ABSTRACT
Despite the increasing use of transcranial magnetic stimulation (TMS) in both research and clinical practice,
the field nonetheless lacks a theoretical framework to predict the impact of TMS on circuits.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleNetwork Control and Functional Context: Mechanisms for TMS Response
Investigator
Danielle Smith Bassett, Desmond Oathes, Theodore Satterthwaite
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
TitleNeural circuit mechanisms underlying hierarchical visual processing in Drosophila
Investigator
Maxwell Holte Turner
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project summary
Understanding how neural circuits give rise to sensory computation and, ultimately, perception, requires
connecting biological features of neural circuits to abstract models of neural computation.
TitleNeuroethics of Predictive MRI Testing: Parental Attitudes Towards Pre-Symptomatic Identification of Autism Spectrum Disorder
Investigator
Kate E. Macduffie
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Machine-learning-based classification of neuroimaging data (hereafter ML-MRI) to predict clinical
diagnoses has increased substantially in the last decade.
TitleNeuronal and Dopaminergic Contributions to Dissimilar Evoked Hemodynamic Responses in the Striatum
Investigator
Lindsay Walton
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI) is a non-invasive
imaging technique that infers the presence of increased brain activity from localized increases in oxygenated
hemoglobin.
TitleNew Proteomic and Genome Engineering Approaches to Decipher Astrocyte Function at Synapses
Investigator
Cagla Eroglu, Scott H Soderling
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Astrocytes are the most abundant glial cells in the human brain. Interactions of astrocytes with synapses via thin
perisynaptic astrocytic processes are critical for proper synaptic connectivity and function.
TitleNew tools to target, identify and characterize astrocytes in the adult nervous system
Investigator
Viviana Gradinaru, Baljit Khakh
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
In order to understand how the CNS encodes, modifies, stores and retrieves information it is necessary to
explore the diverse cell populations that comprise the CNS. There is an emerging consensus that the CNS
cannot be satisfactorily understood solely as a collection of circuits1.
TitleNext-generation optical brain functional imaging platform
Investigator
Qianqian Fang
Institute
northeastern university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
A more thorough understanding of human brain function has profound implications for advancing neuroscience
research and combatting neurological disease.
TitleNon-invasive targeted neuromodulation via focused ultrasound BBB permeabilization
Investigator
Margaret S Livingstone, Nathan J. Mcdannold
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The goal of the proposed project is to test in macaques a technique for non-invasive, safe, reversible,
modulation of neuronal activity in small targeted regions of the primate brain.
TitleNoninvasive Gene Delivery for Monitoring and Perturbing Cell Types and Circuits in Transgenic and Non-Transgenic Animals
Investigator
Viviana Gradinaru
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The use of current and emerging genetically encoded tools could greatly benefit from advanced methods
for gene delivery to the desired cell population.
TitleNWB:N: A Data Standard and Software Ecosystem for Neurophysiology
Investigator
Lydia Lup-Ming Ng, Oliver Ruebel
Institute
university of calif-lawrenc berkeley lab
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Brain function is produced by the coordinated activity of multiple neuronal types that are widely distributed
across many brain regions.
TitleOpenNeuro: An open archive for analysis and sharing of BRAIN Initiative data
Investigator
Russell A Poldrack
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The NIH BRAIN Initiative is supporting a broad portfolio of neuroscience research aimed at
revolutionizing our understanding of the brain.
TitleOptical measurement of causal functional connectivity in posterior parietal cortex
Investigator
Daniel E Wilson
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The mouse posterior parietal cortex (PPC) has emerged as an essential region for decision-making during
memory-guided decision-making tasks.
TitleOptimizing noninvasive modulation of prediction and episodic memory networks via cerebellar stimulation
Investigator
Shruti Dave
Institute
northwestern university at chicago
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY ABSTRACT
The lateral cerebellum (Crus I/II) interacts with two dissociable large-scale brain networks — the executive
control (ECN) and default mode networks (DMN), which support distinct cognitive functions (e.g., prediction
versus episodic memory, respectively).
TitlePARALLEL ANALYSIS OF TRANSCRIPTION AND PROTEIN-DNA INTERACTIONS IN SINGLE CNS CELLS
Investigator
Joseph D Dougherty, Robi D Mitra
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The brain is the most complex organ in the body, consisting of hundreds of molecularly, physiologically, and
anatomically distinct cells.
TitleQuantifying the role of adaptation in olfactory coding through the logic of navigation
Investigator
Nirag Kadakia
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
This project’s long-term goal is a fuller understanding of the neurobiological mechanisms of olfactory sensory
adaptation that facilitate odor discrimination in the natural world.
TitleRAVE: A New Open Software Tool for Analysis and Visualization of Electrocorticography Data
Investigator
Michael S Beauchamp
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
A fast-growing technique in human neuroscience is electrocorticography (ECOG), the only technique
that allows the activity of small population of neurons in the human brain to be directly recorded.
TitleRecombinant Immunolabels for Nanoprecise Brain Mapping Across Scales
Investigator
James S Trimmer
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
Recombinant Immunolabels for Nanoprecise Brain Mapping Across Scales
Understanding brain function and dysfunction requires an understanding of the circuitry of the brain from
molecules to cells to circuits.
TitleRepetitive transcranial ultrasound stimulation for modulating brain rhythms
Investigator
Jacek Dmochowski
Institute
city college of new york
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The goal of the proposed research career development program is to allow the applicant to acquire training in
a new form of brain stimulation using ultrasonic waves.
TitleResource for Multiphoton Characterization of Genetically-Encoded Probes
Investigator
Mikhail Drobizhev
Institute
montana state university - bozeman
Fiscal Year
Funding Opportunities Number
Project Number
Two-photon laser scanning microscopy powers many projects in the.
TitleSpatially Resolved Methylomes to Map Neuronal Cell-Type Connectivity in Tissue
Investigator
Robert Youssefian Henley
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The BRAIN initiative has put forth the development of a neuronal cell-type census as the first step towards
mapping the structure and components of neuronal circuits.