Project Summary Public and private research funders have heavily invested in the application of implantable neurotechnologies to improve the management of treatment-resistant conditions and loss of function (e.g., deep brain stimulation (DBS) systems for recovery after traumatic brain injury (TBI
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Post-trial Access, Clinical Care, Psychosocial Support, and Scientific Progress in Experimental Deep Brain Stimulation Research
Investigator
Joseph J. Fins, Gabriel Lazaro-Munoz
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Title
Postnatal experience shapes gene expression and connectivity development in the cortex
Investigator
Alexander Nevue
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Postnatal sensory experience has a profound effect on the maturation, composition, and connectivity of cortical cell types, but systematic analyses of these changes have not yet been feasible.
Title
Pre-motor neural circuits enable versatile and sequential limb movements
Investigator
Julie H Simpson
Institute
university of california santa barbara
Fiscal Year
Funding Opportunities Number
Project Number
Abstract Movements are measurable outputs of the nervous system and simple movements can be combined to compose complicated behaviors. We use limb tracking and connectome analyses to map the neural circuits controlling the elemental leg movements in Drosophila grooming.
Title
Probing form and function of memory representations in the hippocampus of memory expert birds
Investigator
Emily Lambert Mackevicius
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract Mental disorders that affect the hippocampus disrupt people’s ability to form one-shot memories. My goal is to lead an independent lab, linking biological properties of hippocampal neurons to the ability to perform memory- guided cognitive behaviors.
Title
Processing of visual information by spatial memory circuits in the avian brain
Investigator
Hannah L Payne
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT. Research Project: Spatial memory – memory of where an event happened or an object was located – depends on the hippocampus in a wide range of vertebrate species, including mammals and birds. In humans, most spatial memories are formed through visual experience.
Title
Role of coordinated multi-area reactivations during transitions between automatic and flexible behaviors.
Investigator
Maksim V Bazhenov, Joshua D Berke, Karunesh Ganguly
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Abstract Sleep occupies a large part of our lives and is widely believed to perform essential functions. During sleep, the neuronal rules of engagement and population dynamics are clearly different than waking.
Title
Role of cortical connections to higher-order thalamic nuclei in visual decision-making
Investigator
Ariana R Andrei
Institute
university of texas hlth sci ctr houston
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY To guide decisions, visual information must flow from primary visual cortex (V1) to prefrontal cortex (PFC), via multiple, parallel cortico-cortical and cortico-thalamo-cortical connections.
Title
Role of multi-regional neuronal reactivations in reward-based memories
Investigator
Celine Drieu
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The goal of this project is to provide the building blocks for an independent research program focused on the neural basis of reward-based memory across distributed brain networks.
Title
Scientific and Public Outreach of Cell Type Taxonomies (SPOCTT) Initiative
Investigator
Kaitlyn Casimo, Jeremy A Miller
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Single cell transcriptomics has transformed the field of brain cell type classification, allowing simultaneous measurement of enough molecular features from enough cells to categorize neurons quantitively and with high conservation across brain areas and species.
Title
Sensing and manipulating neuromodulatory signaling in vivo
Investigator
Haining Zhong
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Neuromodulation, such as that mediated by the neuromodulators norepinephrine, acetylcholine, and dopamine, imposes powerful control over brain function. It regulates the excitability, synaptic plasticity, and other aspects of neuronal function.
Title
Sex, Physiological State, and Genetic Background Dependent Molecular Characterization of CircuitsGoverning Parental Behavior
Investigator
Brandon Logeman
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT Parental care is essential for offspring well-being and survival yet requires a significant invest from adults without immediate benefit, suggesting the existence of hard-wired mechanisms governing its control.
Title
Systematic characterization of spinal cord stimulation effects on dorsal horn populations
Investigator
Andrei D Sdrulla
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
There is a substantial need to understand the fundamental biological mechanisms of neuromodulation therapies in order to improve clinical delivery and outcomes (RFA-NS-20-006).
Title
The development of multimodal dynamics in a short-term memory system
Investigator
Gregory Patrick Davis
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT Persistent activity in neural circuits supports a variety of brain functions from motor control to navigation to perceptual decision-making.
Title
The Impact of Vitamin D on mTOR Signaling, Seizures, and Motor Behavior in a Mouse Model of Hyperactive mTOR Induced Epilepsy and Ataxia
Investigator
David Narvaiz
Institute
baylor university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract Increased mammalian target of rapamycin (mTOR) signaling is a known cause of treatment resistant epilepsy.
Title
The Neuroimaging Brain Chart Software Suite
Investigator
Christos Davatzikos, Yong Fan, Ilya M Nasrallah, Haochang Shou
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
This study proposes to refine, integrate and disseminate the NeuroImaging Brain Chart (NIBCh) software toolbox and machine learning (ML) model library, an ecosystem of software components enabling constructive integration, statistical harmonization, and ML-centric data analyses across studies.
Title
Thermal-plex: fluidic-free, rapid sequential multiplexed imaging of RNA and protein in brain tissues
Investigator
Peng Yin
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Multiplexed imaging of brain cells and tissues can reveal critical details about the abundance and spatial organization of molecular targets.
Title
Time-varying spatiotemporal causal interactions in the functional brain networks
Investigator
Nan Xu
Institute
georgia institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
This proposal describes a five-year career development program to prepare the candidate, Dr.
Title
Tracking Flow of Attention in Visual Circuits Across the Brain
Investigator
Bilal Haider
Institute
georgia institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Sensory processing is a way to understand the nervous system in action. Behavioral context strongly affects sensory processing. For example, a brief visual stimulus is easier to detect if it appears in a predictable spatial location.
Title
UC Irvine Center for the production and distribution of cell-type-specific viral targeting reagents
Investigator
Gordon J Fishell, Xiangmin Xu
Institute
university of california-irvine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Gaining genetic access to specific cell types in rodents, non-human primates and other vertebrate species is critical for enabling targeted circuit manipulations to understand normal brain function and brain.
Title
Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform
Investigator
Patrick Goodwill
Institute
magnetic insight, inc.
Fiscal Year
Funding Opportunities Number
Project Number
In this SBIR grant proposal, “Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform,” we will develop the RF subsystem for a clinical magnetic particle imaging (MPI) platform to enable three classes of MPI applications: cell tracking, functional imaging, and endogen