PROJECT SUMMARY
Social insects show robust and complex behaviors, and have served as important study systems in ethology
for decades.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleRepresentation and modulation of social information in the ant chemosensory system
Investigator
Daniel Kronauer
Institute
rockefeller university
Fiscal Year
Funding Opportunities Number
Project Number
TitleResolving Spatiotemporal Determinants of Cell Specification in Corticogenesis with Latent Space Methods
Investigator
Genevieve Lauren Stein-O'brien
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
High-throughput profiling of hundreds of thousands of cells in the central nervous system (CNS) is currently
underway.
TitleResource Core 3 - Teaching/Training/Dissemination Core (TTDC)
Investigator
Maisie Ky Lo
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Resource Core 3 - Teaching/Training/Dissemination Core (TTDC)
Leads: Maisie Lo PhD and Kristin Overton PhD
Summary
The TTDC’s teaching mission specifically leverages our educational infrastructure for advancing the
application of modern neurotechnology methods in short (3-day) or extended-format (
TitleRevealing neural circuits underlying zebrafish behavior using mesoscopic light field microscopy
Investigator
Oliver Strides Cossairt, Geoffrey J Goodhill
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
A critical step towards understanding how neural circuits drive behavior is the ability to record the activity of all
neurons in an organism while it interacts with its environment in an unconstrained manner.
TitleRNA-programmable cell type targeting and manipulation across vertebrate nervous systems
Investigator
Z Josh Huang
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Systematic experimental access to diverse neuronal cell types is a prerequisite to deciphering brain circuit
organization, function, and dysfunction.
TitleScalable 3D molecular imaging and data analysis for cell census generation
Investigator
Steve Presse, Douglas Shepherd
Institute
arizona state university-tempe campus
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
This project is a collaboration across two universities and multiple scientific disciplines to develop new scalable
3D molecular imaging and analysis approaches for cell type identification within human brain tissue.
TitleScalable integration of cell types and connectivity in the motor cortex of rodents and non-human primates
Investigator
Forrest Christie Collman, Nuno Macarico Da Costa, R Clay Reid
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The BICCN has recently completed a broad survey of the cellular components of motor cortex, including
transcriptomic profiling, patch-seq, multiplexed FISH, inter-areal connectivity, and single neuron morphology.
Missing from this view is a detailed picture of how individual neurons
TitleScalable tools for consistent identification of neuronal cell types in mouse and human
Investigator
Staci A Sorensen, Uygar Sumbul
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The proposed work will address a critical gap in our understanding of neuronal phenotypes and cell types by
developing machine learning algorithms and cloud-based software for the integration of multiple modality
characterizations large and growing datasets of cortical neurons in mou
TitleSecondary analysis of functional MRI and resting state connectivity in white matter
Investigator
John C Gore, Bennett A. Landman
Institute
vanderbilt university medical center
Fiscal Year
Funding Opportunities Number
Project Number
Abstract / Summary
This proposal aims to perform novel, secondary analyses on large archives of publicly-available fMRI
studies in order to quantify the functional characteristics of white matter (WM) and their changes during
normal aging and in the progression to Alzheimer’s Disease (AD).
TitleSensiTrak: Automated Assessment of Forelimb Sensation
Investigator
Andrew Michael Sloan
Institute
vulintus, llc
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
In this Phase I STTR project, Vulintus, Inc., in collaboration with Columbia University, proposes
to develop and test ‘SensiTrak,’ an automated, high-throughput behavioral system designed to
finely measure somatosensory function in rodent models.
TitleSex hormone regulation of Lateral Habenula circuitry for reward and aversion encoding
Investigator
Brandy A. Briones
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
This proposal seeks to investigate sex hormone effects on reward and aversion-related behaviors through
mapping of Lateral Habenula (LHb) circuits.
TitleSmall molecule regulation of endogenous transcription factors for circuit-specific neuromodulation
Investigator
Gerald R. Crabtree
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Methods for regulating cellular processes within distinct populations of neurons are needed to elucidate
relationships between molecular mechanisms, circuits, and behavior; and to develop cell type- or circuit-
selective treatments for neurological disorders.
TitleStability and Robustness of Hippocampal Representations of Space
Investigator
John C Doyle, Carlos Lois, Evgueniy Vassilev Lubenov, Athanassios Siapas
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
How does the brain balance the need to preserve prior knowledge with the necessity to continuously learn
new information? The tradeoff between stability and plasticity is inherent in both biological and artificial
learning systems constrained by finite resources and capacity.
TitleStimulation of novel spinal respiratory circuit to restore breathing in ventilator-dependent patients with SCI.
Investigator
Daniel Lu
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Respiratory failure after spinal cord injury (SCI) impairs the health of the injured patients, and respiratory failure
is the leading cause of death in patients with SCI.
TitleStrategy to map electrical synaptic connectivity in neural networks
Investigator
Sue A Aicher, Stephen C Massey, Catherine W Morgans, Christophe P. Ribelayga
Institute
university of texas hlth sci ctr houston
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
Electrical synapses, also known as gap junctions, occur frequently in all nervous systems, including the human
brain. They are composed of connexins, arranged to form intercellular channels between adjacent, coupled
cells. Connexin36 (Cx36) is the predominant connexin in the CNS.
TitleStructural variation in neuronal circuits as a basis for functional and behavioral individuality
Investigator
Bassem A Hassan, Wei-Chung Allen Lee, Benjamin De Bivort
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A fundamental gap in our knowledge of the nervous system is understanding how variations in wiring and
connectivity of neuronal circuits relate to variability in neural computations and behavior.
TitleStructure and function of spontaneous network activity during circuit formation
Investigator
Arnaldo Carreira-Rosario
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Towards the end of nervous system development, neural circuits are extremely plastic. Small perturbations
during this time can cause lifelong circuit and behavioral changes.
TitleThalamocortical Responsive Neurostimulation for the Treatment of Lennox-Gastaut Syndrome
Investigator
Martha J Morrell
Institute
neuropace, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Lennox-Gastaut Syndrome (LGS) is a devastating form of childhood onset epilepsy with cognitive
dysfunction and very frequent generalized onset seizures (GOS) often leading to injury.
TitleThe encoding of uncertainty in the Drosophila compass system
Investigator
Jan Drugowitsch, Rachel Wilson
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Strategic behaviors often take account of uncertainty. For example, if we are presented with two conflicting
pieces of information, we give less weight to the more uncertain source of information – i.e., the source of
information that leads to lower accuracy overall.
TitleThe first adaptable, 3D-formfitting microelectrode array for organoid-based models of neurological and neurodegenerative diseases
Investigator
Oliver Graudejus
Institute
bmseed, llc
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The proposed work aims at the development of an enhanced organoid-based in vitro pre-clinical drug
screening platform for neurological and neurodegenerative brain diseases.