Our senses aren’t passive. Rather, we actively seek relevant information via sampling movements.
However, experiments in sensory systems often restrict sampling movements to simplify stimulus delivery
and allow large scale imaging and electrophysiology.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Active sensing at the sensory surface: glomerular signals for olfactory navigation by freely-moving mice
Investigator
Matthew C Smear
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
Project Number
Title
Activity-dependent mechanisms for memory circuit maturation.
Investigator
Sarah Leinwand
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Adult behavior is the product of neural circuits that have been sculpted during development by
genetic programs and experience in the form of neural activity.
Title
Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease: An Investigation of STN LFP Biomarkers In Sleep Dysregulation and Repair
Investigator
Aviva Abosch, Casey Harrison Halpern, Clete A Kushida, John A Thompson
Institute
university of nebraska medical center
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Parkinson’s disease (PD) is a neurodegenerative disorder that leads to both motor and non-motor symptoms.
While there is as yet no cure for PD, medical and surgical therapies have been developed that effectively target
the motor symptoms of PD.
Title
An Ethical Approach to Detecting Covert Consciousness
Investigator
Michael J Young
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Alarming shortcomings of the bedside behavioral examination in reliably detecting consciousness generate
profound dilemmas for clinicians and families facing decisions about continuation of life-sustaining therapy, pain
control, prognostication, and resource allocation in patients wi
Title
An integrated platform for studying sensory networks in the vertebrate brain
Investigator
Ethan Kime Scott
Institute
university of queensland
Fiscal Year
Funding Opportunities Number
Project Number
7. Project Summary/Abstract
Human experience is shaped by our senses, which receive diverse inputs from our
environment. These varied inputs, however, all contribute to a single integrated
representation in our minds of the outside world.
Title
Bicoastal Marmoset Breeding Center
Investigator
Xiaoqin Wang
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The common marmoset (Callithrix jacchus) has experienced unprecedented growth in research across the
United States and is rapidly emerging as a likely keystone biomedical model system in the next chapter of
scientific discovery.
Title
Bidirectional Interactions of Cortex and Basal Ganglia During Action Selection
Investigator
Allison Elizabeth Girasole
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Selecting future actions based on previous experiences is key to an animal's survival. This process, known as
action selection, depends on the proper function of cortical and subcortical basal ganglia circuits.
Title
Biophysical modeling of the functional MRI signal through parametric variations in neuronal activation and blood vessel anatomy using realistic synthetic microvascular networks
Investigator
Grant Hartung
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
The most widespread tool for measuring brain activity noninvasively in humans is functional magnetic resonance
imaging (fMRI), which typically tracks changes in blood flow and oxygenation using the blood-oxygenation-level-
dependent (BOLD) signal.
Title
Brain States and Flexible Behavior
Investigator
Santiago Jaramillo, David Mccormick, Cristopher M Niell
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
To survive in dynamic environments, the nervous system must be able to generate flexible behavior —
seamlessly weaving together past experience with the present context to achieve future goals.
Title
Brainstem circuits of corticospinal neurons
Investigator
Gordon M Shepherd
Institute
northwestern university at chicago
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Corticospinal axonal projections are critical for mammalian motor control.
Title
Cell type selective viral tools to interrogate and correct non-human primate and human brain circuitry
Investigator
Franck K Kalume, Ed Lein, Boaz Pirie Levi, Jonathan T Ting
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Abstract:
Many cell types together assemble the functional circuitry of the human brain. For over a century, neuroscientists
have categorized brain cell types by their features, including shape, position, physiology, molecules, and
function.
Title
Central neuronal circuitry for homeostatic thermoregulation modulated by brain temperature
Investigator
Lily Y Jan
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Maintenance of body temperature at the optimal level is crucial for survival, and it requires homeostatic
feedback regulation based on monitoring the temperature of internal organs as well as the environment.
Homeostatic thermoregulation in response to changes of brain temp
Title
Characterizing the structure of motor cortex activity across multiple behaviors for improved brain-machine interfaces
Investigator
Karen Elizabeth Schroeder
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract. Candidate and career goals: I am an engineer by training, with a strong background in
neural engineering and the development of motor brain-machine interfaces (BMIs). My career goal is to establish
an independent nonhuman primate (NHP) laboratory with two primary aims.
Title
Circuit and cellular mechanisms underlying hierarchical recruitment of motor neurons.
Investigator
Brandon J Mark
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A fundamentally important motor pattern for terrestrial animals is walking. Walking requires precise
control of large numbers of motor neurons.
Title
Circuit dynamics of sensorimotor integration and decision making in octopus
Investigator
Galit Pelled
Institute
michigan state university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The goal of this proposal is to identify fundamental sensorimotor circuits associated with
goal-oriented gripping movement by using high-dimensional biological, analytical and robotics
technologies.
Title
Cloud-based Software Framework to Simplify and Standardize Real-Time fMRI
Investigator
Jonathan D Cohen, Kenneth A Norman
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: (30 lines of text max)
We propose to create an open-source cloud-based software system for real-time fMRI neurofeedback
experiments.
Title
Collaborative Expansion of Marmoset Colonies for Neuroscience Research
Investigator
Jon E Levine, Jeffrey A. Rogers, Corinna Nicole Ross
Institute
university of wisconsin-madison
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Demand for the common marmoset (Callithrix jacchus) in biomedical research has increased tremendously over
the past five years, as they have emerged as a critical biomedical model system in a variety of study disciplines.
The increased use of marmosets has been most acute in neuroscience, wh
Title
Combined Topological and Machine Learning Tools for Neuroscience
Investigator
Michael Hawrylycz, Partha Pratim Mitra, Yusu Wang
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Two major recent advances have raised the possibility of fundamental breakthroughs in both
basic and clinical neuroscience: the development of new tools to probe the nervous system with
single-cell resolution as well as brain-wide scope, and breakthroughs in machine learning
methods for handling com
Title
Context-dependent neural processing of leg proprioception in Drosophila
Investigator
Sweta Agrawal
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Proprioception is critical for effective motor control: dysfunctions of the proprioceptive system can impair
balance, motor coordination, and motor learning.
Title
Coordinating center for collaborative marmoset research
Investigator
Donald F. Conrad, Jon E Levine, Corinna Nicole Ross
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
The common marmoset (Callithrix jacchus) has emerged as a critically important and tractable non-human
primate (NHP) model for neuroscience research accommodating genetic manipulation and directed breeding.
Several barriers to the adoption of marmoset models by the neuroscie