Project Summary
Understanding cell-type-specific gene functions, expression dynamics, and regulatory
mechanisms in complex brains is still challenging.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleMachine learning analyses of single-cell multi-modal data for understanding cell-type functional genomics and gene regulation
Investigator
Daifeng Wang
Institute
university of wisconsin-madison
Fiscal Year
Funding Opportunities Number
Project Number
TitleMachine Learning Augmented Discovery of AAV Capsids for Cell Type Specific Access into Human Neurons and Glia
Investigator
Tomasz Nowakowski, David V Schaffer, Vikaas Singh Sohal
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The human brain contains an astonishing diversity of neuronal and glial cell types distributed across dozens of
functional areas.
TitleMechanisms of Transplanted Cortical Interneuron Survival and Function
Investigator
Benjamin Rakela
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Cortical interneurons (cINs) are inhibitory cells that are born in surplus far from the cortex. During prenatal
timepoints, cIN precursors migrate into the mouse visual cortex (V1) where only a fraction are selected to
survive.
TitleMesh electronics for understanding space encoding in the amphibian brain
Investigator
Lisa Giocomo, Guosong Hong, Lauren A O'connell
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Many animals rely on spatial cognition for daily survival in order to recognize familiar places and process movements
through or between locations. A variety of space-encoding cells in the hippocampus are important for spatial behaviors
in mammals.
TitleMicroscope system for large scale optical imaging of neuronal activity using kilohertz frame rates
Investigator
Jacob R Glaser
Institute
microbrightfield, llc
Fiscal Year
Funding Opportunities Number
Project Number
This project aims to develop the 2P-ActivityScope™, a revolutionary new microscope based on a technological breakthrough called second-generation Scanned Line Angular Projection (SLAP2) two photon laser scanning microscopy that was recently developed by Dr.
TitleMolecular and circuit mechanisms of nausea-associated behaviors
Investigator
Chuchu Zhang
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project summary
Nausea is an unpleasant sensation of visceral malaise often accompanied by an involuntary urge to vomit.
Nausea responses to toxin ingestion and infection are evolutionarily beneficial survival behaviors that
avoid or expel toxins which may cause peripheral tissue damage.
TitleMolecular and sensory foundations of vestibular reflex circuit assembly in the larval zebrafish
Investigator
Dena Goldblatt
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY: Behavioral dysfunction in neurodevelopmental diseases often arises from aberrant
neural circuit assembly. However, the developmental logic that dictates circuit organization, function, and
ultimately behavior remains unresolved due to the complexity of most circuits.
TitleMotor Recovery through Plasticity-Inducing Cortical Stimulation
Investigator
Steven C. Cramer, Jeffrey G Ojemann
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Limited recovery of function after stroke remains a major problem for millions. Disability persists in
many, especially when hand function is limited. Existing therapies are limited and many have difficulties with
activities of daily living, even after rehabilitation.
TitleMulti-probe minimally invasive endomicroscope
Investigator
Antonio Miguel Caravaca Aguirre
Institute
modendo inc.
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
This project seeks to develop a multi-probe ultrathin endomicroscope to enable high-resolution imaging and
photo-stimulation at multiple sites within currently inaccessible regions of the brain.
TitleMultimodal dissociation of posterior cingulate cortex contributions to episodic memory
Investigator
Seth Ryan Koslov
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Episodic memory is the ability to recall details about prior experiences. Researchers have historically relied on
controlled item-recognition paradigms, in complement to autobiographical recall tasks, to investigate the
biological substrates of episodic memory.
TitleNetwork based neuro-modulation for mesial temporal lobe epilepsy
Investigator
Behnaam Aazhang, Sandipan Pati Bankim Behari Pati, Nitin Tandon, Gregory A Worrell
Institute
university of texas hlth sci ctr houston
Fiscal Year
Funding Opportunities Number
Project Number
TitleNeural basis of facial individual recognition in paper wasps
Investigator
Michael J Sheehan
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
The neural circuits of animals, including humans, are the combined product of adaptation by natural selection
and the evolutionary history of a species.
TitleNeural circuit control of fluid and solute clearance during sleep
Investigator
Patrick James Drew, Hajime Hirase, Douglas H Kelley, Laura Diane Lewis, Maiken Nedergaard
Institute
university of rochester
Fiscal Year
Funding Opportunities Number
Project Number
Program abstract: This proposal aims to identify the neural circuit mechanisms that control periarterial
cerebrospinal fluid (CSF) pumping and glymphatic clearance of fluid and solutes.
TitleNeural circuit mechanisms for multisensory associative learning
Investigator
Roudabeh Behnia, Ashok Litwin-Kumar
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The brain uses sensory representations to assess risk and predict reward in order to adjust behavior. Per
ception is a multisensory process. To make reliable predictions, it is advantageous for the brain to combine
more than one sensory modality to represent the world.
TitleNeural coding of natural stimuli in freely moving macaque
Investigator
Valentin Dragoi
Institute
university of texas hlth sci ctr houston
Fiscal Year
Funding Opportunities Number
Project Number
Despite the fact that visual perception represents such a fundamental aspect of our everyday life, our knowledge
of the underlying neural coding of natural stimuli is woefully lacking.
TitleNeural mechanisms of behavioral coordination in Hydra
Investigator
Alison Hanson
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
How do animals coordinate their many parts to generate coherent, adaptive behavior?
TitleNeural mechanisms of taste and metabolic state integration in the brainstem
Investigator
Nilay Yapici
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The taste of food is a critical factor that determines whether an organism will accept or reject a food source.
TitleNEURODEVELOPMENTAL FUNCTION OF HCFC1
Investigator
Victoria L Castro
Institute
university of texas el paso
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Mutation of HCFC1 causes a multiple congenital anomaly syndrome characterized by inborn errors of cobalamin
metabolism, intractable epilepsy, intellectual disability, and motor dysfunction.
TitleNeurodevelopmental role of a tRNA methyltransferase underlying intellectual disability
Investigator
Kimberly Rose R. Madhwani
Institute
brown university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Gene regulation at multiple levels is critical for nervous system development and function.
TitleNew Methodologies for Connectomics
Investigator
Xiaotang Lu
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT ABSTRACT
The nervous systems of animals are comprised of neurons connected by a large number of synapses.
The resulting neural networks underlie animal behavior and contribute to the storage of learned
information in many species.