Scale in-vivo Recording and Stimulation
Investigator
Shadi Dayeh
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
We propose to develop novel neurorecording devices using sequential thin-film transistors that are capable of
recording and stimulating brain activity with thousands of channels using only 8 wires and to demonstrate
broadband recordings with large area coverage in fully awake, chronically i
TitleIntegrative analysis of genomics and imaging data from the BRAIN Initiative and other public data sources
Investigator
Mark Bender Gerstein, Avram J Holmes
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Constructing an integrated picture of human brain function requires understanding how the effects of molecular
and genetic factors propagate upwards, through many intervening layers of structure and interaction, to
influence behavioral, psychiatric and cognitive traits.
TitleIntegrative analysis of multiomic datasets for discovery of molecular underpinnings of large-scale human brain networks
Investigator
Mikail Rubinov
Institute
vanderbilt university
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
Brain-mapping initiatives are acquiring increasingly large and comprehensive neuroimaging and multiomic—
e.g. genomic and transcriptomic—datasets.
TitleInterferometric Speckle Visibility Spectroscopy for Brain Activity Associated Cerebral Blood Flow Monitoring
Investigator
Changhuei Yang
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Optical monitoring of brain activities is intrinsically associated with a range of operational advantages:
a. non-ionizing and safe radiation, b. simple and relatively lightweight apparatus, c. readily available
commercial optical advanced systems that can be cross adapted for our usage.