Funded Awards

Abstract: In this proposed research project, we seek to develop an advanced brain SPECT system that offers a unique hyperspectral imaging capability substantiated by an excellent energy resolution (e.g.,

Electroencephalography (EEG) measures the brain’s local field potential from the surface of the scalp. This method is useful for studying cognitive processes, neurological states, and medical conditions.

Project summary The heterogeneity from the vast number of cell types in the brain presents a major challenge in our understanding of how brain works and in our treatment of neurological disorders.

Abstract Advances in non-invasive monitoring of human brain function under normal and pathological conditions will lead to breakthroughs in our understanding of the brain in health and disease, and lead to the development of devices available for everyday use, with applications such as monitoring

PROJECT SUMMARY / ABSTRACT Functional MRI (fMRI) is today the predominant tool for noninvasive imaging of brain function, which has revolutionized our understanding of the human brain.

ABSTRACT Perceptually guided behavior involves a complex and dynamic interplay between external inputs and internal states that are related, for example, to alertness, motivation, expectations and attention.

Project Summary Schizophrenia is a debilitating mental illness affecting an estimated 1% of the global population.

Project Summary Learning and performing complex skills such as speech or music requires precise control of motor variability. While elevated motor variability can spur the learning of new behaviors, excessive variability can impair performance of learned skills.

ABSTRACT The generation of scientifically rich, high resolution neuroimaging volumes continues to increase in extent and rate due to the advancement of new Electron Microscopy (EM) and X-ray Microtomography (XRM) imaging sys- tems and data processing methodologies.

Years of study and theory about the unique role of the hippocampus in storing new memories has led to a general idea that the hippocampus generates a unique output code for every unique experience, that is projected back to the neocortex, where it becomes coupled to attributes of the experience t

Project Summary/Abstract The proposed project will demonstrate the feasibility of generating a complete synapse-level brain map (connectome) by developing a serial-section electron microscopy pipeline that could scale to a whole mouse brain.

Project Summary: Center for whole mouse brain connectomics using high-throughput integrated volumetric electron microscopy (HIVE) Two fundamental components of the structural basis of brain function are cell type composition and the wiring diagram between those cells.

PROJECT SUMMARY To understand complex neural pathways and networks and their remarkable ability to generate human behaviors, it is critical to precisely map brain connectomics in vivo.

SUMMARY This ambitious proposal will establish an integrated experimental-computational platform to create the first comprehensive brain-wide mesoscale connectivity map in a non-human primate, the common marmoset (Callithrix jacchus),.

Project Summary Mapping the brain-wide connections of neurons provides a foundation for understanding the structure and functions of a brain.

Project Summary/Abstract (30 lines of text limit) The ~1 billion neurons that form the human brainstem are organized at multiple scales, ranging from their cell type-specific patterns of dendritic arborization, to local circuits embedded within large-scale projection systems spanning the brainste

Project Summary/Abstract Volume electron microscopy is the only technique to-date that provides both sufficient resolution (100 μm) for the dense reconstruction of neuronal wiring diagrams.

Project Summary / Abstract Upcoming brain-wide descriptions of synaptic connectivity are poised to transform our understanding of brain circuitry in the same way single-cell genomics has revolutionized our understanding of cell type diversity.

SUMMARY High-throughput connectomics is needed to generate the TB-, PB- and EB-scale wiring diagrams of mammalian brains, but is limited to the few research institutes (e.g., Janelia, Allen, Max Planck) with sufficient infrastructure.

ABSTRACT Single-cell transcriptomics has revolutionized our understanding of neuronal diversity and enabled high-throughput characterization of molecular cell types across brain areas and species.