Project Summary
The goal of this proposed research is to optimize a dual-use calcium ion sensor for recording single-cell activity
from the entire dorsal cortex or hippocampus of freely-moving mice.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleOptimization of CaMPARI for large-scale, cellular-resolution activity recording in freely-moving mice
Investigator
Robert E. Campbell, Hod Michael Dana, Marie-Eve Paquet
Institute
cleveland clinic lerner com-cwru
Fiscal Year
Funding Opportunities Number
Project Number
TitleOptimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulation
Investigator
Samuel Andrew Hires, Yulong Li
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
Neuromodulators regulate addiction, attention, cognition, mood, memory, motivation, sleep, and more through
their influence on brain circuits. Classic tools for measuring neuromodulation in the brain have poor spatial and
temporal resolution.
TitlePlatform technologies for scalable highly multiplexed proteomic phenotyping of the brain
Investigator
Kwanghun Chung, Hong-Wei Dong, Matthew P Frosch, Guoping Feng, Peng Yin
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
The complexity of the mammalian brain is unparalleled by any other organs, and understanding its cellular
composition and their brain-wide organization is essential to understand the brain functions and dysfunctions.
Extensive efforts have been made toward mapping brain cells through various lenses,
TitlePrinciples of sensorimotor processing in zebrafish thermosensation
Investigator
Martin Haesemeyer
Institute
ohio state university
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
It is our long-term goal to understand computations that underlie sensori-motor transformations in the context
of thermoregulatory behaviors. Generating appropriate behaviors in response to sensory stimuli is critical for
the survival of any animal.
TitleProject 2
Investigator
Anna Devor
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
We propose to investigate the role of neuromodulation in the phenomenon of “whole-cortex” activity of
the pial neurovascular circuit.
TitleQuantitative Diffuse Correlation Spectroscopy for Assessing Human Brain Function
Investigator
Ulas Sunar
Institute
wright state university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Acute brain injuries can lead to secondary brain damage that worsens the outcome. Reduced cerebral blood
flow can induce ischemia, while excess blood flow can cause hemorrhage.
TitleReal-time Aberration Sensor for Large-Scale Microscopy Deep in the Mouse and Adult Zebrafish Brain
Investigator
Steven Graham Adie
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Optical imaging holds tremendous promise in our endeavor to understand brain functions. The major challenges
for optical brain imaging are depth and speed.
TitleRedefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine Learning
Investigator
Peter V. Kochunov, Paul M Thompson
Institute
university of maryland baltimore
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
This application will combine the strengths of two large scale NIH-funded initiatives to understand disorder-
related patterns in the human brain: Connectomes Related to Human Disease (CRHD) and Enhancing
Neuroimaging Genetics through Meta-Analysis (ENIGMA).
TitleRepresentation and modulation of social information in the ant chemosensory system
Investigator
Daniel Kronauer
Institute
rockefeller university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Social insects show robust and complex behaviors, and have served as important study systems in ethology
for decades.
TitleResolving Spatiotemporal Determinants of Cell Specification in Corticogenesis with Latent Space Methods
Investigator
Genevieve Lauren Stein-O'brien
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
High-throughput profiling of hundreds of thousands of cells in the central nervous system (CNS) is currently
underway.
TitleResource Core 3 - Teaching/Training/Dissemination Core (TTDC)
Investigator
Maisie Ky Lo
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Resource Core 3 - Teaching/Training/Dissemination Core (TTDC)
Leads: Maisie Lo PhD and Kristin Overton PhD
Summary
The TTDC’s teaching mission specifically leverages our educational infrastructure for advancing the
application of modern neurotechnology methods in short (3-day) or extended-format (
TitleRevealing neural circuits underlying zebrafish behavior using mesoscopic light field microscopy
Investigator
Oliver Strides Cossairt, Geoffrey J Goodhill
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
A critical step towards understanding how neural circuits drive behavior is the ability to record the activity of all
neurons in an organism while it interacts with its environment in an unconstrained manner.
TitleRNA-programmable cell type targeting and manipulation across vertebrate nervous systems
Investigator
Z Josh Huang
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Systematic experimental access to diverse neuronal cell types is a prerequisite to deciphering brain circuit
organization, function, and dysfunction.
TitleRobotically-actuated, low-noise, concurrent TMS-EEG-fMRI system
Investigator
Chunlei Liu, Michael Lustig, Angel V Peterchev
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The ability to noninvasively modulate and image the brain with spatial and temporal precision is highly desirable
for understanding brain circuits in health and disease.
TitleRobust modeling of within- and across-area population dynamics using recurrent neural networks
Investigator
Lee Miller, Chethan Pandarinath
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
Over the past several decades, the ability to record from large populations of neurons (e.g., multi-electrode
arrays, neuropixels, calcium imaging) has increased exponentially, promising new avenues for understanding
the brain.
TitleScalable 3D molecular imaging and data analysis for cell census generation
Investigator
Steve Presse, Douglas Shepherd
Institute
arizona state university-tempe campus
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
This project is a collaboration across two universities and multiple scientific disciplines to develop new scalable
3D molecular imaging and analysis approaches for cell type identification within human brain tissue.
TitleScalable integration of cell types and connectivity in the motor cortex of rodents and non-human primates
Investigator
Forrest Christie Collman, Nuno Macarico Da Costa, R Clay Reid
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The BICCN has recently completed a broad survey of the cellular components of motor cortex, including
transcriptomic profiling, patch-seq, multiplexed FISH, inter-areal connectivity, and single neuron morphology.
Missing from this view is a detailed picture of how individual neurons
TitleScalable tools for consistent identification of neuronal cell types in mouse and human
Investigator
Staci A Sorensen, Uygar Sumbul
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The proposed work will address a critical gap in our understanding of neuronal phenotypes and cell types by
developing machine learning algorithms and cloud-based software for the integration of multiple modality
characterizations large and growing datasets of cortical neurons in mou
TitleSecondary analysis of functional MRI and resting state connectivity in white matter
Investigator
John C Gore, Bennett A. Landman
Institute
vanderbilt university medical center
Fiscal Year
Funding Opportunities Number
Project Number
Abstract / Summary
This proposal aims to perform novel, secondary analyses on large archives of publicly-available fMRI
studies in order to quantify the functional characteristics of white matter (WM) and their changes during
normal aging and in the progression to Alzheimer’s Disease (AD).
TitleSelective Control of Synaptically-Connected Circuit Elements by Interluminescence
Investigator
Ute H Hochgeschwender, Christopher I Moore
Institute
central michigan university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
A wealth of new tools can directly control output of specific neurons on fast (e.g., optogenetic) or sustained (e.g.,
chemogenetic) time scales.