Optical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation Deep brain stimulation (DBS) directly stimulates brain tissue via implanted electrodes.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Optical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation
Investigator
Xue Han
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
Title
Pinpointing the Cerebellum's Contribution to Social Reward Processing
Investigator
Haroon Skander Popal
Institute
temple univ of the commonwealth
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The cerebellum has long been thought to solely process motor information. Yet, there is a growing literature
that points to a role of the cerebellum in processes across multiple domains.
Title
Ribo-STAMPEDE: novel tools for molecular profiling of brain cell types
Investigator
Giordano Lippi, Eugene Wei-Ming Yeo
Institute
scripps research institute, the
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A detailed and comprehensive census of central nervous system (CNS) cell types and states is essential to our
understanding of the neural substrates of cognition and behavior.
Title
Role of Endocannabinoid System in Seizure Sensitivity in Eclampsia
Investigator
Maria Jones-Muhammad
Institute
university of mississippi med ctr
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Preeclampsia, a hypertensive disorder of pregnancy, can advance to eclampsia, when the mother
displays novel seizures. The mechanisms that cause some preeclampsia patients to advance to
eclampsia are unknown.
Title
Role of neuronal ensembles in cortical plasticity during learning and development
Investigator
Alejandro Akrouh
Institute
columbia univ new york morningside
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The brain undergoes extensive synaptic plasticity and circuit refinement during development. Similar
changes recur throughout life during learning in a more narrowly constrained manner.
Title
Scalable electron tomography for connectomics
Investigator
Mark H Ellisman, Wei-Chung Allen Lee
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
A fundamental goal in neuroscience is understanding how neural network function arises from circuit structure.
However, the immense complexity of most brain networks has been a significant barrier to progress.
Title
Scalable Molecular Pipelines for FAIR and Reusable BICAN Molecular Data
Investigator
Jesse Gillis, Timothy L Tickle, Owen R White
Institute
broad institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
This project will create scalable resources that will be critical to the development of BRAIN Initiative Cell Atlas
Network (BICAN) consortium brain atlases. This team will focus on the development of common molecular
data processing pipelines that are cloud-native and FAIR.
Title
Scalable technologies for brain-wide connectomics of transcriptomic cell types: focus on brainstem
Investigator
Jayaram Chandrashekar, Karel Svoboda
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project summary, Scalable technologies for brain-wide connectomics of
transcriptomic cell types: focus on brainstem
This proposal is to develop a scalable pipeline to combine high-resolution morphology and molecular
classification of individual neurons to define morpho-molecular cell types in the br
Title
Secondary analysis of resting state MEG data using the Human Neocortical Neurosolver software tool for cellular and circuit-level interpretation
Investigator
Stephanie Ruggiano Jones
Institute
brown university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The neuroscience community is experiencing a revolution in its ability to share and analyze vast amounts of
human brain imaging data, with support from the BRAIN Initiative and other substantial data-sharing efforts.
Title
Simultaneous high-throughput functional, transcriptomic and connectivity profiling using FUNseq
Investigator
Andreas Tolias, Anthony M Zador
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Recent advances in technology driven by the BRAIN Initiative have yielded new methods for characterizing the ac-
tivity, transcriptome, and microscale anatomy of neurons throughout the brain, and have increased the throughput
of these techniques by orders of magnitude.
Title
Spatiotemporal epigenomic and chromosomal architectural cell atlas of developing human brains
Investigator
Chongyuan Luo
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The adult human brain is comprised of numerous cell types exhibiting specific transcriptomic and epigenomic
signatures associated with their spatial location, connectivity, and function.
Title
Statistical machine learning tools for understanding neural ensemble representations and dynamics
Investigator
Uri Tzvi Eden, Loren M Frank, Alan David Kaplan
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
The brain is a massively interconnected network of specialized circuits.
Title
Systematic identification of enhancers to target the breadth of excitatory and inhibitory neuronal cell types in the cerebral cortex
Investigator
Paola Arlotta, Benjamin E Deverman, Gordon J Fishell, Yating Wang
Institute
broad institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
In this proposal we aim to identify gene regulatory elements that permit the targeting and
manipulation of brain circuit models of human brain function.
Title
Thalamus in the middle: computations in multi-regional neural circuits
Investigator
Adam G Carter, Jayaram Chandrashekar, Jorge H Jaramillo, Karel Svoboda, Bosiljka Tasic
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Summary, Overall (Thalamus in the middle: computations in multi-regional neural
circuits)
This collaborative project aims to uncover the logic of signal routing from subcortical areas to the frontal cortex
through the thalamus.
Title
The Disadvantage Exposome as a Driver of Alzheimer’s Disease Pathology
Investigator
Margo Heston
Institute
university of wisconsin-madison
Fiscal Year
Funding Opportunities Number
Project Number
1 PROJECT SUMMARY
2 Alzheimer's disease (AD) is the most common form of dementia worldwide, incurring a projected healthcare
3 burden of $1 trillion in the United States alone by 2060.
Title
The Heart and the Mind: An Integrative Approach to Brain-Body Interactions in the Zebrafish
Investigator
Florian Engert, Mark C Fishman, Adrienne L Fairhall, Jeff W Lichtman, Joshua T Vogelstein
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
The heart and the mind: an integrative approach to brain-body interactions in the
zebrafish
Our current U19 has focused primarily on Exteroception, which can be defined as the accumulated sensory experience
originating from events in the outside world.
Title
Tools for gene editing in marmosets
Investigator
Richard L Huganir, Christopher A Ross, James H. Segars, Xiaoqin Wang
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Tools for Gene Editing in Marmosets
SUMMARY
The goal of this proposal is to create an efficient new set of tools and techniques for the generation of
genetically modified marmosets suitable for use as models of brain physiology and function.
Title
Understanding how cortex supports flexible sensory representations
Investigator
Katherine Charlotte Wood
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Learning is a fundamental function of the brain: sensory representations must be flexible to adjust to changes in
environmental demands and experience, thus allowing us to adapt to the world around us.
Title
Virtual observatory of the cortex: organelles, cells, circuits, and dynamics
Investigator
Forrest Christie Collman, Nuno Macarico Da Costa, R Clay Reid, Hyunjune Sebastian Seung
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
We propose to create VOrtex, a Virtual Observatory for the Cortex: Spanning the Scales of Organelles, Cells,
Circuits, and Dynamics.
Title
Wearable RF-EEG Cap for closed loopTMS/fMRI/EEG Applications
Investigator
Lucia Isabel Navarro De Lara
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Functional MRI (fMRI) is the prevailing method for both basic research and clinical functional neuroimaging in
humans.