Funded Awards

This study proposes to refine, integrate and disseminate the NeuroImaging Brain Chart (NIBCh) software toolbox and machine learning (ML) model library, an ecosystem of software components enabling constructive integration, statistical harmonization, and ML-centric data analyses across studies.

Project Summary Multiplexed imaging of brain cells and tissues can reveal critical details about the abundance and spatial organization of molecular targets.

This proposal describes a five-year career development program to prepare the candidate, Dr.

PROJECT SUMMARY The maintenance and function of the nervous system depends on cell-cell interactions among neuronal and non-neuronal cell populations, which occur through physically binding cell membrane surface or secreted proteins, triggering signaling cascades that activate cell-type gene regu

PROJECT SUMMARY Sensory processing is a way to understand the nervous system in action. Behavioral context strongly affects sensory processing. For example, a brief visual stimulus is easier to detect if it appears in a predictable spatial location.

Abstract The human brain is estimated to contain over 100 billion neurons that are wired together by more than 100 trillion synapses.

PROJECT SUMMARY/ABSTRACT An important longstanding goal in neuroscience research is to understand how large-scale spatiotemporal patterns of neural activity emerge in the brain and whether they have a direct role in shaping the brain’s computational processes and thereby mammalian behavior.

Project Summary Gaining genetic access to specific cell types in rodents, non-human primates and other vertebrate species is critical for enabling targeted circuit manipulations to understand normal brain function and brain.

In this SBIR grant proposal, “Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform,” we will develop the RF subsystem for a clinical magnetic particle imaging (MPI) platform to enable three classes of MPI applications: cell tracking, functional imaging, and endogen

Optical monitoring of brain activities is intrinsically associated with various operational advantages, including low-cost and portable noninvasive bedside continuous monitoring capabilities.

Project Summary Visual attention differences are a promising diagnostic marker for autism spectrum conditions (ASC).

PROJECT SUMMARY Poor sleep is common in neurodevelopment disorders such as autism spectrum disorder (ASD), with up to 93% of ASD individuals reporting sleep problems.

Project Summary Many advances in modern neuroscience rely on electrophysiological recordings of large neural populations (e.g. many hundreds of cells) or high-resolution measurements of animal behavior (e.g. from video).

PROJECT SUMMARY Understanding information flow in cortical circuits requires understanding both the anatomical connectivity between neurons and the way in which inputs to a neuron are integrated to generate a spiking output.

ABSTRACT BRAIN Initiative-funded, large-scale approaches to classify neurons based on transcriptomic, morphological and electrical properties have unveiled dozens of unique cell classes in the mouse brain.

The goal of this project is to develop a Wireless, fully Implantable, bidirectional Cortical Neuroprosthetic System (W-ICONS) for restoring sensorimotor function through an interface with intact upper limb areas of primary motor and sensory cortex.

The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative promotes the development and application of technologies to describe the temporal and spatial dynamics of cell types and neural circuits in the brain.

Project Summary The BRAIN Initiative Cell Atlas Network (BICAN) will generate comprehensive molecular taxonomies and organizational principles of cell type diversity in the human and non-human primate extending comprehensive BICCN work in the mouse.

PROJECT SUMMARY Brain image data collected by the neuroscience community will continue to grow dramatically in the next 5-10 years as the push to image physically larger volumes, such as whole brains from humans and other primates, becomes a focus.

Abstract An outstanding challenge of brain research is to link the cross-scale functional perspectives from the cellular and molecular level to the circuit and systems level.