Project Summary To determine the anatomical basis of complex neural behavior, it is critical to have the ability to trace more than one circuit simultaneously in the same animal.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Developing Novel Trans-Synaptic Viral Vectors for Orthogonal or Rapid Circuit Tracing
Investigator
Euiseok J Kim
Institute
university of california santa cruz
Fiscal Year
Funding Opportunities Number
Project Number
Title
Development of a combined Gamma/Positron system for molecular imaging of the human brain at sub-500 micron spatial resolution
Investigator
Shiva Abbaszadeh, Lars R Furenlid, Michael A King
Institute
university of arizona
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY We are proposing a new approach to a hybrid imaging modality that has been called “b+g” or “pamma-positron” Imaging [Gri07] that promises to simultaneously overcome 1) the sensitivity limits of single-gamma-ray-photon emission imaging, 2) the challenge of distinguishing between two differ
Title
Development of Quantum Magnetic Tunneling Junction Sensor Arrays for Brain Magnetoencephalography (MEG) under Natural Settings
Investigator
Jerome N Sanes, Gang Xiao
Institute
brown university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary The long-term objective of this project is to develop a revolutionary quantum mechanical solid-state magnetometer designed to non-invasively detect femtoTesla (fT) scale magnetic fields derived from the brain’s electrical activities during natural human experiences.
Title
Dissecting modular and redundant organization of cortical circuits
Investigator
Shaul Druckmann, Nuo Li
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Abstract In many cognitive processes, information is processed in a parallel manner across many brain regions.
Title
Dissemination of the Human Neocortical Neurosolver (HNN) software for circuit level interpretation of human MEG/EEG
Investigator
Stephanie Ruggiano Jones
Institute
brown university
Fiscal Year
Funding Opportunities Number
Project Number
HNN U24 DISSEMINATION PROJECT SUMMARY The Human Neocortical Neurosolver (HNN) neural modeling tool was developed with BRAIN Initiative funding (R01EB022889: 09/2016–06/2020) to meet the Initiative’s goal to “develop innovative technologies to understand brain circuits and ensembles of circuits th
Title
Distinct contributions of converging neural pathways to auditory learning
Investigator
Santiago Jaramillo, James Murray
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT Effective interpretation of sensory stimuli relies on the ability to discriminate stimulus features and link them to appropriate behavioral responses depending on past experience.
Title
Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchrony
Investigator
Zoe Rebecca Donaldson, Yevgenia Kozorovitskiy, John Rogers
Institute
northwestern university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The vertebrate brain has evolved to enable complex social interactions, essential for survival. Brains of animals engaged in a shared social interaction exhibit inter-brain synchronization of neural activity, detectable at several levels of analysis.
Title
ENABLING SUBMILLISECOND-TIMESCALE TWO-PHOTON RECORDING OF VOLTAGE DYNAMICS IN THREE DIMENSIONS IN VIVO
Investigator
Laurent Bourdieu, Francois St-Pierre
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT Because neurons integrate and process information via modulation of their membrane potential, the ability to monitor voltage is critical to understanding how single and groups of neurons compute.
Title
Functions of locus coeruleus norepinephrine neurons in decision making across multiple timescales
Investigator
Jeremiah Yaacov Cohen, Daniel Hans O'connor
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY Norepinephrine (NE) is a neurotransmitter released by a small number of neurons in the locus coeruleus (LC), with extensive innervation of the neocortex. Prior work in humans and other mammals led to the hypothesis that LC-NE neurons modulate multiple forms of decision making.
Title
Functions of the Cortical Amygdala in social behavior
Investigator
Antonio V Aubry
Institute
icahn school of medicine at mount sinai
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Aggression is an evolutionarily conserved behavior that controls social hierarchies and protects valuable resources like mates, food, and territory. In most cases, aggression is a necessary, adaptive component of social behavior.
Title
High-throughput 3D mapping of large mammalian brains via integration of precision tissue sectioning and light sheet imaging
Investigator
Ji Wang, Nicholas Bruce Evans, Hsuan Lee, Jeffrey Stirman
Institute
lifecanvas technologies, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Whole-brain mapping at the cellular and subcellular levels is crucial to systematically understand brain functions and disorders.
Title
High-throughput engineering of ligand-selective fluorescent biosensors for detecting endogenous and exogenous opioids
Investigator
Andre Berndt, Michael R Bruchas
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT Neuropeptide modulation of neuronal circuits is strongly linked to many crucial behaviors such as exploration, stress, memory formation, learning, and many pathophysiological conditions.
Title
High-throughput measurement of neuronal projections and synapses using Synapse-seq
Investigator
Evan Z Macosko
Institute
broad institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY The brain is composed of thousands of highly specialized cell types that form very specific synaptic connections with each other. Together, these connections form neural circuits that are the structural basis of brain function.
Title
Highly multiplexed circuit mapping using barcoded rabies viruses and in situ sequencing.
Investigator
Ian R Wickersham, Shenqin Yao
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT Understanding the function of neural circuits requires thorough investigation of two circuit elements: cell types and connectivity.
Title
Hybrid TMS/MRI system for regionally tailored causal mapping of human cortical circuits and connectivity
Investigator
Berkin Bilgic, Susie Yi Huang, Aapo Nummenmaa, Jason P Stockmann
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary. We propose a new coil array that will enable next-generation causal brain mapping with unprecedented flexibility, resolution and precision.
Title
Identifying human-specific neural progenitors and their role in neurodevelopment
Investigator
Sumin Jang
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT Humans have highly advanced cognitive abilities and motor skills, characteristics which are reflected in the enlarged size and cell diversity of our central nervous system (CNS).
Title
Identifying the neural mechanisms of goal-directed decision-making in Parkinson's disease using closed-loop deep brain stimulation
Investigator
Colin Hoy
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
TITLE: IDENTIFYING THE NEURAL MECHANISMS OF GOAL-DIRECTED DECISION-MAKING IN PARKINSON’S DISEASE USING CLOSED-LOOP DEEP BRAIN STIMULATION PROJECT SUMMARY People with Parkinson’s disease commonly suffer from non-motor symptoms, including motivation deficits, that impact quality of life more than c
Title
Implications of Prefrontal Cortex Development for Adolescent Reward Seeking Behavior
Investigator
Gabriela Manzano Nieves
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY As we get older, we learn to modulate our behaviors to optimize reward outcomes. These adaptive choices are orchestrated by current sensory conditions, internal cognitive states, and future expectations.
Title
Improving Recruitment, Engagement, and Access for Community Health Equity for BRAIN Next-Generation Human Neuroimaging Research and Beyond (REACH for BRAIN)
Investigator
Susie Yi Huang, Jonathan David Jackson, Francis X Shen
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract Although BRAIN 2.0 called for the BRAIN Initiative to “prioritize diversity and inclusion as a fundamental pillar,” research with the human neuroimaging technologies being developed by BRAIN Initiative continues to rely on non-representative convenience samples.
Title
Integrating single-cell connectivity, gene expression, and function in zebra finches
Investigator
Justus M Kebschull
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The courtship song of male zebra finches is a classical model for learning complex motor behaviors and shows important parallels to human speech and communication. Male zebra finches learn a song from an adult tutor and then reproduce this song throughout adulthood.