Two major recent advances have raised the possibility of fundamental breakthroughs in both
basic and clinical neuroscience: the development of new tools to probe the nervous system with
single-cell resolution as well as brain-wide scope, and breakthroughs in machine learning
methods for handling com
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleCombined Topological and Machine Learning Tools for Neuroscience
Investigator
Michael Hawrylycz, Partha Pratim Mitra, Yusu Wang
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
TitleConnecting neural circuit architecture and experience-driven probabilistic computations
Investigator
Zachary Peter Kilpatrick
Institute
university of colorado
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: Organisms' actions and decisions are guided by experience. Models of such behavior often
appeal to the formalism of probabilistic inference, in which expectations about the world build up sequentially
due to past observations.
TitleContext-dependent neural processing of leg proprioception in Drosophila
Investigator
Sweta Agrawal
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Proprioception is critical for effective motor control: dysfunctions of the proprioceptive system can impair
balance, motor coordination, and motor learning.
TitleCoordinating center for collaborative marmoset research
Investigator
Donald F. Conrad, Jon E Levine, Corinna Nicole Ross
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
The common marmoset (Callithrix jacchus) has emerged as a critically important and tractable non-human
primate (NHP) model for neuroscience research accommodating genetic manipulation and directed breeding.
Several barriers to the adoption of marmoset models by the neuroscie
TitleCortical circuitry supporting flexible audiovisual interactions and behaviors
Investigator
Andrea Rayne Hasenstaub
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Interactions between the auditory and visual systems are among the most well-established cases of
crossmodal interplay, yet the overwhelming bulk of the sensory physiology literature reflects studies examining
processing confined to a single modality and we understand comparatively l
TitleCortical-Basal Ganglia Speech Networks
Investigator
Robert Mark Richardson
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Actions are not mediated solely by cortical processes but rely on communication within basal ganglia-
thalamocortical loops. Speech is one example, although how the basal ganglia participate in this uniquely
human behavior is not clear, due to a lack of empirical data.
TitleCorticostriatal contributions to motor exploration and reinforcement
Investigator
Timothy James Gardner, Carlos Lois, Richard D. Mooney, John Pearson
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Complex motor sequences are fundamental to many highly skilled behaviors, ranging from athletics to musical
and vocal expression.
TitleCorticostriatal mechanisms of causal inference and temporal credit assignment.
Investigator
Hyojung Seo
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Learning desired actions from experience requires evaluating alternative actions by integrating the
consequences assigned to each action over time.
TitleCoupling between circadian rhythms and redox signaling in stem cell differentiation and adult neurogenesis
Investigator
Daniel Maxim Iascone
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Circadian rhythms are necessary to coordinate the timing of key behavioral and physiological processes in
mammals [1-3].
TitleCritical Technology Development for 16 Tesla Head-only MRI Superconducting Persistent Magnets: V2
Investigator
Minfeng Xu
Institute
general electric global research ctr
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Advanced brain research demands ultra-high field MRI systems. The 11.7 T Neurospin CEA MRI magnet
pushed the use of superconducting NbTi materials to the limit by using superfluid helium to cool.
TitleCross-frequency coupling: its role in brain function and dysfunction
Investigator
Andrei V Medvedev
Institute
georgetown university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
One of the high priority research areas listed in the BRAIN 2025 Report is a better understanding of the
brain network dynamics across time and space from human electrophysiological recordings.
TitleCrossing space and time: uncovering the nonlinear dynamics of multimodal and multiscale brain activity
Investigator
Shella D Keilholz, Garrett B. Stanley
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
The brain is a complex dynamical system, with a hierarchy of spatial and temporal scales ranging from microns
and milliseconds to centimeters and years. Activity at any given scale contributes to activity at the scales above
it and can influence activity at smaller scales.
TitleData Exploration and Analysis Portal for Brain Research through Advanced Imaging Neuroscience
Investigator
Chun Chieh Fan, Wesley Kurt Thompson
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Population neuroscience requires investigation of brain-behavioral relationships within epidemiological
samples studied in longitudinal designs, including a large number of assessment modalities and with subjects
enrolled at many data collection sites to achieve a large sample and br
TitleDataJoint Pipelines for Neurophysiology
Investigator
Dimitri Yatsenko
Institute
vathes inc.
Fiscal Year
Funding Opportunities Number
Project Number
The field of neuroscience and the BRAIN Initiative in particular are amassing a wealth of informatics resources for managing, analyzing, and sharing data.
TitleDecision-related information at single-neuron resolution in human motor cortex and its implications for neuroprosthetics
Investigator
Sharlene Flesher
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
The long-term goal of my research is to gain a holistic understanding of how movement commands are
generated- including their relationship to sensory feedback and movement context- in order to restore movement
to those who have lost it.
TitleDefining the role of a prefrontal-midbrain circuit in exploratory behavior
Investigator
Victoria L Corbit
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Investigating how neural circuits mediate natural behavior is a critical to our understanding of the brain.
Exploratory behaviors are necessary for rodent survival in the natural world and ubiquitous in freely-moving
rodent experiments.
TitleDetermining computational principles governing neural circuits responsible for feedback and movement control of D. melanogaster flight
Investigator
Itai Cohen
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A principle aim of the NINDS is to determine how motor control is successfully implemented by
the nervous system. Locomotion and balance are complex motor functions that are largely
controlled by complex microcircuits that reside outside the brain.
TitleDeveloping A Mouse Chronic Pain Scale by 3D Imaging and Measurement of Mouse Spontaneous Behaviors
Investigator
Long Ding, Wenqin Luo, Hyun Soo Park
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Rodent models are highly valuable for elucidating the molecular and cellular mechanisms of chronic pain.
Because rodents cannot articulate their sensation, “pain-like” behaviors have been used as the proxy.
However, sensitivity and specificity of many existing methods for measuring r
TitleDeveloping a novel therapeutic for treating tinnitus
Investigator
Luisa L Scott
Institute
cognosetta, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Tinnitus or “ringing in the ears” is a hearing disorder that disproportionately impacts those who are or have served
in the military. There is currently no effective cure for tinnitus.
TitleDeveloping Molecular and Computational Tools to Enable Visualization of Synaptic Plasticity In Vivo
Investigator
Richard L Huganir
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Developing new methodological and analytical tools to address currently insurmountable experimental questions
is crucial to the future of neuroscience.