Project summary: This project will develop and validate a comprehensive toolset of novel technologies for imaging axonal projections across scales, and will deploy this toolset to map a complex system of cortico- subcortical projections in the macaque and human brain.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)
Investigator
Suzanne N Haber, Elizabeth M. C. Hillman, Anastasia Yendiki
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
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Title
Brain dynamics underlying long-term memory consolidation
Investigator
Priya Rajasethupathy
Institute
rockefeller university
Fiscal Year
Funding Opportunities Number
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Abstract The hippocampus has a well-established role in the initial formation and storage of memory. However, little is understood about brain mechanisms that support the re-organization and transfer of memories into longer-term cortical storage.
Title
Brain-wide mapping of neuronal inhibition by novel inverse activity markers
Investigator
Li Ye
Institute
scripps research institute, the
Fiscal Year
Funding Opportunities Number
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Abstract This project aims to develop the first Inverse Activity Marker (IAM) for detecting neuronal inhibition (broadly defined as the decrease of neuronal activities).
Title
Capturing the neural signature of the paraventricular thalamus that underlies individual variability in cue-motivated behavior
Investigator
Shelly Beth Flagel
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
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PROJECT SUMMARY/ABSTRACT Individuals make choices and prioritize actions using complex processes that assign value to rewards and associated stimuli based on prior experience.
Title
Cell type-specific mechanisms of history-dependent perceptual biases in sensory cortex
Investigator
Deepa L Ramamurthy
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Sensory representations are influenced by an animal’s external context, internal state, past experiences, expectations, and future goals.
Title
Center for Advanced Muscle BioElectronics (CAMBER)
Investigator
Muhannad Bakir, Samuel Sober
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
A central goal of neuroscience is to discover how neural circuits control the body’s muscles to produce behavior.
Title
Characterizing Lower Extremity Neurophysiological Responses to Sensory Augmentation after Stroke
Investigator
Jasmine Jamilah Cash
Institute
medical university of south carolina
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT After a stroke, walking ability can be compromised, which can lead to reduced quality of life and decreased ability to perform activities of daily living.
Title
Characterizing odor motion detection in flies
Investigator
Damon Alistair Clark, Thierry Emonet
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Many animals rely on their ability to navigate to the source of airborne odor plumes for survival. Studies dating back a century have shown that insects combine mechanosensory and olfactory cues to navigate, surging upwind when detecting odor but go crosswind or downwind when losing the signal.
Title
Circuit architecture and dynamics of the insular cortex underlying motivational behaviors
Investigator
Tianyi Mao, Haining Zhong
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The insular cortex (IC) is a multimodal hub that integrates interoceptive and exteroceptive information to control diverse aspects of animal behaviors related to cognition, emotion, and motivation.
Title
Circuit mechanisms of arbitration between distinct reinforcement learning systems
Investigator
Margaret Louise Demaegd
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Animals can exhibit goal-directed behaviors in novel environments, despite limited experience with them. How does the brain make and use inferences about the underlying statistics and generative structure of environments to guide behavior?
Title
Circuit-specific, chemogenetic neuromodulation in nonhuman primates.
Investigator
Serge E Przedborski, Charles E Schroeder
Institute
nathan s. kline institute for psych res
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT ‒ UG3/UH3 Deep Brain Stimulation (DBS), applied to areas like the subthalamic nucleus (STN), is a standard treatment for Parkinson Disease (PD), however, DBS has inherent surgical risks as well as potential for infections and adverse side effects.
Title
Cognitive and Neural Strategies for Latent Feature Inference
Investigator
Tahra Eissa
Institute
university of colorado
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The world around us has a statistical structure that we can use to improve our choices. Learning the underlying structure by identifying key features, such as the rate of change, is useful for adapting and optimizing our decision-making strategies.
Title
Commercial translation of high-density carbon fiber electrode arrays for multi-modal analysis of neural microcircuits
Investigator
Rajmohan Bhandari, Cynthia Anne Chestek, Daniel Powell, Florian Solzbacher
Institute
blackrock microsystems
Fiscal Year
Funding Opportunities Number
Project Number
The ability to measure and manipulate local brain circuit activity in living, behaving animals is essential to understanding the complexities of brain function and dysfunction.
Title
Contextual modulation of visual decision-making across the visual hierarchy
Investigator
Pamela Reinagel
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract In sensory decision-making, choices are influenced by non-sensory factors such as motivation, attention, and recent trial history.
Title
CONVERGENT PROCESSING ACROSS VISUAL AND HAPTIC CIRCUITS FOR 3D SHAPE PERCEPTION
Investigator
Charles E Connor, Daniel Hans O'connor
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
THEORETICAL FRAMEWORK: Vision and touch share a critical function—perception of 3D object shape.
Title
Cortical assembly formation through excitatory/inhibitory circuit plasticity
Investigator
Brent D. Doiron, Anne-Marie Michelle Oswald
Institute
university of chicago
Fiscal Year
Funding Opportunities Number
Project Number
Cortical assembly formation through excitatory/inhibitory circuit plasticity. Project Summary Throughout the brain, sensory information is thought to be represented by the joint activity of neurons that form functionally connected assemblies.
Title
Cortical circuit dynamics underlying multisensory decision making
Investigator
Christopher R Fetsch
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary To navigate and guide locomotion in a complex 3D environment, humans and animals must make countless judgments of their direction of self-motion, or heading.
Title
Cross-modal sensory interactions, processing, and representation in the Drosophila brain
Investigator
Itai Cohen, Noah John Cowan, Jessica Fox, Sung Soo Kim
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
Robust navigation, which is critical for an animal’s survival, requires the processing of complex sensory information spanning different modalities and time scales.
Title
Deconstructing the sertonin system in the mouse brain
Investigator
Liqun Luo, Scott Warren Linderman
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Serotonin is an evolutionarily conserved neurotransmitter that modulates the activity of excitatory and inhibitory neurons throughout the entire mammalian brain and is thus essential for diverse aspects of physiology and behavior.
Title
Developing novel neural network tools for accurate and interpretable dynamical modeling of neural circuits
Investigator
Christopher Versteeg
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract In recent years, the number of neurons that we can record simultaneously has seen an exponential increase, presenting a daunting challenge: how do we analyze these complex and high-dimensional datasets to gain insight into how neural circuits perform computation?