Project Summary
The Child Mind Institute’s Healthy Brain Network (HBN) is an ongoing initiative focused on creating and
sharing a biobank of brain and behavioral data now being collected from 10,000 New York City area children
and adolescents (ages 5-21).
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleBRAIN Initiative: Assessing development of event-related cortical network dynamics
Investigator
Scott Makeig, Michael Peter Milham, Arnaud Delorme
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
TitleBRAIN Viral Vector Services and Distribution Core
Investigator
Kimberly Ritola
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
The BRAIN Viral Vector Service and Distribution Core will serve as a resource for the maintenance,
propagation, and distribution of viral vectors that are used by neuroscientists for neural circuit
identification and manipulation, as well as for preclinical translational studies.
TitleBRAINShare: Sharing Data in BRAIN Initiative Studies
Investigator
Amy L Mcguire, Sameer Anil Sheth
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Data sharing is essential to promote equity and maximize the impact of the significant investment in the BRAIN
Initiative.
TitleCell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment
Investigator
Anton Arkhipov, Li-Huei Tsai
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment
Patterned sensory stimulation (PSS) is a non-invasive technique for manipulating brain activity and states,
typically employing periodic light flicker or auditory tones presented at regular intervals.
TitleCell type atlasing of whole human brains using HOLiS: an optimized pipeline for staining, clearing, imaging, and analysis
Investigator
Elizabeth M. C. Hillman, Pavel Osten, Zhuhao Wu
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary (Abstract)
Gaining a comprehensive understanding of brain-wide cellular organization in the human brain has long been
recognized as a critical foundation for understanding complex brain functions, including who we are as humans.
In this project we propose to take on this challenge an
TitleCellular and Neural Network Mechanism of Transcranial Electric Stimulation
Investigator
Dominique M Durand
Institute
case western reserve university
Fiscal Year
Funding Opportunities Number
Project Number
Unveiling mechanisms of neural stimulation technologies is an important goal of the Brain Initiative (RFA-NS-20-006).
TitleCellular Mechanisms of Transcranial Magnetic Stimulation in Cerebellar Cortex
Investigator
Padmavathi Sundaram Patel
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Abstract: Our goal is to develop a cellular level understanding of how transcranial magnetic stimulation (TMS)
may activate neurons in the human cerebellum (Cb) using (i) electrophysiological measurements in an in vitro
turtle Cb, (ii) computational modeling of the induced electric (E) fields in the
TitleCharacterization of in vivo neuronal and inter-neuronal responses to transcranial focused ultrasound
Investigator
Bin He
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
Non-invasive neuromodulation approaches have been developed to enable the modulation of neural tissue without necessitating invasive surgical procedures.
TitleCircuit and Cognitive Mechanisms of Striatal Deep Brain Stimulation
Investigator
Alik S Widge
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Neurostimulation, including invasive methods like deep brain stimulation (DBS), is an increasingly important approach to treating mental illness. It offers the possibility of directly targeting the circuit dysfunctions that produce mental disorders.
TitleComprehensive and multi-resolution mapping of cell morphology and wiring through X-ray holographic nano-tomography
Investigator
Alexandra Teodora Joita Pacureanu, Wei-Chung Allen Lee
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
A fundamental goal in neuroscience is understanding how information is processed in neuronal circuits.
However, the immense complexity of most brain networks has been a significant barrier to progress.
TitleConnecting late-life depression and cognition with statistical physics based connectomics and sparse Frechet regression
Investigator
Alex Leow, Yichao Wu, Liang Zhan
Institute
university of illinois at chicago
Fiscal Year
Funding Opportunities Number
Project Number
Recently, several lines of evidence have supported that synaptic dysfunction represents one of
the earliest brain changes in Alzheimer’s disease (AD), leading to hyper-excitation in neuronal
circuits.
TitleControl of the time course of dopamine release through optimized electrical brain stimulation.
Investigator
Stephen Leigh Cowen, Michael L Heien, Timothy Lewis
Institute
university of arizona
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Electrical stimulation of deep brain structures is an essential tool for the causal investigation of neural systems
that regulate learning and decision making.
TitleConverting Value into Action: Computations in Corticostriatal Circuits for Flexible Decision Making
Investigator
Linda Amarante
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
To flexibly execute behavior, choices are made based on previous outcomes that will maximize reward.
Crucially, learning the value of each action to obtain a reward is thought to drive this decision making process.
In a value-based decision making framework, these values are first co
TitleCorrelating molecular behavioral phenotypes in a marmoset model of Huntingtons disease
Investigator
Ali H Brivanlou
Institute
rockefeller university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The common marmoset provides a very relevant primate model for understanding the organization of the human
nervous system and the diseases that affect it.
TitleDefining motor neuron diversity from embryo to adulthood and generating tools for in vivo and in vitro access
Investigator
Tulsi Patel
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
In order to understand neurological diseases, it is essential to identify the affected neuronal cell types,
create model systems that accurately recapitulate normal function and disease phenotypes, and develop tools
that allow cellular manipulations.
TitleDefining Targets for Tic Detection and Suppression in Tourette Syndrome Deep Brain Stimulation
Investigator
Christopher R Butson, Aysegul Gunduz, Michael S Okun
Institute
university of florida
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Tourette syndrome (TS) is a continuous lifelong condition that is highly prevalent, socially disabling, and in some severe
cases, physically injurious.
TitleDeveloping cell type-specific enhancers and connectivity mapping pipelines for marmosets
Investigator
Guoping Feng, Partha Pratim Mitra
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Although genetic tools have dramatically advanced our understanding of brain function, they have
largely been confined to mice.
TitleDevelopment of a high throughput system for molecular imaging of different cell types in mouse brain tissues
Investigator
Gaurav Chopra, Julia Laskin
Institute
purdue university
Fiscal Year
Funding Opportunities Number
Project Number
Development of a high throughput system for molecular imaging of different cell types in mouse brain
tissues
Mass spectrometry imaging (MSI) is a powerful tool for developing detailed molecular maps of biological
tissues with high specificity and sensitivity.
TitleDiscovering the molecular genetic principles of cell type organization through neurobiology-guided computational analysis of single cell multi-omics data sets
Investigator
Z Josh Huang
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Understanding the biological principles of cell type diversity and organization is necessary for deciphering
neural circuits underlying brain function.
TitleDisentangling hippocampal and cortical contributions to episodic memory
Investigator
Alexa Tompary
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
This application describes a 5-year plan to investigate the neural dynamics that underpin distortion in memory,
integrating computational modeling approaches with functional neuroimaging (fMRI) and non-invasive brain
stimulation techniques (TMS).