DESCRIPTION (provided by applicant): We propose to combine whole brain 2-photon imaging of neural activity in behaving larval zebrafish with detailed anatomical and connectivity information extracted from the same animals.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Neural circuits in zebrafish: form, function and plasticity
Investigator
Constance L Cepko, Florian Engert, Jeff W Lichtman, Haim Sompolinsky
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
Title
Novel Genetic Strategy for Sparse Labeling and Manipulation of Mammalian Neurons
Investigator
Xiangdong William Yang
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Cajal revolutionized the study of the brain through the use of the Golgi stain to label cells sparsely and stochastically in a fashion that revealed a neuron's morphology in its entirety.
Title
Novel technologies for nontoxic transsynaptic tracing
Investigator
Ian R Wickersham
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Genetic tools have dramatically increased the power and resolution of neuroscientific experiments, allowing monitoring and perturbation of specific neuronal populations within the brain, often in the context of complex cognitive and behavioral paradigms.
Title
Remote regulation of neural activity
Investigator
Sarah Amy Stanley
Institute
rockefeller university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): A fundamental goal of neuroscience is to understand the function(s) of defined neural populations in a complex organism. We propose to develop and validate a technology for non- invasive modulation of neural activity in vivo.
Title
Revealing the connectivity and functionality of brain stem circuits
Investigator
Darwin K Berg, Martin Deschenes, Yoav Shai Freund, Martyn D Goulding, David Kleinfeld, Per M Knutsen
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Neuronal circuits in the brainstem control life-sustaining functions, in addition to driving and gating active sensation through taste, smell, and touch.
Title
The role of patterned activity in neuronal codes for behavior
Investigator
John H.r. Maunsell
Institute
university of chicago
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): A key aspect of brain function is how the activity of neuronal populations encodes information that is used to guide behavior.
Title
Towards a Complete Description of the Circuitry Underlying Memory replay.
Investigator
Ivan Soltesz
Institute
university of california-irvine
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The function of a brain region is an emergent property of many cell types.
Title
Towards quantitative cell type-based mapping of the whole mouse brain
Investigator
Pavel Osten
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The mouse brain comprises ~70 million neurons and ~30 million glia and other cells. Neurons have been traditionally classified based on their morphology, connectivity, stimulus-response, gene expression, and location in the brain.
Title
Ultra-Multiplexed Nanoscale In Situ Proteomics for Understanding Synapse Types
Investigator
Mark Bathe, Edward S. Boyden, Peng Yin
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Significant work is ongoing to reveal how different cell types in the brain contribute to behavior and pathology, and how they change in plasticity and disease, empowered by new genetic, optical, and physiological tools.
Title
Vertically integrated approach to visual neuroscience: microcircuits to behavior
Investigator
Thomas Euler, Andrew D Huberman, Markus Meister, Hyunjune Sebastian Seung, Rachel O Wong
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Visual neuroscience is finally beginning to achieve a "vertically integrated" understanding of the retina, bridging all levels from molecules to microcircuits to behavior.