Funded Awards

The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.

To see more NIH-funded awards and associated publications, please visit the NIH RePORTER

Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
TitleA Dry Electrode for Universal Accessibility to EEG
Investigator
Walid Soussou
Institute
quasar, inc.
Fiscal Year
Funding Opportunities Number

Electroencephalography (EEG) measures the brain’s local field potential from the surface of the scalp. This method is useful for studying cognitive processes, neurological states, and medical conditions.

TitleA scalable cloud-based framework for multi-modal mapping across single neuron omics, morphology and electrophysiology
Investigator
Bing-Xing Huo
Institute
broad institute, inc.
Fiscal Year
Funding Opportunities Number

Project Summary Categorizing individual neurons into different groups, or cell types, is a classical approach to studying the nervous system.

TitleA visualization interface for BRAIN single cell data, integrating transcriptomics, epigenomics and spatial assays
Investigator
Maximilian Haeussler
Institute
university of california santa cruz
Fiscal Year
Funding Opportunities Number

PROJECT SUMMARY / ABSTRACT The BRAIN Initiative’s -omics data archive NeMO contains all the BICCN single cell single cell data, more than one million files at the time of writing.

TitleAdvancing fMRI Acquisition through Dissemination of EPTI- An Efficient Distortion-Free Multi-Contrast Imaging Technology
Investigator
Fuyixue Wang
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number

PROJECT SUMMARY / ABSTRACT Functional MRI (fMRI) is today the predominant tool for noninvasive imaging of brain function, which has revolutionized our understanding of the human brain.

TitleAn optical-genetic toolbox for monitoring and controlling diverse neuromodulatory circuits governing complex behaviors in primates
Investigator
Karl A. Deisseroth, Eyal J Seidemann
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number

ABSTRACT Perceptually guided behavior involves a complex and dynamic interplay between external inputs and internal states that are related, for example, to alertness, motivation, expectations and attention.

TitleAnalysis of modulation of the metabotropic glutamate receptor type 5 in a novel heritable model of drug abuse vulnerability
Investigator
Loren D Peeters
Institute
east tennessee state university
Fiscal Year
Funding Opportunities Number

Project Summary Schizophrenia is a debilitating mental illness affecting an estimated 1% of the global population.

TitleBeyond dopamine: dual neuromodulator regulation of motor variability and learning
Investigator
Drew Clinton Schreiner
Institute
duke university
Fiscal Year
Funding Opportunities Number

Project Summary Learning and performing complex skills such as speech or music requires precise control of motor variability. While elevated motor variability can spur the learning of new behaviors, excessive variability can impair performance of learned skills.

TitleBoss: A cloud-based data archive for electron microscopy and x-ray microtomography
Investigator
Brock A. Wester
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number

ABSTRACT The generation of scientifically rich, high resolution neuroimaging volumes continues to increase in extent and rate due to the advancement of new Electron Microscopy (EM) and X-ray Microtomography (XRM) imaging sys- tems and data processing methodologies.

TitleBottom-Up, Top-Down, and Local Interactions in the Generation and Consolidation of Cortical Representations of Sequential Experience
Investigator
Bruce L Mcnaughton
Institute
university of california-irvine
Fiscal Year
Funding Opportunities Number

Years of study and theory about the unique role of the hippocampus in storing new memories has led to a general idea that the hippocampus generates a unique output code for every unique experience, that is projected back to the neocortex, where it becomes coupled to attributes of the experience t

TitleBrain dynamics underlying long-term memory consolidation
Investigator
Priya Rajasethupathy
Institute
rockefeller university
Fiscal Year
Funding Opportunities Number

Abstract The hippocampus has a well-established role in the initial formation and storage of memory. However, little is understood about brain mechanisms that support the re-organization and transfer of memories into longer-term cortical storage.

TitleCapturing the neural signature of the paraventricular thalamus that underlies individual variability in cue-motivated behavior
Investigator
Shelly Beth Flagel
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number

PROJECT SUMMARY/ABSTRACT Individuals make choices and prioritize actions using complex processes that assign value to rewards and associated stimuli based on prior experience.

TitleCell type-specific mechanisms of history-dependent perceptual biases in sensory cortex
Investigator
Deepa L Ramamurthy
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number

PROJECT SUMMARY Sensory representations are influenced by an animal’s external context, internal state, past experiences, expectations, and future goals.

TitleCenter for Advanced Muscle BioElectronics (CAMBER)
Investigator
Muhannad Bakir, Samuel Sober
Institute
emory university
Fiscal Year
Funding Opportunities Number

A central goal of neuroscience is to discover how neural circuits control the body’s muscles to produce behavior.

TitleCharacterizing Lower Extremity Neurophysiological Responses to Sensory Augmentation after Stroke
Investigator
Jasmine Jamilah Cash
Institute
medical university of south carolina
Fiscal Year
Funding Opportunities Number

PROJECT SUMMARY/ABSTRACT After a stroke, walking ability can be compromised, which can lead to reduced quality of life and decreased ability to perform activities of daily living.

TitleCharacterizing odor motion detection in flies
Investigator
Damon Alistair Clark, Thierry Emonet
Institute
yale university
Fiscal Year
Funding Opportunities Number

Many animals rely on their ability to navigate to the source of airborne odor plumes for survival. Studies dating back a century have shown that insects combine mechanosensory and olfactory cues to navigate, surging upwind when detecting odor but go crosswind or downwind when losing the signal.

TitleCircuit architecture and dynamics of the insular cortex underlying motivational behaviors
Investigator
Tianyi Mao, Haining Zhong
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number

PROJECT SUMMARY The insular cortex (IC) is a multimodal hub that integrates interoceptive and exteroceptive information to control diverse aspects of animal behaviors related to cognition, emotion, and motivation.

TitleCircuit mechanisms of arbitration between distinct reinforcement learning systems
Investigator
Margaret Louise Demaegd
Institute
new york university
Fiscal Year
Funding Opportunities Number

PROJECT SUMMARY Animals can exhibit goal-directed behaviors in novel environments, despite limited experience with them. How does the brain make and use inferences about the underlying statistics and generative structure of environments to guide behavior?

TitleCircuit-specific, chemogenetic neuromodulation in nonhuman primates.
Investigator
Serge E Przedborski, Charles E Schroeder
Institute
nathan s. kline institute for psych res
Fiscal Year
Funding Opportunities Number

ABSTRACT ‒ UG3/UH3 Deep Brain Stimulation (DBS), applied to areas like the subthalamic nucleus (STN), is a standard treatment for Parkinson Disease (PD), however, DBS has inherent surgical risks as well as potential for infections and adverse side effects.

TitlecloudSLEAP: Maximizing accessibility to deep learning-based motion capture
Investigator
Talmo D. Pereira
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number

cloudSLEAP – PROJECT SUMMARY/ABSTRACT Understanding how the brain produces complex behavior is a central goal of neuroscience, but quantifying behavior is technically challenging, particularly in unrestrained and naturalistic settings.

TitleCognitive and Neural Strategies for Latent Feature Inference
Investigator
Tahra Eissa
Institute
university of colorado
Fiscal Year
Funding Opportunities Number

PROJECT SUMMARY The world around us has a statistical structure that we can use to improve our choices. Learning the underlying structure by identifying key features, such as the rate of change, is useful for adapting and optimizing our decision-making strategies.

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