Project Summary
We propose to develop and test a novel noninvasive neuromodulation technique integrating transcranial
focused ultrasound (tFUS) with electrophysiological source imaging (ESI) to allow real-time evidence-based
neuromodulation with spatio-temporal precision for brain research and manag
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleElectrophysiological source imaging guided transcranial focused ultrasound
Investigator
Bin He
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
TitleElementary Neuronal Ensembles to Whole Brain Networks: Ultrahigh Resolution Imaging of Function and Connectivity in Humans
Investigator
Kamil Ugurbil
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT:
The strategic plan of the NIH's BRAIN Initiative (BRAIN 2025: A scientific Vision) calls for transformative
technological developments with MRI to achieve “submillimeter spatial resolution descriptions of neuronal
activity, functional and structural connectivity, and network analysis in t
TitleEnabling ethical participation in innovative neuroscience on mental illness and addiction: towards a new screening tool enhancing informed consent for transformative research on the human brain
Investigator
Laura W Roberts
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Great discoveries in neuroscience hold promise for reducing the burden of many of the most disabling
conditions that threaten human health on a global scale, including mental illnesses and addictions.
Increasingly, exceptionally innovative science inspires hope that these devastating brain-based dis
TitleEnabling Shared Analysis and Processing of Large Neurophysiology Data
Investigator
William J Schroeder
Institute
kitware, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Understanding brain function is key to improving health care and advancing a number of scientific initiatives.
The treatment of degenerative brain diseases such as Alzheimer's, Parkinson’s, and ALS is becoming
increasingly important as the current US population ages and li
TitleEngineering optogenetic tools for studying neuropeptide activity
Investigator
Alexander Robert French
Institute
purdue university
Fiscal Year
Funding Opportunities Number
Project Number
7. Project Summary/Abstract
Opioid receptors (ORs), consisting of -, -, and -ORs, are neuropeptide receptors that are broadly involved
in regulating analgesia, mood, reward, and motor coordination.
TitleEnsemble neural dynamics in the medial prefrontal cortex underlying cognitive flexibility and reinforcement learning
Investigator
Surya Ganguli, Mark J Schnitzer
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The prefrontal cortex is thought to play a crucial role in cognitive flexibility, in part by updating a person's
expectations about the external world and the likely consequences of candidate actions based on the feedback
gained from past actions.
TitleEthical Safeguards for Exit and Withdrawal from Implanted Neurotechnology Research
Investigator
Lauren Sankary
Institute
cleveland clinic lerner com-cwru
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Research participants face complex decisions about the surgical removal of implanted devices
upon exiting clinical trials of implanted neurotechnology.
TitleEthics of Patients and Care Partners Perspectives on Personality Change in Parkinsons disease and Deep Brain Stimulation
Investigator
Cynthia M. S. Kubu
Institute
cleveland clinic lerner com-cwru
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
In our work with patients with neurological disorders, we often encounter patients and families who are afraid.
They are afraid that due to their neurodegenerative disorder or potential treatment, such as neurosurgery, they
will cease to exist – they will no longer be who they “are”.
TitleFluidic microdrives for minimally invasive actuation of flexible electrodes
Investigator
Jacob T. Robinson
Institute
rice university
Fiscal Year
Funding Opportunities Number
Project Number
Fluidic Microdrives for Minimally Invasive Implantation and Actuation of Flexible Neural
Electrodes
Abstract
Flexible microelectrodes that match the mechanical properties of the brain promise to increase the quality and
longevity of neural recordings by reducing chronic inflammatory reactions; howev
TitleFrom microscale structure to population coding of normal and learned behavior
Investigator
Wiliam Mcintyre Debello, Mark H Ellisman, Brian J Fischer, Jose L Pena
Institute
albert einstein college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
This study aims to understand how the ensemble activity and network architecture of a neuronal population
guides natural and learned behavior.
TitleGABAergic circuit interactions within the behaving mouse dLGN
Investigator
Martha E Bickford, William Guido
Institute
university of louisville
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The flow of visual information from the retina, through the dorsal lateral geniculate nucleus
(dLGN) to the cortex, is regulated by behavior. However, the dynamic circuit interactions that occur in
the dLGN of awake animals, and their modulation by behavior, have yet to be revealed.
TitleGated Diffuse Correlation Spectroscopy for functional imaging of the human brain
Investigator
Maria Angela Franceschini
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
With this grant application we aim to dramatically improve over the capabilities of functional near-infrared
spectroscopy (fNIRS) by developing a completely novel approach to measure human brain function.
TitleGenetic analyses of complete circuit formation in Caenorhabditis elegans
Investigator
Steven Jay Cook
Institute
columbia univ new york morningside
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Despite the central importance of neural circuit development to brain function and behavior, we lack the genetic
information required to assemble a complete circuit.
TitleGenetically Encoded Activity Sensors for Photoacoustic Imaging of the Brain
Investigator
Oliver Griesbeck, Daniel Razansky
Institute
max planck institute for neurobiology
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
New tools for large-scale recording of neuronal activity in a living and behaving brain are essential for a
better understanding of brain function, efficient analysis and treatment of neuronal disorders.
TitleGenetically encoded indicators for large-scale sensing of neuromodulatory signaling in behaving animals
Investigator
Axel Nimmerjahn, Lin Tian, Mark E Vonzastrow, John T Williams
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
Brain functions are executed by intricately coordinated networks of neurons, whose modes of operation are
highly sensitive to a constellation of neuromodulators.
TitleGenetically-targeted hemodynamic functional imaging
Investigator
Alan Jasanoff
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
The dominant techniques for brain-wide functional imaging in humans and opaque mammals make use of he-
modynamic contrast that results from coupling between neural activity and changes in blood flow and can be
detected by noninvasive imaging methods including functional magnetic resonance imaging (f
TitleHigh density multielectrode arrays with spatially selective unidirectional and rotating fields for investigation of neuronal networks
Investigator
Shalom Michaeli
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
In response to the BRAIN initiative RFA-NS-17-003 “New Technologies and Novel Approaches for Large-Scale
Recording and Modulation in the Nervous System (U01)”, in this project we aim at accomplishing selective
stimulation and recordings at ultra-high cellular level spatial resolution of distinct axo
TitleHigh Throughput Approaches for Cell-Specific Synapse Characterization
Investigator
Alison L Barth, Marcel P Bruchez
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT DESCRIPTION
Synapses are formed, broken and reformed dynamically both during development, normal
function and in response to activity.
TitleHigh throughput mapping of neuronal circuitry using DNA sequencing
Investigator
Anthony M Zador
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The long-term goal of these investigations is to develop methods based on high-
throughput DNA sequencing for determining neuronal circuitry. Neurons transmit
information to distant brain regions via long-range axonal projections.
TitleHigh Throughput of Protein-based Voltage Probes
Investigator
Vincent A Pieribone
Institute
john b. pierce laboratory, inc.
Fiscal Year
Funding Opportunities Number
Project Number
A significant motivation of the BRAIN Initiative is the desire to understand information processing in
neuronal tissues in situ.