PROJECT SUMMARY/ABSTRACT Because neurons integrate and process information via modulation of their membrane potential, the ability to monitor voltage is critical to understanding how single and groups of neurons compute.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
ENABLING SUBMILLISECOND-TIMESCALE TWO-PHOTON RECORDING OF VOLTAGE DYNAMICS IN THREE DIMENSIONS IN VIVO
Investigator
Laurent Bourdieu, Francois St-Pierre
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Title
Functions of locus coeruleus norepinephrine neurons in decision making across multiple timescales
Investigator
Jeremiah Yaacov Cohen, Daniel Hans O'connor
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY Norepinephrine (NE) is a neurotransmitter released by a small number of neurons in the locus coeruleus (LC), with extensive innervation of the neocortex. Prior work in humans and other mammals led to the hypothesis that LC-NE neurons modulate multiple forms of decision making.
Title
Functions of the Cortical Amygdala in social behavior
Investigator
Antonio V Aubry
Institute
icahn school of medicine at mount sinai
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Aggression is an evolutionarily conserved behavior that controls social hierarchies and protects valuable resources like mates, food, and territory. In most cases, aggression is a necessary, adaptive component of social behavior.
Title
High-throughput 3D mapping of large mammalian brains via integration of precision tissue sectioning and light sheet imaging
Investigator
Ji Wang, Nicholas Bruce Evans, Hsuan Lee, Jeffrey Stirman
Institute
lifecanvas technologies, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Whole-brain mapping at the cellular and subcellular levels is crucial to systematically understand brain functions and disorders.
Title
High-throughput engineering of ligand-selective fluorescent biosensors for detecting endogenous and exogenous opioids
Investigator
Andre Berndt, Michael R Bruchas
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT Neuropeptide modulation of neuronal circuits is strongly linked to many crucial behaviors such as exploration, stress, memory formation, learning, and many pathophysiological conditions.
Title
High-throughput measurement of neuronal projections and synapses using Synapse-seq
Investigator
Evan Z Macosko
Institute
broad institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY The brain is composed of thousands of highly specialized cell types that form very specific synaptic connections with each other. Together, these connections form neural circuits that are the structural basis of brain function.
Title
Highly multiplexed circuit mapping using barcoded rabies viruses and in situ sequencing.
Investigator
Ian R Wickersham, Shenqin Yao
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT Understanding the function of neural circuits requires thorough investigation of two circuit elements: cell types and connectivity.
Title
Identifying human-specific neural progenitors and their role in neurodevelopment
Investigator
Sumin Jang
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT Humans have highly advanced cognitive abilities and motor skills, characteristics which are reflected in the enlarged size and cell diversity of our central nervous system (CNS).
Title
Identifying the neural mechanisms of goal-directed decision-making in Parkinson's disease using closed-loop deep brain stimulation
Investigator
Colin Hoy
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
TITLE: IDENTIFYING THE NEURAL MECHANISMS OF GOAL-DIRECTED DECISION-MAKING IN PARKINSON’S DISEASE USING CLOSED-LOOP DEEP BRAIN STIMULATION PROJECT SUMMARY People with Parkinson’s disease commonly suffer from non-motor symptoms, including motivation deficits, that impact quality of life more than c
Title
Implications of Prefrontal Cortex Development for Adolescent Reward Seeking Behavior
Investigator
Gabriela Manzano Nieves
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY As we get older, we learn to modulate our behaviors to optimize reward outcomes. These adaptive choices are orchestrated by current sensory conditions, internal cognitive states, and future expectations.
Title
Improving Recruitment, Engagement, and Access for Community Health Equity for BRAIN Next-Generation Human Neuroimaging Research and Beyond (REACH for BRAIN)
Investigator
Susie Yi Huang, Jonathan David Jackson, Francis X Shen
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract Although BRAIN 2.0 called for the BRAIN Initiative to “prioritize diversity and inclusion as a fundamental pillar,” research with the human neuroimaging technologies being developed by BRAIN Initiative continues to rely on non-representative convenience samples.
Title
Integrative Analysis of Adaptive Information Processing and Learning-Dependent Circuit Reorganization in the Auditory System
Investigator
Wiliam Mcintyre Debello, Mark H Ellisman, Brian J Fischer, Jose L Pena
Institute
albert einstein college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Abstract Decades of research have revealed the principles of information processing that give rise to auditory spatial tuning and experience-dependent adaptive plasticity in the owl auditory system.
Title
Intersubject Synchrony in Neural and Behavioral Representations of Social Uncertainty Among Adults and Adolescents
Investigator
William John Mitchell
Institute
temple univ of the commonwealth
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Uncertainty is an often pervasive, stressful experience that arises when making judgments about others' beliefs, intentions, or emotions (i.e., ambiguous social situations). Excessive uncertainty can have pernicious effects upon memory, mood, and physical and mental outcomes.
Title
Intrinsic and Extrinsic factors regulating neurogenic competence in hypothalamic tanycytes
Investigator
Leighton Hosea Duncan
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Hypothalamic tanycytes have limited postnatal neurogenic competence, but the extrinsic and intrinsic factors that promote this are not well understood. My predoctoral research identified a defined developmental window during which neurogenic competence is lost from hypothalamic tanycytes.
Title
Investigating the Recruitment of Different Neuronal Subpopulations by Intracortical Micro Stimulation Using Two Photon-Microscopy
Investigator
Christopher Hughes
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Intracortical microstimulation (ICMS) of the sensory cortices is an emerging approach to restore sensation to people who have lost it due to neurological injury or disease.
Title
Investigations of cAMP-dependent brain-barrier permeability in choroid plexus
Investigator
Dario Xavier Figueroa Velez
Institute
boston children's hospital
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The choroid plexus (ChP) comprises a network of cells that form a critical brain barrier that can mediate secondary damage in certain brain disorders and trauma. The Lehtinen lab has developed a suite of tools to study the ChP across development ex vivo and in vivo.
Title
Large-scale calcium and voltage imaging to illuminate neural mechanisms of visual experience
Investigator
Michelle Redinbaugh
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: The majority of lived experience depends on neural activity conveying sensory information about the world.
Title
Live spike sorting for multichannel and high-channel recordings
Investigator
Tim Chifong Lei, Achim Klug
Institute
popneuron, llc
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this project is to create two prototypes of a novel live spike sorting system which can be used by investigators to spike sort streams of neural data recorded by multi-channel, high channel and ultra-high channel probes.
Title
Local Circuit Control of Rapid Plasticity and Tunable Ensemble Formation in the Hippocampus
Investigator
Attila Losonczy, Ivan Soltesz
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract Neural representations supporting spatial and episodic learning form, and transform rapidly in the mammalian hippocampus.
Title
Manipulation of neuron identity towards in-vivo circuit reprogramming in the cerebral cortex
Investigator
Lee O Vaasjo
Institute
tulane university of louisiana
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Sub-Cerebral Projection Neurons (SCPNs) are a clinically relevant neuron class that controls voluntary movement and whose loss in Amyotrophic Lateral Sclerosis and Fronto-temporal dementia or injury (e.g., damaged by spinal cord injury) leads to paralysis.