Development of a high throughput system for molecular imaging of different cell types in mouse brain
tissues
Mass spectrometry imaging (MSI) is a powerful tool for developing detailed molecular maps of biological
tissues with high specificity and sensitivity.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Development of a high throughput system for molecular imaging of different cell types in mouse brain tissues
Investigator
Gaurav Chopra, Julia Laskin
Institute
purdue university
Fiscal Year
Funding Opportunities Number
Project Number
Title
Discovering the molecular genetic principles of cell type organization through neurobiology-guided computational analysis of single cell multi-omics data sets
Investigator
Z Josh Huang
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Understanding the biological principles of cell type diversity and organization is necessary for deciphering
neural circuits underlying brain function.
Title
Disentangling hippocampal and cortical contributions to episodic memory
Investigator
Alexa Tompary
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
This application describes a 5-year plan to investigate the neural dynamics that underpin distortion in memory,
integrating computational modeling approaches with functional neuroimaging (fMRI) and non-invasive brain
stimulation techniques (TMS).
Title
Dissecting active neural circuits regulating sensory and affective pain
Investigator
Akihiko Ozawa
Institute
florida atlantic university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Opioids as a pain medication has been the most preferred pain treatments in order to provide quick relief from
severe pain. Decades of opioid abuse have triggered negative impact on pain therapies.
Title
Dissecting sodium appetite circuits in the mammalian brain
Investigator
Yuki Oka
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Internal sodium balance is critical for many physiological functions, including osmoregulation and action
potentials. Deciphering the mechanisms that control sodium intake is essential for understanding the
principles of appetite regulation and sodium homeostasis in the body.
Title
Dissecting the role of neuronal-astroglial interactions in sleep homeostasis
Investigator
Ashley Miranda Ingiosi
Institute
washington state university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Insufficient sleep, sleep disorders, and resulting problems with health and cognition are increasingly common
in the United States.
Title
Dissecting the roles of timing in a canonical neural computation
Investigator
Damon Alistair Clark
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary [30 lines max]
Timing is critical to neural processing. Nowhere is that clearer than in visual motion detection. To detect
motion, neurons transmit visual information with different latencies, or delays, allowing the circuit to compare
visual scenes over time.
Title
Effects of abnormal early experience on IT circuitry
Investigator
Margaret S Livingstone
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The goal of the proposed research is to probe object-recognition circuitry in inferotemporal cortex by specific
manipulations of early visual experience.
Title
Engineered AAV Identification, Validation, and Dissemination Pipeline for Brain Cell Type-Specific Manipulation Across Species
Investigator
Andrew S Fox, Viviana Gradinaru, Timothy Francis Shay, Lin Tian
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY:
This team initiative will provide the broad neuroscience community with a cell type-specific adeno-
associated virus (AAV) armamentarium for easy and non-invasive implementation of novel and
emerging molecular tools for anatomical and functional analysis of the nervous system in rod
Title
Enhancing the spatial control of non-invasive brain stimulation by magnetic temporal interference
Investigator
John Gustaf Wilhelm Samuelsson
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Electromagnetic brain stimulation is a safe and proven way of controlling neural activity non-invasively with no
implanted hardware or injected biochemical agents.
Title
Ethical and Policy Aspects of Cortical Visual Prosthetics Research: An Empirical Neuroethics Study
Investigator
Peter David Zuk
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Brain-computer interfaces (BCIs) have emerged as a promising modality for restoring physiological functions
such as mobility, communication, and visual perception.
Title
Ethologically relevant short term memory in the olfactory bulb
Investigator
Matthew C Smear
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Short-term memory is an essential component of cognition. Here, we will investigate an ethologically
relevant form of short-term memory that guides navigation behavior: memory of odor concentration across
sniffs.
Title
Flexible normalization in ferret V1: computational modeling and 2-photon imaging
Investigator
Theoden I Netoff, Cheryl A. Olman, Gordon Brawn Smith
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The remarkable efficiency of human perception derives from the fact that we do not process each stimulus as a
novel event. Instead, past experiences and scene context inform internal, working models of the world that
allow us to generate predictions for our physical environment.
Title
fMRI physiological signatures of aging and Alzheimer's Disease
Investigator
Catherine Elizabeth Chang
Institute
vanderbilt university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
The growing availability of large functional magnetic resonance imaging (fMRI) datasets has enabled new
investigations into functional systems of the human brain.
Title
From synapses to genes through morphology: an integrated characterization of cell types based on connectomics and transcriptomics data
Investigator
Forrest Christie Collman, Nuno Macarico Da Costa, R Clay Reid
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The goal of this project is to create a unified framework for understanding the relationship between
neuronal gene expression and connectivity in mouse visual cortex, by using morphology as a key
linking modality.
Title
Functional and cell-type specific axonal pathways in the primate brain
Investigator
R Clay Reid
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Over the past decade, there have been transformative advances in three areas of mammalian neuroscience.
First, our ability to record from large populations of neurons has dramatically increased with the advent of new
electrode technologies and improved multiphoton imaging.
Title
Genetic and neural mechanisms underlying emerging social behavior in zebrafish
Investigator
Florian Engert, Mark C Fishman
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
Genetic and neural mechanisms underlying emerging social behavior in zebrafish
Our goal is to understand emerging collective behaviors of groups, such as schooling and shoaling in fish.
Our approach is to dissect basic sensorimotor transformations in the zebrafish, which we believe play a
fundamenta
Title
Harmonizing and Archiving of Large-scale Infant Neuroimaging Data
Investigator
Gang Li
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
The first postnatal years are an exceptionally dynamic and critical period of structural and functional development
of the human brain. Many neurodevelopmental disorders are the consequence of abnormal brain development
during this stage.
Title
Hemogenetic imaging technology for circuit-specific analysis of primate brain function
Investigator
Alan Jasanoff
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Primate brains contain cortical areas that exhibit selective engagement in high-level sensory or behavioral
operations. The functional specialization of these regions is thought to be central to primate-specific cognitive
faculties and to associated disorders.
Title
Heritability and cognitive implications of structural-functional connectome coupling
Investigator
Amy Kuceyeski
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
The human brain is an unimaginably complicated system of interconnected neurons that is capable of complex
thought, emotion and behavior.