The brain is a massively interconnected network of specialized circuits.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleStatistical machine learning tools for understanding neural ensemble representations and dynamics
Investigator
Uri Tzvi Eden, Loren M Frank, Alan David Kaplan
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
TitleSystematic identification of enhancers to target the breadth of excitatory and inhibitory neuronal cell types in the cerebral cortex
Investigator
Paola Arlotta, Benjamin E Deverman, Gordon J Fishell, Yating Wang
Institute
broad institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
In this proposal we aim to identify gene regulatory elements that permit the targeting and
manipulation of brain circuit models of human brain function.
TitleThalamus in the middle: computations in multi-regional neural circuits
Investigator
Adam G Carter, Jayaram Chandrashekar, Jorge H Jaramillo, Karel Svoboda, Bosiljka Tasic
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Summary, Overall (Thalamus in the middle: computations in multi-regional neural
circuits)
This collaborative project aims to uncover the logic of signal routing from subcortical areas to the frontal cortex
through the thalamus.
TitleThe Disadvantage Exposome as a Driver of Alzheimer’s Disease Pathology
Investigator
Margo Heston
Institute
university of wisconsin-madison
Fiscal Year
Funding Opportunities Number
Project Number
1 PROJECT SUMMARY
2 Alzheimer's disease (AD) is the most common form of dementia worldwide, incurring a projected healthcare
3 burden of $1 trillion in the United States alone by 2060.
TitleThe Heart and the Mind: An Integrative Approach to Brain-Body Interactions in the Zebrafish
Investigator
Florian Engert, Mark C Fishman, Adrienne L Fairhall, Jeff W Lichtman, Joshua T Vogelstein
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
The heart and the mind: an integrative approach to brain-body interactions in the
zebrafish
Our current U19 has focused primarily on Exteroception, which can be defined as the accumulated sensory experience
originating from events in the outside world.
TitleThe interaction of cortical and subcortical processing in natural sensory behavior
Investigator
Cristopher M Niell, Michael Wehr
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Our brains have evolved to extract relevant sensory information from rich and complex natural environments in
order to drive appropriate behavior.
TitleThe Neural Circuit Basis of Olfactory Navigation in Adult Drosophila
Investigator
Katherine Nagel
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
In order to forage effectively for food, the brain must integrate innate and learned information about the
value of different food odors and use this information to select navigational motor programs.
TitleThe Spatial and Temporal Scale of Neuromodulation in Mouse Sensory Cortex
Investigator
Jacob Reimer
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
The neuromodulators acetylcholine (ACh) and norepinephrine (NE) are associated with an
activated cortical brain state characterized by an increase in the reliability of cortical responses
to external stimuli and enhanced performance on behavioral tasks.
TitleTools for gene editing in marmosets
Investigator
Richard L Huganir, Christopher A Ross, James H. Segars, Xiaoqin Wang
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Tools for Gene Editing in Marmosets
SUMMARY
The goal of this proposal is to create an efficient new set of tools and techniques for the generation of
genetically modified marmosets suitable for use as models of brain physiology and function.
TitleTracking the emergence of internal models
Investigator
Elizabeth A Buffalo, Adrienne L Fairhall
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Central to human and animal cognition is the idea of internal models: an internal repository of
knowledge about the structure of the world and its affordances that enables prediction and
planning. The existence of such models is fundamental to experience.
TitleUltrafast high-contrast voltage imaging in freely moving animals
Investigator
Jerome Mertz
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
We propose to develop a targeted illumination confocal (TICO) microscope to enable high speed,
large-scale voltage imaging in the brain. This microscope will be based on the combination of two
key strategies. The first strategy is high-speed confocal microscopy based on line scanning.
TitleUnderstanding feedforward and feedback signaling between neuronal populations
Investigator
Adam Kohn, Christian Machens, Byron M. Yu
Institute
albert einstein college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Most perceptual, cognitive, and motor functions rely on neuronal activity distributed across multiple networks,
often located in different brain areas.
TitleUnderstanding how cortex supports flexible sensory representations
Investigator
Katherine Charlotte Wood
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Learning is a fundamental function of the brain: sensory representations must be flexible to adjust to changes in
environmental demands and experience, thus allowing us to adapt to the world around us.
TitleVirtual observatory of the cortex: organelles, cells, circuits, and dynamics
Investigator
Forrest Christie Collman, Nuno Macarico Da Costa, R Clay Reid, Hyunjune Sebastian Seung
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
We propose to create VOrtex, a Virtual Observatory for the Cortex: Spanning the Scales of Organelles, Cells,
Circuits, and Dynamics.
TitleWearable modular high-density diffuse optical tomography
Investigator
Jason Wayne Trobaugh
Institute
esperimage llc
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
EsperImage, a startup company out of Washington University (WUSTL), will develop high fidelity, wearable,
optical technology that transcends limitations of both previous optical neuroimaging and magnetic resonance
imaging (MRI) tools to provide naturalistic brain imaging in adults a
TitleWearable RF-EEG Cap for closed loopTMS/fMRI/EEG Applications
Investigator
Lucia Isabel Navarro De Lara
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Functional MRI (fMRI) is the prevailing method for both basic research and clinical functional neuroimaging in
humans.
TitleWhole-Brain Functional Imaging and Analysis of Zebrafish Sleep
Investigator
Geoffrey J Goodhill, David Aaron Prober, Thai V. Truong
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Sleep occupies a third of our lives and sleep-related ailments cost an estimated $100 billion per year, yet the
mechanisms governing its regulation remain poorly understood.
TitleA 3D multimodal micron-scale human brain atlas bridging single cell data, neuropathology and neuroradiology
Investigator
Partha Pratim Mitra, Jiangyang Zhang
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Digitized reference brains, also referred to as Common Coordinate Frameworks (CCFs), together
with superposed atlas annotations, are of central importance to neuroscience. They bear the
same relation to neuroscience as do reference genomes and genome annotations to cellular and
molecular biology.
TitleA cellular atlas of the primate and human basal ganglia
Investigator
Jason Daniel Buenrostro, Fei Chen, Gordon J Fishell, Evan Z Macosko
Institute
broad institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The human basal ganglia (BG) are a collection of subcortical regions whose diverse, specialized cell types
influence motor control, emotional regulation, habit formation, and higher cognition.
TitleA community-driven development of the brain imaging data standard (BIDS) to describe macroscopic brain connections
Investigator
Franco Pestilli
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The Brain Imaging Data Structure (BIDS) is a BRAIN initiative (R24 MH114705)
community-driven standard meant to maximize neuroimaging data sharing, and facilitate analysis tool
development.