Project Summary: The broad, long-term goal of this project is to develop a wearable high performance MEG
system that can operate without external shielding that will lead to Advances in Human Neuroscience and
transformative advances in our understanding of the Human Brain ‘in Action and in Context’,
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleA high-performance unshielded wearable brain-computer interface based on microfabricated total-field OPMs
Investigator
Jose Luis Contreras-Vidal, Svenja Knappe
Institute
university of houston
Fiscal Year
Funding Opportunities Number
Project Number
TitleA method for anterograde trans-synaptic tracing
Investigator
Donald B Arnold
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
Although considerable information about neuronal circuits has been generated from experiments where
retrograde transsynaptic tracing has been performed using Rabies Virus, there is no comparable technique for
transsynaptic tracing in the anterograde direction.
TitleA TOF, DOI, MRI compatible PET detector to support sub-millimeter neuroPET imaging
Investigator
Sergei Dolinsky, Robert S Miyaoka
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The overall goal of this research is to develop next generation positron emission tomography (PET) detector
technology to support non-invasive, quantitative brain imaging at spatial and temporal resolutions currently not
achievable with human neuro-PET systems.
TitleAssessing the Effects of Deep Brain Stimulation on Agency
Investigator
Adina L Roskies
Institute
dartmouth college
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Recent advances in neurotechnologies have provided us with the ability to modulate brain function by
direct and indirect interventions.
TitleAuditory brain-computer interface for communication
Investigator
Daniel James Thengone
Institute
brown university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A fundamental end-goal of brain-computer interfaces (BCI) is to enable communication in individuals
with severe motor paralysis. BCIs decode the neural signals and accomplish the intended goal via an effector,
such as a computer cursor or a robotic limb.
TitleBoss: A cloud-based data archive for electron microscopy and x-ray microtomography
Investigator
Brock A. Wester
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
Due to recent technological advances, it is possible to image the high-resolution structure of brain volumes at
spatial extents that are much larger than was previously possible.
TitleBrain-wide correlation of single-cell firing properties to patterns of gene expression
Investigator
Adam Ezra Cohen
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Brain-wide correlation of single-cell firing properties to patterns of gene expression
Every neuron expresses thousands of proteins which, through their interactions with each other
and with other small molecules, imbue the neuron with its functional properties.
TitleBreaking Spatiotemporal Barriers of MR Imaging Technologies to Study Human Brain Function and Neuroenergetics
Investigator
Wei Chen, Xiao-Hong Zhu
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Understanding how neural circuits operate and interconnect at mesoscopic (sub-millimeter) scale, and how
neuroenergetic metabolism and neurotransmitters support brain&nb
TitleC-PAC: A configurable, compute-optimized, cloud-enabled neuroimaging analysis software for reproducible translational and comparative
Investigator
Richard Cameron Craddock, Michael Peter Milham
Institute
child mind institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The BRAIN Initiative is designed to leverage sophisticated neuromodulation, electrophysiological recording,
and macroscale neuroimaging techniques in human and non-human animal models in order to develop a
multilevel understanding of human brain function.
TitleCausally linking dendritic Ca2+ dynamics to CA1 circuit function and spatial learning using novel tools to precisely manipulate an endogenous Ca2+ buffering process
Investigator
Justin O'hare
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
In dendrites, Ca2+ is critical in determining how neurons respond to incoming excitation.
TitleCell atlas of mouse brain-spinal cord connectome
Investigator
Hong-Wei Dong, Huizhong Whit Tao, Li I Zhang
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Although great efforts have been dedicated to characterizing neuronal cell types in the brain, systematic
studies on the brain-spinal cord connectome and associated spinal neuronal types are lacking.
TitleCollaborative Standards for Brain Microscopy
Investigator
Carol Marie Hamilton
Institute
research triangle institute
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Fast microscopy techniques, coupled with recent advances in tissue clearing, are now able to efficiently
produce cellular-resolution images of intact brain samples.
TitleCombined Cortical and Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder
Investigator
Darin D Dougherty, Alik S Widge
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
This project is a pilot clinical trial of a new brain stimulation treatment for obsessive-compulsive disorder. OCD
is a mental illness that affects 4-7 million people in the US. Of those, 50-70% still have substantial symptoms
after being treated with medication or talk therapy.
TitleConnectome 2.0: Developing the next generation human MRI scanner for bridging studies of the micro-, meso- and macro-connectome
Investigator
Peter J. Basser, Susie Yi Huang, Bruce R Rosen, Lawrence L Wald, Thomas Witzel
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
We present Connectome 2.0, the next-generation human MRI scanner for imaging structural anatomy and
connectivity spanning the microscopic, mesoscopic and macroscopic scales.
TitleCrowdsourcing the Fly Connectome
Investigator
Mala Murthy, Hyunjune Sebastian Seung
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
We propose to build a next generation crowdsourcing platform (code named “FlyWire”) for mapping the fly
connectome using transmission electron microscopy images that were acquired at Janelia Research Campus.
FlyWire will depart from EyeWire, a previous crowdsourcing platform, in two
TitleDART2.0: comprehensive cell type-specific behavioral neuropharmacology
Investigator
Michael R Tadross
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT. DART2.0: comprehensive cell type-specific behavioral neuropharmacology
Neuro-active drugs have provided hope to millions.
TitleData Archive for the Brain Initiative (DABI)
Investigator
Dominique Duncan, Nader Pouratian, Arthur W Toga
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The overarching goal of this project is to secure, link, and disseminate BRAIN Initiative data, including
electrophysiology, imaging, behavioral, and clinical data with all pertinent recording and imaging parameters,
coming from participating sites.
TitleData interface and apps for systems neurophysiology and imaging
Investigator
Stephen D Van Hooser
Institute
brandeis university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Technology for recording from the brain is developing at a breakneck pace.
TitleDendritome mapping of genetically-defined and sparsely-labeled cortical and striatal projection neurons
Investigator
Hong-Wei Dong, Xiangdong William Yang
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Integrating molecular, morphological, and connectomic properties is critical for unbiased
classification of neuronal cell types in the mammalian brain.
TitleDevelopment of 7-T MR-compatible TOF-DOI PET Detector and System Technology for the Human Dynamic Neurochemical Connectome Scanner
Investigator
Ciprian Catana
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
We seek support to develop and build the positron emission tomography (PET) detector module for the next
generation 7-Tesla magnetic resonance (MR)-compatible PET brain scanner with dramatically improved
spatio-temporal resolution.