Abstract:
In this proposed research project, we seek to develop an advanced brain SPECT system that offers a
unique hyperspectral imaging capability substantiated by an excellent energy resolution (e.g.,
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title1 mm resolution single-photon spectral imaging of the brain
Investigator
Ling-Jian Meng, Scott Dean Metzler
Institute
university of illinois at urbana-champaign
Fiscal Year
Funding Opportunities Number
Project Number
TitleA recombinant elastin skin substitute for the treatment of burns
Investigator
Stefan Roberts
Institute
insoma bio, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The goal of this project is to optimize and evaluate inSoma Bio’s proprietary recombinant elastin-based
biomaterial, Fractomer®, as an effective, low-cost skin grafting support matrix for the treatment of severe burn
wounds.
TitleA decellularized porcine placenta matrix hydrogel for management of radiation-induced proctitis
Investigator
Jian Jian Li
Institute
briopryme biologics, inc.
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Radiation therapy is a widely used treatment modality for pelvic malignancies such as prostate and cervical
cancer; however, the high doses needed to confer therapeutic benefit often inflict significant damage on the
normal issue in and surrounding the radiation field.
TitleA Digital Health Technology to Prevent Family Violence and Improve Child Mental Health
Investigator
Christopher Hazen, Elizabeth A Stormshak
Institute
northwest prevention science inc
Fiscal Year
Funding Opportunities Number
Project Number
7. Project Summary/Abstract
The COVID-19 pandemic has increased the need for eHealth interventions that target families and children at-
risk of family violence and long-term mental health problems.
TitleA HANDS-FREE LUNG AND CARDIOVASCULAR ASSESSMENT DEVICE (LCAD) FOR THE REMOTE CARE OF PATIENTS WITH CHRONIC CARDIOPULMONARY CONDITIONS
Investigator
Wilman Rene Ortega
Institute
mddriven llc
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The goal of this project is to develop a remote, hands free self-auscultation and electrocardiogram (EKG)
device for at home use in the remote monitoring and management of patients suffering from chronic
cardiopulmonary conditions.
TitleA Novel Bone Targeted Antibiotic Therapy for the Treatment of Infected Fractures
Investigator
Frank H. Ebetino
Institute
biovinc, llc
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Bone fracture is a large medical problem in the US, with 6 million presentations each year, resulting in
very large cost burdens. In addition, the total burden of fractures in the US is growing due to the aging of the
population and increases in osteoporosis.
TitleA Novel Multi-Epitope-Based Universal Vaccine Against Multiple Coronavirus Variants of Concern
Investigator
Hawa Vahed
Institute
techimmune, llc
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
Over the last 2 years humanity has been confronting COVID-19 pandemic caused by the new Corona Virus 2
(SARS-CoV-2) infection.
TitleA novel producer cell line for more efficient manufacturing of viral vector systems
Investigator
Elaine Hamm
Institute
clairigene, llc
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Significant advances in the specific targeting of delivery vectors and the increased therapeutic efficacy of such
vectors for gene delivery have been made, stimulating major interest in the development and
commercialization of therapeutic products focused on gene therapy indications.
TitleA Novel Synthetic Biology-Derived Microbiome Therapeutic to Treat Viral-Induced Acute Respiratory Distress Syndrome (ARDS)
Investigator
Gary Fanger, Christian Furlan Freguia
Institute
rise therapeutics, llc
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Acute respiratory distress syndrome (ARDS) is a severe life-threatening complication that can be caused by
viral infection. The disease is characterized by cytokine-driven hyperinflammation and leukocytes count
changes.
TitleA novel, non-antibiotic, microbiome-directed agent to prevent post-surgical infection
Investigator
John C Alverdy
Institute
covira surgical
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
Covira Surgical, Inc.
TitleA Redesigning Existing Drugs against Indispensable Targets (ReEDIT) platform technology for discovery of novel drugs to treat fungal infections
Investigator
Stephen Parent
Institute
kathera bioscience inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
There is a worldwide need for improved treatment of systemic, life-threatening fungal infections.
Current therapies are limited by the small number of approved drugs, toxicities, drug-drug
interactions, mode of administration, and growing problems of drug resistance and emerging
path
TitleA scalable cloud-based framework for multi-modal mapping across single neuron omics, morphology and electrophysiology
Investigator
Bing-Xing Huo
Institute
broad institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Categorizing individual neurons into different groups, or cell types, is a classical approach to studying the nervous
system. With increasingly more tools being invented to observe the neurons, new criteria were created to
characterize different aspects, or modalities, of the cells.
TitleA Sprayable Tissue-Binding Hydrogel to Prevent Postsurgical Cardiac Adhesions
Investigator
Gregory Grover
Institute
karios technologies, llc
Fiscal Year
Funding Opportunities Number
Project Number
Summary. Currently, there are no approved and available products to prevent postsurgical cardiac adhesions
and hence no standard of care.
TitleA transformative method for functional brain imaging with Speckle Contrast Optical Spectroscopy
Investigator
David A Boas, Xiaojun Cheng
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Advances in non-invasive monitoring of human brain function under normal and pathological conditions will lead
to breakthroughs in our understanding of the brain in health and disease, and lead to the development of devices
available for everyday use, with applications such as monitoring pa
TitleA visualization interface for BRAIN single cell data, integrating transcriptomics, epigenomics and spatial assays
Investigator
Maximilian Haeussler
Institute
university of california santa cruz
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT
The BRAIN Initiative’s -omics data archive NeMO contains all the BICCN single cell single cell data, more
than one million files at the time of writing.
TitleA Vitamin K analog countermeasure for organophosphate poisoning
Investigator
Sherine S Chan
Institute
neuroene therapeutics inc
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Neuroene Therapeutics has discovered a novel class of well-tolerated, brain-penetrating, non-sedating
compounds that are small analogs of Vitamin K (VK) that mimic the form of VK needed for mitochondrial and
neurological health.
TitleAcoustic-anatomic modeling and development of a patient-specific wearable therapeutic ultrasound device for peripheral arterial disease
Investigator
Juliana Elstad
Institute
vibrato medical, inc.
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Peripheral arterial disease (PAD) is a highly prevalent condition that is growing rapidly due to shifting
demographics, affecting 202M people worldwide and 18M in the USA, with an annual growth rate of 6.8%.
Early stages of PAD result in claudication, while the advanced stage of PAD
TitleActivity-based regulome profiling for the discovery of covalent transcription factor inhibitors
Investigator
Alexander Federation
Institute
talus bioscience, inc.
Fiscal Year
Funding Opportunities Number
Project Number
RESEARCH SUMMARY
The human genome encodes more than 1,600 transcription factors (TFs), along with additional
cofactors, chromatin regulators, and structural proteins that collectively execute the regulatory
instructions encoded within the nuclear DNA.
TitleAdvancing fMRI Acquisition through Dissemination of EPTI- An Efficient Distortion-Free Multi-Contrast Imaging Technology
Investigator
Fuyixue Wang
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT
Functional MRI (fMRI) is today the predominant tool for noninvasive imaging of brain function, which has
revolutionized our understanding of the human brain.
TitleAerosolized Chemically Modified Tetracycline Nanoformulation for the Treatment of Acute Respiratory Distress Syndrome
Investigator
Michaela Christina Kollisch-Singule, Juntao Luo
Institute
cmtx biotech, inc.
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
CMTx Biotech is a drug development company working to rescue, develop and commercialize a proprietary
clinical-stage drug candidate, incyclinide (CMT-3 / COL-3), for the treatment of sepsis patients at risk of acute
respiratory distress syndrome (ARDS).