Project Summary
Walking is an essential and conserved behavior across the animal kingdom.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleMapping the neural circuitry underlying walking
Investigator
Sumaira Zamurrad
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
TitleMarkerless Tracking of 3D Posture to Reveal the Sensory Origins of Body Schema
Investigator
Kyle Scott Severson
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this proposed research is to reveal the sensory origins underlying the body schema
representation. Body schema is the brain's internal model of the body's spatial configuration.
TitleMassively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain
Investigator
Danny Jj Wang, Lihong Wang
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT (30 Lines)
The BRAIN initiative (RFA-EB-19-002) has called for the development of entirely new or next-generation
noninvasive human brain imaging tools and methods that will lead to transformative advances in our
understanding of the human brain.
TitleMeasuring Electrical Activity from the Human Brain to Predict Memory Formation and Behavior Across the Lifespan
Investigator
Elizabeth Johnson
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Memory is core to human cognition, undergoes protracted developmental maturation and age-related decline,
and is disrupted in numerous neurological and neuropsychiatric disorders.
TitleModeling developmental gradients and supportive tissue signaling networks using iPSC-derived forebrain organoids embedded in fluidic hydrogels
Investigator
Leon Marcel Bellan, Vivian Gama
Institute
vanderbilt university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Understanding of many aspects of the human brain is currently limited due to the lack of appropriate model
systems that recapitulate the heterogenous nature of the human brain and the ethical and practical limitations
of working with human brain tissue from patients.
TitleMolecular Multi-Species Approach for Trans-Synaptic Labeling of Neural Circuits
Investigator
Gilad Barnea, Marnie E Halpern, Jennifer Mengbo Li, Drew Robson
Institute
dartmouth college
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
It is estimated that the human brain contains an overwhelming 1015 synapses, structures essential for the normal
functioning of neural circuits.
TitleMulti-modal, large-scale characterization of cellular and cell-type-specific effects with electric stimulation in rodent and human brain
Investigator
Soo Yeun Lee
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
The application of electric stimulation (ES) to the brain has been widely used to perturb the physiological and
pathological dynamics of neuronal circuits, with established applications including therapeutic interventions for
neurological disorders such as epilepsy, dementia, and Pa
TitleMultimodal study of infra-slow propagating brain activity
Investigator
Xiao Liu
Institute
pennsylvania state university, the
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The highly-organized intrinsic brain activity, as measured by resting-state functional magnetic resonance imaging
(rsfMRI), is being widely used to measure functional brain connectivity in both healthy subjects and patient
groups, despite the underlying neural mechanisms remain large
TitleMultiplexed Nanoscale Protein Mapping Through Expansion Microscopy and Immuno-SABER
Investigator
Edward S. Boyden, Peng Yin
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Tools for surveying brain cell types and circuits must be scalable, both in the number of molecular targets
visualizable at once, and in the size of the tissues that can be assessed.
TitleNeural basis of causal inference: representations, circuits, and dynamics
Investigator
Gregory C Deangelis
Institute
university of rochester
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The same pattern of neural activity can correspond to multiple events in the world. Signals sweeping across
the retina, for instance, might be generated by a moving object or by the animal's self-motion.
TitleNeural circuitry for observational learning of maternal behavior
Investigator
Amy Lemessurier
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Behaviors essential for survival, including parenting behaviors, are driven by neural circuits that arise from
combinations of genetics and experience-dependent learning.
TitleNeurobiology of Social Behavior: Circuit Analysis in Early Life
Investigator
Maya Opendak
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
My long-termcareer goal is to establish a research laboratory that dissects functional microcircuits supporting
flexible social behavior in typical and perturbed development.
TitleNeuroEthics of Non-Therapeutic Invasive Human Neurophysiologic Research
Investigator
Ashley L Feinsinger, Nader Pouratian
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The BRAIN Initiative has made a significant investment in invasive human neuroscientific studies that take
advantage of unique neurosurgical opportunities to study basic human neuroscience without therapeutic intent.
These non-therapeutic studies are of particular ethical in
TitleNeuroExplorer: Ultra-high Performance Human Brain PET Imager for Highly-resolved In Vivo Imaging of Neurochemistry
Investigator
Richard E. Carson, Hongdi Li, Jinyi Qi
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Research applications of brain Positron Emission Tomography (PET) have been in place for over 40 years.
The combination of quantitative PET systems with novel radiotracers has led to a numerous imaging para-
digms to understand normal brain physiology including neurotransmitter dynamics and receptor
TitleNeurostimulation by Ultrasound: Physical, Biophysical, and Neural Mechanisms
Investigator
Stephen A Baccus, Kim Butts-Pauly, Butrus T Khuri-Yakub, Merritt C Maduke
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The goal of this project is to understand the neurobiological underpinnings of the effects of ultrasound
(US) on neural activity. US can modify action potential activity in neurons in vitro and in vivo without damaging
neural tissue.
TitleNew approaches for chemical-genetic targeting of specific circuits and cell types in the mammalian brain
Investigator
Anton Maximov
Institute
scripps research institute, the
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this research is to establish new robust methods for manipulation of specific circuits and genetically
defined neuron types in brains of model organisms with small molecules.
TitleNobrainer: A robust and validated neural network tool suite for imagers
Investigator
Satrajit Sujit Ghosh
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
There is an increasing need for efficient and robust software to process, integrate, and offer insight across the
diversity of population imaging efforts underway across the BRAIN Initiative and other projects.
TitleNon-invasive Radio Frequency Stimulation of Neurons and Networks
Investigator
Gyorgy Buzsaki, Daniel K Sodickson
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Nonivasive stimulation of the brain in health and disease is an important goal of the Brain Initiative. Current
methods include Transcranial Magnetic Stimulation (TMS), Transcranial Electric Stimulation (TES) and
Transcranial Focused Ultrasound Stimulation (TFUS).
TitleNon-invasive, Deep Brain, and Focal Neuromodulation in Nonhuman Primates
Investigator
Taylor D Webb
Institute
university of utah
Fiscal Year
Funding Opportunities Number
Project Number
The ability to non-invasively perturb specific regions deep in the human brain would enable researchers and clinicians
to study the causal relationships between specific brain structures and behavior.
TitleOpen-source software for multi-scale mapping of the human brain
Investigator
Bruce Fischl, Juan Eugenio Iglesias Gonzalez
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary (maximum 30 lines)
The BRAIN initiative seeks to develop and apply technologies in order to understand of how brain cells interact
in both time and space to give rise to brain function.