Project Summary
A detailed census of the structure and role of cell type specific data in the brain is recognized as one of the most
promising avenues for advancing our understanding of the human brain in health and disease.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleA Community Resource for Single Cell Data in the Brain
Investigator
James C Gee, Michael Hawrylycz, Maryann E Martone, Lydia Lup-Ming Ng, Anthony Philippakis
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
TitleA Confocal Fluorescence Microscopy Brain Data Archive
Investigator
Marcel P Bruchez, Alexander J Ropelewski, Simon C Watkins
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Advancements in the field of microscopy and imaging have pushed the boundaries of what
was once thought possible in many fields of research.
TitleA General Approach for the Development of New Cell-Type-Specific Viral Vectors
Investigator
Michael Eldon Greenberg
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
Our limited ability to genetically access specific cell types within the nervous system constitutes a fundamental
impediment in our efforts to probe brain function and intervene therapeutically, particularly in species lacking
the well-developed genetic resources available in the mo
TitleA magnetic particle imager (MPI) for functional brain imaging in humans
Investigator
Lawrence L Wald
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
In this U01 grant we propose a 5 year engineering development effort to advance Magnetic
Particle Imaging (MPI) to replace MRI as the next-generation functional brain imaging tool for human
neuroscience.
TitleA Molecular and Cellular Atlas of the Marmoset Brain
Investigator
Guoping Feng
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
The complexity of the mammalian brain is unparalleled by any other organ, and understanding its
cellular composition is essential to understand how it gives rise to cognition and behavior.
TitleA multimodal atlas of human brain cell types
Investigator
Ed Lein
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Abstract:
A Multimodal Atlas of Human Brain Cell Types
Cell types are the building blocks of the brain, including the neuron types forming specific neuronal
circuits responsible for perception, cognition and action, and the non-neuronal elements performing other
essential roles for proper brain fun
TitleAccessing the Neuronal Scale: Designing the Next Generation of Compact Ultra High Field MRI Technology for Order-of-Magnitude Sensitivity Increase in Non-Invasive Human Brain Mapping
Investigator
Brian Keith Rutt
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A complete understanding of both normal brain function and neurological disorders / mental illness will
require the deciphering of the complex brain networks that underlie behavior and cognition, at both whole-brain
and microscopic scales.
TitleAchieving ethical integration in the development of novel neurotechnologies
Investigator
Winston Chiong
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
New technologies that modulate brain function have tremendous potential for alleviating the persistent burden
of depression and other neuropsychiatric disorders, but also raise challenging ethical and societal questions
regarding self-ownership and control over our thoughts,
TitleAn academic industrial partnership for the development of high frame-rate transcranial super resolution ultrasound imaging
Investigator
Paul A Dayton, Gianmarco Pinton
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Very recently, the revolutionary technology of contrast enhanced super-resolution ultrasound imaging has been
developed.
TitleAn anatomical cell type atlas of gene expression, morphology and connectivity
Investigator
Hongkui Zeng
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary (Research Segment 2)
The brain circuit is an intricately interconnected network of numerous cell types.
TitleAnatomical characterization of neuronal cell types of the mouse brain
Investigator
Giorgio A Ascoli, Hong-Wei Dong, Byungkook Lim
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY AND ABSTRACT
A comprehensive understanding neuronal cell type diversity is an essential guide to selective manipulation and
illuminating cell type specific functional contributions toward health and disease.
TitleAnatomy
Investigator
Z Josh Huang
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
ANATOMY RESEARCH SEGMENT SUMMARY
The overarching goal of neuroanatomy is to establish a structural framework to integrate multiscale and
multi-modal information and to provide a road map that guides the exploration of neural dynamics and brain
function. “Anatomic” neuron types
TitleBIDS-Derivatives: A data standard for derived data and models in the BRAIN Initiative
Investigator
Russell A Poldrack
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The effective sharing of data requires the development and broad adoption of standards for the
organization of data and metadata.
TitleBrain circuit mapping using light inducible recombinase systems
Investigator
Ali Haydar Cetin
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Mammalian brain is composed of vast numbers of intricately interconnected neurons with various
molecular, anatomical and physiological identities.
TitleCenter for Epigenomics of the Mouse Brain Atlas (CEMBA)
Investigator
Edward M Callaway, Joseph R Ecker
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
OVERVIEW: Project Summary
A comprehensive understanding of how neural circuits spanning the entire brain generate the full repertoire of
perception and behaviors requires a list of brain cell types, as well the means to target each cell type in order
to interrogate the functional interactions that g
TitleCerebellar network mapping with a high-throughput TEM platform
Investigator
Wei-Chung Allen Lee
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
A fundamental goal in neuroscience is to understand how information is processed in neuronal circuits.
Ultimately, we would like to understand the relationship between circuit structure and network function.
However, the immense complexity of most brain networks has been a s
TitleCircuit mechanisms of evidence accumulation during decision-making
Investigator
Zhihao Luo
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Circuit mechanisms underlying evidence accumulation during decision-making
Behavior across many types of decision-making is well described by the gradual accumulation of evidence
toward one of multiple alternatives.
TitleCollaboratory for atlasing cell type anatomy in the female and male mouse brain
Investigator
Pavel Osten
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Even though scientists have been captivated by the diversity of brain cells for well over a century, since the
initial anatomical descriptions by Santiago Ramón y Cajal, it is only recently that the developments in new
technologies allowed us to truly appreciate the astonishing complexity of cell ty
TitleDeep brain stimulation for depression using directional current steering an individualized network targeting
Investigator
Wayne K Goodman, Nader Pouratian, Sameer Anil Sheth
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The public health burden of Treatment Resistant Depression (TRD) has prompted clinical trials of deep brain
stimulation (DBS) that have, unfortunately, produced inconsistent outcomes.
TitleDevelop and validate novel chemogenetic tools to modulate synaptic transmission
Investigator
Susumu Tomita
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Neural circuits encode animal behaviors, and neuroplasticity induces long-lasting
changes in neural circuits and animal behaviors. Neural circuits are formed by billions of
neurons, which communicate mostly through synapses.