DESCRIPTION (provided by applicant): Severe to moderate traumatic brain injury (smTBI) annually afflicts many hundreds of thousands of Americans producing chronic cognitive disabilities that lack effective treatments.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleCentral thalamic stimulation for traumatic brain injury
Investigator
Christopher R Butson, Joseph Thomas Giacino, Jaimie M Henderson, Andre Guelman Machado, Nicholas D Schiff
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
TitleComputational and circuit mechanisms for information transmission in the brain
Investigator
Uri Tzvi Eden, Loren M Frank, Surya Ganguli, Adam Kepecs, Mark Alan Kramer, Christian Machens, Vanessa Tolosa
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The brain is a massively interconnected network of regions, each of which contains neural circuits that process information related to combinations of sensory, motor and internal variables.
TitleCoSMo - Summer School in Computational Sensory-Motor Neuroscience
Investigator
Paul R Schrater
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Major breakthroughs in neuroscience have been achieved through the application of computational models to empirical research.
TitleDynamic network computations for foraging in an uncertain environment
Investigator
Dora Angelaki, Valentin Dragoi, Zachary Samuel Pitkow, Paul R Schrater
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The brain evolved complex recurrent networks to enable flexible behavior in a dynamic and uncertain world, but its computational strategies and underlying mechanisms remain poorly understood.
TitleInterdisciplinary Training in Computational Neuroscience for Researchers from Graduate and Medical Students to Junior Faculty
Investigator
Satish S Nair
Institute
university of missouri-columbia
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Truly integrative and interdisciplinary training in neuroscience is necessary to understand brain function in both normal and pathological states.
TitleLagging or Leading? Linking Substantia Nigra Activity to Spontaneous Motor Sequences
Investigator
Ryan Prescott Adams, Sandeep R Datta, Bernardo L Sabatini
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Behaviors are sequences of actions that are executed in the proper order and correct setting to achieve a goal.
TitleMULTISCALE ANALYSIS OF SENSORY-MOTOR CORTICAL GATING IN BEHAVING MICE
Investigator
Dieter Jaeger, Garrett B. Stanley
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): To address the core question underlying the Obama Brain Initiative to better understand the function of complex brain circuits, we propose a multi-scale recording and data analysis project to study the dynamical interactions between sensory cortex, motor cor
TitleMultiscale Imaging of Spontaneous Activity in Cortex: Mechanisms, Development and Function
Investigator
R Todd Constable, Michael C. Crair
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The purpose of this RFA is to promote the integration of experimental, analytic and theoretical capabilities for the examination of neural circuits and systems.
TitleNetwork basis of action selection
Investigator
Anatol Kreitzer, Takaki Komiyama, Byungkook Lim
Institute
j. david gladstone institutes
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The anatomical substrates and cellular mechanisms underlying reward-dependent learning have been studied for decades, but the specific circuit and network interactions between the cortex, striatum, and midbrain that mediate action selection have not been sys
TitleNeural ensembles underlying natural tracking behavior
Investigator
Ila R. Fiete, Alexander C Huk, Nicholas J Priebe
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The system that controls smooth pursuit eye movements is one of the most accessible, promising systems for understanding how neural circuits transform sensory inputs into actions.
TitleBehavioral readout of spatiotemporal codes dissected by holographic optogenetics
Investigator
Dmitry Rinberg, Shy Shoham
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Two of the most fundamental questions of sensory neuroscience are: 1) how is stimulus information represented by the activity of neurons at different levels of information processing?
TitleCortical circuits and information flow during memory-guided perceptual decisions
Investigator
Mriganka Sur
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Perceptual decision-making involves multiple cognitive components and diverse brain regions.
TitleCrowd coding in the brain:3D imaging and control of collective neuronal dynamics
Investigator
Patrick O Kanold, Wolfgang Losert, Dietmar Plenz
Institute
univ of maryland, college park
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The cortex is a laminated structure that is thought to underlie sequential information processing.
TitleIntegrative Functional Mapping of Sensory-Motor Pathways
Investigator
Michael H Dickinson, Philip J Holmes, Richard S Mann, Rachel Wilson
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The goal of the project team is to develop a robust, multi-lab research framework, enabled by large scale imaging, which will lead to principled integrative models of ethologically-relevant behaviors that incorporate a detailed knowledge of individual cell c
TitleMechanisms of neural circuit dynamics in working memory
Investigator
William Bialek, Carlos D Brody, Hyunjune Sebastian Seung, David W Tank, Samuel Sheng-Hung Wang, Ilana Witten
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Working memory, the ability to temporarily hold multiple pieces of information for mental manipulation, is central to virtually all cognitive abiliies.
TitleNeural circuits in zebrafish: form, function and plasticity
Investigator
Constance L Cepko, Florian Engert, Jeff W Lichtman, Haim Sompolinsky
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): We propose to combine whole brain 2-photon imaging of neural activity in behaving larval zebrafish with detailed anatomical and connectivity information extracted from the same animals.
TitleRevealing the connectivity and functionality of brain stem circuits
Investigator
Darwin K Berg, Martin Deschenes, Yoav Shai Freund, Martyn D Goulding, David Kleinfeld, Per M Knutsen
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Neuronal circuits in the brainstem control life-sustaining functions, in addition to driving and gating active sensation through taste, smell, and touch.
TitleThe role of patterned activity in neuronal codes for behavior
Investigator
John H.r. Maunsell
Institute
university of chicago
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): A key aspect of brain function is how the activity of neuronal populations encodes information that is used to guide behavior.
TitleTowards a Complete Description of the Circuitry Underlying Memory replay.
Investigator
Ivan Soltesz
Institute
university of california-irvine
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The function of a brain region is an emergent property of many cell types.
TitleVertically integrated approach to visual neuroscience: microcircuits to behavior
Investigator
Thomas Euler, Andrew D Huberman, Markus Meister, Hyunjune Sebastian Seung, Rachel O Wong
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Visual neuroscience is finally beginning to achieve a "vertically integrated" understanding of the retina, bridging all levels from molecules to microcircuits to behavior.